thymidine has been researched along with hypoxanthine in 94 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 45 (47.87) | 18.7374 |
| 1990's | 27 (28.72) | 18.2507 |
| 2000's | 11 (11.70) | 29.6817 |
| 2010's | 11 (11.70) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Bloomer, LC; Patil, VD; Townsend, LB; Wise, DS; Wotring, LL | 1 |
| Gangjee, A; Jain, HD; Kisliuk, RL; McGuire, JJ | 1 |
| Gangjee, A; Kisliuk, RL; Lin, X; McGuire, JJ | 1 |
| Aran, JM; Plagemann, PG | 1 |
| Farley, BA; Giuliano, R; LaBella, S; Leary, JF; Rowley, PT | 1 |
| Bagnara, AS; Gero, AM; Matias, C; Nott, SE; O'Sullivan, WJ | 1 |
| Mikami, T; Narita, T; Niikura, M | 1 |
| Nagai, M; Nakamura, H; Olah, E; Prajda, N; Szekeres, T; Weber, G | 1 |
| Chan, TC; Howell, SB | 1 |
| McEachern, D; Miller, BE; Miller, FR | 1 |
| Chang, CC; Li, IC; Trosko, JE | 1 |
| Borman, LS; Branda, RF; Libbus, BL; Ventrone, CH | 1 |
| Booker, L; Browman, GP; Spiegl, P | 1 |
| Laurensse, E; Leyva, A; Peters, GJ; Pinedo, HM | 1 |
| Henderson, JF; Noujaim, MJ; Zombor, G | 1 |
| Akiyama, Y; Kiriyama, Y; Kito, T; Kubota, M; Mikawa, H; Takimoto, T; Tanizawa, A | 2 |
| Brun, R; Kunz, C | 1 |
| Hanson, S; Ullman, B | 1 |
| Bunni, M; Chou, TC; Galivan, J; Johnson, TB; Nair, MG; Priest, D; Rhee, MS | 1 |
| Dinkl, E; Grummt, F; Holst, A; Müller, F; Schwender, S; Zastrow, G; Zentgraf, H | 1 |
| Bast, BJ; De Lau, WB; Heije, K; Valerio, D; Van Loon, AE | 1 |
| Schwartz, JL; Weichselbaum, RR | 1 |
| Bartal, AH; Feit, C; Hirshaut, Y | 1 |
| Houghton, JA; Houghton, PJ; Meyer, WH | 1 |
| Maines, MD; Rowley, PT; Trakshel, GM | 1 |
| Bertino, JR; Handschumacher, RE; Sobrero, AF | 1 |
| Akiyama, M; Awa, AA; Hakoda, M; Kobuke, K; Kyoizumi, S; Yamakido, M | 1 |
| Konola, JT; Lyerla, TA; Raghavan, S; Skiba, MC | 1 |
| deFazio, A; Hughes, JM; Tattersall, MH | 1 |
| Ikewaki, N; Yamaura, N | 1 |
| Heppner, GH; Miller, BE; Miller, FR; Wilburn, DJ | 1 |
| Farley, B; Giuliano, R; LaBella, S; Leary, JF; Ohlsson-Wilhelm, BM; Rowley, PT | 1 |
| Burres, NS; Cass, CE | 1 |
| Fischer, PH; Pangallo, CA; Van Mouwerik, TJ; Willson, JK | 1 |
| Björklund, G; Jernberg, H; Nilsson, K | 1 |
| Chawla, RR; Freed, JJ; Hampton, A; Kappler, F | 1 |
| Moolten, FL | 1 |
| Galloon, T; Harley, EH; Steyn, LM | 1 |
| Matsuya, Y; Takada, M; Yabe, N; Yamane, I | 1 |
| Abidi, TF; Plagemann, PG; Stollar, V; Woffendin, C | 1 |
| Brindley, L; Doyle, MV; Larrick, JW | 1 |
| Harley, EH; Steyn, LM | 1 |
| Plagemann, PG; Wohlhueter, RM | 1 |
| Farley, BA; Ohlsson-Wilhelm, BM; Rowley, PT; Rudolph, NS | 1 |
| Lelie, PN; Stricker, EA; Tiebout, RF; Zeijlemaker, WP | 1 |
| Chen, SH; Lee, CL; Lee, SH; Rozee, KR | 1 |
| Cooper, BA; Watkins, D | 1 |
| Flodgaard, H; Klenow, H | 1 |
| Samuels, LL; Straw, JA | 1 |
| Tebbutt, GM | 1 |
| Mackinnon, WB; Nott, SE; Piper, AA; Tattersall, MH | 1 |
| Clarkson, BD; Doblin, JM; Fried, J; Perez, AG | 1 |
| Rice, A; Wang, AL; Wang, CC | 1 |
| Harasym, CA; Lin, CC; Snyder, FF | 1 |
| Aksamit, RR; Cantoni, GL; Kim, IK | 1 |
| Devraj, R; Gangjee, A; Kisliuk, RL; McGuire, JJ | 1 |
| Egan, MG; Garrow, TA; Rumberger, BG; Shane, B; Sirlin, S; Sirotnak, FM | 1 |
| Kim, JS; Shane, B | 1 |
| Buttke, TM; Van Cleave, S | 1 |
| Bianchi, V; Bonvini, P; Borella, S; Ferraro, P; Reichard, P | 1 |
| Lehman, NL; Moran, RG; Smith, SG | 1 |
| D'Incalci, M; Erba, E; Sen, S; Sessa, C; Vikhanskaya, FL | 1 |
| Barnett, CJ; Grindey, GB; Wilson, TM | 1 |
| Böttger, V; Jantscheff, P; Kaiser, G; Karawajew, L; Micheel, B; Winkler, L | 1 |
| Melton, DW; Wu, CL | 1 |
| DuBow, MS; Saint-Dic, D | 1 |
| Griffith, DA; Jarvis, SM | 1 |
| Cheng, RZ; Li, J; Shammas, MA; Shmookler Reis, RJ | 1 |
| Alfinito, P; Ledeen, RW; Lu, ZH; Wu, G | 1 |
| Cho, EW; Hahm, KS; Kim, KL; Lee, YJ; Park, JH | 1 |
| Chow, M; Koo, J; Ng, P; Rubin, H | 1 |
| Canestrari, JG; McGuire, JJ; Nagel, GS | 1 |
| Calvert, AH; Curtin, NJ; Marshman, E; Newell, DR; Smith, PG | 1 |
| Bolognia, JL; Chakraborty, AK; Kolesnikova, N; Pawelek, JM; Platt, JT; Rachkovsky, M; Sodi, S | 1 |
| Curtin, NJ; Marshman, E; Newell, DR; Taylor, GA; Thomas, HD | 1 |
| Barlow, HC; Calvert, AH; Curtin, NJ; Golding, BT; Griffin, RJ; Newell, DR; Smith, PG; Thomas, HD | 1 |
| Cole, PD; Kamen, BA; Smith, AK | 1 |
| Faessel, HM; Greco, WR; Rustum, YM; Slocum, HK | 1 |
| Yoshida, I | 1 |
| Chen, CJ; Lin, HL; Liu, HW; Tsai, WC; Yen, JH | 1 |
| Crowe, JE; House, FS; McGraw, PA; Yu, X | 1 |
| Burdach, S; Heins, S; Pfeifle, C; Reinhardt, K; Staege, MS | 1 |
| Becker, E; Florin, L; Kaufmann, H; Lipske, C | 1 |
| Chen, F; Fan, L; Tan, WS; Wang, J; Ye, Z; Zhao, L; Zhou, Y | 1 |
| Azeredo, J; Costa, AR; Cunnah, P; Henriques, M; Melton, D; Oliveira, R; Rodrigues, ME | 1 |
| Chen, F; Fan, L; Liu, X; Tan, WS; Ye, Z; Zhao, L | 1 |
| Brovarets', OO; Hovorun, DM; Zhurakivsky, RO | 1 |
| Leamon, CP; Müller, C; Reber, J; Schibli, R; Schlup, C | 1 |
| Bigda, JJ; Koszałka, P | 1 |
| Cheng, TF; Muldoon-Jacobs, K; Patton, GW | 1 |
| Claesson, MH; Schmidt, E; Trempenau, ML; Venning, FA | 1 |
| Furukawa, J; Inoue, K; Kanai, Y; Maeda, J; Matsuo, H; Ohta, K; Takada, T; Yasujima, T; Yuasa, H | 1 |
| Caldana, E; Cassani, B; Castelli, A; Ficara, F; Menale, C; Muggeo, S; Paulis, M; Recordati, C; Scanziani, E; Strina, D; Susani, L; Vezzoni, P; Villa, A | 1 |
94 other study(ies) available for thymidine and hypoxanthine
| Article | Year |
|---|---|
Synthesis and biological activity of a novel adenosine analogue, 3-beta-D-ribofuranosylthieno[2,3-d]pyrimidin-4-one.
Topics: Adenosine; Adenosine Kinase; Animals; Antineoplastic Agents; Biotransformation; In Vitro Techniques; Leukemia L1210; Mice; Pyrimidine Nucleosides | 1985 |
Benzoyl ring halogenated classical 2-amino-6-methyl-3,4-dihydro-4-oxo-5-substituted thiobenzoyl-7H-pyrrolo[2,3-d]pyrimidine antifolates as inhibitors of thymidylate synthase and as antitumor agents.
Topics: Antineoplastic Agents; Cell Line, Tumor; Enzyme Inhibitors; Folic Acid Antagonists; Humans; Pyrimidines; Structure-Activity Relationship; Thymidylate Synthase | 2004 |
Synthesis of N-{4-[(2,4-diamino-5-methyl-4,7-dihydro-3H-pyrrolo[2,3-d]pyrimidin-6-yl)thio]benzoyl}-L-glutamic acid and N-{4-[(2-amino-4-oxo-5-methyl-4,7-dihydro-3H-pyrrolo[2,3-d]pyrimidin-6-yl)thio]benzoyl}-L-glutamic acid as dual inhibitors of dihydrofol
Topics: Animals; Antineoplastic Agents; Cell Line, Tumor; Drug Screening Assays, Antitumor; Escherichia coli; Folic Acid Antagonists; Glutamates; Humans; Models, Molecular; Pyrimidines; Structure-Activity Relationship; Tetrahydrofolate Dehydrogenase; Thymidylate Synthase; Toxoplasma | 2005 |
Nucleoside transport-deficient mutants of PK-15 pig kidney cell line.
Topics: Animals; Biological Transport; Carrier Proteins; Cell Division; Cell Line; Clone Cells; Cytarabine; DNA; Escherichia coli; Flow Cytometry; Floxuridine; Hypoxanthine; Hypoxanthines; Kidney; Kinetics; Membrane Proteins; Methotrexate; Mutation; Nucleoside Transport Proteins; Nucleosides; Plasmids; Recombinant Proteins; Swine; Thymidine; Transfection; Tubercidin; Uridine | 1992 |
Single K562 human leukemia cells express and are inducible for both erythroid and megakaryocytic antigens.
Topics: Antigens, Differentiation; Butyrates; Butyric Acid; Erythrocytes; Flow Cytometry; Glycophorins; Hematopoietic Stem Cells; Humans; Hypoxanthine; Hypoxanthines; Leukemia; Megakaryocytes; Phorbol 12,13-Dibutyrate; Thymidine; Tumor Cells, Cultured | 1992 |
Purine salvage and metabolism in Babesia bovis.
Topics: Adenosine; Adenosine Triphosphate; Animals; Babesia; Biological Transport; Cattle; Cells, Cultured; DNA; Erythrocytes; Guanosine Triphosphate; Hypoxanthine; Hypoxanthines; Inosine Monophosphate; Nucleosides; Purines; RNA; Thymidine | 1990 |
Establishment and characterization of a thymidine kinase deficient avian fibroblast cell line derived from a Japanese quail cell line, QT35.
Topics: Aminopterin; Animals; Bromodeoxyuridine; Cell Division; Cell Line; Clone Cells; Coturnix; Fibroblasts; Floxuridine; Hypoxanthine; Hypoxanthines; Karyotyping; Thymidine; Thymidine Kinase | 1991 |
AZT: a biochemical response modifier of methotrexate and 5-fluorouracil cytotoxicity in human ovarian and pancreatic carcinoma cells.
Topics: Animals; Binding, Competitive; Cell Line; Dose-Response Relationship, Drug; Drug Synergism; Female; Fluorouracil; Humans; Hypoxanthine; Hypoxanthines; In Vitro Techniques; Methotrexate; Ovarian Neoplasms; Pancreatic Neoplasms; Rats; Thymidine; Thymidine Kinase; Tumor Cells, Cultured; Zidovudine | 1991 |
Role of hypoxanthine and thymidine in determining methotrexate plus dipyridamole cytotoxicity.
Topics: Antineoplastic Combined Chemotherapy Protocols; Cell Line; Cyclic AMP; Dipyridamole; Drug Synergism; Female; Humans; Hypoxanthine; Hypoxanthines; Methotrexate; Ovarian Neoplasms; Thymidine | 1990 |
Efficiency of communication between tumour cells in collagen gel cultures.
Topics: Aminopterin; Animals; Cell Communication; Cell Division; Cells, Cultured; Collagen; Dose-Response Relationship, Drug; Hypoxanthine; Hypoxanthines; Mammary Neoplasms, Experimental; Mice; Ouabain; Thioguanine; Thymidine | 1990 |
Thymidylate synthetase gene as a quantitative mutation marker in Chinese hamster cells.
Topics: Animals; Cells, Cultured; Culture Media; Ethyl Methanesulfonate; Gene Expression; Genetic Markers; Hypoxanthine; Hypoxanthines; Leucovorin; Mutation; Thymidine; Thymidylate Synthase; Time Factors; Ultraviolet Rays | 1990 |
Nutritional folate-deficiency in Chinese hamster ovary cells. Chromosomal abnormalities associated with perturbations in nucleic acid precursors.
Topics: Animals; Cell Cycle; Cell Line; Chromosome Aberrations; Cricetinae; Cricetulus; Culture Media; Folic Acid Deficiency; Hypoxanthine; Hypoxanthines; Karyotyping; Mitotic Index; Nucleic Acid Precursors; Thymidine | 1990 |
Differential calcium leucovorin protection of human lymphoid cell lines from methotrexate.
Topics: Cell Division; Cell Line; Drug Antagonism; Humans; Hypoxanthine; Hypoxanthines; Leucovorin; Lymphoid Tissue; Methotrexate; Polyglutamic Acid; Tetrahydrofolates; Thymidine; Uridine | 1985 |
Modulation of cytotoxicity and metabolism of 5-fluorouracil in two intestine cell lines.
Topics: Cell Cycle; Cell Line; DNA; Drug Synergism; Floxuridine; Fluorouracil; Humans; Hypoxanthine; Hypoxanthines; In Vitro Techniques; Inosine; Organophosphorus Compounds; Pentosyltransferases; Pyrimidine Phosphorylases; Ribosemonophosphates; RNA; Thymidine; Thymidylate Synthase | 1986 |
Selection of purine nucleoside analogs based on multiple biological and biochemical parameters.
Topics: Adenosine Triphosphate; Cells, Cultured; Cytidine Triphosphate; DNA; Formates; Guanosine Monophosphate; Guanosine Triphosphate; Humans; Hypoxanthine; Hypoxanthines; Inosine Monophosphate; Phosphorylation; Purine Nucleosides; RNA; Thymidine; Uridine; Uridine Triphosphate | 1986 |
Synergistic effect of methotrexate and 1-beta-D-arabinofuranosylcytosine on the generation of DNA strand breaks in a human promyelocytic leukemia cell line.
Topics: Aphidicolin; Cell Line; Cytarabine; Diterpenes; DNA Damage; Drug Combinations; Drug Synergism; Humans; Hypoxanthine; Hypoxanthines; Leucovorin; Leukemia, Promyelocytic, Acute; Methotrexate; Phosphorylation; Thymidine | 1989 |
In vitro drug sensitivity test for Trypanosoma brucei subgroup bloodstream trypomastigotes.
Topics: Animals; Arsenicals; Diminazene; Hypoxanthine; Hypoxanthines; Leucine; Pentamidine; Phenanthridines; Suramin; Thymidine; Trypanocidal Agents; Trypanosoma brucei brucei | 1989 |
Sequential combination of methotrexate and 1-beta-D-arabinofuranosylcytosine shows synergistic effect on the generation of DNA strand breaks in a human promyelocytic leukemia cell line.
Topics: Arabinofuranosylcytosine Triphosphate; Cycloheximide; Cytarabine; DNA Damage; DNA, Neoplasm; Dose-Response Relationship, Drug; Drug Administration Schedule; Drug Synergism; Humans; Hypoxanthine; Hypoxanthines; Leucovorin; Leukemia, Promyelocytic, Acute; Methotrexate; Thymidine; Tumor Cells, Cultured | 1989 |
AMP deaminase and thymidine kinase deficiencies in a mutant mouse S49 cell clone.
Topics: Adenine; AMP Deaminase; Animals; Cell Division; Clone Cells; Dose-Response Relationship, Drug; Hybrid Cells; Hypoxanthine; Hypoxanthines; Lymphoma; Mice; Mice, Inbred BALB C; Nucleotide Deaminases; Thymidine; Thymidine Kinase; Tumor Cells, Cultured | 1989 |
The enhancement of the activity of 10-propargyl-5,8-dideazafolate and 5,10-dideazatetrahydrofolate by inhibitors of dihydrofolate reductase.
Topics: Animals; Cell Line; Cell Survival; Folic Acid; Folic Acid Antagonists; Hypoxanthine; Hypoxanthines; Liver Neoplasms, Experimental; Quinazolines; Rats; Tetrahydrofolates; Thymidine; Tumor Cells, Cultured | 1989 |
Murine genomic DNA sequences replicating autonomously in mouse L cells.
Topics: Acetyltransferases; Aminopterin; Animals; Antineoplastic Combined Chemotherapy Protocols; Base Sequence; Chloramphenicol O-Acetyltransferase; Culture Media; DNA Replication; DNA Restriction Enzymes; DNA-Binding Proteins; Gene Amplification; Hypoxanthine; Hypoxanthines; L Cells; Mice; Mitosis; Molecular Sequence Data; Plasmids; Sp1 Transcription Factor; Thymidine; Thymidine Kinase; Transcription Factors; Transfection | 1988 |
Production of hybrid hybridomas based on HAT(s)-neomycin(r) double mutants.
Topics: Aminopterin; Antibody Specificity; Azaguanine; Cell Fusion; Cell Line; Drug Resistance; Humans; Hybridomas; Hypoxanthine; Hypoxanthines; Leukocyte Count; Mutation; Neomycin; Phenotype; Thymidine; Transduction, Genetic | 1989 |
Similar sensitivity of human lymphoblast cells proficient or deficient in nucleotide biosynthesis to the cytotoxic and cell cycle effects of 3-aminobenzamide.
Topics: Aminobenzoates; Benzamides; Cell Cycle; Cell Line; Cell Survival; Humans; Hypoxanthine; Hypoxanthines; Lymphocytes; meta-Aminobenzoates; NAD; NAD+ Nucleosidase; Niacinamide; Nucleotides; Poly(ADP-ribose) Polymerase Inhibitors; Thymidine | 1985 |
The use of insulin-enriched culture medium and human-human hybridoma formation: a preliminary study.
Topics: Antibodies, Monoclonal; Cell Fusion; Culture Media; Guanine; Humans; Hybridomas; Hypoxanthine; Hypoxanthines; Insulin; Lymphocytes; Thymidine | 1986 |
Hypoxanthine:guanine phosphoribosyltransferase activity in primary human osteosarcomas. A rationale for therapy with methotrexate-thymidine rescue?
Topics: Antineoplastic Combined Chemotherapy Protocols; Bone Neoplasms; Child; Female; Humans; Hypoxanthine; Hypoxanthine Phosphoribosyltransferase; Hypoxanthines; Lung Neoplasms; Male; Methotrexate; Osteosarcoma; Pentosyltransferases; Thymidine | 1987 |
Regulation of the activity of heme degradative enzymes in K562 erythroleukemic cells: induction by thymidine.
Topics: Bromobenzenes; Cell Line; Cobalt; Enzyme Induction; Heme; Heme Oxygenase (Decyclizing); Hemin; Humans; Hypoxanthine; Hypoxanthines; Leukemia, Erythroblastic, Acute; NADPH-Ferrihemoprotein Reductase; Oxidoreductases; Oxidoreductases Acting on CH-CH Group Donors; Thymidine | 1987 |
Highly selective drug combinations for human colon cancer cells resistant in vitro to 5-fluoro-2'-deoxyuridine.
Topics: Adenocarcinoma; Antineoplastic Combined Chemotherapy Protocols; Biological Transport; Cell Line; Colonic Neoplasms; Drug Resistance; Floxuridine; Humans; Hypoxanthine; Hypoxanthines; Methotrexate; Nucleosides; Quinazolines; Thymidine | 1985 |
Measurement of in vivo HGPRT-deficient mutant cell frequency using a modified method for cloning human peripheral blood T-lymphocytes.
Topics: Cell Line; Cells, Cultured; Clone Cells; DNA Replication; Humans; Hypoxanthine; Hypoxanthine Phosphoribosyltransferase; Hypoxanthines; Interleukin-2; Kinetics; Mutation; T-Lymphocytes; Thymidine | 1988 |
Establishment of a galactocerebrosidase-deficient twitcher mouse cell line that expresses galactocerebrosidase activity in hybrids with control human fibroblasts.
Topics: Aminopterin; Animals; Brain; Cell Division; Cell Line; Fibroblasts; Galactosidases; Galactosylceramidase; Glucosephosphate Dehydrogenase; Humans; Hybrid Cells; Hypoxanthine; Hypoxanthines; Isoenzymes; Karyotyping; Kidney; Leukodystrophy, Globoid Cell; Mice; Mice, Inbred C57BL; Mice, Neurologic Mutants; Ouabain; Ploidies; Thymidine; X Chromosome | 1988 |
Modulation of antifolate cytotoxicity by metabolites from dying cells in a lymphocyte clonal assay.
Topics: Cell Division; Cells, Cultured; Chromatography, High Pressure Liquid; Colony-Forming Units Assay; Drug Resistance; Humans; Hypoxanthine; Hypoxanthines; Lymphocytes; Methotrexate; Thymidine | 1988 |
[Establishment of a HAT selective medium-sensitive mutant human lymphoma cell line].
Topics: Aminopterin; Antineoplastic Combined Chemotherapy Protocols; Burkitt Lymphoma; Cell Line; Humans; Hybridomas; Hypoxanthine; Hypoxanthines; Mutation; Thymidine; Tumor Cells, Cultured | 1988 |
Analysis of tumour cell composition in tumours composed of paired mixtures of mammary tumour cell lines.
Topics: Aminopterin; Animals; Antineoplastic Combined Chemotherapy Protocols; Cell Count; Cell Line; Clone Cells; DNA, Neoplasm; Hypoxanthine; Hypoxanthines; Male; Mammary Neoplasms, Experimental; Methods; Mice; Mice, Inbred BALB C; Thioguanine; Thymidine; Tumor Cells, Cultured; Tumor Stem Cell Assay | 1987 |
Multipotent human hematopoietic cell line K562: lineage-specific constitutive and inducible antigens.
Topics: Antigens; Cell Differentiation; Daunorubicin; Erythrocytes; Granulocytes; Hematopoietic Stem Cells; Humans; Hypoxanthine; Hypoxanthines; Leukemia, Myeloid; Megakaryocytes; Monocytes; Thymidine; Tumor Cells, Cultured | 1987 |
Inhibition of methotrexate-induced differentiation of cultured human choriocarcinoma (BeWo) cells by thymidine.
Topics: Cell Differentiation; Cells, Cultured; Choriocarcinoma; DNA; DNA Replication; Female; Humans; Hypoxanthine; Hypoxanthines; Leucovorin; Methotrexate; Pregnancy; Thymidine; Uterine Neoplasms | 1987 |
Augmentation of methotrexate cytotoxicity in human colon cancer cells achieved through inhibition of thymidine salvage by dipyridamole.
Topics: Cell Line; Cell Survival; Colonic Neoplasms; Dipyridamole; Drug Synergism; Guanine; Humans; Hypoxanthine; Hypoxanthines; Methotrexate; Rectal Neoplasms; Thymidine; Thymine Nucleotides | 1987 |
Establishment of a new human myeloma cell line (U-2030) and selection of a hat-sensitive subline.
Topics: Aminopterin; Antigens, Surface; Antineoplastic Combined Chemotherapy Protocols; Cell Line; Drug Resistance; Humans; Hypoxanthine; Hypoxanthines; Immunoglobulins; Multiple Myeloma; Thymidine | 1987 |
Zwitterionic 3'-O-acyl derivatives of thymidine 5'-phosphate as potential sources of intracellular thymidine 5'-phosphate in cells in culture.
Topics: Acylation; Aminopterin; Animals; Cells, Cultured; DNA Replication; Fibroblasts; Hypoxanthine; Hypoxanthines; Mice; Thymidine; Thymidine Monophosphate; Thymine Nucleotides | 1986 |
In vivo efficacy of HAT therapy against transplantable murine myelomas resistant to purine analogs.
Topics: Aminopterin; Animals; Antineoplastic Combined Chemotherapy Protocols; Drug Resistance; Hypoxanthine; Hypoxanthines; Mice; Mice, Inbred BALB C; Mutation; Plasmacytoma; Thioguanine; Thymidine | 1986 |
Biochemical and genetic properties of HPRT Cape Town.
Topics: Erythrocytes; Guanine; Humans; Hypoxanthine; Hypoxanthine Phosphoribosyltransferase; Hypoxanthines; Kinetics; Leucine; Reference Values; South Africa; Thymidine | 1986 |
Enhanced formation of mouse hybridomas without hat treatment in a serum-free medium.
Topics: Aminopterin; Animals; Cell Division; Cell Fusion; Cell Line; Culture Media; Humans; Hybridomas; Hypoxanthine; Hypoxanthines; Mice; Multiple Myeloma; Spleen; Thymidine | 1986 |
Nucleoside and nucleobase transport and metabolism in wild type and nucleoside transport-deficient Aedes albopictus cells.
Topics: Adenine; Adenosine Triphosphate; Aedes; Animals; Biological Transport; Carrier Proteins; Hypoxanthine; Hypoxanthines; Kinetics; Membrane Proteins; Mutation; Nucleoside Transport Proteins; Nucleosides; Thioinosine; Thymidine; Uracil; Uridine | 1987 |
An improved assay for the detection of interleukin 1.
Topics: Animals; Azaserine; Cell Line; Culture Media; Hypoxanthine; Hypoxanthines; Interleukin-1; Lymphocyte Activation; Male; Methods; Mice; Mice, Inbred C3H; Phytohemagglutinins; Thymidine; Thymus Gland | 1985 |
Intracellular activity of HPRT Cape Town: purine uptake and growth of cultured cells in selective media.
Topics: Cell Division; Cells, Cultured; DNA; Formates; Guanine; Humans; Hypoxanthine; Hypoxanthine Phosphoribosyltransferase; Hypoxanthines; Lymphocytes; Thymidine | 1985 |
S49 mouse lymphoma cells are deficient in hypoxanthine transport.
Topics: Adenine; Animals; Biological Transport; Cell Line; Cricetinae; Cricetulus; Dipyridamole; Hypoxanthine; Hypoxanthine Phosphoribosyltransferase; Hypoxanthines; Lymphoma; Methotrexate; Mice; Permeability; Thymidine; Uridine; Uridine Kinase | 1986 |
Erythroid induction of K562 human leukemia cells: enhancement by purines.
Topics: Adenine; Cell Cycle; Cell Division; Cell Line; Drug Synergism; Guanine; Hemoglobins; Humans; Hypoxanthine; Hypoxanthines; Leukemia; Mycophenolic Acid; Thymidine; Xanthine; Xanthines | 1985 |
A human monoclonal IgG1 lambda anti-hepatitis B surface antibody. Production, properties, and applications.
Topics: Aminopterin; Antibodies, Monoclonal; Antibody Formation; Cell Fusion; Cell Line; Hepatitis B Surface Antigens; Humans; Hypoxanthine; Hypoxanthines; Thymidine | 1985 |
8-Azaguanine resistant African green monkey kidney cell mutants (Vero 153): isolation and characterization.
Topics: Aminopterin; Animals; Azaguanine; Cell Line; Cell Separation; Chlorocebus aethiops; Clone Cells; Culture Media; Drug Resistance; Hypoxanthine; Hypoxanthine Phosphoribosyltransferase; Hypoxanthines; Interferons; Karyotyping; Kidney; Mutation; Thymidine | 1983 |
A critical intracellular concentration of fully reduced non-methylated folate polyglutamates prevents macrocytosis and diminished growth rate of human cell line K562 in culture.
Topics: Cell Division; Cell Line; Cells, Cultured; Folic Acid; Humans; Hypoxanthine; Hypoxanthines; Leukemia, Myeloid; Oxidation-Reduction; Pteroylpolyglutamic Acids; Thymidine; Vitamin B 12 | 1983 |
Both hypoxanthine and adenosine stimulate DNA synthesis independently in serum-starved L cells treated with platelet protein.
Topics: Adenosine; Animals; Blood; Culture Media; DNA Replication; Humans; Hypoxanthine; Hypoxanthines; Kinetics; L Cells; Mice; Platelet-Derived Growth Factor; Thymidine | 1983 |
Improved therapeutic index with high-dose methotrexate: comparison of thymidine-purine rescue with citrovorum factor rescue in mice.
Topics: Animals; Brain Neoplasms; Deoxycytidine; DNA Replication; Dose-Response Relationship, Drug; Hypoxanthine; Hypoxanthines; Inosine; Leucovorin; Leukemia L1210; Methotrexate; Mice; Thymidine; Thymine | 1984 |
A chemotyping scheme for clinical isolates of Haemophilus influenzae.
Topics: Amino Acids; Culture Media; Ear; Eye; Female; Haemophilus Infections; Haemophilus influenzae; Humans; Hypoxanthine; Hypoxanthines; Nose; Paranasal Sinuses; Pharynx; Sputum; Thymidine; Vagina | 1984 |
Critical modulation by thymidine and hypoxanthine of sequential methotrexate-5-fluorouracil synergism in murine L1210 cells.
Topics: Animals; Cell Survival; Drug Synergism; Drug Therapy, Combination; Fluorouracil; Hypoxanthine; Hypoxanthines; Kinetics; Leukemia L1210; Methotrexate; Mice; Thymidine | 1983 |
Factors modifying the synergistic toxicity of deoxycytidine in combination with thymidine plus 5-fluorouracil in HeLa cells.
Topics: Cell Survival; Culture Media; Deoxycytidine; Dose-Response Relationship, Drug; Drug Synergism; Fluorouracil; HeLa Cells; Humans; Hypoxanthine; Hypoxanthines; Interphase; Kinetics; Mitosis; Thymidine | 1983 |
Tritrichomonas foetus: partly defined cultivation medium for study of the purine and pyrimidine metabolism.
Topics: Agar; Animals; Culture Media; Cytoplasmic Granules; Glycogen; Hypoxanthine; Hypoxanthines; Purines; Pyrimidines; Thymidine; Tritrichomonas; Uracil | 1984 |
Purine, thymidylate and amino acid requirements for human lymphocyte transformation and fragile chromosome site expression.
Topics: Amino Acids; Cells, Cultured; Female; Folic Acid; Humans; Hypoxanthine; Hypoxanthines; Lymphocyte Activation; Lymphocytes; Male; Sex Chromosome Aberrations; Thymidine; X Chromosome | 1984 |
Mechanism of the cytostatic activity of 3-deazaaristeromycin, an inhibitor of adenosylhomocysteine hydrolase.
Topics: Adenosine; Adenosylhomocysteinase; Animals; Cell Division; Cell Line; Hydrolases; Hypoxanthine; Hypoxanthines; Kinetics; Macrophages; Mice; Thymidine | 1982 |
Effect of bridge region variation on antifolate and antitumor activity of classical 5-substituted 2,4-diaminofuro[2,3-d]pyrimidines.
Topics: Antineoplastic Agents; Cell Division; Folic Acid; Folic Acid Antagonists; Humans; Hypoxanthine; Hypoxanthines; Kinetics; Lacticaseibacillus casei; Leucovorin; Methotrexate; Molecular Structure; Peptide Synthases; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Pyrimidines; Recombinant Proteins; Structure-Activity Relationship; Thymidine; Thymidylate Synthase; Tumor Cells, Cultured | 1995 |
Rapid decline in folylpolyglutamate synthetase activity and gene expression during maturation of HL-60 cells. Nature of the effect, impact on folate compound polyglutamate pools, and evidence for programmed down-regulation during maturation.
Topics: Blotting, Northern; Cell Division; Cell Line; Dimethyl Sulfoxide; gamma-Glutamyl Hydrolase; Gene Expression Regulation, Enzymologic; Gene Expression Regulation, Neoplastic; Humans; Hypoxanthine; Hypoxanthines; Kinetics; Leukemia, Promyelocytic, Acute; Methotrexate; Peptide Synthases; Pteroylpolyglutamic Acids; RNA, Messenger; Thymidine; Time Factors; Tumor Cells, Cultured | 1995 |
Role of folylpolyglutamate synthetase in the metabolism and cytotoxicity of 5-deazaacyclotetrahydrofolate, an anti-purine drug.
Topics: Animals; Cell Division; Cell Survival; CHO Cells; Cricetinae; Escherichia coli; Glutamates; Glycine; Humans; Hypoxanthine; Hypoxanthines; Mitochondria; Peptide Synthases; Pyrimidines; Tetrahydrofolates; Thymidine; Transfection | 1994 |
Adaptation of a cholesterol deficient human T cell line to growth with lanosterol.
Topics: Aminopterin; Cell Division; Cell Line; Cholesterol; Culture Media, Serum-Free; Humans; Hypoxanthine; Hypoxanthines; Kinetics; Lanosterol; Lipoproteins, LDL; T-Lymphocytes; Thymidine | 1994 |
Effects of mutational loss of nucleoside kinases on deoxyadenosine 5'-phosphate/deoxyadenosine substrate cycle in cultured CEM and V79 cells.
Topics: Adamantane; Adenine; Adenosine; Adenosine Kinase; Animals; Cell Division; Cell Line; Cricetinae; Deoxyadenosines; Deoxycytidine; Deoxycytidine Kinase; Deoxyribonucleotides; DNA; Fibroblasts; Humans; Hypoxanthine; Hypoxanthines; Kinetics; Lymphocytes; Thymidine; Time Factors; Tritium | 1994 |
Cytotoxicity of antifolate inhibitors of thymidylate and purine synthesis to WiDr colonic carcinoma cells.
Topics: Acyltransferases; Antineoplastic Agents; Cell Division; Cell Survival; Colonic Neoplasms; Folic Acid Antagonists; Humans; Hydroxymethyl and Formyl Transferases; Hypoxanthine; Hypoxanthines; Methotrexate; Phosphoribosylglycinamide Formyltransferase; Quinazolines; Tetrahydrofolates; Thiophenes; Thymidine; Thymidylate Synthase; Tumor Cells, Cultured | 1993 |
Mechanism of cytotoxicity of 5,10-dideazatetrahydrofolic acid in human ovarian carcinoma cells in vitro and modulation of the drug activity by folic or folinic acid.
Topics: Antineoplastic Agents; Cell Cycle; DNA, Neoplasm; Drug Screening Assays, Antitumor; Female; Folic Acid; Folic Acid Antagonists; Humans; Hypoxanthine; Hypoxanthines; Leucovorin; Ovarian Neoplasms; Tetrahydrofolates; Thymidine; Time Factors; Tumor Cells, Cultured | 1994 |
Synthesis and antitumor activity of LY288601, the 5,6-dihydro analog of LY231514.
Topics: Animals; Antineoplastic Agents; Cell Line; Cell Survival; Folic Acid Antagonists; Glutamates; Guanine; Humans; Hypoxanthine; Hypoxanthines; Lymphoma; Mice; Molecular Structure; Pemetrexed; Structure-Activity Relationship; Thymidine; Tumor Cells, Cultured | 1993 |
Hybrid hybridomas producing bispecific antibodies to CEA and peroxidase isolated by a combination of HAT medium selection and fluorescence activated cell sorting.
Topics: Animals; Antibodies, Monoclonal; Azaserine; Carcinoembryonic Antigen; Cell Separation; Cells, Cultured; Culture Media; Flow Cytometry; Fluorescent Dyes; Horseradish Peroxidase; Hybridomas; Hypoxanthine; Hypoxanthines; Mice; Rhodamines; Thymidine | 1993 |
Production of a model for Lesch-Nyhan syndrome in hypoxanthine phosphoribosyltransferase-deficient mice.
Topics: Adenine; Adenine Phosphoribosyltransferase; Animals; Brain; Caffeine; Cell Division; Cells, Cultured; Disease Models, Animal; Embryo, Mammalian; Hypoxanthine; Hypoxanthine Phosphoribosyltransferase; Hypoxanthines; Lesch-Nyhan Syndrome; Mice; Mice, Mutant Strains; Purines; Self-Injurious Behavior; Stem Cells; Thymidine | 1993 |
Effect of cis-located human satellite DNA on electroporation efficiency.
Topics: Aminopterin; Cell Line, Transformed; DNA, Satellite; Drug Resistance; Electroporation; Gentamicins; Humans; Hypoxanthine; Hypoxanthines; Plasmids; Thymidine; Transfection | 1995 |
Regulation of nucleobase transport in LLC-PK1 renal epithelia by protein kinase C.
Topics: Animals; Biological Transport; Cell Division; Cycloheximide; Hypoxanthine; Kinetics; LLC-PK1 Cells; Protein Kinase C; Sodium; Tetradecanoylphorbol Acetate; Thymidine | 1996 |
Expression of SV40 large T antigen stimulates reversion of a chromosomal gene duplication in human cells.
Topics: Antigens, Polyomavirus Transforming; Cell Division; Cell Line, Transformed; Cell Transformation, Viral; Clone Cells; Dexamethasone; DNA; Fibroblasts; Gene Deletion; Glucocorticoids; Humans; Hypoxanthine; Hypoxanthine Phosphoribosyltransferase; Lesch-Nyhan Syndrome; Methotrexate; Multigene Family; Recombination, Genetic; RNA, Messenger; Simian virus 40; Thymidine | 1997 |
Opioid receptor and calcium channel regulation of adenylyl cyclase, modulated by GM1, in NG108-15 cells: competitive interactions.
Topics: Adenylate Cyclase Toxin; Adenylyl Cyclases; Aminopterin; Binding, Competitive; Calcium Channels; Cholera Toxin; Cyclic AMP; Enkephalin, Leucine-2-Alanine; Fluorescent Dyes; G(M1) Ganglioside; Glioma; Hybrid Cells; Hypoxanthine; Neuroblastoma; Pertussis Toxin; Receptors, Opioid; Thymidine; Tumor Cells, Cultured; Virulence Factors, Bordetella | 1997 |
Generation and characterization of a novel fusion partner cell line for the production of human macrophage hybridoma.
Topics: Aminopterin; Antimetabolites, Antineoplastic; Azaguanine; Cell Division; Cell Line; Folic Acid Antagonists; HL-60 Cells; Humans; Hybridomas; Hypoxanthine; Hypoxanthine Phosphoribosyltransferase; Macrophages; Mutation; Thymidine | 1997 |
Random population-wide genetic damage induced in replicating cells treated with methotrexate.
Topics: 3T3 Cells; Adenine; Animals; Antimetabolites, Antineoplastic; Cell Cycle; Culture Media; DNA Damage; Folic Acid Antagonists; Hypoxanthine; Methotrexate; Mice; Mutagenicity Tests; Thymidine | 1998 |
Characterization of the effect of AG337, a novel lipophilic thymidylate synthase inhibitor, on human head and neck and human leukemia cell lines.
Topics: Cell Cycle; Cell Division; Culture Media; Drug Resistance; Enzyme Inhibitors; Fetal Blood; Head and Neck Neoplasms; Humans; Hypoxanthine; Inhibitory Concentration 50; Leucovorin; Leukemia; Methotrexate; Quinazolines; Thymidine; Thymidine Phosphorylase; Thymidylate Synthase; Tumor Cells, Cultured | 1999 |
Prevention of thymidine and hypoxanthine rescue from MTA (LY231514) growth inhibition by dipyridamole in human lung cancer cell lines.
Topics: Antimetabolites, Antineoplastic; Carcinoma, Non-Small-Cell Lung; Cell Division; Dipyridamole; Enzyme Inhibitors; Folic Acid Antagonists; Glutamates; Guanine; Humans; Hypoxanthine; Lung Neoplasms; Pemetrexed; Phosphodiesterase Inhibitors; Thymidine; Thymidylate Synthase; Tumor Cells, Cultured | 1999 |
A spontaneous murine melanoma lung metastasis comprised of host x tumor hybrids.
Topics: Aminopterin; Animals; Anti-Bacterial Agents; Antigens, CD; Antineoplastic Combined Chemotherapy Protocols; Cell Movement; Chemotaxis; Flow Cytometry; Gentamicins; Hypoxanthine; Immunoblotting; Lung Neoplasms; Lysosomal Membrane Proteins; Melanoma; Membrane Glycoproteins; Mice; Mice, Inbred BALB C; Microscopy, Electron; Monophenol Monooxygenase; Neoplasm Transplantation; Polymorphism, Restriction Fragment Length; Sequence Analysis, DNA; Thymidine; Time Factors; Tumor Cells, Cultured | 2000 |
Hypoxanthine transport in human tumour cell lines: relationship to the inhibition of hypoxanthine rescue by dipyridamole.
Topics: Affinity Labels; Binding, Competitive; Biological Transport; Carrier Proteins; Cell Division; Chromatography, High Pressure Liquid; Dipyridamole; Dose-Response Relationship, Drug; Drug Interactions; Equilibrative Nucleoside Transport Proteins; Folic Acid Antagonists; Humans; Hypoxanthine; Kinetics; Phosphodiesterase Inhibitors; Sodium; Thioinosine; Thymidine; Tumor Cells, Cultured | 2001 |
In vitro and in vivo properties of novel nucleoside transport inhibitors with improved pharmacological properties that potentiate antifolate activity.
Topics: Animals; Carrier Proteins; Cell Division; Dipyridamole; Dose-Response Relationship, Drug; Drug Synergism; Female; Folic Acid Antagonists; Glutamates; Guanine; Humans; Hypoxanthine; Liver; Membrane Proteins; Mice; Mice, Inbred BALB C; Nucleoside Transport Proteins; Orosomucoid; Pemetrexed; Tetrahydrofolates; Thymidine; Time Factors; Tritium; Tumor Cells, Cultured | 2001 |
Osteosarcoma cells, resistant to methotrexate due to nucleoside and nucleobase salvage, are sensitive to nucleoside analogs.
Topics: Animals; Antimetabolites, Antineoplastic; Biological Transport; Bone Neoplasms; Cattle; Culture Media; Cytarabine; Dialysis; Dipyridamole; Dose-Response Relationship, Drug; Drug Resistance, Neoplasm; Drug Synergism; Fetal Blood; Humans; Hypoxanthine; Methotrexate; Neoplasm Proteins; Nucleotides; Osteosarcoma; Tetrahydrofolate Dehydrogenase; Thymidine; Tumor Cells, Cultured; Vidarabine | 2002 |
Thymidine and hypoxanthine protection patterns of the folic acid-enhanced synergies for combinations of trimetrexate plus a polyglutamylatable inhibitor of purine or thymidylate synthesis against human ileocecal HCT-8 cells.
Topics: Adenocarcinoma; Antineoplastic Agents; Antineoplastic Combined Chemotherapy Protocols; Cecal Neoplasms; Cell Division; Drug Resistance, Multiple; Drug Synergism; Enzyme Inhibitors; Folic Acid; Glutamates; Hematinics; Humans; Hydroxymethyl and Formyl Transferases; Hypoxanthine; Ileal Neoplasms; Peptide Synthases; Phosphoribosylglycinamide Formyltransferase; Pyrimidines; Quinazolines; Thiophenes; Thymidine; Thymidylate Synthase; Trimetrexate; Tumor Cells, Cultured | 2003 |
Spontaneous reactivation of the inactive X chromosome in mouse embryonal carcinoma cells.
Topics: Aminopterin; Animals; Cell Division; Culture Media; Dosage Compensation, Genetic; Drug Resistance; Embryonal Carcinoma Stem Cells; Gene Expression Regulation, Enzymologic; Gene Expression Regulation, Neoplastic; Heterochromatin; Hypoxanthine; Hypoxanthine Phosphoribosyltransferase; In Situ Hybridization, Fluorescence; Neoplastic Stem Cells; RNA, Long Noncoding; RNA, Untranslated; Thymidine; Tumor Cells, Cultured; X Chromosome | 2002 |
In vitro folate deficiency induces apoptosis by a p53, Fas (Apo-1, CD95) independent, bcl-2 related mechanism in phytohaemagglutinin-stimulated human peripheral blood lymphocytes.
Topics: Apoptosis; Cells, Cultured; Down-Regulation; fas Receptor; Folic Acid; Folic Acid Deficiency; Humans; Hypoxanthine; Interleukin-2; Lymphocyte Activation; Phytohemagglutinins; Proto-Oncogene Proteins c-bcl-2; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; S Phase; Thymidine; Tumor Suppressor Protein p53 | 2006 |
An optimized electrofusion-based protocol for generating virus-specific human monoclonal antibodies.
Topics: Aminopterin; Antibodies, Monoclonal; Antibodies, Viral; B-Lymphocytes; Cell Fusion; Cell Line, Tumor; Cell Transformation, Viral; Coculture Techniques; Herpesvirus 4, Human; Humans; Hybridomas; Hypoxanthine; Immunoglobulin G; Influenza A Virus, H3N2 Subtype; Multiple Myeloma; Oligodeoxyribonucleotides; Ouabain; Respiratory Syncytial Virus, Human; Thymidine | 2008 |
Development and characterization of HAT-sensitive Ewing tumour cells for immunotherapy.
Topics: Aminopterin; Antigens, Neoplasm; Azaguanine; Calmodulin-Binding Proteins; Cancer Vaccines; Cell Line, Tumor; Gene Expression Profiling; HLA-A2 Antigen; Humans; Hypoxanthine; Immunotherapy, Active; Oligonucleotide Array Sequence Analysis; Peptides; Proto-Oncogene Protein c-fli-1; RNA-Binding Protein EWS; RNA-Binding Proteins; Sarcoma, Ewing; Thymidine | 2009 |
Supplementation of serum free media with HT is not sufficient to restore growth properties of DHFR-/- cells in fed-batch processes - Implications for designing novel CHO-based expression platforms.
Topics: Animals; Biopharmaceutics; Cell Proliferation; CHO Cells; Cricetinae; Cricetulus; Culture Media, Serum-Free; DNA Primers; Dose-Response Relationship, Drug; Gene Knockout Techniques; Hypoxanthine; Polymerase Chain Reaction; Tetrahydrofolate Dehydrogenase; Thymidine | 2011 |
Insight into the roles of hypoxanthine and thymidine [corrected] on cultivating antibody-producing CHO cells: cell growth, antibody production and long-term stability.
Topics: Animals; Antibodies, Monoclonal; Cell Culture Techniques; CHO Cells; Cricetinae; Cricetulus; Culture Media; Genomic Instability; Humans; Hypoxanthine; Recombinant Proteins; Thymidine | 2012 |
Evaluation of the OSCAR system for the production of monoclonal antibodies by CHO-K1 cells.
Topics: Aminopterin; Animals; Antibodies, Monoclonal; Antineoplastic Combined Chemotherapy Protocols; Cell Proliferation; CHO Cells; Cricetinae; Cricetulus; Genetic Vectors; Hypoxanthine; Hypoxanthine Phosphoribosyltransferase; Recombinant Proteins; Thymidine; Time Factors; Transfection | 2012 |
Biphasic addition strategy of hypoxanthine and thymidine for improving monoclonal antibody production.
Topics: Animals; Antibodies, Monoclonal; Antibody Formation; Batch Cell Culture Techniques; Bioreactors; Cell Count; Cell Culture Techniques; Cell Proliferation; CHO Cells; Cricetinae; Dose-Response Relationship, Drug; Hypoxanthine; Thymidine | 2012 |
The physico-chemical "anatomy" of the tautomerization through the DPT of the biologically important pairs of hypoxanthine with DNA bases: QM and QTAIM perspectives.
Topics: Base Pairing; Computer Simulation; Deoxycytidine; DNA; Hydrogen Bonding; Hypoxanthine; Isomerism; Models, Chemical; Models, Molecular; Oxidation-Reduction; Quantum Theory; Thermodynamics; Thymidine | 2013 |
In vitro and in vivo evaluation of an innocuous drug cocktail to improve the quality of folic acid targeted nuclear imaging in preclinical research.
Topics: Animals; Diagnostic Imaging; Female; Folic Acid Antagonists; Glutamates; Guanine; Humans; Hypoxanthine; KB Cells; Mice; Pemetrexed; Radiopharmaceuticals; Thymidine; Tomography, Emission-Computed, Single-Photon | 2013 |
Wacław Szybalski's contribution to immunotherapy: HGPRT mutation & HAT selection as first steps to gene therapy and hybrid techniques in mammalian cells.
Topics: Aminopterin; Animals; Antibodies, Monoclonal; Antineoplastic Combined Chemotherapy Protocols; Cell Fusion; Genetic Therapy; History, 20th Century; Humans; Hybrid Cells; Hypoxanthine; Hypoxanthine Phosphoribosyltransferase; Immunotherapy; Mammals; Mutation; Thymidine | 2013 |
Can the L5178Y Tk+/- mouse lymphoma assay detect epigenetic silencing?
Topics: Aminopterin; Animals; Antimetabolites, Antineoplastic; Cell Line, Tumor; Cell Survival; Clone Cells; DNA Methylation; Drug Resistance, Neoplasm; Epigenetic Repression; Evaluation Studies as Topic; Hypoxanthine; Leukemia L5178; Mice; Mutagenicity Tests; Mutagens; Mutation; Neoplasm Proteins; Thymidine; Thymidine Kinase; Trifluridine | 2013 |
Enteroantigen (eAg)-binding B lymphocytes in the mouse - phenotype, distribution, function and eAg-specific antibody secretion.
Topics: Aminopterin; Animals; Antibodies; Antigen-Presenting Cells; Antigens, CD19; Antineoplastic Combined Chemotherapy Protocols; B-Lymphocytes; CD4-Positive T-Lymphocytes; Cell Proliferation; Cells, Cultured; Colitis; Female; Hypoxanthine; Interleukin-10; Mice; Mice, Inbred BALB C; Mice, SCID; Receptors, Antigen, B-Cell; Thymidine | 2014 |
Functional identification of SLC43A3 as an equilibrative nucleobase transporter involved in purine salvage in mammals.
Topics: Adenine; Adenine Phosphoribosyltransferase; Adenosine; Amino Acid Transport Systems; Animals; Biological Transport; Dogs; Equilibrative Nucleoside Transporter 1; HEK293 Cells; HeLa Cells; Hepatocytes; Humans; Hypoxanthine; Liver; Lung; Madin Darby Canine Kidney Cells; Mice; Protein Isoforms; Purines; RNA, Small Interfering; Thymidine; Uridine | 2015 |
Chromosome Transplantation: Correction of the Chronic Granulomatous Disease Defect in Mouse Induced Pluripotent Stem Cells.
Topics: Aminopterin; Animals; Base Sequence; Cell Differentiation; Chromosomes, Mammalian; Clone Cells; CRISPR-Cas Systems; Culture Media; Disease Models, Animal; Gene Editing; Genetic Therapy; Granulocytes; Granulomatous Disease, Chronic; Humans; Hypoxanthine; Hypoxanthine Phosphoribosyltransferase; Induced Pluripotent Stem Cells; Male; Mice; NADPH Oxidase 2; Proof of Concept Study; Sequence Deletion; Thioguanine; Thymidine; X Chromosome | 2019 |