thymidine has been researched along with folic acid in 182 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 144 (79.12) | 18.7374 |
| 1990's | 16 (8.79) | 18.2507 |
| 2000's | 16 (8.79) | 29.6817 |
| 2010's | 5 (2.75) | 24.3611 |
| 2020's | 1 (0.55) | 2.80 |
| Authors | Studies |
|---|---|
| Hanna, ML; Taylor, RT | 1 |
| Sutherland, GR | 1 |
| Clements, GB | 1 |
| Bain, B | 1 |
| Baskin, F; Carlin, SC; Friedkin, M; Kraus, P; Rosenberg, RN | 1 |
| Sawula, RV; Zamenhof, PJ; Zamenhof, S | 1 |
| Lietman, PS; Rogers, HJ | 2 |
| Shearer, M; Taylor-Papadimitriou, J; Watling, D | 1 |
| Ganeshaguru, K; Hoffbrand, AV | 1 |
| Hannan, GN; McAuslan, BR; Reilly, W | 1 |
| Neugut, AI; Weinstein, IB | 1 |
| Burchall, JJ | 1 |
| Rozengurt, E; Taylor-Papadimitriou, J | 1 |
| Van Der Weyden, MB | 1 |
| Marquet, J; Zittoun, J; Zittoun, R | 1 |
| Fry, DW; Goldman, ID; White, JC | 1 |
| Sauer, H; Wilmanns, W | 1 |
| Chanarin, I; Laundy, M; Reid, C; Reynolds, EH; Taguchi, H | 1 |
| Oertel, J | 1 |
| Harrap, KR; Jackson, RC; Taylor, GA | 1 |
| Saunders, J; Wickramasinghe, SN; Williams, G | 1 |
| Bushby, SR | 1 |
| Das, KC; Dash, RJ; Mukherjee, M; Rastogi, GK; Sarkar, TK | 1 |
| Cheng, FW; Shane, B; Stokstad, EL | 1 |
| Freisheim, JH; Jansen, G; McAlinden, TP; Prasad, KM; Ratnam, M; Schornagel, JH; Westerhof, GR; Williams, FE | 1 |
| Buckley, DD; Dewald, GW; Jalal, SM; Spurbeck, JL | 1 |
| Brumley, J; Hayman, RJ; Rose, IS; van der Weyden, MB | 1 |
| Aherne, GW; Curtin, NJ; Harris, AL | 1 |
| Cravo, ML; Mason, JB; Rosenberg, IH; Selhub, J | 1 |
| Haataja, R; Kähkönen, M; Leisti, J | 1 |
| Alarcòn, GS; Baggott, JE; Everson, MP; Hardin, JM; Hine, RJ; Koopman, WJ; Krumdieck, CL; Morgan, SL | 1 |
| Butterworth, CE; Cole, P; Hatch, KD; Sauberlich, HE; Soong, SJ; Tamura, T | 1 |
| Kane, MA; Raptis, G; Roth, E; Schreiber, C; Waxman, S | 1 |
| Arbuck, SG; Creaven, PJ; Herrera, L; Mittelman, A; Petrelli, N; Rustum, YM; Trave, F; Zakrzewski, SF | 1 |
| James, SJ; Yin, L | 1 |
| Bunni, M; Chou, TC; Galivan, J; Johnson, TB; Nair, MG; Priest, D; Rhee, MS | 1 |
| Chanarin, I; Deacon, R; Lumb, M; Perry, J | 3 |
| Das, KC; Herbert, V | 1 |
| Hamon, CG; Leeming, RJ; Tomkyns, JG | 1 |
| Borman, LS; Branda, RF | 1 |
| Cazzola, G; Dainotti, E; Maraschio, P; Piantanida, M; Tiepolo, L; Tupler, R | 1 |
| Curtin, NJ; Harris, AL; Newell, DR | 1 |
| Barlowe, CK; Goldman, ID; Matherly, LH; Phillips, VM | 1 |
| Galivan, J; Nimec, Z; Rhee, M | 1 |
| Bassendine, MF; Curtin, NJ; Harris, AL; James, OF | 1 |
| Hamilton-Miller, JM | 1 |
| Pelliccia, F; Rocchi, A | 1 |
| Boiocchi, M; Broggini, M; D'Incalci, M; Erba, E; Lorico, A; Rappa, G; Toffoli, G | 1 |
| Curtin, NJ; Harris, AL | 1 |
| Deshpande, AK; Ghaskadbi, S; Mulherkar, L | 1 |
| Matthews, JH; Wickramasinghe, SN | 1 |
| Boorman, GA; Hong, L; Luster, MI; Pung, O; Tucker, AN | 1 |
| Baker, E; Fratini, A; Sutherland, GR | 1 |
| O'Grady, FW | 1 |
| Baugh, CM; Nair, MG | 1 |
| Baugh, CM; Mercer, LP; Nair, MG | 1 |
| Jungkind, DL; Wood, RC | 2 |
| Canellos, GP; Greenberg, NH; Mead, JA; Schrecker, AW | 1 |
| Daniel, JC | 1 |
| Kuniyoshi, I; Saito, T | 1 |
| MacKinney, AA; Vas, R | 1 |
| Balk, SD; Braun, AC; Whitfield, JF; Youdale, T | 1 |
| Poirier, LA | 1 |
| Catovsky, D; Das, KC; Hoffbrand, V; Tripp, E | 1 |
| Godoy, GA; Soldo, AT | 1 |
| Greig, JB; Jones, JD; Taylor, DM | 1 |
| McBurney, MW; Whitmore, GF | 2 |
| Greenspan, EM; Schreiber, C; Waxman, S | 1 |
| Cooper, M; Koutts, J; Van der Weyden, MB | 1 |
| Harrap, KR; Jackson, RC; Jackson, ST; Tattersall, MH | 1 |
| DaCosta, M; Kamen, B; Rothenberg, SP | 1 |
| Friedkin, M | 1 |
| L'Hélias, C | 1 |
| Herbert, V; Tisman, G | 1 |
| Cooper, M; Firkin, BG; Van der Weyden, MB | 1 |
| Brenner, L; Herbert, V; Tisman, G | 1 |
| Hoffbrand, AV; Houlihan, CM; Scott, JM; Tripp, E | 1 |
| Auletta, AE; Davis, J; Gery, AM; Mead, JA; Mishra, L; Parmar, A | 1 |
| Gorczyca, PA; Kimble, CE; Sinskey, AJ | 1 |
| Carr, HS; Pollak, RD; Rosenkranz, S | 1 |
| Eisenstadt, J; Klein, A; Lengyel, P; Mathews, CK | 1 |
| Borsa, J; Whitmore, GF | 2 |
| Salen, G; Schumacher, HR | 1 |
| Landureau, JC | 1 |
| Green, R; Metz, J; Sive, J | 1 |
| Byrnes, KA; Ghidoni, JJ; Mayfield, ED | 1 |
| Bertino, JR; Chabner, BA; Chello, PL | 1 |
| Hammond, D; Hyman, CB; Lampkin, BC; Pyesmany, A | 1 |
| Bertino, JR; Hryniuk, WM | 1 |
| Bertino, JR; McCullough, JL; O'Brien, P | 1 |
| Hakala, MT | 1 |
| Dickerman, H; Taylor, RT; Weissbach, H | 1 |
| Tilson, MD | 1 |
| Baker, H; Frank, O; Hutner, SH | 1 |
| Baserga, R; Becker, FF; Broome, JD | 1 |
| Grossowicz, N; Mandelbaum-Shavit, F | 1 |
| Das, KC; Hoffbrand, AV | 1 |
| Evans, VJ; Otani, TT; Price, FM; Rotherham, J | 1 |
| Arakawa, T; Higashi, O; Karita, M; Narisawa, K; Yoshida, T | 1 |
| Baserga, R; Marzi, D; Thatcher, D | 1 |
| Evans, VJ; Price, FM; Rotherham, J | 2 |
| Baserga, R; Farber, E | 1 |
| Herbert, V; Waxman, S | 1 |
| Dewey, VC; Kidder, GW | 1 |
| Vennart, J | 1 |
| Taylor, DM; Threlfall, G | 1 |
| Evans, EA | 1 |
| Buck, AT; Taylor, DM; Threlfall, G | 2 |
| Chanarin, I | 1 |
| Besserer, JA; Boritzki, TJ; Elslager, EF; Fry, DW; Jackson, RC; Leopold, WR; Sloan, BJ | 1 |
| Ausina, VR; Coll, PF; Mirelis, BO; Prats, GP; Vernis, JV | 1 |
| Soreng, AL; Yunis, JJ | 1 |
| Kano, Y; Kubota, T; Miura, Y; Sakamoto, S; Sakuraya, K; Taguchi, H; Takaku, F | 1 |
| Akinyanju, OO; Grange, A; Litwinczuk, RA; Wickramasinghe, SN | 1 |
| Dworzak, E; Mohberg, J; Sachsenmaier, W | 1 |
| Glover, TW | 1 |
| Jotterand-Bellomo, M | 1 |
| Arthur, DC; Branda, RF; Danzl, TJ; King, RA; Woods, WG | 1 |
| Calvert, AH; Harrap, KR; Jackman, AL; Taylor, GA | 1 |
| Cooper, BA; Watkins, D | 1 |
| Dinn, J; McGing, P; McKenna, B; Molloy, A; Scott, JM; Weir, DG | 1 |
| Harasym, CA; Lin, CC; Snyder, FF | 1 |
| Beek, B; Jacky, PB; Sutherland, GR | 1 |
| Baker, E; Jacky, PB; Manuel, A; Sutherland, GR | 1 |
| Ariel, M; Grossowicz, N; Holtzer, E; Lavi, H | 1 |
| Hida, K; Kano, Y; Sakamoto, S; Suda, K; Takaku, F | 1 |
| Woodcock-Mitchell, J; Yang, TJ | 1 |
| Altés, R; Ayats, R; Baiget, M; Balanzó, J; Fábrega, J; Gimferrer, E; Guarner, C; Presa, F; Pujol, N; Simón, X | 1 |
| Hinton, L; Sutherland, GR | 1 |
| McKenna, B; Scott, JM; Weir, DG | 1 |
| Das, KC; Herbert, V; Manusselis, C | 1 |
| Barbiroli, B; Bovina, C; Formiggini, G; König, G; Marchetti, M; Tolomelli, B | 1 |
| Fernandes-Costa, F; Metz, J; Miller, H | 1 |
| Devraj, R; Gangjee, A; Kisliuk, RL; McGuire, JJ | 1 |
| Matsuo, Y; Minowada, J; Otani, T; Sur, P | 1 |
| Fort, DW; Kamen, BA; Lark, RH; Marling-Cason, M; Shane, B; Smith, AK; Weitman, SD | 1 |
| D'Incalci, M; Erba, E; Sen, S; Sessa, C; Vikhanskaya, FL | 1 |
| Ames, BN; Blount, BC; Brown, ZA; Hard, R; Horne, DW; Koury, MJ; Koury, ST; Pietenpol, JA | 1 |
| Eckstein, J; Kealey, JT; Santi, DV | 1 |
| Copp, AJ; Fleming, A | 1 |
| Bowman, KJ; Calvert, AH; Curtin, NJ; Golding, BT; Griffin, RJ; Huang, B; Loughlin, PJ; Newell, DR; Turner, RN | 1 |
| Aherne, GW; Benstead, J; Clarke, SJ; Farrugia, DC; Jackman, AL; Pritchard, DM | 1 |
| Jeanteur, P | 1 |
| Artuch, R; Campistol, J; Cardo, E; Colomé, C; Monrós, E; Pineda, M; Vilaseca, MA | 1 |
| Adelman, C; Liu, X; Oppenheim, EW; Stover, PJ | 1 |
| Backus, HH; Bunni, MA; Comijn, L; Jackman, AL; Jansen, G; Mitchell, F; Peters, GJ; Priest, DG; Smid, K; van der Wilt, CL; Veerman, G; Voorn, DA; Wouters, D | 1 |
| Doucette, MM; Stevens, VL | 1 |
| Andreassi, MG; Antonioli, E; Battaglia, D; Biagini, A; Botto, N; Clerico, A; Cocci, F; Colombo, MG; Manfredi, S; Masetti, S | 1 |
| Copp, AJ; Dunlevy, LE; Greene, ND | 1 |
| Faessel, HM; Greco, WR; Rustum, YM; Slocum, HK | 1 |
| TENTORI, L; VIVALDI, G | 1 |
| GROSSOWICZ, N; MANDELBAUM, F | 1 |
| HAEGI, V; MOESCHLIN, S; SCHMID, JR | 1 |
| BAKER, H; FRANK, O; LEEVY, CM; TEN-HOVE, W | 1 |
| COX, RP; FRIEND, C; HADDAD, JR; SILBER, R | 1 |
| LEEVY, CM | 1 |
| FRICK, PG; SCHMID, JR | 1 |
| LIEBERMAN, I; OVE, P | 1 |
| MOORE, AE; POGO, BG | 1 |
| DUNN, MS; VIJAYARAGHAVAN, PK | 1 |
| SAUBERLICH, HE | 1 |
| Bots, ML; Durga, J; Kok, FJ; Schouten, EG; van Boxtel, MP; Verhoef, P | 1 |
| Caudill, MA; Cogger, EA; Hata, H; Hung, J; Li, R; Moriarty, DJ; Perry, CA; Urrutia, TF; Yang, TL | 1 |
| Chen, CJ; Lin, HL; Liu, HW; Tsai, WC; Yen, JH | 1 |
| Chen, F; Chen, W; Gao, J; Hu, Z; Jin, G; Liu, J; Qin, J; Shen, H; Tang, J; Wang, S; Wang, X; Wei, Q; Zhai, X | 1 |
| Chernyshev, A; Fleischmann, T; Kohen, A | 1 |
| Clarke, SJ; Li, KM; Rivory, LP | 1 |
| Nelson, LS; Smith, SW | 1 |
| Chanson, A; Choi, SW; Friso, S; Jang, H; Kim, KC; Liu, Z; Sauer, J; Smith, DE; Zimmerly, EM | 1 |
| Copp, AJ; De Castro, SC; Greene, ND; Leung, KY; Savery, D | 1 |
| Imai, K; Tsurita, G; Yasui, H | 1 |
| Field, MS; Finkelstein, JL; Martiniova, L; Perry, CA; Stover, PJ | 1 |
| Daignan-Fornier, B; Hürlimann, HC; Pinson, B; Saint-Marc, C | 1 |
| Benjamin, SB; Drangowska-Way, A; Hilzendeger, MA; Joshi, C; Ke, W; Lewis, N; Locasale, J; Mony, VK; O'Rourke, EJ; Patti, GJ; Saba, JA; Yao, CH; Zhang, S | 1 |
7 review(s) available for thymidine and folic acid
| Article | Year |
|---|---|
Selection of biochemically variant, in some cases mutant, mammalian cells in culture.
Topics: Adrenal Cortex Hormones; Animals; Antimetabolites; Base Sequence; Carbohydrates; Cell Fusion; Cell Separation; Cells, Cultured; Cricetinae; Dactinomycin; Deoxycytidine; Drug Resistance; Epitopes; Folic Acid; Genes; Genes, Regulator; Guinea Pigs; Hot Temperature; Humans; Immunoglobulins; Mice; Mutation; Nucleosides; Phenotype; Purines; Puromycin; Rabbits; Rats; Temperature; Thymidine; Time Factors; Uracil; Uridine | 1975 |
Synergy of trimethoprim-sulfamethoxazole.
Topics: Animals; Bacteria; Conjugation, Genetic; Dihydropteroate Synthase; Drug Combinations; Drug Resistance, Microbial; Drug Synergism; Folic Acid; Folic Acid Antagonists; Genetics, Microbial; Mice; Microbial Sensitivity Tests; Mutation; Sulfamethoxazole; Tetrahydrofolates; Thymidine; Trimethoprim | 1975 |
Cytogenetic guidelines for fragile X studies tested in routine practice.
Topics: Adolescent; Adult; Cell Count; Cells, Cultured; Child; Child, Preschool; Chromosome Aberrations; Culture Media; Cytogenetics; Diagnostic Tests, Routine; Female; Floxuridine; Folic Acid; Fragile X Syndrome; Genetic Testing; Humans; Infant; Infant, Newborn; Karyotyping; Lymphocytes; Male; Metaphase; Middle Aged; Practice Guidelines as Topic; Quality Assurance, Health Care; Retrospective Studies; Thymidine | 1992 |
Cobalamin-folate interrelations.
Topics: Anemia, Megaloblastic; Animals; Central Nervous System Diseases; Coenzymes; Folic Acid; Folic Acid Deficiency; Formates; Humans; Methionine; Models, Biological; Tetrahydrofolates; Thymidine; Vitamin B 12; Vitamin B 12 Deficiency | 1989 |
The effects of nitrous oxide on cobalamins, folates, and on related events.
Topics: 5-Methyltetrahydrofolate-Homocysteine S-Methyltransferase; Adult; Analgesia; Animals; Carbon; Cell Division; Coenzymes; Female; Fetus; Folic Acid; Humans; Methylmalonyl-CoA Mutase; Nervous System; Nitrous Oxide; Peripheral Nervous System Diseases; Pregnancy; Pteroylpolyglutamic Acids; Rats; Tetanus; Thymidine; Vitamin B 12 | 1982 |
Thymidyl biosynthesis enzymes as antibiotic targets.
Topics: Anti-Bacterial Agents; Drug Design; Enzyme Inhibitors; Flavins; Folic Acid; Humans; Methyltransferases; Thymidine; Thymidylate Synthase | 2007 |
DNA synthesis inhibitors for the treatment of gastrointestinal cancer.
Topics: Antimetabolites, Antineoplastic; Antineoplastic Agents; Antineoplastic Combined Chemotherapy Protocols; Coordination Complexes; Cytidine; Drug Delivery Systems; Folic Acid; Gastrointestinal Neoplasms; Humans; Nanostructures; Nucleic Acid Synthesis Inhibitors; Organoplatinum Compounds; Platinum Compounds; Pyrimidines; Thymidine | 2014 |
3 trial(s) available for thymidine and folic acid
| Article | Year |
|---|---|
Evaluation of the deoxyuridine suppression test by using whole blood samples from folic acid-supplemented subjects.
Topics: Adult; Deoxyuridine; DNA; Erythrocytes; Female; Folic Acid; Humans; Male; Middle Aged; Nutritional Status; Random Allocation; Thymidine; Uterine Cervical Dysplasia; Vitamin B 12 | 1990 |
Additional food folate derived exclusively from natural sources improves folate status in young women with the MTHFR 677 CC or TT genotype.
Topics: Adolescent; Adult; Biological Products; Cytidine; Diet; Erythrocytes; Female; Folic Acid; Genotype; Homocysteine; Humans; Methylenetetrahydrofolate Reductase (NADPH2); Middle Aged; Thymidine | 2006 |
Pemetrexed pharmacokinetics and pharmacodynamics in a phase I/II study of doublet chemotherapy with vinorelbine: implications for further optimisation of pemetrexed schedules.
Topics: Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Area Under Curve; Carcinoma, Non-Small-Cell Lung; Deoxyuridine; Dietary Supplements; Dose-Response Relationship, Drug; Female; Folic Acid; Glutamates; Guanine; Homocysteine; Humans; Lung Neoplasms; Male; Methylmalonic Acid; Middle Aged; Pemetrexed; Thymidine; Thymidylate Synthase; Vinblastine; Vinorelbine; Vitamin B 12 | 2007 |
172 other study(ies) available for thymidine and folic acid
| Article | Year |
|---|---|
Folate-dependent enzymes in cultured Chinese hamster cells: folypolyglutamate synthetase and its absence in mutants auxotrophic for glycine + adenosine + thymidine.
Topics: Adenosine; Adenosine Triphosphate; Animals; Cells, Cultured; Cricetinae; Folic Acid; Glutamates; Glycine; Hydrogen-Ion Concentration; Hypoxanthines; Lung; Magnesium; Mutation; Nucleotides; Peptide Synthases; Rabbits; Tetrahydrofolates; Thymidine; Vitamin B 12 | 1977 |
Heritable fragile sites on human chromosomes I. Factors affecting expression in lymphocyte culture.
Topics: Cells, Cultured; Chromosome Aberrations; Chromosomes, Human; Culture Media; Dose-Response Relationship, Drug; Folic Acid; Humans; Hydrogen-Ion Concentration; Lymphocytes; Methotrexate; Phenotype; Thymidine; Time Factors | 1979 |
Folate requirement for blast cell transformation in mixed leukocyte cultures.
Topics: Asparagine; Culture Media; Folic Acid; Glucose; Glutamine; Glutathione; Humans; Lectins; Lymphocyte Activation; Lymphocyte Culture Test, Mixed; Thymidine; Time Factors; Tritium; Vitamin B 12 | 1975 |
Experimental chemotherapy of neuroblastoma. II. Increased thymidylate synthetase activity in a 5-fluorodeoxyuridine-resistant variant of mouse neuroblastoma.
Topics: Animals; Cell Division; Clone Cells; Drug Resistance; Floxuridine; Folic Acid; Folic Acid Antagonists; Methyltransferases; Mice; Neoplasms, Experimental; Neuroblastoma; Pentosyltransferases; Stimulation, Chemical; Thymidine; Thymidine Kinase; Thymidylate Synthase | 1975 |
Participation of exogenous thymine and thymidine in deoxyribonucleic acid synthesis in Lactobacillus acidophilus.
Topics: Bromodeoxyuridine; Bromouracil; Deoxyadenosines; DNA, Bacterial; Drug Resistance, Microbial; Floxuridine; Folic Acid; Guanosine; Lactobacillus acidophilus; Mutation; Temperature; Thymidine; Thymine; Tritium | 1975 |
Effect of folate and folinate on 3H-thymidine incorporation by transforming human lymphocytes in vitro.
Topics: Concanavalin A; DNA; DNA Replication; Dose-Response Relationship, Drug; Folic Acid; Humans; Leucovorin; Lymphocyte Activation; Lymphocytes; Thymidine; Tritium | 1977 |
The in vitro effect of trimethoprim on blastogenic transformation of human peripheral blood lymphocytes.
Topics: Autoradiography; Cells, Cultured; Concanavalin A; Deoxyuridine; Folic Acid; Formates; Humans; In Vitro Techniques; Leucine; Leucovorin; Lymphocyte Activation; Lymphocytes; Thymidine; Time Factors; Trimethoprim; Uridine | 1977 |
Growth requirements of calf lens epithelium in culture.
Topics: Animals; Blood; Cattle; Cell Division; Cell Line; Culture Media; Epithelial Cells; Fibroblasts; Folic Acid; Lens, Crystalline; Leucovorin; Methotrexate; Mice; Mitomycins; Thymidine | 1978 |
The effect of deoxyuridine, vitamin B12, folate and alcohol on the uptake of thymidine and on the deoxynucleoside triphosphate concentrations in normal and megaloblastic cells.
Topics: Anemia, Macrocytic; Anemia, Megaloblastic; Bone Marrow; Cells, Cultured; Deoxyadenine Nucleotides; Deoxyuridine; DNA; Ethanol; Folic Acid; Humans; Leucovorin; Lymphocytes; Tetrahydrofolates; Thymidine; Thymine Nucleotides; Vitamin B 12 | 1978 |
Stimulation of endothelia cell proliferation by precursors of thymidylate.
Topics: Animals; Aorta; Cattle; Cell Count; Cell Division; Cells, Cultured; Clone Cells; Cornea; Culture Media; Endothelium; Folic Acid; gamma-Glutamyl Hydrolase; Leucovorin; Serum Albumin, Bovine; Thymidine | 1979 |
Growth limitation of BHK-21 cells and its relation to folate metabolism.
Topics: Aminopterin; Animals; Cell Division; Cell Line; Cell Transformation, Neoplastic; Cricetinae; Drug Resistance; Folic Acid; Hypoxanthines; Kidney; Leucovorin; Tetrahydrofolate Dehydrogenase; Thymidine | 1979 |
The development of the diaminopyrimidines.
Topics: Aminopterin; Animals; Anti-Bacterial Agents; Escherichia coli; Folic Acid; Folic Acid Antagonists; History, 20th Century; Pyrimidines; Thymidine | 1979 |
The role of thymidine uptake in the control of cell proliferation.
Topics: Animals; Cattle; Cell Division; Cells, Cultured; Culture Media; Folic Acid; Mice; Thioinosine; Thymidine | 1979 |
Deoxyuridine metabolism in human megaloblastic marrow cells.
Topics: Anemia, Macrocytic; Anemia, Megaloblastic; Bone Marrow; Deoxyuridine; DNA; Folic Acid; Folic Acid Deficiency; Humans; Methotrexate; Thymidine; Thymidylate Synthase; Vitamin B 12; Vitamin B 12 Deficiency | 1979 |
Effect of folate and cobalamin compounds on the deoxyuridine suppression test in vitamin B12 and folate deficiency.
Topics: Deoxyuridine; Folic Acid; Folic Acid Deficiency; Humans; Methotrexate; Thymidine; Vitamin B 12; Vitamin B 12 Deficiency | 1978 |
Rapid separation of low molecular weight solutes from liposomes without dilution.
Topics: Chromatography, Gel; Folic Acid; Inulin; Leucine; Liposomes; Methionine; Methotrexate; Sucrose; Thymidine | 1978 |
Cobalamin dependent methionine synthesis and methyl-folate-trap in human vitamin B12 deficiency.
Topics: 5-Methyltetrahydrofolate-Homocysteine S-Methyltransferase; Bone Marrow; Bone Marrow Cells; Deoxyuridine; Folic Acid; Humans; Methotrexate; Methyltransferases; Tetrahydrofolates; Thymidine; Vitamin B 12 Deficiency | 1977 |
The effect of anticonvulsant drugs on thymidine and deoxyribosenucleic acid synthesis by human marrow cells.
Topics: Anticonvulsants; Bone Marrow; Bone Marrow Cells; Deoxyuridine; DNA; Folic Acid; Humans; Phenytoin; Thymidine; Vitamin B 12 | 1977 |
Effects of kidney extract on the folic acid induced proliferation of the rat kidney.
Topics: Animals; DNA; Female; Folic Acid; Kidney; Mitosis; Rats; Thymidine; Tissue Extracts | 1976 |
Aspects of the biochemical pharmacology of cytembena.
Topics: Acrylates; Animals; Cell Division; DNA Nucleotidyltransferases; DNA, Neoplasm; Dose-Response Relationship, Drug; Folic Acid; Formate-Tetrahydrofolate Ligase; Glycine Hydroxymethyltransferase; Humans; In Vitro Techniques; Leucine; Leucovorin; Leukemia L1210; Methylenetetrahydrofolate Dehydrogenase (NADP); Mice; Rats; Sarcoma, Yoshida; Tetrahydrofolate Dehydrogenase; Tetrahydrofolates; Thymidine; Thymidine Kinase; Thymidylate Synthase; Uridine | 1975 |
Effects of anticonvulsant drugs on the synthesis of DNA and protein by human bone marrow cells in vitro.
Topics: Bone Marrow; Bone Marrow Cells; DNA; Folic Acid; Humans; Leucine; Leucovorin; Phenobarbital; Phenytoin; Protein Biosynthesis; Thymidine | 1976 |
Erythropoiesis and erythropoietin in hypo- and hyperthyroidism.
Topics: Biological Assay; Bone Marrow Examination; Cell Division; Erythrocytes; Erythropoiesis; Erythropoietin; Folic Acid; Hematocrit; Hemoglobinometry; Humans; Hyperthyroidism; Hypothyroidism; Iron; Isoenzymes; L-Lactate Dehydrogenase; Plasma Volume; Polycythemia; Thymidine; Vitamin B 12 | 1975 |
The anti-folate effect of methionine on bone marrow of normal and vitamin B12 deficient rats.
Topics: Animals; Bone Marrow; Deoxyuridine; DNA; Folic Acid; Folic Acid Antagonists; Homocysteine; Liver; Male; Methionine; Methionine Adenosyltransferase; Rats; Thymidine; Vitamin B 12; Vitamin B 12 Deficiency | 1975 |
Molecular events in the membrane transport of methotrexate in human CCRF-CEM leukemia cell lines.
Topics: Affinity Labels; Biological Transport, Active; Carrier Proteins; Folate Receptors, GPI-Anchored; Folic Acid; Humans; Leukemia; Methotrexate; Purines; Receptors, Cell Surface; Thymidine; Tumor Cells, Cultured | 1992 |
Folate-deficient human lymphoblasts: changes in deoxynucleotide metabolism and thymidylate cycle activities.
Topics: Deoxyadenine Nucleotides; Deoxycytosine Nucleotides; Deoxyguanine Nucleotides; Deoxyuridine; Dose-Response Relationship, Drug; Folic Acid; Folic Acid Deficiency; Humans; Lymphocyte Activation; Lymphocytes; Nucleotides; Thymidine; Thymidylate Synthase; Thymine Nucleotides | 1991 |
Mechanism of cell death following thymidylate synthase inhibition: 2'-deoxyuridine-5'-triphosphate accumulation, DNA damage, and growth inhibition following exposure to CB3717 and dipyridamole.
Topics: Cell Division; Cell Survival; Deoxyuracil Nucleotides; Dipyridamole; DNA Damage; Drug Synergism; Folic Acid; Humans; Lung Neoplasms; Quinazolines; Thymidine; Thymidylate Synthase; Time Factors; Tumor Cells, Cultured | 1991 |
Use of the deoxyuridine suppression test to evaluate localized folate deficiency in rat colonic epithelium.
Topics: Animals; Cells, Cultured; Colon; Deoxyuridine; DNA; Epithelium; Fluorouracil; Folic Acid; Male; Rats; Rats, Inbred Strains; Thymidine | 1991 |
Uridine enhances expression of the fragile X chromosome in human lymphocytes.
Topics: Culture Media; Folic Acid; Fragile X Syndrome; Humans; Lymphocytes; Mitosis; Thymidine; Uridine | 1991 |
Methotrexate therapy in rheumatoid arthritis patients diminishes lectin-induced mononuclear cell proliferation.
Topics: Arthritis, Rheumatoid; Cell Division; Cells, Cultured; Culture Media; Deoxyuridine; DNA; Female; Folic Acid; Humans; Lectins; Leukocytes, Mononuclear; Male; Methotrexate; Middle Aged; Phytohemagglutinins; Thymidine; Tritium | 1990 |
Effect of intracellular folate concentration on the modulation of 5-fluorouracil cytotoxicity by the elevation of phosphoribosylpyrophosphate in cultured human KB cells.
Topics: Adenosine; Carcinoma, Squamous Cell; Cell Survival; Fluorouracil; Folic Acid; Glucose; Humans; KB Cells; Leucovorin; Leukemia, Myeloid, Acute; Methotrexate; Nasopharyngeal Neoplasms; Pentosephosphates; Phosphoribosyl Pyrophosphate; Thymidine | 1987 |
Biochemical and pharmacologic basis for potentiation of 5-fluorouracil action by leucovorin.
Topics: Animals; Biotransformation; Cell Division; Colonic Neoplasms; DNA; Drug Synergism; Fluorouracil; Folic Acid; Humans; Leucovorin; Leukemia L1210; Mice; RNA; Stomach Neoplasms; Thymidine; Thymidylate Synthase | 1987 |
Diet-induced DNA damage and altered nucleotide metabolism in lymphocytes from methyl-donor-deficient rats.
Topics: Animals; Choline; Choline Deficiency; Deoxyuridine; Diet; DNA Damage; DNA Replication; Folic Acid; Folic Acid Deficiency; Liver; Lymphocytes; Male; Methionine; NAD; Nucleotides; Rats; Rats, Inbred F344; Reference Values; RNA; Spleen; Thymidine | 1989 |
The enhancement of the activity of 10-propargyl-5,8-dideazafolate and 5,10-dideazatetrahydrofolate by inhibitors of dihydrofolate reductase.
Topics: Animals; Cell Line; Cell Survival; Folic Acid; Folic Acid Antagonists; Hypoxanthine; Hypoxanthines; Liver Neoplasms, Experimental; Quinazolines; Rats; Tetrahydrofolates; Thymidine; Tumor Cells, Cultured | 1989 |
In vitro DNA synthesis by megaloblastic bone marrow: effect of folates and cobalamins on thymidine incorporation and de novo thymidylate synthesis.
Topics: Adolescent; Adult; Aged; Bone Marrow; Deoxyuridine; DNA; Erythrocytes, Abnormal; Female; Folic Acid; Humans; Male; Megaloblasts; Middle Aged; Thymidine; Thymidine Kinase; Thymidine Monophosphate; Vitamin B 12 | 1989 |
The effect of folic acid and 5-formyltetrahydrofolic acid on folate-deficient HEp 2 cells in culture.
Topics: Folic Acid; Folic Acid Deficiency; Formyltetrahydrofolates; Humans; Tetrahydrofolates; Thymidine; Tumor Cells, Cultured | 1989 |
Nutritional folate deficiency in Chinese hamster ovary cells. I. Characterization of the pleiotropic response and its modulation by nucleic acid precursors.
Topics: Animals; Cell Adhesion; Cell Cycle; Cell Division; Cell Line; Cell Survival; Cricetinae; Disease Models, Animal; Female; Flow Cytometry; Folic Acid; Folic Acid Deficiency; Hypoxanthines; Nucleic Acid Precursors; Ovary; Phenotype; Thymidine | 1989 |
Differential expression of the ICF (immunodeficiency, centromeric heterochromatin, facial anomalies) mutation in lymphocytes and fibroblasts.
Topics: Adenosine; Caffeine; Centromere; Child, Preschool; Chromosome Aberrations; Chromosomes; Chromosomes, Human, Pair 1; Chromosomes, Human, Pair 16; Chromosomes, Human, Pair 9; Facial Expression; Female; Fibroblasts; Folic Acid; Humans; Immunologic Deficiency Syndromes; Lymphocytes; Mutation; Thymidine | 1989 |
Modulation of dipyridamole action by alpha 1 acid glycoprotein. Reduced potentiation of quinazoline antifolate (CB3717) cytotoxicity by dipyridamole.
Topics: Biological Transport; Cell Division; Dipyridamole; Drug Synergism; Folic Acid; Folic Acid Antagonists; Humans; Nucleosides; Orosomucoid; Quinazolines; Thymidine; Tumor Cells, Cultured | 1989 |
The effects on 4-aminoantifolates on 5-formyltetrahydrofolate metabolism in L1210 cells. A biochemical basis of the selectivity of leucovorin rescue.
Topics: Adenosine; Animals; Cell Division; Floxuridine; Folic Acid; Kinetics; Leucovorin; Leukemia L1210; Mice; Thymidine | 1987 |
Synergistic growth inhibition of rat hepatoma cells exposed in vitro to N10-propargyl-5,8-dideazafolate with methotrexate or the lipophilic antifolates trimetrexate or metoprine.
Topics: Animals; Antineoplastic Combined Chemotherapy Protocols; Cell Cycle; Deoxyuridine; Folic Acid; Folic Acid Antagonists; Liver Neoplasms, Experimental; Methotrexate; Pyrimethamine; Quinazolines; Rats; Thymidine; Thymidylate Synthase; Trimetrexate | 1987 |
Inhibition of the growth of human hepatocellular carcinoma in vitro and in athymic mice by a quinazoline inhibitor of thymidylate synthase, CB3717.
Topics: Animals; Antineoplastic Agents; Carcinoma, Hepatocellular; Deoxyuridine; Dose-Response Relationship, Drug; Folic Acid; Humans; In Vitro Techniques; Liver Neoplasms; Mice; Mice, Nude; Neoplasm Transplantation; Quinazolines; Thymidine | 1986 |
Reversal of activity of trimethoprim against gram-positive cocci by thymidine, thymine and 'folates'.
Topics: Folic Acid; Microbial Sensitivity Tests; Staphylococcus; Streptococcus; Thymidine; Thymine; Trimethoprim | 1988 |
Synergistic effect of DAPI and thymidylate stress conditions on the induction of common fragile sites.
Topics: Cells, Cultured; Chromosome Fragile Sites; Chromosome Fragility; Culture Media; Female; Fluorescent Dyes; Folic Acid; Gene Expression Regulation; Humans; Indoles; Lymphocytes; Male; Thymidine | 1988 |
Accumulation of DNA strand breaks in cells exposed to methotrexate or N10-propargyl-5,8-dideazafolic acid.
Topics: Cell Cycle; Cell Survival; Cycloheximide; DNA; DNA Damage; Folic Acid; Folic Acid Antagonists; Humans; Methotrexate; Proteins; Quinazolines; Thymidine | 1988 |
Potentiation of quinazoline antifolate (CB3717) toxicity by dipyridamole in human lung carcinoma, A549, cells.
Topics: Carcinoma; Cell Survival; Dipyridamole; DNA; Drug Synergism; Folic Acid; Folic Acid Antagonists; Humans; Lung Neoplasms; Quinazolines; Thymidine; Thymidylate Synthase; Tumor Cells, Cultured | 1988 |
Effects of urethane on mitosis of chick embryo primitive erythrocytes.
Topics: Animals; Chick Embryo; Erythrocytes; Folic Acid; Mitosis; Thymidine; Urethane; Uridine | 1987 |
Acquired folate deficiency in phytohaemagglutinin-stimulated human lymphocytes.
Topics: Cells, Cultured; Culture Media; Deoxyuridine; Dose-Response Relationship, Drug; Folic Acid; Folic Acid Deficiency; Humans; Lymphocyte Activation; Lymphocytes; Phytohemagglutinins; Thymidine | 1986 |
Alteration of bone marrow cell cycle kinetics by diphenylhydantoin: relationship to folate utilization and immune function.
Topics: Animals; Bone Marrow; Bone Marrow Cells; Cell Cycle; Female; Folic Acid; Hematopoietic Stem Cells; Immunity; In Vitro Techniques; Malaria; Mice; Mice, Inbred Strains; Phenytoin; Thymidine; Tritium | 1985 |
Excess thymidine induces folate sensitive fragile sites.
Topics: Base Sequence; Cells, Cultured; Chromosome Fragile Sites; Chromosome Fragility; DNA; Female; Folic Acid; Fragile X Syndrome; Humans; Lymphocytes; Male; Models, Genetic; Repetitive Sequences, Nucleic Acid; Thymidine | 1985 |
Co-trimaxazole therapy: place and prospects.
Topics: Animals; Anti-Bacterial Agents; Bacteria; Bacteriuria; Drug Combinations; Drug Resistance, Microbial; Drug Synergism; Escherichia coli; Fetus; Folic Acid; Folic Acid Antagonists; Humans; Mice; Microbial Sensitivity Tests; Pseudomonas aeruginosa; Pyrimidines; Recurrence; Respiratory Tract Infections; Sulfamethoxazole; Thymidine; Trimethoprim | 1973 |
Synthesis and biological evaluation of isofolic acid.
Topics: Enterococcus faecalis; Folic Acid; Folic Acid Antagonists; Isomerism; Lacticaseibacillus casei; Magnetic Resonance Spectroscopy; Microbial Sensitivity Tests; Pteridines; Structure-Activity Relationship; Thymidine | 1974 |
Synthesis and antifolate activity of isoaminopterin.
Topics: Aminopterin; Enterococcus faecalis; Folic Acid; Folic Acid Antagonists; Lacticaseibacillus casei; Magnetic Resonance Spectroscopy; Structure-Activity Relationship; Thymidine | 1974 |
Factors involved in the synthesis of cyclopropane fatty acids by Streptococcus faecalis.
Topics: Carbon Radioisotopes; Cell Division; Chromatography, Gas; Cyclopropanes; Enterococcus faecalis; Fatty Acids; Folic Acid; Hydrogen-Ion Concentration; Methionine; Methotrexate; Nephelometry and Turbidimetry; Oleic Acids; Temperature; Thymidine; Time Factors | 1974 |
Physiological differences between cyclopropane fatty acid-deficient mutants and the parent strain of Streptococcus faecalis.
Topics: Cell Division; Cell Survival; Chromatography, Thin Layer; Cyclopropanes; Deoxycholic Acid; Drug Resistance, Microbial; Enterococcus faecalis; Fatty Acids; Folic Acid; Hydrogen-Ion Concentration; Kinetics; Methotrexate; Mutation; Pantothenic Acid; Sodium Chloride; Species Specificity; Temperature; Thymidine; Time Factors; Tyrosine | 1974 |
The effect of treatment with cytotoxic agents on mouse spleen dihydrofolate reductase activity.
Topics: Animals; Cyclophosphamide; Floxuridine; Folic Acid; In Vitro Techniques; Leucovorin; Male; Methotrexate; Mice; Nucleosides; Organ Size; Spleen; Tetrahydrofolate Dehydrogenase; Thymidine | 1967 |
Vitamins and growth factors in the nutrition of rabbit blastocysts in vitro.
Topics: Animals; Ascorbic Acid; Biotin; Choline; Embryo, Mammalian; Female; Folic Acid; Hypoxanthines; In Vitro Techniques; Inositol; Niacinamide; Nutritional Physiological Phenomena; Ovum; Pantothenic Acid; Pyridoxine; Rabbits; Riboflavin; Thiamine; Thymidine; Vitamin A; Vitamin B 12; Vitamin B Complex; Vitamin D; Vitamin E; Vitamins | 1967 |
Studies on the microbiological determination of pantethine. I. Nutritional requirements of Lactobacillus bulgaricus B-1 strain.
Topics: Amino Acids; Biological Assay; Caseins; Culture Media; Folic Acid; Hydroxybutyrates; Lactobacillus; Niacinamide; Nicotinic Acids; Riboflavin; Surface-Active Agents; Thymidine; Vitamin B 12 | 1970 |
The assay of diphenylhydantoin effects on growing human lymphocytes.
Topics: Adenosine Triphosphatases; Animals; Anticonvulsants; Carbon Isotopes; DNA; Folic Acid; Folic Acid Antagonists; Growth; Humans; Leucine; Leukocytes; Lymphocytes; Phenytoin; Phosphorus Isotopes; Potassium; Sodium; Thymidine; Tritium | 1973 |
Roles of calcium, serum, plasma, and folic acid in the control of proliferation of normal and Rous sarcoma virus-infected chicken fibroblasts.
Topics: Animals; Avian Sarcoma Viruses; Blood; Calcium; Cell Count; Cell Division; Cell Transformation, Neoplastic; Cells, Cultured; Chickens; Culture Media; Fibroblasts; Folic Acid; Hot Temperature; Plasma; Proteins; Thymidine; Time Factors; Tritium | 1973 |
Folate deficiency in rats bearing the Walker tumor 256 and the Novikoff hepatoma.
Topics: Adenine; Animals; Carcinoma 256, Walker; Carcinoma, Hepatocellular; Choline; Diet; FIGLU Test; Folic Acid; Folic Acid Deficiency; Formates; Glycine; Guanine; Liver Neoplasms; Male; Methionine; Neoplasms, Experimental; Rats; Serine; Thymidine; Vitamin B 12 | 1973 |
Transport of methotrexate into normal haemopoietic cells and into leukaemic cells and its effects on DNA synthesis.
Topics: Bone Marrow; Bone Marrow Cells; Carbon Radioisotopes; Culture Techniques; Cyclic AMP; Dactinomycin; Deoxyuridine; DNA; Folic Acid; Humans; Lectins; Leukemia, Lymphoid; Leukemia, Myeloid; Lymphocyte Activation; Methotrexate; Mitosis; Phosphodiesterase Inhibitors; Puromycin; RNA; Theophylline; Thymidine; Tritium | 1973 |
A requirement for an unconjugated pteridine for the growth of Paramecium aurelia.
Topics: Chromatography, Gel; Culture Media; Darkness; Folic Acid; Light; Paramecium; Pteridines; Spectrometry, Fluorescence; Thymidine | 1974 |
Effects of 2,3,7,8-tetrachlorodibenzo-p-dioxin on stimulated DNA synthesis in the liver and kidney of the rat.
Topics: Animals; Chlorobenzenes; Dioxins; DNA; Dose-Response Relationship, Drug; Female; Folic Acid; Hepatectomy; Kidney; Lead; Liver; Male; Methylcholanthrene; Mitosis; Rats; Rats, Inbred Strains; Starvation; Thymidine; Time Factors; Tritium | 1974 |
Characterization of a Chinese hamster cell with a temperature-sensitive mutation in folate metabolism.
Topics: Adenosine; Animals; Cells, Cultured; Chromatography; Clone Cells; Cricetinae; Cycloheximide; Female; Folic Acid; Genes; Glutamates; Glycine; Mutation; Ovary; Temperature; Tetrahydrofolate Dehydrogenase; Thymidine | 1974 |
The role of folic acid binding proteins (FABP) in the cellular uptake of folates.
Topics: Animals; Blood; Carrier Proteins; Cell Division; Culture Media; Deoxyuridine; DNA; Female; Folic Acid; HeLa Cells; Humans; Kinetics; Lactoglobulins; Lymphocytes; Milk; Protein Binding; Tetrahydrofolates; Thymidine; Tritium | 1974 |
Effect ot trimethoprim on folate metabolism in human bone marrow.
Topics: Adult; Anemia, Macrocytic; Anti-Infective Agents; Bone Marrow; Culture Techniques; Deoxyuridine; Depression, Chemical; DNA; Drug Synergism; Female; Folic Acid; Folic Acid Antagonists; Folic Acid Deficiency; Humans; Male; Middle Aged; Pyrimidines; Thymidine; Thymine; Trimethoprim; Tritium; Vitamin B 12 Deficiency | 1973 |
Isolation and biochemical characterization of folate deficient mutants of Chinese hamster cells.
Topics: Adenosine; Animals; Cell Fusion; Cell Survival; Cells, Cultured; Chromatography, DEAE-Cellulose; Clone Cells; Cricetinae; Crosses, Genetic; Culture Media; DNA; Female; Folic Acid; Glycine; Hybrid Cells; Leucovorin; Methotrexate; Mutation; Ovary; Phenotype; RNA; Tetrahydrofolate Dehydrogenase; Thymidine; Tritium | 1974 |
Factors determining cell sensitivity to methotrexate: studies of folate and deoxyribonucleoside triphosphate pools in five mammalian cell lines.
Topics: Animals; Biological Assay; Cell Count; Cell Line; Cells, Cultured; Deoxyadenosines; Deoxyribonucleotides; Dose-Response Relationship, Drug; Folic Acid; Humans; L Cells; Leukemia L1210; Lymphoma; Methotrexate; Methylenetetrahydrofolate Dehydrogenase (NADP); Mice; Rats; Sarcoma, Yoshida; Thymidine; Thymidylate Synthase | 1974 |
DNA synthesis in chronic myelogenous leukemia cells: comparison of results in cells containing folate binding factor to replicating cells without binder.
Topics: Anemia, Hypochromic; Binding Sites; Bone Marrow Cells; Cells, Cultured; Deoxyuridine; DNA; DNA Replication; Folic Acid; Folic Acid Antagonists; Humans; Leukemia, Myeloid; Leukocytes; Lymphoma, Large B-Cell, Diffuse; Methotrexate; RNA; Thymidine; Tritium; Tuberculosis, Lymph Node; Uridine | 1972 |
The biochemist's outlook on cancer research.
Topics: Aerobiosis; Animals; Antineoplastic Agents; Biochemistry; Carbon Radioisotopes; Cell Transformation, Neoplastic; DNA Replication; England; Folic Acid; Folic Acid Antagonists; Glycolysis; History, 20th Century; Humans; Isotope Labeling; Lactates; Leukemia; Mice; Neoplasms; Research; Tetrahydrofolates; Thymidine; Thymidylate Synthase; Thymine; United States | 1973 |
[Mutations and alterations in the transmission of genetic information in Drosophila melanogaster by injection of diapausing chrysalids (Pieris brassicae) treated with pterins].
Topics: Animals; Cell Fractionation; DNA; Drosophila melanogaster; Extrachromosomal Inheritance; Female; Folic Acid; Folic Acid Deficiency; Insecta; Larva; Male; Metamorphosis, Biological; Mutation; Neoplasms, Experimental; Pigments, Biological; Pterins; Pupa; Sex Ratio; Thymidine; Tissue Extracts; Tritium; Ultracentrifugation | 1972 |
In vitro myelosuppression and immunosuppression by ethanol.
Topics: Bone Marrow; Bone Marrow Cells; Culture Techniques; DNA; Ethanol; Folic Acid; Humans; Lectins; Leukocytes; Lymphocyte Activation; Pyridoxal; Pyridoxine; Streptolysins; Thymidine; Tritium | 1973 |
Defective DNA synthesis in human megaloblastic bone marrow: effects of hydroxy-B 12 5'-deoxyadenosyl-B 12 and methyl-B 12 .
Topics: Anemia, Macrocytic; Anemia, Pernicious; Bone Marrow; Bone Marrow Cells; Cells, Cultured; Deoxyuridine; DNA; Folic Acid; Humans; Thymidine; Thymine Nucleotides; Tritium; Vitamin B 12; Vitamin B 12 Deficiency | 1973 |
The dU suppression test using 125 I-UdR to define biochemical megaloblastosis.
Topics: Anemia, Macrocytic; Bone Marrow; Deoxyuridine; DNA; Folic Acid; Folic Acid Deficiency; Humans; In Vitro Techniques; Iodine Isotopes; Methods; Thymidine; Thymine; Tritium; Vitamin B 12; Vitamin B 12 Deficiency | 1973 |
Studies on the uptake of synthetic conjugated folates by human marrow cells.
Topics: Anemia, Macrocytic; Biological Transport; Bone Marrow; Bone Marrow Cells; Coenzymes; Deoxyuridine; DNA; Folic Acid; Glutamates; Humans; Lymphocytes; Pyrimidines; Structure-Activity Relationship; Thymidine; Tritium | 1973 |
The effect of folate and folate analogs upon dihydrofolate reductase and DNA synthesis in kidneys of normal mice.
Topics: Animals; Biological Transport; Carbon Radioisotopes; Chromatography, DEAE-Cellulose; Deoxyuridine; DNA; Folic Acid; Folic Acid Antagonists; Isotope Labeling; Kidney; Male; Methotrexate; Mice; Mice, Inbred Strains; Spectrophotometry, Ultraviolet; Structure-Activity Relationship; Thymidine; Time Factors; Tritium; Ultracentrifugation; Ultrafiltration; Xanthopterin | 1974 |
Repair of lesions induced in human liver cell DNA by N-nitroso compounds as measured by the bromodeoxyuridine photolysis method.
Topics: Alkylation; Bromodeoxyuridine; Carcinogens; Cell Line; Cells, Cultured; DNA; DNA Repair; Folic Acid; Humans; In Vitro Techniques; Liver; Mannose; Morpholines; Nitroso Compounds; Nitrosoguanidines; Oleic Acids; Photolysis; Thymidine; Tritium | 1974 |
Studies with hydroxyurea. VI. Effects of hydroxyurea on the metabolism of sensitive and resistant strains of Escherichia coli.
Topics: Carbamates; Depression, Chemical; DNA, Bacterial; Drug Resistance, Microbial; Escherichia coli; Folic Acid; Genetics, Microbial; Hydroxyurea; Models, Biological; Nucleosides; Oxidation-Reduction; Thioctic Acid; Thymidine; Tritium; Urea; Urethane; Vitamin B 12 | 1967 |
Further studies on the requirement for formyl residues in the synthesis of bacteriophage T4 proteins.
Topics: Bacterial Proteins; Carbon Isotopes; Coliphages; Depression, Chemical; DNA, Bacterial; DNA, Viral; Escherichia coli; Folic Acid; Folic Acid Antagonists; Formates; Lysine; Mutation; Pyrimidines; RNA, Transfer; Thymidine; Tritium; Viral Proteins | 1968 |
Studies relating to the mode of action of methotrexate. 3. Inhibition of thymidylate synthetase in tissue culture cells and in cell-free systems.
Topics: Animals; Carcinoma, Ehrlich Tumor; Cell-Free System; Chromatography, Ion Exchange; Cricetinae; Culture Techniques; Deoxyuridine; DNA; Embryo, Mammalian; Escherichia coli; Folic Acid; Histocytochemistry; Kinetics; L Cells; Leucovorin; Methotrexate; Mice; Nucleotides; RNA; Thymidine; Transferases; Tritium | 1969 |
Metabolism of leukocytes in a case of acute leukemia.
Topics: Autoradiography; Child; DNA; Female; Folic Acid; Humans; Leukemia, Lymphoid; Leukocyte Count; Leukocytes; Methotrexate; Prednisone; Thymidine; Tritium; Uridine; Vincristine; Vitamin B 12 | 1967 |
[Biological role of vitamin B 12: analysis of strict vitamin requirement of cell line of insects in vitro].
Topics: Aminopterin; Cell Division; Cell Line; Coleoptera; Culture Techniques; Folic Acid; Folic Acid Deficiency; Methionine; Nucleic Acids; Nucleotides; Purines; Thymidine; Vitamin B 12; Vitamin B 12 Deficiency | 1970 |
Effect of trimethoprim on folate-dependent DNA synthesis in human bone marrow.
Topics: Anti-Infective Agents; Bone Marrow; Culture Techniques; Deoxyuridine; DNA; Ethanol; Folic Acid; Folic Acid Antagonists; Humans; Methotrexate; Pyrimidines; Thymidine; Trimethoprim; Tritium | 1972 |
Response of the rat kidney to folic acid administration. I. Biochemical studies.
Topics: Amidohydrolases; Animals; Autoradiography; Carbon Isotopes; Carboxy-Lyases; DNA; DNA Nucleotidyltransferases; Folic Acid; Kidney; Male; Orotic Acid; Oxidoreductases; Phosphotransferases; Rats; RNA; Stimulation, Chemical; Subcellular Fractions; Thymidine; Transferases; Tritium | 1972 |
Antitumor activity of a folate-cleaving enzyme, carboxypeptidase G 1 .
Topics: Animals; Antineoplastic Agents; Carboxypeptidases; Carcinoma 256, Walker; Cell Division; Cell Line; Cells, Cultured; Clone Cells; Deoxyuridine; Depression, Chemical; DNA, Neoplasm; Female; Folic Acid; Folic Acid Deficiency; Humans; Injections, Intraperitoneal; Leukemia L1210; Liver; Lymphoma; Male; Mice; Mice, Inbred AKR; Mice, Inbred DBA; Mice, Inbred Strains; Neoplasms, Experimental; Rats; Sarcoma 180; Thymidine; Time Factors; Tritium | 1972 |
Congenital familial megaloblastic anemia.
Topics: Anemia, Macrocytic; Bone Marrow; Cobalt Isotopes; Deoxyuridine; Female; Folic Acid; Hemoglobins; Humans; In Vitro Techniques; Infant; Infant, Newborn; Methods; Orotic Acid; Phosphates; Thymidine; Vitamin B 12 | 1971 |
Treatment of leukemia with large doses of methotrexate and folinic acid: clinical-biochemical correlates.
Topics: Adolescent; Adult; Aged; Child; Child, Preschool; Deoxyuridine; DNA, Neoplasm; Female; Folic Acid; Humans; Leukemia; Leukemia, Lymphoid; Male; Methotrexate; Middle Aged; Tetrahydrofolate Dehydrogenase; Thymidine; Tritium | 1969 |
Inhibition of growth of leukemia cells by enzymic folate depletion.
Topics: Animals; Carboxypeptidases; Carcinoma 256, Walker; Cell Line; Culture Media; Depression, Chemical; Folic Acid; Humans; Hypoxanthines; In Vitro Techniques; Leucovorin; Leukemia L1210; Leukemia, Experimental; Methotrexate; Pseudomonas; Serine; Thymidine | 1971 |
Homofolate and tetrahydrohomofolate, inhibitors of purine synthesis.
Topics: Animals; Culture Media; Culture Techniques; Folic Acid; Glycine; Leucovorin; Methotrexate; Neoplasms, Experimental; Purines; Sarcoma, Experimental; Thymidine | 1971 |
Control of one-carbon metabolism in a methionine-B12 auxotroph of Escherichia coli.
Topics: Carbon; Carbon Isotopes; Enzyme Repression; Escherichia coli; Feedback; Folic Acid; Ligases; Methionine; Mutation; Oxidoreductases; Tetrahydrofolate Dehydrogenase; Thymidine; Transferases; Vitamin B 12 | 1966 |
A dissimilar effect of folic acid upon growth of the rat kidney and small bowel.
Topics: Animals; Autoradiography; Cell Division; DNA; Female; Folic Acid; Intestine, Small; Kidney; Rats; Stimulation, Chemical; Thymidine; Tritium | 1970 |
Antagonists of growth inhibition of Crithidia by allopurinol, a guanine analog.
Topics: Allopurinol; Folic Acid; Hypoxanthines; Mercaptopurine; Pteridines; Thymidine; Trypanosoma | 1970 |
Effect of L-asparaginase on DNA synthesis in regenerating liver and in other dividing tissues.
Topics: Age Factors; Animals; Asparaginase; DNA; Folic Acid; Hepatectomy; Horses; Immune Sera; Intestines; Isoproterenol; Kidney; Kidney Tubules; Liver; Liver Regeneration; Lymphoid Tissue; Mice; Mitosis; Nephrectomy; Parotid Gland; Rats; Spleen; Thymidine; Tritium | 1970 |
Transport of folinate and related compounds in Pediococcus cerevisiae.
Topics: Aminopterin; Biological Transport; Folic Acid; Glucose; Hydrogen-Ion Concentration; Kinetics; Methotrexate; Pediococcus; Temperature; Thymidine; Tritium | 1970 |
Lymphocyte transformation in megaloblastic anaemia: morphology and DNA synthesis.
Topics: Anemia, Macrocytic; Anemia, Pernicious; Chromosomes; Culture Techniques; Deoxyuridine; DNA; Folic Acid; Folic Acid Deficiency; Humans; Lectins; Lymphocyte Activation; Lymphocytes; Thymidine; Tritium; Vitamin B 12; Vitamin B 12 Deficiency | 1970 |
Some aspects of the role of vitamin B 12 and folic acid in DNA-thymidine sy nthesis in a neoplastic C3H mouse cell strain.
Topics: Adenine; Animals; Carbon Isotopes; Cell Line; Chromatography, Paper; Culture Media; Culture Techniques; Deoxyuridine; DNA, Neoplasm; Folic Acid; Formates; Hydroxocobalamin; Mice; Neoplasms; Stimulation, Chemical; Thymidine; Vitamin B 12 | 1971 |
Hypersegmentation of megakaryocytes in a folic acid deficient child.
Topics: Bone Marrow; Cell Nucleus; Child; Child, Preschool; DNA; Female; Folic Acid; Folic Acid Deficiency; Homocystinuria; Humans; Infant; Iron; Male; Megakaryocytes; Thymidine; Tritium | 1971 |
Cell proliferation in mouse kidney after a single injection of folic acid.
Topics: Animals; Autoradiography; Bicarbonates; Carbonates; DNA; Fasting; Female; Folic Acid; Injections, Intraperitoneal; Injections, Subcutaneous; Kidney; Male; Methods; Mice; Mitosis; Sex; Thymidine; Tritium | 1968 |
Some aspects of the role of folic acid in nucleic acid synthesis in a neoplastic C3H mouse cell strain.
Topics: Animals; Carbon Isotopes; Cell Transformation, Neoplastic; Culture Techniques; DNA, Neoplasm; Folic Acid; Mice; Neoplasm Transplantation; Neoplasms, Experimental; Orotic Acid; RNA, Neoplasm; Thymidine; Uridine | 1968 |
Differential effects of hydroxyurea on survival of proliferating cells in vivo.
Topics: Animals; Cell Biology; Depression, Chemical; DNA; Epithelial Cells; Folic Acid; Hydroxyurea; Intestine, Small; Isoproterenol; Kidney; Liver Regeneration; Lymphoid Tissue; Male; Mice; Mitosis; Necrosis; Rats; Salivary Glands; Thymidine; Tongue; Tritium | 1969 |
Mechanism of pyrimethamine-induced megaloblastosis in human bone marrow.
Topics: Anemia, Macrocytic; Bone Marrow; Bone Marrow Diseases; Chorioretinitis; Culture Techniques; Deoxyuridine; DNA; Erythrocytes; Female; Fluorouracil; Folic Acid; Folic Acid Antagonists; Humans; Methotrexate; Middle Aged; Nucleotides; Oxidation-Reduction; Pyrimethamine; Thymidine; Tritium | 1969 |
Cell killing studies on the mode of action of methotrexate on L-cells in vitro.
Topics: Amino Acids; Cell Division; Culture Media; Culture Techniques; Folic Acid; Humans; L Cells; Methotrexate; Nucleotides; Thymidine; Time Factors | 1969 |
2,4-diamino-5, 6,7,8-tetrahydroquinazoline, a new pteridine antagonist.
Topics: Animals; Depression, Chemical; Eukaryota; Folic Acid; Growth; Pteridines; Pterins; Quinazolines; Thymidine; Thymine | 1969 |
Radiotoxicology of tritium and 14C compounds.
Topics: Adrenal Cortex Hormones; Animals; Bone Marrow; Carbon Isotopes; Folic Acid; Gonadal Steroid Hormones; Gonads; Humans; Kidney; Liver; Maximum Allowable Concentration; Radiation Effects; Radiation Protection; Rats; Thymidine; Tritium; Water | 1969 |
Modification of folic acid-induced changes in renal nucleic acid and protein synthesis by actinomycin D and cycloheximide.
Topics: Animals; Carbon Isotopes; Cycloheximide; Dactinomycin; Depression, Chemical; DNA Replication; Folic Acid; Kidney; Lysine; Male; Protein Biosynthesis; Rats; RNA; Stimulation, Chemical; Thymidine; Time Factors; Tritium; Uridine | 1969 |
Control of self-irradiation decomposition of tritium-labelled compounds at high specific activity.
Topics: Alcohols; Drug Stability; Ethanol; Folic Acid; Formates; Histidine; Leucine; Methotrexate; Nucleosides; Penicillin G; Radiation-Protective Agents; Thymidine; Tritium; Tyrosine; Uridine | 1966 |
The effect of folic acid on growth and deoxyribonucleic acid synthesis in the rat kidney.
Topics: Animals; Autoradiography; Body Weight; DNA; Folic Acid; Kidney; Organ Size; Phosphorus Isotopes; Radioisotope Renography; Rats; RNA; Thymidine | 1966 |
Studies of the changes in growth and DNA synthesis in the rat kidney during experimentally induced renal hypertrophy.
Topics: Animals; Body Weight; DNA; Folic Acid; Hypertrophy; Kidney; Nephrectomy; Phosphorus Isotopes; Rats; RNA; Thymidine; Tritium | 1967 |
Biochemical pharmacology of the lipophilic antifolate, trimetrexate.
Topics: Animals; Cell Line; Culture Techniques; Deoxyuridine; Drug Resistance; Folic Acid; Folic Acid Antagonists; Humans; Kinetics; Leucovorin; Leukemia L1210; Lymphocytes; Methotrexate; Mice; Mice, Inbred Strains; Quinazolines; Ribonucleotides; Thymidine; Trimetrexate | 1984 |
Exogenous thymidine and reversal of the inhibitory effect of sulfamethoxazole-trimethoprim on streptococci.
Topics: Agar; Anti-Bacterial Agents; Caseins; Culture Media; Drug Combinations; Folic Acid; Protein Hydrolysates; Streptococcus; Sulfamethoxazole; Thymidine; Trimethoprim; Trimethoprim, Sulfamethoxazole Drug Combination | 1984 |
Constitutive fragile sites and cancer.
Topics: Adolescent; Adult; Animals; Caffeine; Cells, Cultured; Child; Chromosome Fragile Sites; Chromosome Fragility; Chromosome Mapping; Female; Floxuridine; Folic Acid; Gorilla gorilla; Humans; Male; Middle Aged; Neoplasms; Pan troglodytes; Thymidine | 1984 |
Effects of leucovorin and methylcobalamin with N2O anesthesia.
Topics: Bone Marrow; Deoxyuridine; DNA; Folic Acid; Humans; Leucovorin; Nitrous Oxide; Thymidine; Time Factors; Vitamin B 12 | 1984 |
Folate levels and deoxyuridine suppression tests in protein-energy malnutrition.
Topics: Bone Marrow; Child, Preschool; Deoxyuridine; DNA; Erythrocytes; Erythropoiesis; Folic Acid; Humans; Infant; Kwashiorkor; Protein-Energy Malnutrition; Thymidine; Vitamin B 12 | 1983 |
Thymidine kinase-deficient mutants of Physarum polycephalum. Biochemical characterization.
Topics: Bromodeoxyuridine; Deoxycytidine Kinase; DNA; DNA, Mitochondrial; Floxuridine; Folic Acid; Mutation; Physarum; Thymidine; Thymidine Kinase | 1980 |
FUdR induction of the X chromosome fragile site: evidence for the mechanism of folic acid and thymidine inhibition.
Topics: Cells, Cultured; DNA; Female; Floxuridine; Folic Acid; Humans; Intellectual Disability; Lymphocytes; Male; Sex Chromosome Aberrations; Sex Chromosomes; Thymidine; Thymidine Monophosphate; Thymidylate Synthase; X Chromosome | 1981 |
[Autosomal fragile sites].
Topics: Adolescent; Adult; Bromodeoxyuridine; Child; Child, Preschool; Chromosome Aberrations; Chromosome Banding; Chromosome Disorders; Chromosome Fragile Sites; Chromosome Fragility; Chromosomes; Chromosomes, Human, 6-12 and X; Distamycins; Female; Folic Acid; Humans; Infant; Infant, Newborn; Male; Phenotype; Thymidine | 1984 |
Folate metabolism and chromosomal stability in the fragile X syndrome.
Topics: Adult; Bone Marrow; Cells, Cultured; Chromosome Fragile Sites; Chromosome Fragility; DNA; Erythrocytes; Female; Fibroblasts; Folic Acid; Fragile X Syndrome; Humans; Karyotyping; Kinetics; Lymphocytes; Male; Pedigree; Sex Chromosome Aberrations; Sister Chromatid Exchange; Thymidine | 1984 |
Modulation of anti-metabolite effects. Effects of thymidine on the efficacy of the quinazoline-based thymidylate synthetase inhibitor, CB3717.
Topics: Animals; Antimetabolites, Antineoplastic; Cells, Cultured; Deoxyuridine; Folic Acid; Leukemia L1210; Male; Methyltransferases; Mice; Mice, Inbred DBA; Quinazolines; Thymidine; Thymidylate Synthase | 1984 |
A critical intracellular concentration of fully reduced non-methylated folate polyglutamates prevents macrocytosis and diminished growth rate of human cell line K562 in culture.
Topics: Cell Division; Cell Line; Cells, Cultured; Folic Acid; Humans; Hypoxanthine; Hypoxanthines; Leukemia, Myeloid; Oxidation-Reduction; Pteroylpolyglutamic Acids; Thymidine; Vitamin B 12 | 1983 |
The role of methionine in the intracellular accumulation and function of folates.
Topics: Animals; Cercopithecus; DNA Replication; Folic Acid; Macaca fascicularis; Methionine; Mice; Mice, Inbred Strains; Pteroylpolyglutamic Acids; Rats; Rats, Inbred Strains; Species Specificity; Thymidine; Tritium | 1983 |
Purine, thymidylate and amino acid requirements for human lymphocyte transformation and fragile chromosome site expression.
Topics: Amino Acids; Cells, Cultured; Female; Folic Acid; Humans; Hypoxanthine; Hypoxanthines; Lymphocyte Activation; Lymphocytes; Male; Sex Chromosome Aberrations; Thymidine; X Chromosome | 1984 |
Fragile sites in chromosomes: possible model for the study of spontaneous chromosome breakage.
Topics: Adolescent; Adult; Cell Nucleus; Cells, Cultured; Child; Chromosome Aberrations; Chromosome Fragile Sites; Chromosome Fragility; Culture Media; Dose-Response Relationship, Drug; Female; Folic Acid; Humans; Lymphocytes; Male; Middle Aged; Thymidine | 1983 |
Heritable fragile sites on human chromosomes. X. New folate-sensitive fragile sites: 6p23, 9p21, 9q32, and 11q23.
Topics: Child; Child, Preschool; Chromosome Fragile Sites; Chromosome Fragility; Chromosomes, Human; Chromosomes, Human, 6-12 and X; Culture Media; Dose-Response Relationship, Drug; Female; Folic Acid; Humans; Infant, Newborn; Karyotyping; Male; Pedigree; Thymidine | 1983 |
Physiological and enzymatic properties of a thymidine-requiring Pediococcus cerevisiae mutant.
Topics: Aminopterin; Folic Acid; Leucovorin; Methotrexate; Methyltransferases; Mutation; Pediococcus; Tetrahydrofolate Dehydrogenase; Thymidine; Thymidylate Synthase | 1982 |
5-Methyltetrahydrofolate related enzymes and DNA polymerase alpha activities in bone marrow cells from patients with vitamin B12 deficient megaloblastic anemia.
Topics: 5-Methyltetrahydrofolate-Homocysteine S-Methyltransferase; 5,10-Methylenetetrahydrofolate Reductase (FADH2); Adult; Aged; Alcohol Oxidoreductases; Anemia, Macrocytic; Anemia, Megaloblastic; Bone Marrow; Bone Marrow Cells; Deoxyuridine; DNA Polymerase II; DNA-Directed DNA Polymerase; Female; Folic Acid; Humans; Hydroxocobalamin; Leucovorin; Male; Methylenetetrahydrofolate Reductase (NADPH2); Middle Aged; Tetrahydrofolates; Thymidine; Vitamin B 12; Vitamin B 12 Deficiency | 1982 |
Effect of antiserum on leukemia L5178Y cells: [3H]thymidine incorporation does not reflect DNA synthesis.
Topics: Animals; Antibodies, Neoplasm; Biological Transport; DNA Replication; DNA, Neoplasm; Folic Acid; Leukemia, Experimental; Mice; Thymidine; Thymidine Kinase; Thymidylate Synthase | 1982 |
[Macrocytosis in the liver patient: study of blood folate and vitamin B 12, and thymidine synthesis in hematopoietic cells].
Topics: Adult; Anemia, Macrocytic; Anemia, Megaloblastic; Female; Folic Acid; Hematopoietic Stem Cells; Humans; Liver Cirrhosis; Male; Thymidine; Vitamin B 12 | 1982 |
Heritable fragile sites on human chromosomes. VI. Characterization of the fragile site at 12q13.
Topics: Cells, Cultured; Chromosome Aberrations; Chromosome Disorders; Chromosomes, Human, 6-12 and X; Epidermolysis Bullosa; Folic Acid; Humans; Hydrogen-Ion Concentration; Lymphocytes; Pedigree; Thymidine | 1981 |
How vitamin B12 acts.
Topics: Anemia, Macrocytic; Anemia, Megaloblastic; Animals; Folic Acid; Humans; Methionine; Pteroylpolyglutamic Acids; S-Adenosylmethionine; Thymidine; Vitamin B 12 Deficiency | 1981 |
The effect of folate analogues on the thymidine utilization by human and rat marrow cells and the effect on the deoxyuridine suppression test.
Topics: Anemia, Megaloblastic; Animals; Bone Marrow; Deoxyuridine; Folic Acid; Humans; Male; Rats; Rats, Inbred Strains; Thymidine; Vitamin B 12 | 1981 |
The induction of functional vitamin B-12 deficiency in rats by exposure to nitrous oxide.
Topics: Animals; Bone Marrow; Deoxyuridine; Disease Models, Animal; DNA; Female; Folic Acid; Formyltetrahydrofolates; Nitrous Oxide; Rats; Thymidine; Vitamin B 12; Vitamin B 12 Deficiency | 1980 |
In vitro DNA synthesis by bone marrow cells and PHA-stimulated lymphocytes. Suppression by nonradioactive thymidine of the incorporation of 3H-deoxyuridine into DNA: enhancement of incorporation when inadequate vitamin B12 or folate is corrected.
Topics: Bone Marrow; Cells, Cultured; Deoxyuridine; DNA; Folic Acid; Folic Acid Deficiency; Humans; Lymphocytes; Phytohemagglutinins; Thymidine; Vitamin B 12; Vitamin B 12 Deficiency | 1980 |
Distribution of pteroylglutamates during liver regeneration after partial hepatectomy in folic acid-deficient rats.
Topics: Animals; DNA; Folic Acid; Folic Acid Deficiency; Liver; Liver Regeneration; Male; Pteroylpolyglutamic Acids; Rats; Thymidine; Time Factors | 1980 |
Synthesis of DNA as shown by the deoxyuridine suppression test is normal in the vitamin B12-deficient fruit bat (Rosettus Aegyptiacus).
Topics: Animals; Bone Marrow; Cells, Cultured; Chiroptera; Deoxyuridine; DNA; Folic Acid; Lymphocytes; Methotrexate; Thymidine; Vitamin B 12; Vitamin B 12 Deficiency | 1980 |
Effect of bridge region variation on antifolate and antitumor activity of classical 5-substituted 2,4-diaminofuro[2,3-d]pyrimidines.
Topics: Antineoplastic Agents; Cell Division; Folic Acid; Folic Acid Antagonists; Humans; Hypoxanthine; Hypoxanthines; Kinetics; Lacticaseibacillus casei; Leucovorin; Methotrexate; Molecular Structure; Peptide Synthases; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Pyrimidines; Recombinant Proteins; Structure-Activity Relationship; Thymidine; Thymidylate Synthase; Tumor Cells, Cultured | 1995 |
Reversal of methotrexate-induced folate pool depletion by thymidine in a human leukemia cell line in vitro.
Topics: Antibodies, Monoclonal; Antineoplastic Combined Chemotherapy Protocols; Cell Division; Fluorescent Antibody Technique; Folic Acid; Humans; Interferon-gamma; Leukemia, Myeloid; Methotrexate; Thymidine; Tumor Cells, Cultured | 1993 |
Accumulation of 5-methyltetrahydrofolic acid and folylpolyglutamate synthetase expression by mitogen stimulated human lymphocytes.
Topics: Cells, Cultured; Folic Acid; Humans; Kinetics; Lymphocyte Activation; Lymphocytes; Peptide Synthases; Phytohemagglutinins; RNA, Messenger; Tetrahydrofolates; Thymidine | 1993 |
Mechanism of cytotoxicity of 5,10-dideazatetrahydrofolic acid in human ovarian carcinoma cells in vitro and modulation of the drug activity by folic or folinic acid.
Topics: Antineoplastic Agents; Cell Cycle; DNA, Neoplasm; Drug Screening Assays, Antitumor; Female; Folic Acid; Folic Acid Antagonists; Humans; Hypoxanthine; Hypoxanthines; Leucovorin; Ovarian Neoplasms; Tetrahydrofolates; Thymidine; Time Factors; Tumor Cells, Cultured | 1994 |
Apoptosis of late-stage erythroblasts in megaloblastic anemia: association with DNA damage and macrocyte production.
Topics: Anemia, Megaloblastic; Animals; Apoptosis; Cells, Cultured; Cyclin-Dependent Kinase Inhibitor p21; Cyclins; DNA Damage; DNA Replication; Erythroblasts; Erythrocytes, Abnormal; Erythropoiesis; Female; Folic Acid; Folic Acid Deficiency; Humans; Mice; Thymidine; Thymidylate Synthase; Tumor Suppressor Protein p53; Uracil | 1997 |
Role of the conserved tryptophan 82 of Lactobacillus casei thymidylate synthase.
Topics: Catalysis; Conserved Sequence; Crystallography, X-Ray; Folic Acid; Kinetics; Lacticaseibacillus casei; Mutagenesis; Mutation; Plasmids; Thymidine; Thymidylate Synthase; Tryptophan | 1995 |
Embryonic folate metabolism and mouse neural tube defects.
Topics: Animals; Central Nervous System; Deoxyuracil Nucleotides; DNA-Binding Proteins; Embryo, Mammalian; Female; Folic Acid; Humans; Male; Methionine; Mice; Mice, Inbred CBA; Mutation; Neural Tube Defects; Paired Box Transcription Factors; PAX3 Transcription Factor; Pyrimidines; Tetrahydrofolates; Thymidine; Thymidine Monophosphate; Transcription Factors | 1998 |
Potentiation of the cytotoxicity of thymidylate synthase (TS) inhibitors by dipyridamole analogues with reduced alpha1-acid glycoprotein binding.
Topics: Animals; Antineoplastic Agents; Biological Transport; Cell Division; Cell Survival; Dipyridamole; Drug Synergism; Enzyme Inhibitors; Folic Acid; Leukemia L1210; Mice; Molecular Structure; Orosomucoid; Protein Binding; Quinazolines; Structure-Activity Relationship; Thymidine; Thymidylate Synthase; Tumor Cells, Cultured | 1999 |
Balb/c mice as a preclinical model for raltitrexed-induced gastrointestinal toxicity.
Topics: Animals; Antimetabolites, Antineoplastic; Deoxyuridine; Diarrhea; Digestive System; Dose-Response Relationship, Drug; Folic Acid; Intestinal Mucosa; Intestine, Large; Intestine, Small; Male; Maximum Tolerated Dose; Mice; Mice, Inbred BALB C; Mice, Inbred DBA; Quinazolines; Thiophenes; Thymidine; Thymidylate Synthase; Weight Loss | 2000 |
[Nutrition, genetic polymorphism, and cancer].
Topics: Colorectal Neoplasms; DNA; DNA Repair; Folic Acid; Genotype; Humans; Methylenetetrahydrofolate Reductase (NADPH2); Neoplasms; Nutritional Physiological Phenomena; Oxidoreductases Acting on CH-NH Group Donors; Polymorphism, Genetic; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Risk Factors; Tetrahydrofolates; Thymidine; Uridine | 2000 |
Children with stroke: polymorphism of the MTHFR gene, mild hyperhomocysteinemia, and vitamin status.
Topics: Adolescent; Case-Control Studies; Child; Child, Preschool; Cytosine; Female; Folic Acid; Genetic Predisposition to Disease; Genotype; Humans; Hyperhomocysteinemia; Infant; Male; Methylenetetrahydrofolate Reductase (NADPH2); Oxidoreductases Acting on CH-NH Group Donors; Point Mutation; Polymorphism, Genetic; Pyridoxine; Secondary Prevention; Stroke; Thymidine; Vitamin B 12; Vitamins | 2000 |
Heavy chain ferritin enhances serine hydroxymethyltransferase expression and de novo thymidine biosynthesis.
Topics: Base Sequence; DNA Primers; Ferritins; Folic Acid; Glycine Hydroxymethyltransferase; Humans; Iron; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Thymidine; Tumor Cells, Cultured | 2001 |
Modulation of both endogenous folates and thymidine enhance the therapeutic efficacy of thymidylate synthase inhibitors.
Topics: Animals; Antimetabolites, Antineoplastic; Cell Division; Colonic Neoplasms; Diet; Dose-Response Relationship, Drug; Drug Synergism; Enzyme Inhibitors; Female; Fluorouracil; Folic Acid; Folic Acid Antagonists; Glutamates; Guanine; Leucovorin; Mice; Mice, Inbred BALB C; Mice, Inbred C3H; Pemetrexed; Quinazolines; Thiophenes; Thymidine; Thymidine Kinase; Thymidylate Synthase | 2001 |
Some aspects of the role of vitamin B12 in nucleic acid synthesis in a neoplastic C3H mouse cell strain. I. Growth studies.
Topics: Adenine; Adenosine; Animals; Cell Division; Cytidine; Deoxyadenosines; Deoxycytidine; Deoxyuridine; DNA, Neoplasm; Folic Acid; Guanine; Mice; Nucleic Acid Precursors; Nucleosides; Pyrimidines; Thymidine; Tumor Cells, Cultured; Uridine; Vitamin B 12 | 1970 |
Folate receptor function is regulated in response to different cellular growth rates in cultured mammalian cells.
Topics: Caco-2 Cells; Carrier Proteins; Cell Division; Cells, Cultured; Folate Receptors, GPI-Anchored; Folic Acid; Humans; Receptors, Cell Surface; Thymidine | 2001 |
Methylenetetrahydrofolate reductase gene C677T polymorphism, homocysteine, vitamin B12, and DNA damage in coronary artery disease.
Topics: Aged; Alleles; Carotid Artery Diseases; Coronary Angiography; Cytosine; DNA; DNA Damage; DNA Mutational Analysis; DNA Primers; Female; Folic Acid; Genotype; Homocysteine; Humans; Male; Methylenetetrahydrofolate Reductase (NADPH2); Micronucleus Tests; Middle Aged; Oxidoreductases Acting on CH-NH Group Donors; Point Mutation; Polymerase Chain Reaction; Polymorphism, Genetic; Risk Factors; Thymidine; Vitamin B 12 | 2003 |
Homocysteine is embryotoxic but does not cause neural tube defects in mouse embryos.
Topics: Animals; Central Nervous System; DNA; Dose-Response Relationship, Drug; Embryo, Mammalian; Female; Fetus; Folic Acid; Homocysteine; Humans; Intracellular Signaling Peptides and Proteins; Male; Membrane Proteins; Mice; Mice, Inbred Strains; Neural Tube Defects; Pregnancy; Pregnancy Complications; Somites; Thymidine | 2003 |
Thymidine and hypoxanthine protection patterns of the folic acid-enhanced synergies for combinations of trimetrexate plus a polyglutamylatable inhibitor of purine or thymidylate synthesis against human ileocecal HCT-8 cells.
Topics: Adenocarcinoma; Antineoplastic Agents; Antineoplastic Combined Chemotherapy Protocols; Cecal Neoplasms; Cell Division; Drug Resistance, Multiple; Drug Synergism; Enzyme Inhibitors; Folic Acid; Glutamates; Hematinics; Humans; Hydroxymethyl and Formyl Transferases; Hypoxanthine; Ileal Neoplasms; Peptide Synthases; Phosphoribosylglycinamide Formyltransferase; Pyrimidines; Quinazolines; Thiophenes; Thymidine; Thymidylate Synthase; Trimetrexate; Tumor Cells, Cultured | 2003 |
[Thymidine in experimental macrocytic anemia in the folic acid deficient rat].
Topics: Anemia; Anemia, Macrocytic; Animals; Folic Acid; Humans; Rats; Thymidine; Thymine | 1953 |
Sparing of folinic acid by thymidine.
Topics: Folic Acid; Leucovorin; Nucleosides; Nucleotides; Thymidine | 1961 |
PERNICIOUS ANAEMIA: AN ERYTHROKINETIC AND AUTORADIOGRAPHIC STUDY, USING H3-THYMIDINE, H3-URIDINE AND H3-CYTIDINE.
Topics: Anemia; Anemia, Pernicious; Autoradiography; Bone Marrow Examination; Cytidine; DNA; Erythrocytes; Folic Acid; Hematocrit; Humans; Iron; Nucleosides; Pyrimidines; RNA; Thymidine; Tritium; Uridine; Vitamin B 12 | 1964 |
FOLIC ACID DEFICIENCY AND HEPATIC DNA SYNTHESIS.
Topics: Avitaminosis; Carbon Tetrachloride Poisoning; Chemical and Drug Induced Liver Injury; DNA; Folic Acid; Folic Acid Deficiency; Hepatitis; Liver Diseases; Liver Regeneration; Metabolism; Necrosis; Pharmacology; Rats; Research; Thymidine; Uracil; Vitamin B 12 | 1964 |
ENZYME STUDIES IN VIRUS-INDUCED NEOPLASMS. I. THE EFFECT OF A MURINE LEUKEMIA ON ENZYMES OF ONE-CARBON METABOLISM AND ON PHOSPHOMONOESTERASES.
Topics: Alkaline Phosphatase; Animals; Carbon; Esterases; Folic Acid; Histocytochemistry; Leukemia; Leukemia Virus, Murine; Leukemia, Experimental; Ligases; Liver; Metabolism; Mice; Oxidoreductases; Phosphoric Monoester Hydrolases; Research; Spleen; Splenectomy; Thymidine | 1964 |
HEPATIC DNA SYNTHESIS AND REGENERATION.
Topics: Adrenal Cortex Hormones; Anabolic Agents; Autoradiography; Biopsy; Diet; Diet Therapy; DNA; Drug Therapy; Folic Acid; Glucagon; Hepatitis; Hepatitis A; Liver Cirrhosis; Liver Regeneration; Metabolism; Minerals; Oxygen Inhalation Therapy; RNA; Steroids; Thymidine; Toxicology; Tritium; Vitamin B 12 | 1964 |
[NUTRITIONAL FOLIC ACID DEFICIENCY ANEMIA. STUDIES WITH H3-LABELLED FOLIC ACID, CO58-LABELLED VITAMIN B12, FE59- AND H3-LABELLED THYMIDIN].
Topics: Anemia; Anemia, Macrocytic; Corrinoids; Folic Acid; Folic Acid Deficiency; Humans; Radioisotopes; Thymidine; Vitamin B 12 | 1965 |
Control of growth of mammalian cells in culture with folic acid, thymidine, and purines.
Topics: Folic Acid; Nucleosides; Nucleotides; Purines; Thymidine; Tissue Culture Techniques | 1960 |
Effect of folic acid on in vitro uptake of labeled thymidine by leukemic cells.
Topics: Biochemical Phenomena; Folic Acid; In Vitro Techniques; Leukemia; Lymphoma; Lymphoma, Non-Hodgkin; Nucleosides; Nucleotides; Thymidine | 1961 |
Effect of thymidine, citrovorum factor, folic acid and degradation products of vitamin B12 on red blood cell counts in experimental anemia in male mice.
Topics: Anemia; Animals; Blood Cell Count; Erythrocytes; Folic Acid; Leucovorin; Male; Mice; Thiamine; Thymidine; Vitamin B 12 | 1952 |
The relationship of folic acid, vitamin B12 and thymidine in the nutrition of Leuconostoç citrovorum 8081.
Topics: Bacteria; Corrinoids; Folic Acid; Humans; Leuconostoc; Leucovorin; Thymidine; Vitamin B 12 | 1949 |
Folate and the methylenetetrahydrofolate reductase 677C-->T mutation correlate with cognitive performance.
Topics: Aged; Cognition; Cross-Sectional Studies; Cytosine; Erythrocytes; Female; Folic Acid; Genotype; Humans; Male; Methylenetetrahydrofolate Reductase (NADPH2); Middle Aged; Neuropsychological Tests; Point Mutation; Polymorphism, Genetic; Serum; Statistics as Topic; Thymidine | 2006 |
In vitro folate deficiency induces apoptosis by a p53, Fas (Apo-1, CD95) independent, bcl-2 related mechanism in phytohaemagglutinin-stimulated human peripheral blood lymphocytes.
Topics: Apoptosis; Cells, Cultured; Down-Regulation; fas Receptor; Folic Acid; Folic Acid Deficiency; Humans; Hypoxanthine; Interleukin-2; Lymphocyte Activation; Phytohemagglutinins; Proto-Oncogene Proteins c-bcl-2; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; S Phase; Thymidine; Tumor Suppressor Protein p53 | 2006 |
Polymorphisms in thymidylate synthase gene and susceptibility to breast cancer in a Chinese population: a case-control analysis.
Topics: 3' Untranslated Regions; 5' Untranslated Regions; Adult; Aged; Breast Neoplasms; Case-Control Studies; China; Female; Folic Acid; Gene Frequency; Genetic Predisposition to Disease; Genotype; Humans; Middle Aged; Mutagenesis, Insertional; Polymorphism, Genetic; Postmenopause; Reproductive History; Sequence Deletion; Tandem Repeat Sequences; Thymidine; Thymidylate Synthase | 2006 |
Case files of the New York City Poison Control Center: antidotal strategies for the management of methotrexate toxicity.
Topics: Antidotes; Antimetabolites, Antineoplastic; Child; Fluid Therapy; Folic Acid; gamma-Glutamyl Hydrolase; Hemoperfusion; Humans; Infusions, Intravenous; Leucovorin; Male; Methotrexate; New York City; Poison Control Centers; Poisoning; Renal Dialysis; Thymidine; Treatment Outcome; Vitamin B Complex | 2008 |
Folate supplementation differently affects uracil content in DNA in the mouse colon and liver.
Topics: Age Factors; Animals; Colon; Dietary Supplements; DNA; Folic Acid; Gas Chromatography-Mass Spectrometry; Lacticaseibacillus casei; Liver; Male; Mice; Mice, Inbred C57BL; Mutation; Thymidine; Thymidine Monophosphate; Uracil; Vitamin B Complex | 2011 |
Nucleotide precursors prevent folic acid-resistant neural tube defects in the mouse.
Topics: Animals; Body Patterning; Cell Proliferation; Disease Models, Animal; Embryo, Mammalian; Female; Folic Acid; Histones; Litter Size; Male; Maternal Exposure; Mice; Mice, Mutant Strains; Neural Tube Defects; Pregnancy; Purine Nucleosides; Pyrimidine Nucleosides; Statistics, Nonparametric; Thymidine | 2013 |
Maternal dietary uridine causes, and deoxyuridine prevents, neural tube closure defects in a mouse model of folate-responsive neural tube defects.
Topics: Animals; Deoxyuridine; Disease Models, Animal; Female; Folic Acid; Folic Acid Deficiency; Glycine Hydroxymethyltransferase; HeLa Cells; Humans; Maternal Nutritional Physiological Phenomena; Mice; Neural Tube; Neural Tube Defects; Pregnancy; Thymidine; Uracil; Uridine | 2015 |
Serine hydroxymethyltransferase: a key player connecting purine, folate and methionine metabolism in Saccharomyces cerevisiae.
Topics: 5-Methyltetrahydrofolate-Homocysteine S-Methyltransferase; Aminoimidazole Carboxamide; Carbon-Nitrogen Ligases; Folic Acid; Gene Expression Regulation, Fungal; Glycine Hydroxymethyltransferase; Histidine; Leucovorin; Methionine; Mutation; Purines; Ribonucleotides; Saccharomyces cerevisiae; Saccharomyces cerevisiae Proteins; Tetrahydrofolates; Thymidine; Trans-Activators; Transcriptional Activation | 2015 |
Dietary serine-microbiota interaction enhances chemotherapeutic toxicity without altering drug conversion.
Topics: Animals; Caenorhabditis elegans; Dietary Supplements; Escherichia coli; Floxuridine; Folic Acid; Food-Drug Interactions; Gastrointestinal Microbiome; Serine; Thymidine; Uracil Nucleotides | 2020 |