Compounds > thymidine
Page last updated: 2024-08-17

thymidine and didanosine

thymidine has been researched along with didanosine in 21 studies

Research

Studies (21)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's6 (28.57)18.2507
2000's11 (52.38)29.6817
2010's3 (14.29)24.3611
2020's1 (4.76)2.80

Authors

AuthorsStudies
Albert, J; Cox, SW; Uhlén, M; Wahlberg, J; Wahren, B1
Badr, MZ; Youssef, JA1
Ayisi, NK; Gupta, SV; Qualtiere, LF1
Back, DJ; Barry, MG; Veal, GJ; Wild, MJ1
Baba, M; Hashimoto, KI; Okamoto, M; Shigeta, S; Tsunoda, R1
Merigan, TC; Palmer, S; Shafer, RW1
Bellos, N; Eron, JJ; Esinhart, J; Grosso, R; Jemsek, J; Murphy, RL; Parenti, DM; Peterson, D; Pottage, J; Rashbaum, BC; Schoellkopf, N; Sepulveda, G; Stevens, M; Swindells, S1
Boado, RJ; Li, JY; Pardridge, WM1
Asboe, D; Datta, D; Gazzard, BG; Mandalia, S; Morlese, J; Moyle, GJ1
Aboulker, JP; Brun-Vézinet, F; Descamps, D; Flandre, P; Izopet, J; Joly, V; Meiffrédy, V; Tamalet, C1
Barreiro, P; Camino, N; de Mendoza, C; Núñez, M; Paxinos, E; Soriano, V1
Bates, M; Chappey, C; Clair, MS; Fisher, R; Lanier, ER; Parkin, N; Ross, L; Tisdale, M1
Götte, M; Kuritzkes, DR; Liang, F; Miranda, LR1
Kiseleva, IaIu; Pliasunova, OA; Pokrovskaia, NV; Pokrovskiĭ, AG1
Bacheler, L; Koontz, D; Mellors, JW; Parikh, UM1
Biglia, A; Blanco, JL; De Lazzari, E; Gatell, JM; Laguno, M; Larrousse, M; León, A; Lonca, M; Mallolas, J; Martinez, E; Milinkovic, A; Pumarola, T1
Bussmann, H; DeGruttola, V; Essex, M; Gaseitsiwe, S; Marlink, RG; Moyo, S; Musonda, R; Novitsky, V; Thomas, A; Van Widenfelt, E; Wester, CW1
Benichou, S; Calvez, V; Fourati, S; Guenzel, CA; Katlama, C; Maidou-Peindara, P; Malet, I; Marcelin, AG; Morand-Joubert, L; Peytavin, G; Sayon, S; Simon, A; Soulie, C; Wirden, M1
Afzal, S; Drivsholm, N; Fuchs, A; Gelpi, M; Knudsen, AD; Kofoed, KF; Kühl, JT; Køber, L; Lebech, AM; Lindegaard, B; Lundgren, J; Mocroft, A; Nielsen, SD; Nordestgaard, BG; Sigvardsen, PE1
Gelpi, M; Knudsen, AD; Kofoed, KF; Larsen, KB; Lebech, AM; Lindegaard, B; Lundgren, J; Mocroft, A; Nielsen, SD1
Benfield, T; Gelpi, M; Gerstoft, J; Hove-Skovsgaard, M; Høgh, J; Jensen, AMR; Nielsen, SD; Storgaard, H1

Trials

2 trial(s) available for thymidine and didanosine

ArticleYear
A comparison of stavudine, didanosine and indinavir with zidovudine, lamivudine and indinavir for the initial treatment of HIV-1 infected individuals: selection of thymidine analog regimen therapy (START II).
    AIDS (London, England), 2000, Jul-28, Volume: 14, Issue:11

    Topics: Adolescent; Adult; Anti-HIV Agents; Antiretroviral Therapy, Highly Active; CD4 Lymphocyte Count; Didanosine; Dideoxynucleosides; Female; HIV Infections; HIV Protease Inhibitors; HIV-1; Humans; Indinavir; Lamivudine; Male; Reverse Transcriptase Inhibitors; Stavudine; Thymidine; Viral Load; Zidovudine

2000
Predictive factors and selection of thymidine analogue mutations by nucleoside reverse transcriptase inhibitors according to initial regimen received.
    Antiviral therapy, 2003, Volume: 8, Issue:1

    Topics: Anti-HIV Agents; Didanosine; Dideoxynucleosides; Drug Resistance, Viral; Drug Therapy, Combination; HIV Infections; HIV Reverse Transcriptase; HIV-1; Humans; Mutation; Predictive Value of Tests; Reverse Transcriptase Inhibitors; Selection, Genetic; Thymidine; Zalcitabine; Zidovudine

2003

Other Studies

19 other study(ies) available for thymidine and didanosine

ArticleYear
Loss of synergistic response to combinations containing AZT in AZT-resistant HIV-1.
    AIDS research and human retroviruses, 1992, Volume: 8, Issue:7

    Topics: Antiviral Agents; Cells, Cultured; Didanosine; Drug Resistance, Microbial; Drug Synergism; HIV-1; Humans; Thymidine; Zidovudine

1992
Disruption of mitochondrial energetics and DNA synthesis by the anti-AIDS drug dideoxyinosine.
    Toxicology letters, 1992, Volume: 60, Issue:2

    Topics: Animals; Didanosine; DNA; Male; Mitochondria, Liver; Oxygen Consumption; Rats; Rats, Inbred Strains; Thymidine

1992
Modified tetrazolium-based colorimetric method for determining the activities of anti-HIV compounds.
    Journal of virological methods, 1991, Volume: 33, Issue:3

    Topics: Antiviral Agents; Cell Line; Colorimetry; Didanosine; Foscarnet; HIV-1; Humans; Phosphonoacetic Acid; Tetrazolium Salts; Thymidine; Zalcitabine; Zidovudine

1991
Effects of dideoxyinosine and dideoxycytidine on the intracellular phosphorylation of zidovudine in human mononuclear cells.
    British journal of clinical pharmacology, 1994, Volume: 38, Issue:4

    Topics: Analysis of Variance; B-Lymphocytes; Cell Line; Cells, Cultured; Didanosine; Drug Interactions; Humans; Leukocytes, Mononuclear; Lymphocyte Activation; Phosphorylation; Phytohemagglutinins; Thymidine; Zalcitabine; Zidovudine

1994
Stavudine selectively induces apoptosis in HIV type 1-infected cells.
    AIDS research and human retroviruses, 1997, Jan-20, Volume: 13, Issue:2

    Topics: Anti-HIV Agents; Apoptosis; Cell Line; Didanosine; DNA Fragmentation; Down-Regulation; HIV Reverse Transcriptase; HIV-1; Humans; Nevirapine; Proto-Oncogene Proteins c-bcl-2; Pyridines; Reverse Transcriptase Inhibitors; Stavudine; T-Lymphocytes; Thymidine; Zalcitabine; Zidovudine

1997
Hydroxyurea enhances the activities of didanosine, 9-[2-(phosphonylmethoxy)ethyl]adenine, and 9-[2-(phosphonylmethoxy)propyl]adenine against drug-susceptible and drug-resistant human immunodeficiency virus isolates.
    Antimicrobial agents and chemotherapy, 1999, Volume: 43, Issue:8

    Topics: Adenine; Anti-HIV Agents; Antineoplastic Agents; Didanosine; DNA, Viral; Drug Resistance, Microbial; HIV Reverse Transcriptase; HIV-1; Humans; Hydroxyurea; Inhibitory Concentration 50; Microbial Sensitivity Tests; Organophosphonates; Organophosphorus Compounds; Reverse Transcriptase Inhibitors; Tenofovir; Thymidine

1999
Differential kinetics of transport of 2',3'-dideoxyinosine and adenosine via concentrative Na+ nucleoside transporter CNT2 cloned from rat blood-brain barrier.
    The Journal of pharmacology and experimental therapeutics, 2001, Volume: 299, Issue:2

    Topics: Adenosine; Animals; Biological Transport; Blood-Brain Barrier; Clone Cells; Didanosine; Kinetics; Membrane Transport Proteins; Oocytes; Rats; RNA, Messenger; Thymidine; Xenopus

2001
Hyperlactataemia and lactic acidosis during antiretroviral therapy: relevance, reproducibility and possible risk factors.
    AIDS (London, England), 2002, Jul-05, Volume: 16, Issue:10

    Topics: Acidosis, Lactic; Adult; Anti-HIV Agents; Cross-Sectional Studies; Didanosine; Dideoxynucleosides; Female; HIV Infections; Humans; Lactic Acid; Longitudinal Studies; Male; Multivariate Analysis; Prospective Studies; Reproducibility of Results; Risk Factors; Sex Factors; Thymidine

2002
Different viral rebound following discontinuation of antiretroviral therapy in cases of infection with viruses carrying L74V or thymidine-associated mutations.
    Journal of clinical microbiology, 2004, Volume: 42, Issue:2

    Topics: Acquired Immunodeficiency Syndrome; Amino Acid Substitution; Anti-HIV Agents; CD4 Lymphocyte Count; Didanosine; Female; Genotype; HIV; Humans; Hydroxyurea; Male; Mutagenesis, Site-Directed; Mutation; RNA, Viral; Thymidine; Time Factors; Viral Load

2004
Phenotypic impact of HIV reverse transcriptase M184I/V mutations in combination with single thymidine analog mutations on nucleoside reverse transcriptase inhibitor resistance.
    AIDS (London, England), 2004, Aug-20, Volume: 18, Issue:12

    Topics: Adenine; Algorithms; Anti-HIV Agents; Databases, Genetic; Didanosine; Dideoxynucleosides; Drug Resistance, Multiple, Viral; HIV; HIV Infections; Humans; Mutation; Organophosphonates; Organophosphorus Compounds; Phenotype; Reverse Transcriptase Inhibitors; Stavudine; Tenofovir; Thymidine; Zalcitabine; Zidovudine

2004
The L74V mutation in human immunodeficiency virus type 1 reverse transcriptase counteracts enhanced excision of zidovudine monophosphate associated with thymidine analog resistance mutations.
    Antimicrobial agents and chemotherapy, 2005, Volume: 49, Issue:7

    Topics: Adenosine Triphosphate; Anti-HIV Agents; Base Sequence; Didanosine; DNA Primers; Drug Resistance, Viral; HIV Infections; HIV Reverse Transcriptase; HIV-1; Humans; Molecular Sequence Data; Mutation; Reverse Transcriptase Inhibitors; Thymidine; Zidovudine

2005
[In vitro selection and phenotyping of HIV-1 mutants resistant to azidothymidine and didanosine].
    Antibiotiki i khimioterapiia = Antibiotics and chemoterapy [sic], 2005, Volume: 50, Issue:5-6

    Topics: Didanosine; Drug Resistance, Viral; HIV-1; Mutation; Reverse Transcriptase Inhibitors; Stavudine; Thymidine; Zidovudine

2005
The K65R mutation in human immunodeficiency virus type 1 reverse transcriptase exhibits bidirectional phenotypic antagonism with thymidine analog mutations.
    Journal of virology, 2006, Volume: 80, Issue:10

    Topics: Adenine; Amino Acid Substitution; Anti-HIV Agents; Arginine; Didanosine; Dideoxynucleosides; Drug Resistance, Multiple, Viral; Genotype; HIV Reverse Transcriptase; HIV-1; Humans; Lysine; Organophosphonates; Phenotype; Point Mutation; Reverse Transcriptase Inhibitors; Tenofovir; Thymidine; Zalcitabine; Zidovudine

2006
Antiretroviral activity of didanosine in patients with different clusters of reverse transcriptase mutations.
    AIDS (London, England), 2006, Sep-11, Volume: 20, Issue:14

    Topics: Didanosine; HIV Infections; HIV Reverse Transcriptase; Humans; Mutation; Nucleosides; Prospective Studies; Reverse Transcriptase Inhibitors; RNA, Viral; Thymidine; Treatment Outcome; Viral Load

2006
The reverse transcriptase 67N 70R 215Y genotype is the predominant TAM pathway associated with virologic failure among HIV type 1C-infected adults treated with ZDV/ddI-containing HAART in southern Africa.
    AIDS research and human retroviruses, 2007, Volume: 23, Issue:7

    Topics: Africa, Southern; Antiretroviral Therapy, Highly Active; Didanosine; Drug Resistance, Multiple, Viral; Evolution, Molecular; Female; Genotype; HIV Infections; HIV-1; Humans; Male; Molecular Sequence Data; Mutation; Reverse Transcriptase Inhibitors; RNA-Directed DNA Polymerase; Thymidine; Treatment Failure; Zidovudine

2007
E17A mutation in HIV-1 Vpr confers resistance to didanosine in association with thymidine analog mutations.
    Antiviral research, 2012, Volume: 93, Issue:1

    Topics: Adult; Aged; Anti-HIV Agents; Didanosine; Drug Resistance, Viral; Female; Genes, vpr; HEK293 Cells; HeLa Cells; HIV Infections; HIV-1; Humans; Male; Microbial Sensitivity Tests; Middle Aged; Molecular Sequence Data; Mutation; Polymorphism, Genetic; Protein Transport; Thymidine; Virus Replication; vpr Gene Products, Human Immunodeficiency Virus

2012
Prior exposure to thymidine analogs and didanosine is associated with long-lasting alterations in adipose tissue distribution and cardiovascular risk factors.
    AIDS (London, England), 2019, 03-15, Volume: 33, Issue:4

    Topics: Adipose Tissue; Adult; Aged; Anti-HIV Agents; Cardiovascular Diseases; Denmark; Didanosine; Female; HIV Infections; Humans; Longitudinal Studies; Male; Middle Aged; Risk Factors; Thymidine

2019
Long-lasting alterations in adipose tissue density and adiponectin production in people living with HIV after thymidine analogues exposure.
    BMC infectious diseases, 2019, Aug-09, Volume: 19, Issue:1

    Topics: Adiponectin; Adipose Tissue; Adult; Anti-HIV Agents; Biomarkers; Cross-Sectional Studies; Didanosine; Female; HIV Infections; Humans; Intra-Abdominal Fat; Longitudinal Studies; Male; Middle Aged; Subcutaneous Fat; Thymidine

2019
Insulin resistance in people living with HIV is associated with exposure to thymidine analogues and/or didanosine and prior immunodeficiency.
    BMC infectious diseases, 2022, May-28, Volume: 22, Issue:1

    Topics: Diabetes Mellitus, Type 2; Didanosine; Female; HIV Infections; Humans; Insulin Resistance; Male; Middle Aged; Obesity; Obesity, Abdominal; Thymidine

2022