thymidine has been researched along with (north)-methanocarbathymidine in 20 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 16 (80.00) | 29.6817 |
| 2010's | 4 (20.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Clercq, ED; Folkers, G; Marquez, VE; Russ, P; Scapozza, L; Schelling, P | 1 |
| Agbaria, R; Ford, H; Huleihel, M; Johns, DG; Konson, A; Manor, E; Marquez, VE; Zalah, L | 1 |
| Agbaria, R; Ben-Zvi, Z; Candotti, F; Elezra, M; Ford, H; Johns, DG; Marquez, VE; Morris, JC; Noy, R | 1 |
| Agbaria, R; Ben-Zvi, Z; Candotti, F; Ford, H; Johns, DG; Manor, E; Marquez, VE; Morris, JC; Noy, R | 1 |
| Agbaria, R; Barchi, JJ; Ben-Kasus, T; Green, KM; Marquez, VE; Nicklaus, MC | 1 |
| Claus, MT; Johner, R; Marquez, VE; Scapozza, L; Schelling, P; Schulz, GE | 1 |
| Agbaria, R; Ford, H; Huleihel, M; Johns, DG; Kelley, JA; Marquez, VE; Talishanisky, M | 1 |
| Agbaria, R; Burnette, A; Dorjsuren, D; Huleihel, M; Marquez, VE; Roberts, PE; Sei, S; Shoemaker, RH; Zhu, W | 1 |
| Keith, KA; Kern, ER; Prichard, MN; Quenelle, DC | 1 |
| Agbaria, R; Cohen, S; Dvir-Ginzberg, M; Konson, A | 1 |
| Bailey, KW; Chu, CK; Gadthula, S; Sidwell, RW; Smee, DF; Wandersee, MK; Wong, MH | 1 |
| Agbaria, R; Hughes, SH; Marquez, VE; Sei, S | 1 |
| Glazer, RI; Hurst, BL; Rahman, A; Sidwell, RW; Smee, DF; Wong, MH | 1 |
| Keith, KA; Kern, ER; Moyer, RW; Prichard, MN; Quenelle, DC; Turner, PC | 1 |
| Boyer, PL; Comin, MJ; Hughes, SH; Liao, C; Marquez, VE; Vu, BC | 1 |
| Barnard, DL; Humphreys, DE; Hurst, BL; Smee, DF | 1 |
| Bernstein, DI; Bravo, FJ; Cardin, RD; Clark, JR; Earwood, JD; Glazer, R; Rahman, A | 1 |
| Collins, DJ; Glazer, R; Quenelle, DC; Rahman, A; Rice, TL | 1 |
| Dwight, TA; Jung, ME; Seth, PP; Swayze, EE; Vigant, F; Østergaard, ME | 1 |
| Bernstein, DI; Bravo, FJ; Cardin, RD; Glazer, RI; Pullum, DA; Rahman, A; Shen, H; Wang, M | 1 |
1 review(s) available for thymidine and (north)-methanocarbathymidine
| Article | Year |
|---|---|
The history of N-methanocarbathymidine: the investigation of a conformational concept leads to the discovery of a potent and selective nucleoside antiviral agent.
Topics: Animals; Antiviral Agents; Chlorocebus aethiops; Herpesvirus 1, Human; Humans; Mice; Mice, Inbred BALB C; Models, Chemical; Nucleosides; Simplexvirus; Thymidine; Vero Cells | 2006 |
19 other study(ies) available for thymidine and (north)-methanocarbathymidine
| Article | Year |
|---|---|
Synthesis and biological evaluation of 5-substituted derivatives of the potent antiherpes agent (north)-methanocarbathymine.
Topics: Antiviral Agents; Cell Division; Cell Line; Cell Line, Tumor; Herpesviridae; Herpesvirus 1, Human; Herpesvirus 2, Human; Herpesvirus 3, Human; Humans; Kinetics; Molecular Conformation; Poxviridae; Pyrimidine Nucleosides; Structure-Activity Relationship; Thymidine Kinase; Thymine; Vaccinia virus; Viral Plaque Assay | 2003 |
Metabolic pathways of N-methanocarbathymidine, a novel antiviral agent, in native and herpes simplex virus type 1 infected Vero cells.
Topics: Animals; Antiviral Agents; Chlorocebus aethiops; Cytopathogenic Effect, Viral; Ganciclovir; Herpesvirus 1, Human; Phosphorylation; Polyphosphates; Thymidine; Vero Cells | 2002 |
Pharmacokinetics and organ distribution of N-methanocarbathymidine, a novel thymidine analog, in mice bearing tumors transduced with the herpes simplex thymidine kinase gene.
Topics: Adenocarcinoma; Animals; Antimetabolites, Antineoplastic; Chromatography, High Pressure Liquid; Colonic Neoplasms; Drug Screening Assays, Antitumor; Enzyme Inhibitors; Genetic Therapy; Injections, Intraperitoneal; Male; Mice; Mice, Inbred C57BL; Neoplasm Proteins; Neoplasm Transplantation; Prodrugs; Simplexvirus; Thymidine; Thymidine Kinase; Tissue Distribution; Transfection; Tumor Cells, Cultured | 2002 |
Antitumor activity and metabolic activation of N-methanocarbathymidine, a novel thymidine analogue with a pseudosugar rigidly fixed in the northern conformation, in murine colon cancer cells expressing herpes simplex thymidine kinase.
Topics: Animals; Antineoplastic Agents; Antiviral Agents; Cell Division; Chromatography, High Pressure Liquid; DNA; Dose-Response Relationship, Drug; Genetic Therapy; Herpes Simplex; Hydrolysis; Inhibitory Concentration 50; Mice; Models, Chemical; Neoplasm Transplantation; Phosphorylation; RNA; Thymidine; Thymidine Kinase; Time Factors; Tumor Cells, Cultured | 2002 |
Experimental and structural evidence that herpes 1 kinase and cellular DNA polymerase(s) discriminate on the basis of sugar pucker.
Topics: Animals; Antineoplastic Agents; Antiviral Agents; Cell Line, Tumor; Chlorocebus aethiops; DNA; DNA-Directed DNA Polymerase; Herpesvirus 1, Human; Mice; Models, Molecular; Molecular Conformation; Nuclear Magnetic Resonance, Biomolecular; Structure-Activity Relationship; Substrate Specificity; Thymidine; Thymidine Kinase; Transfection; Vero Cells | 2004 |
Biochemical and structural characterization of (South)-methanocarbathymidine that specifically inhibits growth of herpes simplex virus type 1 thymidine kinase-transduced osteosarcoma cells.
Topics: Antiviral Agents; Binding Sites; Cell Division; Cell Line, Tumor; Crystallography, X-Ray; Dose-Response Relationship, Drug; Ganciclovir; Herpesvirus 1, Human; Humans; Inhibitory Concentration 50; Kinetics; Models, Chemical; Models, Molecular; Osteosarcoma; Phosphorylation; Protein Binding; Protein Conformation; Thymidine; Thymidine Kinase; Time Factors; Transfection | 2004 |
Dynamics of the antiviral activity of N-methanocarbathymidine against herpes simplex virus type 1 in cell culture.
Topics: Animals; Chlorocebus aethiops; Cytopathogenic Effect, Viral; Dose-Response Relationship, Drug; Herpesvirus 1, Human; Thymidine; Time Factors; Vero Cells; Virus Replication | 2005 |
Potent antiviral activity of north-methanocarbathymidine against Kaposi's sarcoma-associated herpesvirus.
Topics: Antiviral Agents; Herpesvirus 8, Human; Humans; Inhibitory Concentration 50; Sarcoma, Kaposi; Thymidine; Tumor Cells, Cultured | 2005 |
Activity and mechanism of action of N-methanocarbathymidine against herpesvirus and orthopoxvirus infections.
Topics: Animals; Antiviral Agents; Cells, Cultured; DNA, Viral; Female; Herpesviridae Infections; Humans; Mice; Mice, Inbred BALB C; Phosphorylation; Poxviridae Infections; Thymidine; Thymidine Kinase | 2006 |
Entrapment of retroviral vector producer cells in three-dimensional alginate scaffolds for potential use in cancer gene therapy.
Topics: Alginates; Animals; Antiviral Agents; Cell Culture Techniques; Cells, Immobilized; Ganciclovir; Genetic Therapy; Genetic Vectors; Glucuronic Acid; Herpes Simplex; Hexuronic Acids; Mice; Neoplasms, Experimental; Retroviridae; Thymidine; Thymidine Kinase; Tumor Cells, Cultured | 2007 |
Cell line dependency for antiviral activity and in vivo efficacy of N-methanocarbathymidine against orthopoxvirus infections in mice.
Topics: Animals; Antiviral Agents; Cell Line; Cowpox; Cowpox virus; Humans; Mice; Mice, Inbred BALB C; Rabbits; Respiratory Tract Infections; Thymidine; Vaccinia; Vaccinia virus | 2007 |
Efficacy of N-methanocarbathymidine in treating mice infected intranasally with the IHD and WR strains of vaccinia virus.
Topics: Administration, Oral; Animals; Antiviral Agents; Cidofovir; Cytosine; Injections, Intraperitoneal; Mice; Organophosphonates; Survival Analysis; Thymidine; Vaccinia; Vaccinia virus; Viral Plaque Assay | 2007 |
Vaccinia virus lacking the deoxyuridine triphosphatase gene (F2L) replicates well in vitro and in vivo, but is hypersensitive to the antiviral drug (N)-methanocarbathymidine.
Topics: Animals; Antiviral Agents; Female; Green Fluorescent Proteins; Humans; Mice; Mice, Inbred BALB C; Pyrimidines; Pyrophosphatases; Recombinant Fusion Proteins; Sequence Deletion; Thymidine; Vaccinia; Vaccinia virus; Viral Plaque Assay; Virulence; Virus Replication | 2008 |
D-(+)-iso-methanocarbathymidine: a high-affinity substrate for herpes simplex virus 1 thymidine kinase.
Topics: Adenosine Triphosphate; Antiviral Agents; Binding Sites; Cell Line; Enzyme Inhibitors; Herpesvirus 1, Human; Humans; Models, Molecular; Nucleosides; Osteoblasts; Stereoisomerism; Substrate Specificity; Thymidine; Thymidine Kinase | 2008 |
Antiviral activities and phosphorylation of 5-halo-2'-deoxyuridines and N-methanocarbathymidine in cells infected with vaccinia virus.
Topics: Animals; Antiviral Agents; Bromodeoxyuridine; Cell Line, Tumor; Chlorocebus aethiops; Deoxyuridine; Floxuridine; Humans; Idoxuridine; Mice; Phosphorylation; Thymidine; Thymidine Kinase; Vaccinia; Vaccinia virus; Vero Cells; Viral Plaque Assay | 2008 |
N-Methanocarbathymidine is more effective than acyclovir for treating neonatal herpes simplex virus infection in guinea pigs.
Topics: Acyclovir; Animals; Animals, Newborn; Antiviral Agents; Disease Models, Animal; Guinea Pigs; Herpes Simplex; Humans; Infant, Newborn; Pregnancy Complications, Infectious; Survival Analysis; Thymidine; Treatment Outcome | 2011 |
Efficacy of orally administered low dose N-methanocarbathymidine against lethal herpes simplex virus type-2 infections of mice.
Topics: Administration, Oral; Animals; Antiviral Agents; Disease Models, Animal; Dose-Response Relationship, Drug; Female; Herpes Simplex; Herpesvirus 2, Human; Humans; Mice; Mice, Inbred BALB C; Survival Rate; Thymidine | 2011 |
Synthesis and duplex-stabilizing properties of fluorinated N-methanocarbathymidine analogues locked in the C3'-endo conformation.
Topics: Models, Molecular; Molecular Conformation; Molecular Structure; Nucleic Acid Conformation; Oligonucleotides; Thymidine | 2014 |
Efficacy of N-methanocarbathymidine against genital herpes simplex virus type 2 shedding and infection in guinea pigs.
Topics: Acute Disease; Animals; Antiviral Agents; Disease Models, Animal; Female; Guinea Pigs; Herpes Genitalis; Herpesvirus 2, Human; Recurrence; Thymidine; Virus Shedding | 2015 |