Compounds > thymidine 5'-triphosphate
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thymidine 5'-triphosphate and quinazolines

thymidine 5'-triphosphate has been researched along with quinazolines in 9 studies

Research

Studies (9)

TimeframeStudies, this research(%)All Research%
pre-19901 (11.11)18.7374
1990's6 (66.67)18.2507
2000's0 (0.00)29.6817
2010's0 (0.00)24.3611
2020's2 (22.22)2.80

Authors

AuthorsStudies
Cranford, SK; Fernandes, DJ1
Aherne, GW; Boyle, FT; Brown, M; Gibson, W; Hardcastle, A; Jackman, AL; Kelland, LR; Kimbell, R1
Aherne, W; Boyle, FT; Hardcastle, A; Jackman, AL; Kimbell, R1
Aherne, GW; Hardcastle, A; Jackman, AL; Raynaud, F1
Horowitz, RW; Ladner, RD; Schwartz, EL; Wadler, S; Zhang, H1
Furusho, K; Kubota, M; Wakazono, Y1
Andis, SL; Bewley, JR; Chen, VJ; Iversen, PW; Mendelsohn, LG; Schultz, RM; Seitz, DE; Shih, C; Tonkinson, JL1
Huang, G; Li, W; Liu, H; Luo, S; Lv, X; Wang, Y; Zhou, D1
Barat, C; Breton, Y; Desrosiers, V; Ouellet, M; Tremblay, MJ1

Other Studies

9 other study(ies) available for thymidine 5'-triphosphate and quinazolines

ArticleYear
Dissociation of thymidylate biosynthesis from DNA biosynthesis by 5-fluoro-2'-deoxyuridine and 5,8-dideazaisofolic acid.
    Cancer research, 1986, Volume: 46, Issue:4 Pt 1

    Topics: Deoxyguanine Nucleotides; DNA; DNA Polymerase II; Dose-Response Relationship, Drug; Floxuridine; Folic Acid Antagonists; Humans; Leukemia; Pyrimethamine; Quinazolines; Thymidine Monophosphate; Thymidylate Synthase; Thymine Nucleotides

1986
Mechanisms of acquired resistance to the quinazoline thymidylate synthase inhibitor ZD1694 (Tomudex) in one mouse and three human cell lines.
    British journal of cancer, 1995, Volume: 71, Issue:5

    Topics: Animals; Antineoplastic Agents; Carrier Proteins; Deoxyuracil Nucleotides; Drug Resistance; Female; Folate Receptors, GPI-Anchored; Folic Acid; Folic Acid Antagonists; Humans; Kinetics; Leukemia L1210; Lymphocytes; Methotrexate; Mice; Neoplasm Proteins; Ovarian Neoplasms; Peptide Synthases; Polyglutamic Acid; Proteins; Quinazolines; Receptors, Cell Surface; Thiophenes; Thymidylate Synthase; Thymine Nucleotides; Tumor Cells, Cultured

1995
The duration of the inhibition of thymidylate synthase in intact L1210 cells exposed to two different classes of quinazoline analogues.
    Advances in experimental medicine and biology, 1993, Volume: 338

    Topics: Animals; Antineoplastic Agents; Cell Division; Deoxyuracil Nucleotides; Drug Screening Assays, Antitumor; Folic Acid; Folic Acid Antagonists; Leukemia L1210; Mice; Quinazolines; Structure-Activity Relationship; Thiophenes; Thymidylate Synthase; Thymine Nucleotides

1993
Immunoreactive dUMP and TTP pools as an index of thymidylate synthase inhibition; effect of tomudex (ZD1694) and a nonpolyglutamated quinazoline antifolate (CB30900) in L1210 mouse leukaemia cells.
    Biochemical pharmacology, 1996, May-17, Volume: 51, Issue:10

    Topics: Animals; Deoxyuracil Nucleotides; Dipeptides; Dose-Response Relationship, Drug; Folic Acid Antagonists; Leukemia, Experimental; Mice; Mice, Inbred Strains; Quinazolines; Radioimmunoassay; Thiophenes; Thymidylate Synthase; Thymine Nucleotides; Tumor Cells, Cultured

1996
Measurement of deoxyuridine triphosphate and thymidine triphosphate in the extracts of thymidylate synthase-inhibited cells using a modified DNA polymerase assay.
    Biochemical pharmacology, 1997, Sep-01, Volume: 54, Issue:5

    Topics: Adenocarcinoma; Antimetabolites, Antineoplastic; Colonic Neoplasms; Deoxyuracil Nucleotides; DNA-Directed DNA Polymerase; Dose-Response Relationship, Drug; Enzyme Inhibitors; Humans; Kinetics; Pyrophosphatases; Quinazolines; Templates, Genetic; Thiophenes; Thymidylate Synthase; Thymine Nucleotides; Tumor Cells, Cultured

1997
Increased cell killing and mutagenecity by DNA alkylating agents in cells with decreased TTP pools.
    Advances in experimental medicine and biology, 1998, Volume: 431

    Topics: Alkylating Agents; Cell Survival; Dose-Response Relationship, Drug; Enzyme Inhibitors; Ethyl Methanesulfonate; HL-60 Cells; Humans; Hypoxanthine Phosphoribosyltransferase; Kinetics; Methylnitronitrosoguanidine; Mutagens; Quinazolines; Thiophenes; Thymidylate Synthase; Thymine Nucleotides

1998
Cellular pharmacology of MTA: a correlation of MTA-induced cellular toxicity and in vitro enzyme inhibition with its effect on intracellular folate and nucleoside triphosphate pools in CCRF-CEM cells.
    Seminars in oncology, 1999, Volume: 26, Issue:2 Suppl 6

    Topics: Acid Anhydride Hydrolases; Antimetabolites, Antineoplastic; Deoxyribonucleotides; Enzyme Inhibitors; Folic Acid; Folic Acid Antagonists; Glutamates; Guanine; Humans; Methotrexate; Nucleoside-Diphosphate Kinase; Nucleoside-Triphosphatase; Pemetrexed; Quinazolines; Ribonucleotides; Tetrahydrofolates; Thiophenes; Thymidylate Synthase; Thymine Nucleotides; Tumor Cells, Cultured

1999
Folic acid alleviates age-related cognitive decline and inhibits apoptosis of neurocytes in senescence-accelerated mouse prone 8: deoxythymidine triphosphate biosynthesis as a potential mechanism.
    The Journal of nutritional biochemistry, 2021, Volume: 97

    Topics: Aging; Animals; Apoptosis; Brain; Cognitive Dysfunction; Dietary Supplements; Folic Acid; Male; Memory; Mice; Morris Water Maze Test; Neurons; Quinazolines; Telomere Shortening; Thiophenes; Thymidylate Synthase; Thymine Nucleotides; Uracil

2021
Thymidylate synthase is essential for efficient HIV-1 replication in macrophages.
    Virology, 2021, Volume: 561

    Topics: Cells, Cultured; Enzyme Inhibitors; HIV-1; Humans; Macrophages; Quinazolines; RNA Interference; RNA, Small Interfering; SAM Domain and HD Domain-Containing Protein 1; Thiophenes; Thymidylate Synthase; Thymine Nucleotides; Virus Replication

2021