thymidine 5'-triphosphate has been researched along with methotrexate in 16 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 8 (50.00) | 18.7374 |
| 1990's | 5 (31.25) | 18.2507 |
| 2000's | 1 (6.25) | 29.6817 |
| 2010's | 2 (12.50) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Adachi, S; Hashimoto, H; Kasai, Y; Kubota, M; Mikawa, H; Sano, H; Shimizu, T | 1 |
| Bakker, MA; Bökkerink, JP; De Abreu, RA; De Bruijn, CH; Hulscher, TW; Schretlen, ED; van Baal, JM | 1 |
| Fischer, PH; Kunugi, K; Vazquez-Padua, MA | 1 |
| Akiyama, Y; Kiriyama, Y; Kitoh, T; Kubota, M; Mikawa, H; Takimoto, T; Tanizawa, A | 1 |
| Beck, WR; Chang, JD; Isselbacher, EM; Nusbaum, NJ; Wright, GE | 1 |
| Fischer, PH; Pangallo, CA; Van Mouwerik, TJ; Willson, JK | 1 |
| Fischer, PH; Reznikoff, CA; Vazquez-Padua, MA | 1 |
| Bestwick, RK; Mathews, CK; Moffett, GL | 1 |
| Bover, L; Cabral, S; Leis, S; Mordoh, J; Nembrot, M | 1 |
| Aherne, GW; Boyle, FT; Brown, M; Gibson, W; Hardcastle, A; Jackman, AL; Kelland, LR; Kimbell, R | 1 |
| Ahluwalia, GS; Gao, WY; Johns, DG; Mitsuya, H | 1 |
| Hamzeh, FM; Lietman, PS; Saito, H; Wachsman, M | 1 |
| Andis, SL; Bewley, JR; Chen, VJ; Iversen, PW; Mendelsohn, LG; Schultz, RM; Seitz, DE; Shih, C; Tonkinson, JL | 1 |
| Fagny, C; Robberecht, P; Svoboda, M; Vandevelde, M | 1 |
| Cabezas-Herrera, J; Chazarra, S; Fernández-Pérez, MP; Montenegro, MF; Piñero-Madrona, A; Rodríguez-López, JN; Sáez-Ayala, M; Sánchez-del-Campo, L | 1 |
| Cabezas-Herrera, J; Chazarra, S; Fernández-Pérez, MP; Freter, R; Goding, CR; Middleton, M; Montenegro, MF; Piñero-Madrona, A; Rodríguez-López, JN; Sáez-Ayala, M; Sánchez-Del-Campo, L | 1 |
16 other study(ies) available for thymidine 5'-triphosphate and methotrexate
| Article | Year |
|---|---|
Increased methotrexate-induced DNA strand breaks and cytotoxicity following mutational loss of thymidine kinase.
Topics: Cell Line; Cell Survival; DNA Damage; DNA, Neoplasm; Humans; Hypoxanthine Phosphoribosyltransferase; Kinetics; Leukemia, Promyelocytic, Acute; Methotrexate; Methylnitronitrosoguanidine; Mutagenesis; Thymidine Kinase; Thymine Nucleotides | 1991 |
Effects of methotrexate on purine and pyrimidine metabolism and cell-kinetic parameters in human malignant lymphoblasts of different lineages.
Topics: Cell Cycle; Cell Survival; Deoxyguanine Nucleotides; Humans; Leukemia; Lymphocytes; Methotrexate; Polyglutamic Acid; Purines; Pyrimidines; RNA; Thymine Nucleotides; Tumor Cells, Cultured | 1988 |
Enzyme regulatory site-directed drugs: study of the interactions of 5'-amino-2', 5'-dideoxythymidine (5'-AdThd) and thymidine triphosphate with thymidine kinase and the relationship to the stimulation of thymidine uptake by 5'-AdThd in 647V cells.
Topics: 5'-Nucleotidase; Dideoxynucleosides; Feedback; Humans; Methotrexate; Nucleotidases; Thymidine; Thymidine Kinase; Thymidine Phosphorylase; Thymine Nucleotides; Tumor Cells, Cultured | 1989 |
Ara-CTP metabolism following hydroxyurea or methotrexate treatment in human leukemia cell lines.
Topics: Arabinofuranosylcytosine Triphosphate; Arabinonucleotides; Cytarabine; Deoxycytidine; Deoxycytosine Nucleotides; Drug Synergism; Humans; Hydroxyurea; Leukemia; Leukemia, Promyelocytic, Acute; Methotrexate; Thymine Nucleotides; Tumor Cells, Cultured | 1989 |
Enhancement of methotrexate cytotoxicity by uracil analogues that inhibit deoxyuridine triphosphate nucleotidohydrolase (dUTPase) activity.
Topics: Animals; Cattle; Cell Cycle; Cell Survival; Cells, Cultured; DNA; DNA Glycosylases; Humans; In Vitro Techniques; Methotrexate; Mice; N-Glycosyl Hydrolases; Pyrophosphatases; Thymine Nucleotides; Uracil; Uracil-DNA Glycosidase | 1986 |
Augmentation of methotrexate cytotoxicity in human colon cancer cells achieved through inhibition of thymidine salvage by dipyridamole.
Topics: Cell Line; Cell Survival; Colonic Neoplasms; Dipyridamole; Drug Synergism; Guanine; Humans; Hypoxanthine; Hypoxanthines; Methotrexate; Rectal Neoplasms; Thymidine; Thymine Nucleotides | 1987 |
Perturbation of thymidine kinase regulation: a novel chemotherapeutic approach.
Topics: Cell Division; Cell Survival; Cells, Cultured; Humans; Idoxuridine; Methotrexate; Thymidine; Thymidine Kinase; Thymine Nucleotides; Ureter; Urinary Bladder | 1986 |
Selective expansion of mitochondrial nucleoside triphosphate pools in antimetabolite-treated HeLa cells.
Topics: Deoxyadenine Nucleotides; Deoxycytosine Nucleotides; Deoxyguanine Nucleotides; Deoxyribonucleotides; DNA; Floxuridine; HeLa Cells; Humans; Methotrexate; Mitochondria; Ribonucleotides; Thymine Nucleotides | 1982 |
Dipyridamole inhibits reversion by thymidine of methotrexate effect and increases drug uptake in Sarcoma 180 cells.
Topics: Animals; Biological Transport; Deoxycytidine; Deoxyuridine; Dipyridamole; DNA Replication; Drug Antagonism; Kinetics; Methotrexate; Mice; Sarcoma 180; Thymidine; Thymine Nucleotides | 1984 |
Mechanisms of acquired resistance to the quinazoline thymidylate synthase inhibitor ZD1694 (Tomudex) in one mouse and three human cell lines.
Topics: Animals; Antineoplastic Agents; Carrier Proteins; Deoxyuracil Nucleotides; Drug Resistance; Female; Folate Receptors, GPI-Anchored; Folic Acid; Folic Acid Antagonists; Humans; Kinetics; Leukemia L1210; Lymphocytes; Methotrexate; Mice; Neoplasm Proteins; Ovarian Neoplasms; Peptide Synthases; Polyglutamic Acid; Proteins; Quinazolines; Receptors, Cell Surface; Thiophenes; Thymidylate Synthase; Thymine Nucleotides; Tumor Cells, Cultured | 1995 |
2',3'-Didehydro-3'-deoxythymidine: regulation of its metabolic activation by modulators of thymidine-5'-triphosphate biosynthesis.
Topics: Amides; Biotransformation; Biphenyl Compounds; Cell Line; Deoxyguanosine; Floxuridine; HIV; HIV Reverse Transcriptase; HIV-1; Humans; Hydroxyurea; Kinetics; Methotrexate; Models, Biological; Phosphorylation; Pyrazoles; Reverse Transcriptase Inhibitors; Ribonucleosides; Ribose; RNA-Directed DNA Polymerase; Stavudine; Thymidine Kinase; Thymine Nucleotides; Tumor Cells, Cultured | 1996 |
Anticytomegaloviral activity of methotrexate associated with preferential accumulation of drug by cytomegalovirus-infected cells.
Topics: Antiviral Agents; Cell Line; Chromatography, Thin Layer; Cytomegalovirus; Dose-Response Relationship, Drug; Fibroblasts; Folic Acid Antagonists; Humans; Lung; Methotrexate; Thymine Nucleotides; Virus Replication | 1996 |
Cellular pharmacology of MTA: a correlation of MTA-induced cellular toxicity and in vitro enzyme inhibition with its effect on intracellular folate and nucleoside triphosphate pools in CCRF-CEM cells.
Topics: Acid Anhydride Hydrolases; Antimetabolites, Antineoplastic; Deoxyribonucleotides; Enzyme Inhibitors; Folic Acid; Folic Acid Antagonists; Glutamates; Guanine; Humans; Methotrexate; Nucleoside-Diphosphate Kinase; Nucleoside-Triphosphatase; Pemetrexed; Quinazolines; Ribonucleotides; Tetrahydrofolates; Thiophenes; Thymidylate Synthase; Thymine Nucleotides; Tumor Cells, Cultured | 1999 |
Ribonucleotide reductase and thymidine phosphorylation: two potential targets of azodicarbonamide.
Topics: Animals; Antineoplastic Agents; Azo Compounds; Deoxycytosine Nucleotides; Deoxyguanine Nucleotides; Drug Interactions; Hydroxyurea; Immunosuppressive Agents; Methotrexate; Phosphorylation; Ribonucleotide Reductases; Thymidine; Thymine Nucleotides; Tumor Cells, Cultured | 2002 |
Melanoma coordinates general and cell-specific mechanisms to promote methotrexate resistance.
Topics: Amino Acid Sequence; Animals; Antimetabolites, Antineoplastic; Apoptosis; Cell Line, Tumor; Cell Proliferation; Cell Survival; Checkpoint Kinase 1; Drug Resistance, Neoplasm; E2F1 Transcription Factor; Enzyme Activation; Folic Acid; Humans; Melanoma; Methotrexate; Mice; Molecular Sequence Data; Protein Kinases; Protein Processing, Post-Translational; S Phase Cell Cycle Checkpoints; Skin Neoplasms; Tetrahydrofolate Dehydrogenase; Thymidylate Synthase; Thymine Nucleotides; Transcription, Genetic | 2012 |
Directed phenotype switching as an effective antimelanoma strategy.
Topics: Apoptosis; Catechin; Cell Differentiation; Cell Line, Tumor; DNA Damage; E2F1 Transcription Factor; Humans; Melanoma; Methotrexate; Microphthalmia-Associated Transcription Factor; Phenotype; Thymine Nucleotides | 2013 |