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thymidine 5'-triphosphate and fluorouracil

thymidine 5'-triphosphate has been researched along with fluorouracil in 18 studies

Research

Studies (18)

TimeframeStudies, this research(%)All Research%
pre-19902 (11.11)18.7374
1990's12 (66.67)18.2507
2000's2 (11.11)29.6817
2010's2 (11.11)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Fujiwara, Y; Morikage, T; Nishio, K; Ohe, Y; Ohmori, T; Saijo, N; Sugimoto, Y1
Allegra, CJ; Grem, JL1
Gonçalves, O; Meuth, M; Trudel, M1
Fischer, PH; Grem, JL1
Erlichman, C; Hedley, DW; Jamieson, GP; Pressacco, J; Wiley, JS1
Allegra, CJ; Geoffroy, FJ; Grem, JL; Sinha, B1
Heiden, T; Lewin, F; Skog, S; Tribukait, B1
Horowitz, R; Mao, X; Schwartz, EL; Wadler, S1
Elstein, KH; Kavlock, RJ; Lau, C; Mole, ML; Rogers, JM; Setzer, RW; Zucker, RM1
Aherne, GW; Allegra, CJ; Geoffroy, F; Grem, JL; Hardcastle, A; Ismail, A; Ren, Q; Van Groeningen, CJ1
Erlichman, C; Kaufmann, SH; Mullany, S; Svingen, PA1
Harwood, FG; Houghton, JA; Tillman, DM1
Gao, WY; Johns, DG; Mitsuya, H; Tanaka, M1
Berkenblit, R; Damle, S; Haynes, H; Kaleya, R; Ladner, RD; Murgo, A; Schechner, R; Wadler, S1
Aubert, C; Catalin, J; Ciccolini, J; Cuq, P; Evrard, A; Formento, P; Milano, G; Peillard, L; Pelegrin, A1
Cao, D; Kim, B; Leffert, JJ; McCabe, J; Pizzorno, G1
Grogan, BC; Guminski, AF; Parker, JB; Stivers, JT1
Damelin, LH; Jivan, R; Mavri-Damelin, D; Mynhardt, C; Peres, J; Prince, S; Veale, RB1

Reviews

1 review(s) available for thymidine 5'-triphosphate and fluorouracil

ArticleYear
The genetic consequences of the Thy- mutation to CHO cells.
    Basic life sciences, 1985, Volume: 31

    Topics: Adenine Phosphoribosyltransferase; Alkylating Agents; Animals; Carbon-Nitrogen Ligases; Cell Line; Cricetinae; Cytarabine; Cytidine Triphosphate; Deoxycytosine Nucleotides; Deoxyribonucleotides; DNA; Drug Resistance; Female; Fluorouracil; Genes; Hypoxanthine Phosphoribosyltransferase; Ligases; Mutation; Ovary; Phenotype; Thymidine; Thymine Nucleotides; Ultraviolet Rays

1985

Trials

1 trial(s) available for thymidine 5'-triphosphate and fluorouracil

ArticleYear
Phase II/pharmacodynamic trial of dose-intensive, weekly parenteral hydroxyurea and fluorouracil administered with interferon alfa-2a in patients with refractory malignancies of the gastrointestinal tract.
    Journal of clinical oncology : official journal of the American Society of Clinical Oncology, 1999, Volume: 17, Issue:6

    Topics: Adult; Aged; Aged, 80 and over; Antineoplastic Combined Chemotherapy Protocols; Carcinoma; Deoxyuracil Nucleotides; Dose-Response Relationship, Drug; Drug Administration Schedule; Female; Fluorouracil; Humans; Hydroxyurea; Interferon alpha-2; Interferon-alpha; Leukocytes, Mononuclear; Male; Middle Aged; Pancreatic Neoplasms; Prospective Studies; Recombinant Proteins; Stomach Neoplasms; Thymine Nucleotides; Treatment Outcome

1999

Other Studies

16 other study(ies) available for thymidine 5'-triphosphate and fluorouracil

ArticleYear
Mechanisms of collateral sensitivity to fluorouracil of a cis-diamminedichloroplatinum(II)-resistant human non-small lung cancer cell line.
    British journal of cancer, 1992, Volume: 65, Issue:6

    Topics: Adenocarcinoma; Biological Transport; Carcinoma, Non-Small-Cell Lung; Cisplatin; DNA Damage; Drug Resistance; Fluorouracil; Humans; In Vitro Techniques; Lung Neoplasms; RNA, Neoplasm; Thymine Nucleotides; Tumor Cells, Cultured; Uridine

1992
Sequence-dependent interaction of 5-fluorouracil and arabinosyl-5-azacytosine or 1-beta-D-arabinofuranosylcytosine.
    Biochemical pharmacology, 1991, Jul-05, Volume: 42, Issue:2

    Topics: Antineoplastic Combined Chemotherapy Protocols; Azacitidine; Cell Division; Cell Line; Cell Nucleus; Cell Survival; Colonic Neoplasms; Cytarabine; Cytidine; Deoxycytosine Nucleotides; DNA, Neoplasm; Drug Administration Schedule; Drug Interactions; Fluorouracil; Humans; Nucleic Acids; Thymine Nucleotides; Tumor Stem Cell Assay

1991
Augmentation of 5-fluorouracil cytotoxicity in human colon cancer cells by dipyridamole.
    Cancer research, 1985, Volume: 45, Issue:7

    Topics: Cell Division; Cell Line; Cell Survival; Colonic Neoplasms; Dipyridamole; Dose-Response Relationship, Drug; Drug Synergism; Fluorouracil; Humans; Nucleosides; Thymine Nucleotides

1985
Modulation of the equilibrative nucleoside transporter by inhibitors of DNA synthesis.
    British journal of cancer, 1995, Volume: 72, Issue:4

    Topics: Antimetabolites; Carrier Proteins; Cytarabine; DNA; Fluoresceins; Fluorouracil; Humans; Membrane Proteins; Nucleoside Transport Proteins; Purine Nucleosides; Thymine Nucleotides; Tumor Cells, Cultured

1995
Enhanced cytotoxicity with interleukin-1 alpha and 5-fluorouracil in HCT116 colon cancer cells.
    Oncology research, 1994, Volume: 6, Issue:12

    Topics: Biotransformation; Cell Division; Colonic Neoplasms; DNA, Neoplasm; Drug Synergism; Fluorouracil; Humans; Interleukin-1; Prodrugs; Receptors, Interleukin-1; Recombinant Proteins; RNA, Neoplasm; Thymidine; Thymine Nucleotides; Tumor Cells, Cultured; Tumor Stem Cell Assay; Uridine; Uridine Triphosphate

1994
DNA synthesis after combined treatment with cisplatin and 5-fluorouracil of a mouse ascites tumor growing in vivo.
    Anti-cancer drugs, 1994, Volume: 5, Issue:1

    Topics: Animals; Antineoplastic Combined Chemotherapy Protocols; Cell Cycle; Chromatography, High Pressure Liquid; Cisplatin; Cross-Linking Reagents; DNA, Neoplasm; Fluorouracil; Male; Mice; Neoplasms, Experimental; Thymidine; Thymidylate Synthase; Thymine Nucleotides; Tumor Cells, Cultured

1994
Effect of interferon on 5-fluorouracil-induced perturbations in pools of deoxynucleotide triphosphates and DNA strand breaks.
    Cancer chemotherapy and pharmacology, 1996, Volume: 38, Issue:6

    Topics: Antineoplastic Agents; Antineoplastic Combined Chemotherapy Protocols; Base Sequence; Deoxyribonucleotides; DNA Damage; DNA, Neoplasm; Drug Synergism; Fluorouracil; HT29 Cells; Humans; Interferon alpha-2; Interferon-alpha; Recombinant Proteins; Thymine Nucleotides; Tumor Cells, Cultured

1996
Nucleoside-mediated mitigation of 5-fluorouracil-induced toxicity in synchronized murine erythroleukemic cells.
    Toxicology and applied pharmacology, 1997, Volume: 146, Issue:1

    Topics: Animals; Antimetabolites, Antineoplastic; Cell Cycle; Deoxycytidine; Deoxyguanine Nucleotides; Embryo, Mammalian; Female; Flow Cytometry; Fluorouracil; Leukemia, Erythroblastic, Acute; Mice; Pregnancy; Rats; Rats, Sprague-Dawley; Thymidine; Thymine Nucleotides

1997
Modulation of fluorouracil cytotoxicity by interferon-alpha and -gamma.
    Molecular pharmacology, 1998, Volume: 53, Issue:2

    Topics: DNA Fragmentation; DNA Repair; DNA, Neoplasm; Drug Administration Schedule; Drug Interactions; Fluorouracil; Humans; Interferon-alpha; Interferon-gamma; RNA, Neoplasm; Thymine Nucleotides; Tumor Cells, Cultured

1998
Effect of adding the topoisomerase I poison 7-ethyl-10-hydroxycamptothecin (SN-38) to 5-fluorouracil and folinic acid in HCT-8 cells: elevated dTTP pools and enhanced cytotoxicity.
    Cancer chemotherapy and pharmacology, 1998, Volume: 42, Issue:5

    Topics: Adenocarcinoma; Antineoplastic Combined Chemotherapy Protocols; Camptothecin; Cell Cycle; Cell Survival; Deoxyuracil Nucleotides; DNA Topoisomerases, Type I; Dose-Response Relationship, Drug; Drug Synergism; Enzyme Inhibitors; Fluorouracil; Humans; Intestinal Neoplasms; Irinotecan; Leucovorin; Thymidylate Synthase; Thymine Nucleotides; Topoisomerase I Inhibitors; Tumor Cells, Cultured

1998
Ratio of 2'-deoxyadenosine-5'-triphosphate/thymidine-5'-triphosphate influences the commitment of human colon carcinoma cells to thymineless death.
    Clinical cancer research : an official journal of the American Association for Cancer Research, 1995, Volume: 1, Issue:7

    Topics: Cell Death; Cell Survival; Clone Cells; Deoxyadenine Nucleotides; Deoxyadenosines; Fluorouracil; Humans; Kinetics; Leucovorin; Nucleosomes; Thymine; Thymine Nucleotides; Tumor Cells, Cultured; Tumor Stem Cell Assay

1995
Suppression of replication of multidrug-resistant HIV type 1 variants by combinations of thymidylate synthase inhibitors with zidovudine or stavudine.
    Molecular pharmacology, 1999, Volume: 55, Issue:3

    Topics: Anti-HIV Agents; Antimetabolites; Drug Interactions; Drug Resistance, Microbial; Drug Resistance, Multiple; Floxuridine; Fluorouracil; HIV-1; Humans; Mutation; Reverse Transcriptase Inhibitors; Stavudine; Thymidylate Synthase; Thymine Nucleotides; Virus Replication; Zidovudine

1999
Enhanced antitumor activity of 5-fluorouracil in combination with 2'-deoxyinosine in human colorectal cell lines and human colon tumor xenografts.
    Clinical cancer research : an official journal of the American Association for Cancer Research, 2000, Volume: 6, Issue:4

    Topics: Analysis of Variance; Animals; Antineoplastic Combined Chemotherapy Protocols; Apoptosis; Cell Division; Colonic Neoplasms; Colorectal Neoplasms; Drug Synergism; fas Receptor; Fluorouracil; Humans; Inhibitory Concentration 50; Inosine; Mice; Mice, Nude; Neoplasm Transplantation; Thymidylate Synthase; Thymine Nucleotides; Transplantation, Heterologous; Tritium; Tumor Cells, Cultured

2000
Abnormalities in uridine homeostatic regulation and pyrimidine nucleotide metabolism as a consequence of the deletion of the uridine phosphorylase gene.
    The Journal of biological chemistry, 2005, Jun-03, Volume: 280, Issue:22

    Topics: Adenosine; Animals; Antimetabolites, Antineoplastic; Blotting, Southern; Cytidine; Deoxyribonucleotides; DNA-Directed DNA Polymerase; Fluorouracil; Gene Deletion; Guanosine; Intestinal Mucosa; Kidney; Kinetics; Liver; Lung; Mice; Mice, Transgenic; Nucleotides; Pentobarbital; Pyrimidines; Reverse Transcriptase Polymerase Chain Reaction; Ribonucleotides; RNA, Messenger; Thymine Nucleotides; Time Factors; Tissue Distribution; Uridine; Uridine Phosphorylase

2005
Effect of the thymidylate synthase inhibitors on dUTP and TTP pool levels and the activities of DNA repair glycosylases on uracil and 5-fluorouracil in DNA.
    Biochemistry, 2011, Feb-08, Volume: 50, Issue:5

    Topics: Animals; Cell Line; Chickens; Deoxyuracil Nucleotides; DNA; DNA Damage; DNA Glycosylases; DNA Repair; Enzyme Inhibitors; Fluorouracil; HeLa Cells; Humans; Kinetics; Mice; Thymidylate Synthase; Thymine Nucleotides; Uracil

2011
Metformin-induced alterations in nucleotide metabolism cause 5-fluorouracil resistance but gemcitabine susceptibility in oesophageal squamous cell carcinoma.
    Journal of cellular biochemistry, 2018, Volume: 119, Issue:1

    Topics: Animals; Antineoplastic Combined Chemotherapy Protocols; Carcinoma, Squamous Cell; Cell Line, Tumor; Deoxycytidine; Deoxycytidine Kinase; Drug Resistance, Neoplasm; Drug Synergism; Esophageal Neoplasms; Esophageal Squamous Cell Carcinoma; Fluorouracil; Gemcitabine; Gene Expression Regulation, Neoplastic; Humans; Metformin; Mice; Thymidine Kinase; Thymidylate Synthase; Thymine Nucleotides; Up-Regulation; Xenograft Model Antitumor Assays

2018