thymidine 5'-triphosphate has been researched along with 2'-deoxycytidine 5'-triphosphate in 141 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 51 (36.17) | 18.7374 |
| 1990's | 29 (20.57) | 18.2507 |
| 2000's | 37 (26.24) | 29.6817 |
| 2010's | 21 (14.89) | 24.3611 |
| 2020's | 3 (2.13) | 2.80 |
| Authors | Studies |
|---|---|
| Chawla, RR; Hampton, A; Kappler, F | 1 |
| Mellors, JW; Radzio, J; Sheen, CW; Sluis-Cremer, N; Zelina, S | 1 |
| Amblard, F; Bassit, L; Bondada, L; Coats, SJ; Detorio, M; Grier, J; Hernandez-Santiago, BI; Koontz, D; Mellors, JW; Rapp, KL; Schinazi, RF; Sluis-Cremer, N | 1 |
| Meanwell, NA | 1 |
| Fuchs, JA; Manwaring, JD | 1 |
| Plunkett, W; Xu, YZ | 1 |
| Allegra, CJ; Grem, JL | 1 |
| Glattke, M; Kohalmi, SE; Kunz, BA; McIntosh, EM | 1 |
| Brumley, J; Hayman, RJ; Rose, IS; van der Weyden, MB | 1 |
| Nucci, R; Rossi, M; Vaccaro, C; Whitehead, EP | 1 |
| Nucci, R; Raia, CA; Rossi, M; Vaccaro, C; Whitehead, EP | 1 |
| Höglund, L; Pontis, E; Reichard, P | 1 |
| Eriksson, S; Jansson, O | 1 |
| Chiba, P; Eher, R; Knapp, W; Köller, U; Kraupp, M; Salamon, J; Szekeres, T; Tihan, T | 1 |
| Chubb, S; Grindey, GB; Heinemann, V; Hertel, LW; Plunkett, W; Sen, A; Xu, YZ | 1 |
| Bartolucci, S; Bouchard, J; Momparler, LF; Momparler, RL; Nucci, R; Raia, CA; Rossi, M; Sepe, S; Vaccaro, C | 1 |
| Schroeder, AL; Srivastava, VK | 1 |
| Fyfe, JA; Sherman, PA | 1 |
| Frick, LW; Nelson, DJ | 1 |
| Bhalla, K; Birkhofer, M; Cole, J; Graham, G; Grant, S; Li, GR; MacLaughlin, W; Volsky, DJ | 1 |
| Akiyama, Y; Kiriyama, Y; Kitoh, T; Kubota, M; Mikawa, H; Takimoto, T; Tanizawa, A | 1 |
| Chavez, F; Dosanjh, MK; Essigmann, JM; Goodman, MF; Singer, B | 1 |
| Heinemann, V; Plunkett, W | 1 |
| Razzaki, T; Sinha, NK | 1 |
| Duran, HL; Wani, AA | 1 |
| Eriksson, S; Skog, S; Tribukait, B; Wallström, B | 1 |
| Danenberg, PV; Ibric, LL; Peterson, AR; Peterson, H | 1 |
| Dresler, SL; Frattini, MG; Robinson-Hill, RM | 1 |
| Hori, T; Murata, M; Takahashi, E; Tsuji, H; Tsuji, S | 1 |
| Bianchi, V; Pontis, E; Reichard, P | 3 |
| Meuth, M; Nalbantoglu, J; Phear, G | 1 |
| Hiraoka, O; Hirota, Y; Koyama, Y; Tanaka, S; Wataya, Y; Yoshioka, A | 1 |
| Lagergren, J; Reichard, P | 1 |
| Gonçalves, O; Meuth, M; Trudel, M | 1 |
| Reichard, P | 1 |
| Miller, JH; Newman, CN | 2 |
| Cohen, A; Ullman, B | 1 |
| Danhauser, LL; Rustum, YM | 1 |
| Berezney, R; Smith, HC; Tubo, RA | 1 |
| Creaven, P; Marquet, J; Rustum, Y; Zittoun, J; Zittoun, R | 1 |
| Kasper, LH; Pfefferkorn, ER | 1 |
| Bestwick, RK; Mathews, CK; Moffett, GL | 1 |
| Cheng, YC; Ruth, JL | 1 |
| Furman, PA; Lambe, CU; Nelson, DJ | 1 |
| Tanaka, K; Tanaka, S; Wataya, Y; Yoshioka, A | 1 |
| Appel, H; Leyva, A; Pinedo, HM | 1 |
| Jackson, RC | 1 |
| Ikegami, S; Nagano, H; Okano, K | 1 |
| Griffiths, TD; Ling, SY | 1 |
| Snyder, RD | 1 |
| Ashman, CR; Davidson, RL | 1 |
| Ganeshaguru, K; Hoffbrand, AV; Lee, N; Piga, A; Prentice, HG; Russell, NH; Smyth, JF | 1 |
| Bestwick, RK; Mathews, CK | 1 |
| Nucci, R; Raia, CA; Rella, R; Rossi, M; Sepe, S; Vaccaro, C | 1 |
| Maley, F; Maley, GF | 2 |
| Chabner, BA; Ellims, PH; Kao, AY | 1 |
| Ellims, PH; Van der Weyden, MB | 1 |
| Schwartz, SA | 1 |
| Divita, G; Goody, RS; Rittinger, K | 1 |
| Bianchi, V; Darè, E; Jenssen, D; Zhang, LH | 1 |
| Kazimierczuk, Z; Piróth, Z; Sasvári-Székely, M; Staub, M | 1 |
| Kohalmi, SE; Kunz, BA; Roche, HM | 1 |
| Eriksson, S; Hultgren, C; Karlsson, A; Meyerhans, A; Plikat, U; Vartanian, JP; Wain-Hobson, S; Wang, L | 1 |
| Avidan, O; Bakhanashvili, M; Hizi, A | 1 |
| Aulabaugh, AE; Boone, LR; Boyd, FL; Daluge, SM; Davis, MG; Freeman, GA; Miller, WH; Painter, GR; VanDraanen, NA; Wilson, JE | 1 |
| Xing, W | 1 |
| Alur, P; Dornadula, G; Laughlin, MA; Pomerantz, RJ; Zhang, H | 1 |
| Björnberg, O; Nyman, PO | 1 |
| Cox, S; Palmer, S | 1 |
| Arzumanov, AA; Dyatkina, NB; Gosselin, G; Imbach, JL; Krayevsky, AA; Meyer, A; Rayner, B; Semizarov, DG; Vichier-Guerre, S | 1 |
| Bianchi, LC; Bianchi, V; Borella, S; Calderazzo, F; Ferraro, P; Rampazzo, C; Reichard, P; Skog, S | 1 |
| Meuth, M | 1 |
| Nielsen, CJ; Papermaster, SF; Ussery, MA; Wood, OL; Zhang, H | 1 |
| Anderson, KS; Kerr, SG | 1 |
| Guo, MJ; Hildbrand, S; Leumann, CJ; McLaughlin, LW; Waring, MJ | 1 |
| Fujikawa, K; Kamiya, H; Kasai, H | 1 |
| Amacker, M; Faraj, A; Gosselin, G; Hübscher, U; Imbach, JL; Maga, G; Mathé, C; Sommadossi, JP; Spadari, S | 1 |
| Kumari, D; Usdin, K | 1 |
| Kuchta, RD; Mazurkiewicz, A; Richardson, FC; Richardson, KA | 1 |
| Chaney, SG; Vaisman, A | 1 |
| Enger, MD; Gurley, LR; Ratliff, RL; Tobey, RA; Walters, RA | 1 |
| Heeger, P; Mynatt, RL; Truett, AA; Truett, GE; Walker, JA; Warman, ML | 1 |
| Berger, M; McMinn, DL; Ogawa, AK; Romesberg, FE; Schultz, PG; Wu, Y | 1 |
| Chimploy, K; Mathews, CK; Tassotto, ML | 1 |
| Barnett, YA; Curran, MD; Hyland, PL; Keegan, AL; McKenna, PG; Middleton, D | 1 |
| Berry, SE; Davis, TW; de Wind, N; Hwang, HS; Kinsella, TJ; Schupp, JE | 1 |
| Ishikawa, F; Saito, M; Saneyoshi, M; Shudo, K; Tomikawa, A; Yamada, R; Yamaguchi, T | 1 |
| Amin, S; Geacintov, NE; Kolbanovskiy, A; Zhuang, P | 1 |
| Anderson, JN; Balzarini, J; Camarasa, MJ; De Clercq, E; Karlsson, A; Pérez-Pérez, MJ; Perno, CF; San-Félix, A; Velázquez, S | 1 |
| Cantor, CR; Denissenko, MF; Leppin, AL; Rodi, CP; Shchepinov, MS; Smylie, KJ; Wörl, RJ | 1 |
| Fagny, C; Robberecht, P; Svoboda, M; Vandevelde, M | 1 |
| Collins, S; Gerard, GF; Smith, MD | 1 |
| Eklund, H; Eliasson, R; Färnegårdh, M; Jordan, A; Uhlin, U; Uppsten, M | 1 |
| Mathews, CK; Song, S; Wheeler, LJ | 1 |
| Barroso, JF; Elholm, M; Flatmark, T | 1 |
| Cases-González, CE; Menéndez-Arias, L | 1 |
| Fiala, KA; Suo, Z | 1 |
| Dong, Y; Fiala, KA; Roettger, MP; Sompalli, S; Suo, Z | 1 |
| Konigsberg, W; Wang, J; Yang, G | 1 |
| Hayakawa, H; Ishibashi, T; Ito, R; Sekiguchi, M | 1 |
| Hamby, K; Persson, K; Ugozzoli, LA | 1 |
| Eckert, KA; Hamid, S | 1 |
| Cramer, J; Restle, T | 1 |
| Aggarwal, AK; Johnson, RE; Nair, DT; Prakash, L; Prakash, S | 1 |
| Broyde, S; Patel, DJ; Rechkoblit, O; Shapiro, R; Wang, L; Zhang, L | 1 |
| Bernardi, P; Bianchi, V; Ferraro, P; Nicolosi, L; Reichard, P | 1 |
| Adams, S; Andreu, AL; Ashley, N; Naviaux, RK; Poulton, J; Slama, A; Suomalainen, A; Zeviani, M | 1 |
| Chi, LM; Lam, SL | 2 |
| Arakawa, H; Kamahori, M; Kambara, H; Karasawa, K; Maeda, M; Munakata, E; Obinata, R; Suzuki, S | 1 |
| Konigsberg, W; Lee, HR; Wang, M | 1 |
| Iams, TA; McKee, EE; Morris, GW; Slepchenko, KG | 1 |
| Saada, A | 1 |
| Broyde, S; Donny-Clark, K | 1 |
| Choi, JY; Egli, M; Guengerich, FP; Pence, MG | 1 |
| Abdulovic, AL; Chabes, A; Kumar, D; Kunkel, TA; Nilsson, AK; Viberg, J | 1 |
| Andreu, AL; González-Vioque, E; Martí, R; Torres-Torronteras, J | 1 |
| Christodoulou, E; Crow, YJ; de Carvalho, LP; Ennis-Adeniran, V; Goldstone, DC; Groom, HC; Haire, LF; Hedden, JJ; Kelly, G; Rice, GI; Stoye, JP; Taylor, IA; Walker, PA; Webb, M; Yap, MW | 1 |
| Kore, AR; Senthilvelan, A; Shanmugasundaram, M; Srinivasan, B | 1 |
| Cho, BP; Vaidyanathan, VG; Xu, L | 1 |
| Chabes, A; Krogan, NJ; Roguev, A; Rozenzhak, S; Russell, P; Sánchez, A; Sharma, S | 1 |
| Cafarelli, TM; Godoy, VG; Rands, TJ | 1 |
| Fijalkowska, IJ; Gawel, D; Jonczyk, P; Schaaper, RM | 1 |
| Koag, MC; Kou, Y; Lee, S; Ouzon-Shubeita, H | 1 |
| Alian, A; Marx, A | 1 |
| Buckland, RJ; Chabes, A; Chittoor, B; Kunkel, TA; Nilsson, AK; Watt, DL | 1 |
| Creech, A; Loechler, EL; Sholder, G | 1 |
| Anderson, PL; Bushman, LR; Castillo-Mancilla, JR; Chen, X; MaWhinney, S; McAllister, KB; Seifert, SM; Zheng, JH | 1 |
| Anderson, PL; Bushman, LR; Chen, X; Klein, B; McAllister, KJ | 1 |
| Egli, M; Guengerich, FP; Patra, A; Zhang, Q | 1 |
| Bianchi, V; Crescenzi, M; Donsante, S; Franzolin, E; Gurtner, A; Loffredo, D; Losanno, L; Pajalunga, D; Passaro, N; Rampazzo, C; Russo, A; Stevanoni, M; Zribi, S | 1 |
| Aggarwal, AK; Buku, A; Choudhury, JR; Jain, R; Johnson, RE; Prakash, L; Prakash, S | 1 |
| Wetmore, SD; Wilson, KA | 1 |
| Hassan, C; Herdewijn, P; Louis, D; Marlière, P; Pezo, V; Sargueil, B | 1 |
| González-Pacanowska, D; Martínez-Arribas, B; Pérez-Moreno, G; Requena, CE; Ruíz-Pérez, LM; Vidal, AE | 1 |
| Chang, ZF; González-Pacanowska, D; Huang, CY; Yagüe-Capilla, M | 1 |
| Dubovskaja, V; Jasponė, A; Kapustina, Ž; Lubys, A; Mackevičius, G | 1 |
4 review(s) available for thymidine 5'-triphosphate and 2'-deoxycytidine 5'-triphosphate
| Article | Year |
|---|---|
Deoxyribonucleoside-induced selective modulation of cytotoxicity and mutagenesis.
Topics: Alkylating Agents; Animals; Azaguanine; Cell Line; Cell Survival; Cricetinae; Deoxyadenosines; Deoxycytidine; Deoxycytosine Nucleotides; Deoxyguanosine; Deoxyribonucleosides; DNA; Drug Resistance; Drug Synergism; Floxuridine; Leukemia L1210; Lung; Methylation; Methylnitronitrosoguanidine; Mice; Mutagens; Mutation; Thymidine; Thymidylate Synthase; Thymine Nucleotides | 1985 |
The genetic consequences of the Thy- mutation to CHO cells.
Topics: Adenine Phosphoribosyltransferase; Alkylating Agents; Animals; Carbon-Nitrogen Ligases; Cell Line; Cricetinae; Cytarabine; Cytidine Triphosphate; Deoxycytosine Nucleotides; Deoxyribonucleotides; DNA; Drug Resistance; Female; Fluorouracil; Genes; Hypoxanthine Phosphoribosyltransferase; Ligases; Mutation; Ovary; Phenotype; Thymidine; Thymine Nucleotides; Ultraviolet Rays | 1985 |
Ribonucleotide reductase and deoxyribonucleotide pools.
Topics: Allosteric Regulation; Animals; Binding Sites; Cell Cycle; Cell Line; Deoxyadenosines; Deoxycytosine Nucleotides; Deoxyribonucleotides; DNA; Kinetics; Macromolecular Substances; Models, Biological; Mutation; Protein Conformation; Ribonucleotide Reductases; Substrate Specificity; Thymidine; Thymine Nucleotides | 1985 |
A kinetic model of regulation of the deoxyribonucleoside triphosphate pool composition.
Topics: Animals; Antimetabolites; Deoxyadenine Nucleotides; Deoxycytosine Nucleotides; Deoxyguanine Nucleotides; Deoxyribonucleosides; Deoxyribonucleotides; DNA; Humans; Kinetics; Liver Neoplasms, Experimental; Models, Biological; Nucleic Acid Synthesis Inhibitors; Ribonucleoside Diphosphate Reductase; Thermodynamics; Thymidylate Synthase; Thymine Nucleotides | 1984 |
1 trial(s) available for thymidine 5'-triphosphate and 2'-deoxycytidine 5'-triphosphate
| Article | Year |
|---|---|
Analysis of the Endogenous Deoxynucleoside Triphosphate Pool in HIV-Positive and -Negative Individuals Receiving Tenofovir-Emtricitabine.
Topics: Adult; Anti-HIV Agents; Case-Control Studies; Deoxyadenine Nucleotides; Deoxycytosine Nucleotides; Deoxyguanine Nucleotides; Emtricitabine; Female; HIV Infections; HIV-1; Humans; Leukocytes, Mononuclear; Linear Models; Male; Tenofovir; Thymine Nucleotides | 2016 |
136 other study(ies) available for thymidine 5'-triphosphate and 2'-deoxycytidine 5'-triphosphate
| Article | Year |
|---|---|
Design of species- or isozyme-specific enzyme inhibitors. 1. Effect of thymidine substituents on affinity for the thymidine site of hamster cytoplasmic thymidine kinase.
Topics: Animals; Cricetinae; Cytoplasm; Deoxycytidine; Deoxyuridine; Humans; In Vitro Techniques; Isoenzymes; Kidney; Kinetics; Methods; Mitochondria; Structure-Activity Relationship; Substrate Specificity; Thymidine; Thymidine Kinase; Thymine Nucleotides | 1979 |
Mechanisms by which the G333D mutation in human immunodeficiency virus type 1 Reverse transcriptase facilitates dual resistance to zidovudine and lamivudine.
Topics: Anti-HIV Agents; Drug Resistance, Multiple, Viral; HIV Reverse Transcriptase; HIV-1; Humans; Kinetics; Lamivudine; Models, Molecular; Mutation; Reverse Transcriptase Inhibitors; Thermodynamics; Zidovudine | 2008 |
Anti-human immunodeficiency virus activity, cross-resistance, cytotoxicity, and intracellular pharmacology of the 3'-azido-2',3'-dideoxypurine nucleosides.
Topics: Anti-HIV Agents; Cell Line, Tumor; Cell Survival; Cells, Cultured; Dideoxynucleosides; HIV Infections; HIV-1; Humans; Molecular Structure; Reverse Transcriptase Inhibitors | 2009 |
Synopsis of some recent tactical application of bioisosteres in drug design.
Topics: Cytochrome P-450 Enzyme System; Drug Design | 2011 |
Nucleoside triphosphate pools in minicells of Escherichia coli.
Topics: Adenosine Triphosphate; Cytidine Triphosphate; Deoxyadenine Nucleotides; Deoxycytosine Nucleotides; Deoxyguanine Nucleotides; Escherichia coli; Guanosine Triphosphate; Nucleotides; Thymine Nucleotides; Uridine Triphosphate | 1977 |
Modulation of deoxycytidylate deaminase in intact human leukemia cells. Action of 2',2'-difluorodeoxycytidine.
Topics: Antimetabolites, Antineoplastic; Carbon Radioisotopes; Cell Extracts; Chromatography, High Pressure Liquid; Cytidine Deaminase; DCMP Deaminase; Deoxycytidine; Deoxycytosine Nucleotides; Gemcitabine; Humans; Leukemia, Lymphoid; Leukemia, Myeloid; Thymine Nucleotides; Tumor Cells, Cultured | 1992 |
Sequence-dependent interaction of 5-fluorouracil and arabinosyl-5-azacytosine or 1-beta-D-arabinofuranosylcytosine.
Topics: Antineoplastic Combined Chemotherapy Protocols; Azacitidine; Cell Division; Cell Line; Cell Nucleus; Cell Survival; Colonic Neoplasms; Cytarabine; Cytidine; Deoxycytosine Nucleotides; DNA, Neoplasm; Drug Administration Schedule; Drug Interactions; Fluorouracil; Humans; Nucleic Acids; Thymine Nucleotides; Tumor Stem Cell Assay | 1991 |
Mutational specificity of DNA precursor pool imbalances in yeast arising from deoxycytidylate deaminase deficiency or treatment with thymidylate.
Topics: Base Sequence; DCMP Deaminase; Deoxycytosine Nucleotides; DNA Mutational Analysis; DNA Replication; DNA, Fungal; Genes, Suppressor; Molecular Sequence Data; Mutagenesis; RNA, Fungal; RNA, Transfer; Saccharomyces cerevisiae; Structure-Activity Relationship; Thymine Nucleotides | 1991 |
Folate-deficient human lymphoblasts: changes in deoxynucleotide metabolism and thymidylate cycle activities.
Topics: Deoxyadenine Nucleotides; Deoxycytosine Nucleotides; Deoxyguanine Nucleotides; Deoxyuridine; Dose-Response Relationship, Drug; Folic Acid; Folic Acid Deficiency; Humans; Lymphocyte Activation; Lymphocytes; Nucleotides; Thymidine; Thymidylate Synthase; Thymine Nucleotides | 1991 |
Hill coefficient ratios give binding ratios of allosteric enzyme effectors; inhibition, activation, and squatting in deoxycytidylate aminohydrolase (EC 3.5.4.12)
Topics: Allosteric Regulation; Allosteric Site; Animals; DCMP Deaminase; Deoxycytosine Nucleotides; Enzyme Activation; Kinetics; Mathematics; Perissodactyla; Spleen; Thymine Nucleotides | 1991 |
Allosteric modifier and substrate binding of donkey deoxycytidylate aminohydrolase (EC 3.5.4.12)
Topics: Adamantane; Allosteric Regulation; Allosteric Site; Amino Acids; Animals; DCMP Deaminase; Deoxycytosine Nucleotides; Enzyme Activation; Kinetics; Macromolecular Substances; Molecular Weight; Perissodactyla; Protein Conformation; Spleen; Thymine Nucleotides | 1991 |
Deoxyribonucleotide metabolism in hydroxyurea-resistant V79 hamster cells.
Topics: Animals; Cell Line; Cricetinae; Deoxycytosine Nucleotides; Deoxyguanine Nucleotides; Deoxyribonucleotides; DNA; Drug Resistance; Hydroxyurea; Thymine Nucleotides | 1991 |
Direct photoaffinity-labelling of human deoxycytidine kinase with the feedback inhibitor dCTP.
Topics: Affinity Labels; Deoxycytidine Kinase; Deoxycytosine Nucleotides; Feedback; Humans; Macromolecular Substances; Molecular Weight; Nucleosides; Nucleotides; Phosphotransferases; Photochemistry; Spleen; Thymine Nucleotides | 1990 |
Concordant changes of pyrimidine metabolism in blasts of two cases of acute myeloid leukemia after repeated treatment with ara-C in vivo.
Topics: Adolescent; Adult; Arabinofuranosylcytosine Triphosphate; Cytarabine; DCMP Deaminase; Deoxycytidine Kinase; Deoxycytosine Nucleotides; Drug Resistance; Female; Humans; Leukemia, Myeloid, Acute; Male; Pyrimidines; Thymine Nucleotides | 1990 |
Inhibition of ribonucleotide reduction in CCRF-CEM cells by 2',2'-difluorodeoxycytidine.
Topics: Cell Line; Cytidine; Deoxycytidine; Deoxycytosine Nucleotides; DNA; Gemcitabine; Humans; Hydroxyurea; Oxidation-Reduction; Ribonucleoside Diphosphate Reductase; Ribonucleotides; Thymine Nucleotides | 1990 |
5-AZA-2'-deoxycytidine synergistic action with thymidine on leukemic cells and interaction of 5-AZA-dCMP with dCMP deaminase.
Topics: Animals; Azacitidine; Cell Line; Cell Survival; DCMP Deaminase; Decitabine; Deoxycytosine Nucleotides; DNA, Neoplasm; Drug Synergism; Humans; Methylation; Mice; Nucleotide Deaminases; Thymidine; Thymine Nucleotides | 1986 |
Deoxyribonucleoside triphosphate pools in mutagen sensitive mutants of Neurospora crassa.
Topics: Deoxyadenine Nucleotides; Deoxycytosine Nucleotides; Deoxyguanine Nucleotides; Deoxyribonucleotides; DNA, Fungal; Genes, Fungal; Histidine; Hydroxyurea; Mutation; Neurospora; Neurospora crassa; Thymine Nucleotides | 1989 |
Enzymatic assay for deoxyribonucleoside triphosphates using synthetic oligonucleotides as template primers.
Topics: Base Sequence; Cells, Cultured; Deoxyadenine Nucleotides; Deoxycytosine Nucleotides; Deoxyguanine Nucleotides; Deoxyribonucleotides; DNA-Directed DNA Polymerase; Humans; Micrococcus; Oligonucleotides; Perchlorates; Poly dA-dT; Reference Standards; Templates, Genetic; Thymine Nucleotides; Tritium | 1989 |
Effects of 3'-azido-3'-deoxythymidine on the deoxynucleoside triphosphate pools of cultured human cells.
Topics: Deoxyadenine Nucleotides; Deoxycytosine Nucleotides; Deoxyguanine Nucleotides; Dose-Response Relationship, Drug; Humans; Nucleoside-Phosphate Kinase; Thymine Nucleotides; Tumor Cells, Cultured; Zidovudine | 1989 |
2'-Deoxycytidine protects normal human bone marrow progenitor cells in vitro against the cytotoxicity of 3'-azido-3'-deoxythymidine with preservation of antiretroviral activity.
Topics: Bone Marrow; CD4-Positive T-Lymphocytes; Cell Survival; Cells, Cultured; Colony-Forming Units Assay; Deoxycytidine; Deoxycytosine Nucleotides; Hematopoiesis; HIV; Humans; Phosphorylation; Thymine Nucleotides; Zidovudine | 1989 |
Ara-CTP metabolism following hydroxyurea or methotrexate treatment in human leukemia cell lines.
Topics: Arabinofuranosylcytosine Triphosphate; Arabinonucleotides; Cytarabine; Deoxycytidine; Deoxycytosine Nucleotides; Drug Synergism; Humans; Hydroxyurea; Leukemia; Leukemia, Promyelocytic, Acute; Methotrexate; Thymine Nucleotides; Tumor Cells, Cultured | 1989 |
Effect of 3' flanking neighbors on kinetics of pairing of dCTP or dTTP opposite O6-methylguanine in a defined primed oligonucleotide when Escherichia coli DNA polymerase I is used.
Topics: Base Composition; Base Sequence; Cloning, Molecular; Deoxycytosine Nucleotides; DNA Polymerase I; Escherichia coli; Guanine; Kinetics; Magnetic Resonance Spectroscopy; Molecular Sequence Data; Oligodeoxyribonucleotides; Templates, Genetic; Thymine Nucleotides | 1989 |
Modulation of deoxynucleotide metabolism by the deoxycytidylate deaminase inhibitor 3,4,5,6-tetrahydrodeoxyuridine.
Topics: Cell Line; Cytarabine; Cytidine Diphosphate; DCMP Deaminase; Deoxycytidine; Deoxycytidine Kinase; Deoxycytosine Nucleotides; Deoxyuridine; Hydroxyurea; Kinetics; Nucleotide Deaminases; Ribonucleotide Reductases; T-Lymphocytes; Tetrahydrouridine; Thymine Nucleotides | 1989 |
Effect of variations in the conditions of DNA synthesis upon the accuracy of DNA replication.
Topics: Bacteriophage phi X 174; Base Sequence; Deoxycytosine Nucleotides; Deoxyguanine Nucleotides; Deoxyribonucleotides; Deoxyuracil Nucleotides; Diphosphates; DNA Replication; DNA-Directed DNA Polymerase; DNA, Viral; Intercalating Agents; Manganese; Mutation; Thymine Nucleotides | 1985 |
Site-specific gap-misrepair mutagenesis by O4-ethylthymine.
Topics: Alkyl and Aryl Transferases; Deoxycytosine Nucleotides; DNA Repair; DNA Restriction Enzymes; DNA-Directed DNA Polymerase; Escherichia coli; Mutation; Plasmids; Thymine; Thymine Nucleotides; Transferases | 1987 |
Deoxyribonucleoside triphosphate metabolism and the mammalian cell cycle. Effects of hydroxyurea on mutant and wild-type mouse S49 T-lymphoma cells.
Topics: Animals; Cell Cycle; Cell Line; Deoxyadenine Nucleotides; Deoxycytidine Kinase; Deoxycytosine Nucleotides; Deoxyguanine Nucleotides; Deoxyribonucleotides; Hydroxyurea; Lymphoma; Mice; Mutation; Purine-Nucleoside Phosphorylase; Ribonucleotide Reductases; T-Lymphocytes; Thymidine Kinase; Thymine Nucleotides | 1987 |
In situ enzymology of DNA replication and ultraviolet-induced DNA repair synthesis in permeable human cells.
Topics: Cell Line; Cell Membrane Permeability; Deoxycytosine Nucleotides; Deoxyguanine Nucleotides; Deoxyribonucleotides; DNA; DNA Polymerase II; DNA Polymerase III; DNA Repair; DNA Replication; DNA-Directed DNA Polymerase; Fibroblasts; Humans; Potassium Chloride; Thymine Nucleotides; Ultraviolet Rays | 1988 |
Fragile X expression in thymidine-prototrophic and auxotrophic human-mouse somatic cell hybrids under low and high thymidylate stress conditions.
Topics: Animals; Bromodeoxyuridine; Cell Cycle; Deoxycytosine Nucleotides; Fragile X Syndrome; Gene Expression Regulation; Humans; Hybrid Cells; Male; Mice; Multigene Family; Replicon; Sex Chromosome Aberrations; Thymidine; Thymidine Monophosphate; Thymine Nucleotides | 1988 |
Regulation of pyrimidine deoxyribonucleotide metabolism by substrate cycles in dCMP deaminase-deficient V79 hamster cells.
Topics: Animals; Cell Division; Cell Line; Cricetinae; Cytidine Diphosphate; DCMP Deaminase; Deoxycytidine; Deoxycytidine Monophosphate; Deoxycytosine Nucleotides; Deoxyribonucleotides; Deoxyuridine; DNA; Nucleotide Deaminases; Pyrimidines; Thymidine; Thymidine Monophosphate; Thymine Nucleotides; Uridine Diphosphate | 1987 |
Interrelations between substrate cycles and de novo synthesis of pyrimidine deoxyribonucleoside triphosphates in 3T6 cells.
Topics: Animals; Cell Cycle; Cell Line; Deoxycytosine Nucleotides; Deoxyribonucleosides; Deoxyuracil Nucleotides; Dipyridamole; DNA Replication; Fibroblasts; Hydroxyurea; Mice; Phosphorylation; Thymidine Monophosphate; Thymine Nucleotides | 1986 |
Next-nucleotide effects in mutations driven by DNA precursor pool imbalances at the aprt locus of Chinese hamster ovary cells.
Topics: Adenine Phosphoribosyltransferase; Animals; Base Composition; Base Sequence; Cell Line; Cricetinae; Cricetulus; Deoxycytosine Nucleotides; DNA Replication; DNA-Directed DNA Polymerase; Female; Fibroblasts; Mutation; Ovary; Pentosyltransferases; Thymine Nucleotides | 1987 |
Deoxyribonucleoside-triphosphate imbalance death: deoxyadenosine-induced dNTP imbalance and DNA double strand breaks in mouse FM3A cells and the mechanism of cell death.
Topics: Animals; Cell Survival; Deoxyadenosines; Deoxycytosine Nucleotides; Deoxyribonucleosides; DNA; Mice; Nucleic Acid Conformation; Thymine Nucleotides; Time Factors | 1987 |
Purine deoxyribonucleosides counteract effects of hydroxyurea on deoxyribonucleoside triphosphate pools and DNA synthesis.
Topics: Animals; Cell Line; Cricetinae; Deoxyadenine Nucleotides; Deoxyadenosines; Deoxycytosine Nucleotides; Deoxyguanine Nucleotides; Deoxyguanosine; DNA; Hydroxyurea; Nucleotides; Purine Nucleosides; Thymine Nucleotides | 1987 |
Changes of deoxyribonucleoside triphosphate pools induced by hydroxyurea and their relation to DNA synthesis.
Topics: Cells, Cultured; Deoxyadenine Nucleotides; Deoxycytosine Nucleotides; Deoxyguanine Nucleotides; DNA; Hydroxyurea; Ribonucleotide Reductases; Thymine Nucleotides | 1986 |
Response of CHO cell DNA polymerase alpha to dCTP and dTTP pool imbalance: relation to DNA synthesis inhibition, survival and mutation.
Topics: Animals; Aphidicolin; Cell Line; Cell Survival; Cricetinae; Deoxycytosine Nucleotides; Deoxyribonucleotides; Diterpenes; DNA; DNA Polymerase II; Drug Resistance; Female; Methylnitronitrosoguanidine; Mutation; Ovary; Thymine Nucleotides; Ultraviolet Rays | 1985 |
Analysis of the drug synergism between thymidine and arabinosyl cytosine using mouse S49 T lymphoma mutants.
Topics: Animals; Cells, Cultured; Cytarabine; Deoxycytosine Nucleotides; Drug Synergism; Lymphoma; Mice; Mutation; Thymidine; Thymine Nucleotides | 1985 |
Potential for selective enhancement of the in vivo metabolism of 1-beta-D-arabinofuranosylcytosine in rats by thymidine pretreatment.
Topics: Animals; Biotransformation; Colonic Neoplasms; Cytarabine; Deoxycytosine Nucleotides; Drug Therapy, Combination; Female; Rats; Rats, Inbred F344; Thymidine; Thymine Nucleotides | 1985 |
The nuclear matrix continues DNA synthesis at in vivo replicational forks.
Topics: Animals; Bromodeoxyuridine; Cell Nucleus; Centrifugation, Density Gradient; Chromatin; Deoxycytosine Nucleotides; DNA Replication; Kinetics; Male; Rats; Rats, Inbred Strains; Ribonucleases; Thymine Nucleotides | 1985 |
Modulation of 1-beta-D-arabinofuranosylcytosine metabolism by thymidine in human acute leukemia.
Topics: Acute Disease; Cytarabine; Deoxycytosine Nucleotides; DNA; Drug Interactions; Drug Therapy, Combination; Humans; Leukemia; Thymidine; Thymine Nucleotides | 1985 |
Hydroxyurea inhibition of growth and DNA synthesis in Toxoplasma gondii: characterization of a resistant mutant.
Topics: Animals; Cells, Cultured; Deoxycytosine Nucleotides; DNA; Drug Resistance; Fibroblasts; Humans; Hydroxyurea; Mutation; Ribonucleotide Reductases; RNA; Thymine Nucleotides; Toxoplasma | 1982 |
Selective expansion of mitochondrial nucleoside triphosphate pools in antimetabolite-treated HeLa cells.
Topics: Deoxyadenine Nucleotides; Deoxycytosine Nucleotides; Deoxyguanine Nucleotides; Deoxyribonucleotides; DNA; Floxuridine; HeLa Cells; Humans; Methotrexate; Mitochondria; Ribonucleotides; Thymine Nucleotides | 1982 |
Nucleoside analogues with clinical potential in antivirus chemotherapy. The effect of several thymidine and 2'-deoxycytidine analogue 5'-triphosphates on purified human (alpha, beta) and herpes simplex virus (types 1, 2) DNA polymerases.
Topics: Antiviral Agents; Deoxycytosine Nucleotides; DNA Polymerase I; DNA Polymerase II; DNA, Viral; Humans; Kinetics; Nucleic Acid Synthesis Inhibitors; Pyrimidine Nucleotides; Simplexvirus; Templates, Genetic; Thymine Nucleotides | 1981 |
Effect of acyclovir on the deoxyribonucleoside triphosphate pool levels in Vero cells infected with herpes simplex virus type 1.
Topics: Acyclovir; Animals; Antiviral Agents; Cell Line; Chlorocebus aethiops; Deoxyadenine Nucleotides; Deoxycytosine Nucleotides; Deoxyguanine Nucleotides; Deoxyribonucleotides; Guanine; Phosphonoacetic Acid; Simplexvirus; Thymine Nucleotides | 1982 |
An improved method for the quantitative determination of deoxyribonucleoside triphosphates in cell extracts.
Topics: Animals; Carcinoma, Ehrlich Tumor; Cell Extracts; Chromatography, High Pressure Liquid; Deoxyadenine Nucleotides; Deoxycytosine Nucleotides; Deoxyguanine Nucleotides; Deoxyribonucleotides; Male; Methylamines; Mice; Oxidation-Reduction; Periodic Acid; Ribonucleotides; Thymine Nucleotides; Tissue Extracts | 1984 |
Diverse deoxyribonucleotide profiles in cultured human cells with differential sensitivity to thymidine.
Topics: B-Lymphocytes; Cell Line; Deoxycytosine Nucleotides; Deoxyguanine Nucleotides; Deoxyribonucleotides; Humans; Melanoma; T-Lymphocytes; Thymidine; Thymine Nucleotides | 1984 |
Changes in deoxyribonucleoside triphosphate pools in the starfish oocyte during maturation and early embryogenesis.
Topics: Animals; Aphidicolin; Deoxyadenine Nucleotides; Deoxycytosine Nucleotides; Deoxyguanine Nucleotides; Deoxyribonucleotides; Diterpenes; Female; Oocytes; Oogenesis; Ovum; Starfish; Thymine Nucleotides; Zygote | 1983 |
Deoxynucleoside triphosphate pool changes and UV-induced depression of DNA synthesis.
Topics: Animals; Cricetinae; Cricetulus; Deoxycytosine Nucleotides; Deoxyribonucleotides; DNA Replication; Female; Ovary; Thymine Nucleotides; Time Factors; Ultraviolet Rays | 1984 |
Deoxyribonucleoside triphosphate pools in human diploid fibroblasts and their modulation by hydroxyurea and deoxynucleosides.
Topics: Cells, Cultured; Deoxyadenine Nucleotides; Deoxycytosine Nucleotides; Deoxyguanine Nucleotides; Deoxyribonucleosides; Deoxyribonucleotides; Diploidy; Fibroblasts; Humans; Hydroxyurea; Thymine Nucleotides | 1984 |
Mutagen-induced changes in cellular deoxycytidine triphosphate and thymidine triphosphate in Chinese hamster ovary cells.
Topics: Animals; Cell Line; Cell Survival; Cricetinae; Cricetulus; Deoxycytosine Nucleotides; Female; Kinetics; Mutagens; Ovary; Sulfuric Acid Esters; Sulfuric Acids; Thymine Nucleotides; Ultraviolet Rays | 1983 |
Bromodeoxyuridine mutagenesis in mammalian cells is related to deoxyribonucleotide pool imbalance.
Topics: Animals; Bromodeoxyuridine; Cell Line; Deoxycytosine Nucleotides; Deoxyribonucleotides; Deoxyuracil Nucleotides; Mutation; Thymine Nucleotides | 1981 |
Studies on the biochemical sequelae of therapy in Thy-acute lymphoblastic leukaemia with the adenosine deaminase inhibitor 2' deoxycoformycin.
Topics: Adenosine Deaminase; Adenosylhomocysteinase; Adolescent; Adult; Bone Marrow; Coformycin; Deoxyadenine Nucleotides; Deoxycytosine Nucleotides; Deoxyguanine Nucleotides; Humans; Hydrolases; Leukemia, Lymphoid; Leukocyte Count; Male; Pentostatin; Ribonucleosides; Thymine Nucleotides | 1981 |
Unusual compartmentation of precursors for nuclear and mitochondrial DNA in mouse L cells.
Topics: Animals; Cell Compartmentation; Cell Nucleus; Deoxyadenine Nucleotides; Deoxycytosine Nucleotides; Deoxyguanine Nucleotides; Deoxyribonucleotides; DNA; L Cells; Mice; Mitochondria; Phosphorus Radioisotopes; Thymine Nucleotides; Tritium; Uridine | 1982 |
Reversal of the effect of the allosteric ligands of dCMP-aminohydrolase and stabilization of the enzyme in the T form.
Topics: Ammonium Sulfate; Cross-Linking Reagents; DCMP Deaminase; Deoxycytidine Monophosphate; Deoxycytosine Nucleotides; Glycerol; Ligands; Mercaptoethanol; Mercury; Nucleotide Deaminases; Organomercury Compounds; Protein Conformation; Thymine Nucleotides | 1982 |
Allosteric transitions associated with the binding of substrate and effector ligands to T2 phage induced deoxycytidylate deaminase.
Topics: Circular Dichroism; DCMP Deaminase; Deoxycytosine Nucleotides; Enzyme Induction; Kinetics; Mathematics; Nucleotide Deaminases; Substrate Specificity; T-Phages; Thymine Nucleotides | 1982 |
Deoxycytidylate deaminase. Purification and some properties of the enzyme isolated from human spleen.
Topics: DCMP Deaminase; Deoxycytidine Monophosphate; Deoxycytosine Nucleotides; Enzyme Activation; Humans; Hydrogen-Ion Concentration; Molecular Weight; Nucleotide Deaminases; Spleen; Thymine Nucleotides | 1981 |
Kinetic mechanism and inhibition of human liver thymidine kinase.
Topics: Adenosine Triphosphate; Deoxycytosine Nucleotides; Humans; Kinetics; Liver; Magnesium; Purine Nucleotides; Substrate Specificity; Thymidine Kinase; Thymine Nucleotides | 1981 |
Preferential utilization of bromodeoxyuridine and iododeoxyuridine triphosphates by DNA polymerase gamma in vitro.
Topics: Deoxycytosine Nucleotides; Deoxyuracil Nucleotides; DNA; DNA Polymerase III; DNA-Directed DNA Polymerase; Idoxuridine; Substrate Specificity; Thymine Nucleotides | 1981 |
Human immunodeficiency virus reverse transcriptase substrate-induced conformational changes and the mechanism of inhibition by nonnucleoside inhibitors.
Topics: Antiviral Agents; Base Sequence; Binding Sites; Deoxycytosine Nucleotides; DNA Primers; Enzyme Inhibitors; HIV Reverse Transcriptase; HIV-1; Mathematics; Models, Theoretical; Molecular Sequence Data; Protein Conformation; Reverse Transcriptase Inhibitors; RNA-Directed DNA Polymerase; Spectrometry, Fluorescence; Thermodynamics; Thymine Nucleotides | 1995 |
Molecular analysis of mutations in the hprt gene of V79 hamster fibroblasts: effects of imbalances in the dCTP, dGTP and dTTP pools.
Topics: Animals; Cell Line; Cricetinae; Cytidine; DCMP Deaminase; Deoxycytosine Nucleotides; Deoxyguanine Nucleotides; DNA Replication; Fibroblasts; Hypoxanthine Phosphoribosyltransferase; Mutation; Thymidine; Thymine Nucleotides | 1995 |
A novel effect of the new antileukemic drug, 2-chloro-2'-deoxyadenosine, in human lymphocytes.
Topics: Cells, Cultured; Child; Child, Preschool; Cladribine; Deoxycytidine; Deoxycytosine Nucleotides; Deoxyuracil Nucleotides; DNA; Humans; Kinetics; Lymphocytes; Palatine Tonsil; Thymidine; Thymine Nucleotides; Time Factors; Tritium | 1994 |
Elevated intracellular dCTP levels reduce the induction of GC-->AT transitions in yeast by ethyl methanesulfonate or N-methyl-N'-nitro-N- nitrosoguanidine but increase alkylation-induced GC-->CG transversions.
Topics: Alkylation; Base Sequence; Deoxycytosine Nucleotides; DNA Mutational Analysis; DNA Repair; DNA Replication; DNA, Fungal; Ethyl Methanesulfonate; Genes, Fungal; Genes, Suppressor; Guanine; Methylnitronitrosoguanidine; Molecular Sequence Data; Mutagenesis, Site-Directed; Mutagens; Nucleic Acid Heteroduplexes; Point Mutation; Saccharomyces cerevisiae; Thymine; Thymine Nucleotides | 1993 |
Restriction and enhancement of human immunodeficiency virus type 1 replication by modulation of intracellular deoxynucleoside triphosphate pools.
Topics: CD4 Antigens; Cells, Cultured; Deoxyadenine Nucleotides; Deoxycytidine; Deoxycytosine Nucleotides; Deoxyguanine Nucleotides; HIV-1; Humans; Proviruses; Thymidine; Thymine Nucleotides; Transcription, Genetic; Virus Replication | 1994 |
Mutational studies of human immunodeficiency virus type 1 reverse transcriptase: the involvement of residues 183 and 184 in the fidelity of DNA synthesis.
Topics: Base Sequence; Deoxyadenine Nucleotides; Deoxycytosine Nucleotides; Deoxyguanine Nucleotides; DNA Replication; DNA, Viral; Electrophoresis, Polyacrylamide Gel; HIV Reverse Transcriptase; HIV-1; Humans; Kinetics; Molecular Sequence Data; Mutation; RNA-Directed DNA Polymerase; Thymine Nucleotides | 1996 |
DNA polymerase activity of hepatitis B virus particles: differential inhibition by L-enantiomers of nucleotide analogs.
Topics: Deoxycytosine Nucleotides; Deoxyguanine Nucleotides; DNA-Directed DNA Polymerase; DNA, Viral; Emtricitabine; Hepatitis B virus; Humans; Isotope Labeling; Nucleic Acid Synthesis Inhibitors; Nucleotides; Templates, Genetic; Thymine Nucleotides; Zalcitabine | 1996 |
Effects of dNTPs on the sister-chromatid exchange (SCE) frequency in human lymphocytes.
Topics: Bromodeoxyuridine; Cells, Cultured; Deoxyadenine Nucleotides; Deoxycytosine Nucleotides; Deoxyguanine Nucleotides; Dose-Response Relationship, Drug; Humans; Sister Chromatid Exchange; T-Lymphocytes; Thymine Nucleotides | 1996 |
Amphipathic domains in the C terminus of the transmembrane protein (gp41) permeabilize HIV-1 virions: a molecular mechanism underlying natural endogenous reverse transcription.
Topics: Animals; Deoxyadenine Nucleotides; Deoxycytosine Nucleotides; Deoxyguanine Nucleotides; HIV Envelope Protein gp41; HIV Reverse Transcriptase; HIV-1; Humans; Mice; Permeability; Rats; Thymine Nucleotides; Transcription, Genetic; Virion | 1996 |
The dUTPases from herpes simplex virus type 1 and mouse mammary tumour virus are less specific than the Escherichia coli enzyme.
Topics: Animals; Deoxycytosine Nucleotides; Deoxyuracil Nucleotides; Escherichia coli; Herpesvirus 1, Human; Humans; Hydrolysis; Mammary Tumor Virus, Mouse; Mice; Pyrophosphatases; Substrate Specificity; Thymine Nucleotides | 1996 |
Increased activation of the combination of 3'-azido-3'-deoxythymidine and 2'-deoxy-3'-thiacytidine in the presence of hydroxyurea.
Topics: Anti-HIV Agents; Cell Line; Deoxycytosine Nucleotides; Drug Synergism; Hydroxyurea; Lamivudine; Phosphorylation; Thymine Nucleotides; Zidovudine | 1997 |
Stereoisomers of deoxynucleoside 5'-triphosphates as substrates for template-dependent and -independent DNA polymerases.
Topics: Deoxyadenine Nucleotides; Deoxycytosine Nucleotides; DNA Primers; DNA-Directed DNA Polymerase; Electrophoresis, Polyacrylamide Gel; HIV Reverse Transcriptase; Humans; Stereoisomerism; Structure-Activity Relationship; Templates, Genetic; Thymine Nucleotides | 1997 |
Cell cycle-dependent metabolism of pyrimidine deoxynucleoside triphosphates in CEM cells.
Topics: Cell Line; Deoxycytosine Nucleotides; DNA; DNA Replication; G1 Phase; S Phase; Thymine Nucleotides | 1997 |
Sensitivity of a mutator gene in Chinese hamster ovary cell to deoxynucleoside triphosphate pool alterations.
Topics: Animals; CHO Cells; Cricetinae; Deoxyadenine Nucleotides; Deoxycytosine Nucleotides; Deoxyguanine Nucleotides; Emetine; Female; Mutation; Ovary; Protein Synthesis Inhibitors; Thymidine; Thymine Nucleotides | 1981 |
Palindromic oligonucleotide-directed enzymatic determination of 2'-deoxythymidine 5'-triphosphate and 2'-deoxycytidine 5'-triphosphate in human cells.
Topics: Adult; Cell Line; Chromatography, High Pressure Liquid; Deoxycytosine Nucleotides; Fetal Blood; Humans; Kinetics; Magnesium; Oligonucleotides; Reproducibility of Results; Sensitivity and Specificity; Thymine Nucleotides | 1997 |
RNA dependent DNA replication fidelity of HIV-1 reverse transcriptase: evidence of discrimination between DNA and RNA substrates.
Topics: Deoxycytosine Nucleotides; Deoxyguanine Nucleotides; DNA Primers; DNA Replication; DNA, Viral; Escherichia coli; HIV Reverse Transcriptase; HIV-1; Kinetics; Recombinant Proteins; Substrate Specificity; Thymine Nucleotides | 1997 |
Inhibition of DNA polymerase reactions by pyrimidine nucleotide analogues lacking the 2-keto group.
Topics: Base Sequence; Deoxycytosine Nucleotides; Deoxyribonucleotides; DNA Polymerase I; DNA Primers; Escherichia coli; Indicators and Reagents; Molecular Structure; Nucleic Acid Synthesis Inhibitors; Polymerase Chain Reaction; Pyridines; Pyridones; Pyrimidine Nucleotides; Structure-Activity Relationship; Taq Polymerase; Thymine Nucleotides | 1998 |
The mutations induced by oxidatively damaged nucleotides, 5-formyl-dUTP and 5-hydroxy-dCTP,in Escherichia coli.
Topics: Bacterial Proteins; Deoxyadenine Nucleotides; Deoxycytidine; Deoxycytosine Nucleotides; Deoxyguanine Nucleotides; Deoxyuracil Nucleotides; Deoxyuridine; DNA Mutational Analysis; DNA Repair; Escherichia coli; Escherichia coli Proteins; Genome, Bacterial; Lac Repressors; Models, Genetic; Mutagenesis; Nucleic Acid Hybridization; Oxidants; Point Mutation; Repressor Proteins; Sequence Analysis, DNA; Thymine Nucleotides | 1998 |
Molecular basis for the enantioselectivity of HIV-1 reverse transcriptase: role of the 3'-hydroxyl group of the L-(beta)-ribose in chiral discrimination between D- and L-enantiomers of deoxy- and dideoxy-nucleoside triphosphate analogs.
Topics: Anti-HIV Agents; Carbohydrates; Catalysis; Deoxycytosine Nucleotides; Deoxyribonucleosides; Dideoxynucleosides; Dideoxynucleotides; DNA; Drug Resistance, Microbial; HIV Reverse Transcriptase; Humans; Hydroxyl Radical; Isoleucine; Kinetics; Nevirapine; Recombinant Fusion Proteins; Reverse Transcriptase Inhibitors; Ribose; Templates, Genetic; Thymine Nucleotides; Tyrosine; Zidovudine | 1999 |
Sequencing errors in reactions using labeled terminators.
Topics: Deoxyadenine Nucleotides; Deoxycytosine Nucleotides; Dideoxyadenosine; DNA Primers; DNA-Directed DNA Polymerase; Inosine Triphosphate; Polymerase Chain Reaction; Potassium Chloride; Quality Control; Sensitivity and Specificity; Sequence Analysis, DNA; Templates, Genetic; Thymine Nucleotides | 1999 |
Polymerization of 2'-fluoro- and 2'-O-methyl-dNTPs by human DNA polymerase alpha, polymerase gamma, and primase.
Topics: Deoxycytosine Nucleotides; Deoxyguanine Nucleotides; Deoxyribonucleotides; DNA Polymerase gamma; DNA Polymerase I; DNA Primase; DNA-Directed DNA Polymerase; Humans; Thymine Nucleotides; Uridine Triphosphate | 2000 |
The efficiency and fidelity of translesion synthesis past cisplatin and oxaliplatin GpG adducts by human DNA polymerase beta.
Topics: Antineoplastic Agents; Base Sequence; Cisplatin; Deoxycytosine Nucleotides; DNA Adducts; DNA Polymerase beta; DNA Primers; DNA Repair; DNA Replication; Humans; Kinetics; Molecular Sequence Data; Organoplatinum Compounds; Oxaliplatin; Recombinant Proteins; Thymine Nucleotides; Time Factors | 2000 |
Effects of X-irradiation on DNA precursor metabolism and deoxyribonucleoside triphosphate pools in Chinese hamster cells.
Topics: Animals; CHO Cells; Cricetinae; Cytidine; Deoxyadenine Nucleotides; Deoxycytidine; Deoxycytosine Nucleotides; Deoxyguanine Nucleotides; Deoxyribonucleotides; DNA Damage; DNA Repair; DNA Replication; Dose-Response Relationship, Radiation; Intracellular Fluid; RNA; S Phase; Thymidine; Thymine Nucleotides | 1974 |
Preparation of PCR-quality mouse genomic DNA with hot sodium hydroxide and tris (HotSHOT).
Topics: Aging; Animals; Buffers; Deoxyadenine Nucleotides; Deoxycytosine Nucleotides; Deoxyguanine Nucleotides; DNA; Hot Temperature; Hydrogen-Ion Concentration; Indicators and Reagents; Magnesium Chloride; Mice; Polymerase Chain Reaction; Sodium Hydroxide; Solubility; Taq Polymerase; Thymine Nucleotides | 2000 |
Universal bases for hybridization, replication and chain termination.
Topics: Base Pairing; Deoxyadenine Nucleotides; Deoxycytosine Nucleotides; DNA; DNA Replication; DNA-Directed DNA Polymerase; Drug Stability; Hot Temperature; Hydrogen Bonding; Isoquinolines; Methylation; Nucleic Acid Hybridization; Nucleosides; Oligonucleotides; Substrate Specificity; Templates, Genetic; Thymine Nucleotides | 2000 |
Ribonucleotide reductase, a possible agent in deoxyribonucleotide pool asymmetries induced by hypoxia.
Topics: Animals; Cells, Cultured; Cricetinae; Deoxyadenine Nucleotides; Deoxycytosine Nucleotides; Deoxyguanine Nucleotides; Deoxyribonucleotides; Hydrogen-Ion Concentration; Hydroxyurea; Hypoxia; Mice; Models, Chemical; Nucleic Acid Synthesis Inhibitors; Oxygen; Recombinant Proteins; Ribonucleotide Reductases; Thymine Nucleotides; Time Factors | 2000 |
Effect of a dCTP:dTTP pool imbalance on DNA replication fidelity in Friend murine erythroleukemia cells.
Topics: Adenine Phosphoribosyltransferase; Animals; Clone Cells; Deoxycytosine Nucleotides; DNA Mutational Analysis; DNA Replication; Exons; Leukemia, Erythroblastic, Acute; Mice; Mutation; Polymerase Chain Reaction; Polymorphism, Single-Stranded Conformational; Sequence Analysis, DNA; Thymidine Kinase; Thymine Nucleotides; Tumor Cells, Cultured | 2000 |
Selective radiosensitization of drug-resistant MutS homologue-2 (MSH2) mismatch repair-deficient cells by halogenated thymidine (dThd) analogues: Msh2 mediates dThd analogue DNA levels and the differential cytotoxicity and cell cycle effects of the dThd a
Topics: Adenovirus E1A Proteins; Animals; Antimetabolites, Antineoplastic; Base Pair Mismatch; Bromodeoxyuridine; Cell Cycle; Cell Line, Transformed; Deoxycytosine Nucleotides; DNA; DNA Repair; DNA-Binding Proteins; Dose-Response Relationship, Drug; Humans; Idoxuridine; Kinetics; Mice; Mice, Knockout; MutS Homolog 2 Protein; Proto-Oncogene Proteins; Radiation-Sensitizing Agents; Thioguanine; Thymine Nucleotides | 2000 |
Recognition of 2'-deoxy-l-ribonucleoside 5'-triphosphates by human telomerase.
Topics: Deoxyadenine Nucleotides; Deoxycytosine Nucleotides; Deoxyguanine Nucleotides; Deoxyribonucleotides; Humans; Kinetics; Stereoisomerism; Substrate Specificity; Telomerase; Thymine Nucleotides | 2000 |
Base sequence dependence of in vitro translesional DNA replication past a bulky lesion catalyzed by the exo- Klenow fragment of Pol I.
Topics: 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide; Base Sequence; Carcinogens, Environmental; Catalysis; Deoxyadenine Nucleotides; Deoxycytosine Nucleotides; Deoxyguanine Nucleotides; Deoxyguanosine; DNA Damage; DNA Polymerase I; DNA Primers; DNA Replication; Guanine; Kinetics; Mutagenesis; Mutagens; Polydeoxyribonucleotides; Pyrimidine Nucleotides; Sequence Analysis, DNA; Templates, Genetic; Thymine Nucleotides | 2001 |
Exploitation of the low fidelity of human immunodeficiency virus type 1 (HIV-1) reverse transcriptase and the nucleotide composition bias in the HIV-1 genome to alter the drug resistance development of HIV.
Topics: Anti-HIV Agents; Antimetabolites; Deoxycytosine Nucleotides; Drug Resistance, Microbial; Genome, Viral; HIV Reverse Transcriptase; HIV-1; Reverse Transcriptase Inhibitors; Spiro Compounds; Thymidine; Thymine Nucleotides; Uridine | 2001 |
Matrix-induced fragmentation of P3'-N5' phosphoramidate-containing DNA: high-throughput MALDI-TOF analysis of genomic sequence polymorphisms.
Topics: Amides; Deoxycytosine Nucleotides; DNA; Genotype; Humans; Hydrolysis; Oligonucleotides; Phosphoric Acids; Picolinic Acids; Polymorphism, Single Nucleotide; Receptors, Adrenergic, beta-3; Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization; Thymine Nucleotides | 2001 |
Ribonucleotide reductase and thymidine phosphorylation: two potential targets of azodicarbonamide.
Topics: Animals; Antineoplastic Agents; Azo Compounds; Deoxycytosine Nucleotides; Deoxyguanine Nucleotides; Drug Interactions; Hydroxyurea; Immunosuppressive Agents; Methotrexate; Phosphorylation; Ribonucleotide Reductases; Thymidine; Thymine Nucleotides; Tumor Cells, Cultured | 2002 |
Excess dNTPs minimize RNA hydrolysis during reverse transcription.
Topics: Avian Sarcoma Viruses; Deoxyadenine Nucleotides; Deoxycytosine Nucleotides; Deoxyguanine Nucleotides; DNA, Complementary; Drug Stability; Electrophoresis, Agar Gel; Half-Life; Hot Temperature; Hydrolysis; Magnesium; Moloney murine leukemia virus; Nucleic Acid Denaturation; RNA; RNA-Directed DNA Polymerase; Thymine Nucleotides; Transcription, Genetic; Viral Proteins | 2002 |
Structure of the large subunit of class Ib ribonucleotide reductase from Salmonella typhimurium and its complexes with allosteric effectors.
Topics: Allosteric Regulation; Allosteric Site; Amino Acid Sequence; Binding Sites; Crystallography, X-Ray; Cysteine; Deoxyadenine Nucleotides; Deoxycytosine Nucleotides; Dimerization; Escherichia coli; Macromolecular Substances; Models, Molecular; Molecular Sequence Data; Oxidation-Reduction; Protein Conformation; Protein Subunits; Ribonucleotide Reductases; Salmonella typhimurium; Sequence Homology, Amino Acid; Thymine Nucleotides | 2003 |
Deoxyribonucleotide pool imbalance stimulates deletions in HeLa cell mitochondrial DNA.
Topics: Base Pairing; Blotting, Southern; Deoxyadenine Nucleotides; Deoxycytosine Nucleotides; Deoxyguanine Nucleotides; Deoxyribonucleotides; DNA, Mitochondrial; Gastrointestinal Diseases; Gene Deletion; HeLa Cells; Humans; Mitochondria; Mitochondrial Encephalomyopathies; Point Mutation; Polymerase Chain Reaction; Thymidine; Thymine Nucleotides | 2003 |
Nucleotide interconversions. IX. The regulatory influence of deoxycytidine 5'-triphosphate and deoxythymidine 5'-triphosphate on deoxycytidylate deaminase.
Topics: Aminohydrolases; Cytosine Nucleotides; DCMP Deaminase; Deoxycytosine Nucleotides; Humans; Nucleotides; Polyphosphates; Thymidine; Thymine Nucleotides | 1962 |
Tight binding of deoxyribonucleotide triphosphates to human thymidine kinase 2 expressed in Escherichia coli. Purification and partial characterization of its dimeric and tetrameric forms.
Topics: Binding Sites; Cell Line, Tumor; Chaperonin 10; Chaperonin 60; Cloning, Molecular; Culture Media, Conditioned; Deoxyadenine Nucleotides; Deoxycytosine Nucleotides; Dimerization; Enzyme Inhibitors; Escherichia coli; Ethanol; Humans; Isoenzymes; Kinetics; Models, Molecular; Recombinant Fusion Proteins; Solubility; Spectrometry, Fluorescence; Substrate Specificity; Thymidine Kinase; Thymine Nucleotides; Tryptophan | 2003 |
Increased G-->A transition frequencies displayed by primer grip mutants of human immunodeficiency virus type 1 reverse transcriptase.
Topics: Base Sequence; Deoxycytosine Nucleotides; DNA Primers; DNA Replication; DNA, Viral; HIV Reverse Transcriptase; Humans; Molecular Sequence Data; Mutation; Templates, Genetic; Thymine Nucleotides; Transcription, Genetic | 2004 |
Pre-steady-state kinetic studies of the fidelity of Sulfolobus solfataricus P2 DNA polymerase IV.
Topics: Archaeal Proteins; Base Pair Mismatch; Binding Sites; Catalysis; Deoxycytosine Nucleotides; DNA Polymerase beta; DNA Replication; DNA, Archaeal; Enzyme Stability; Kinetics; Models, Chemical; Protein Binding; Recombinant Proteins; Substrate Specificity; Sulfolobus; Thymine Nucleotides | 2004 |
Pre-steady-state kinetic studies of the fidelity of human DNA polymerase mu.
Topics: Binding Sites; Buffers; Deoxyadenine Nucleotides; Deoxycytosine Nucleotides; Deoxyguanine Nucleotides; Deoxyribonucleotides; DNA; DNA Nucleotidylexotransferase; DNA Primers; DNA-Directed DNA Polymerase; Enzyme Activation; Enzyme Stability; Humans; Kinetics; Peptide Chain Elongation, Translational; Ribonucleotides; Substrate Specificity; Templates, Genetic; Thymine Nucleotides; Uridine Triphosphate | 2004 |
Base selectivity is impaired by mutants that perturb hydrogen bonding networks in the RB69 DNA polymerase active site.
Topics: Alanine; Amino Acid Substitution; Base Pair Mismatch; Binding Sites; Deoxyadenine Nucleotides; Deoxycytosine Nucleotides; Deoxyguanine Nucleotides; DNA-Directed DNA Polymerase; Enterobacter; Hydrogen Bonding; Kinetics; Nucleotides; Phenylalanine; Substrate Specificity; Thymine Nucleotides; Toluene; Tyrosine; Viral Proteins | 2005 |
Multiple enzyme activities of Escherichia coli MutT protein for sanitization of DNA and RNA precursor pools.
Topics: Deoxyadenine Nucleotides; Deoxycytosine Nucleotides; Deoxyguanine Nucleotides; DNA Replication; DNA, Bacterial; Escherichia coli Proteins; Guanine; Guanosine Triphosphate; Hydrolysis; Kinetics; Multienzyme Complexes; Phosphoric Monoester Hydrolases; Pyrophosphatases; RNA, Bacterial; Thymine Nucleotides; Transcription, Genetic | 2005 |
Four-color multiplex reverse transcription polymerase chain reaction--overcoming its limitations.
Topics: Color; Deoxyadenine Nucleotides; Deoxycytosine Nucleotides; Deoxyguanine Nucleotides; DNA Primers; DNA Probes; DNA, Complementary; Gene Expression; Reverse Transcriptase Polymerase Chain Reaction; Taq Polymerase; Thymine Nucleotides | 2005 |
Effect of DNA polymerase beta loop variants on discrimination of O6-methyldeoxyguanosine modification present in the nucleotide versus template substrate.
Topics: Alkylating Agents; Amino Acid Substitution; Animals; Arginine; Base Sequence; Deoxycytosine Nucleotides; Deoxyguanosine; DNA Damage; DNA Polymerase beta; DNA Primers; Glutamic Acid; Lysine; Methionine; Methylnitrosourea; Molecular Sequence Data; Protein Structure, Tertiary; Rats; Substrate Specificity; Templates, Genetic; Thymine Nucleotides | 2005 |
Pre-steady-state kinetic characterization of the DinB homologue DNA polymerase of Sulfolobus solfataricus.
Topics: Archaeal Proteins; Deoxyadenine Nucleotides; Deoxycytosine Nucleotides; Deoxyguanine Nucleotides; DNA; DNA-Directed DNA Polymerase; Kinetics; Thymine Nucleotides | 2005 |
Hoogsteen base pair formation promotes synthesis opposite the 1,N6-ethenodeoxyadenosine lesion by human DNA polymerase iota.
Topics: Base Pairing; Crystallization; Deoxyadenosines; Deoxycytosine Nucleotides; DNA Damage; DNA Polymerase I; DNA Primers; Humans; Hydrogen Bonding; Kinetics; Models, Molecular; Mutagens; Nucleic Acid Conformation; Protein Conformation; Thymine Nucleotides | 2006 |
Mutagenic nucleotide incorporation and hindered translocation by a food carcinogen C8-dG adduct in Sulfolobus solfataricus P2 DNA polymerase IV (Dpo4): modeling and dynamics studies.
Topics: Binding Sites; Carcinogens; Computational Biology; Computer Simulation; Deoxyadenine Nucleotides; Deoxycytosine Nucleotides; Deoxyguanine Nucleotides; Deoxyguanosine; Deoxyribonucleotides; DNA; DNA Adducts; DNA Polymerase beta; Imidazoles; Models, Molecular; Motion; Mutagenesis; Nucleic Acid Conformation; Sulfolobus solfataricus; Thymine Nucleotides | 2006 |
Mitochondrial deoxynucleotide pool sizes in mouse liver and evidence for a transport mechanism for thymidine monophosphate.
Topics: Animals; Biological Transport, Active; Deoxyadenine Nucleotides; Deoxycytosine Nucleotides; Deoxyguanine Nucleotides; Deoxyuracil Nucleotides; Male; Mice; Mice, Inbred C57BL; Mitochondria, Liver; Thymidine Monophosphate; Thymine Nucleotides | 2006 |
Defects in maintenance of mitochondrial DNA are associated with intramitochondrial nucleotide imbalances.
Topics: Cell Membrane Permeability; Deoxycytosine Nucleotides; Deoxyribonucleotides; DNA Helicases; DNA Polymerase gamma; DNA-Directed DNA Polymerase; DNA, Mitochondrial; Humans; Mitochondrial Diseases; Mitochondrial Proteins; Models, Biological; Mutation; Phosphorus Radioisotopes; Syndrome; Thymidine Kinase; Thymine Nucleotides | 2007 |
NMR investigation of primer-template models: structural effect of sequence downstream of a thymine template on mutagenesis in DNA replication.
Topics: Base Pair Mismatch; Base Sequence; Deoxycytosine Nucleotides; Dinucleotide Repeats; DNA Primers; DNA Replication; Models, Chemical; Models, Genetic; Mutagenesis; Nuclear Magnetic Resonance, Biomolecular; Nucleic Acid Conformation; Templates, Genetic; Thymine Nucleotides | 2007 |
Nuclear magnetic resonance investigation of primer--template models: formation of a pyrimidine bulge upon misincorporation.
Topics: Adenine; Base Pair Mismatch; Base Pairing; Cytosine; Deoxyadenine Nucleotides; Deoxycytosine Nucleotides; DNA Primers; DNA Replication; Guanine; Models, Genetic; Nuclear Magnetic Resonance, Biomolecular; Templates, Genetic; Thymidine; Thymine Nucleotides | 2008 |
Development of bioluminescent pyrophosphate assay using pyruvate phosphate dikinase and its application to single-nucleotide polymorphism analysis.
Topics: Deoxyadenine Nucleotides; Deoxycytosine Nucleotides; Deoxyguanine Nucleotides; Diphosphates; DNA; Luciferases; Luminescent Measurements; Models, Biological; Polymorphism, Single Nucleotide; Pyruvate, Orthophosphate Dikinase; ras Proteins; Reproducibility of Results; Thionucleotides; Thymine Nucleotides; Tumor Suppressor Protein p53 | 2008 |
The reopening rate of the fingers domain is a determinant of base selectivity for RB69 DNA polymerase.
Topics: 2-Aminopurine; Adenine Nucleotides; Base Pair Mismatch; Biocatalysis; Calcium; Catalytic Domain; Deoxycytosine Nucleotides; DNA-Directed DNA Polymerase; Kinetics; Magnesium; Models, Molecular; Oligodeoxyribonucleotides; Protein Structure, Tertiary; Recombinant Proteins; Rhodium; Spectrometry, Fluorescence; Substrate Specificity; Thymine Nucleotides; Viral Proteins | 2009 |
Origin of pyrimidine deoxyribonucleotide pools in perfused rat heart: implications for 3'-azido-3'-deoxythymidine-dependent cardiotoxicity.
Topics: Animals; Chromatography, High Pressure Liquid; Cytidine; Cytidine Triphosphate; Deoxyadenine Nucleotides; Deoxycytidine; Deoxycytosine Nucleotides; Deoxyguanine Nucleotides; Deoxyuridine; Heart; In Vitro Techniques; Male; Perfusion; Phosphorylation; Pyrimidine Nucleotides; Rats; Rats, Sprague-Dawley; Reverse Transcriptase Inhibitors; Thymine Nucleotides; Uracil; Uridine; Uridine Monophosphate; Uridine Triphosphate; Zidovudine | 2009 |
Fishing in the (deoxyribonucleotide) pool.
Topics: Animals; Antimetabolites; Cytidine; Cytidine Triphosphate; Deoxyadenine Nucleotides; Deoxycytidine; Deoxycytosine Nucleotides; Deoxyguanine Nucleotides; Deoxyuridine; Heart; Humans; Mitochondria; Mitochondrial Diseases; Models, Biological; Phosphorylation; Pyrimidine Nucleotides; Rats; Thymine Nucleotides; Uracil; Uridine; Uridine Monophosphate; Uridine Triphosphate; Zidovudine | 2009 |
Influence of local sequence context on damaged base conformation in human DNA polymerase iota: molecular dynamics studies of nucleotide incorporation opposite a benzo[a]pyrene-derived adenine lesion.
Topics: Base Pair Mismatch; Base Pairing; Base Sequence; Benzopyrenes; Carcinogens, Environmental; Computer Simulation; Deoxyadenine Nucleotides; Deoxycytosine Nucleotides; Deoxyguanine Nucleotides; DNA Adducts; DNA Damage; DNA Polymerase iota; DNA-Directed DNA Polymerase; Humans; Hydrogen Bonding; Magnesium; Models, Molecular; Nucleic Acid Conformation; Thymine Nucleotides | 2009 |
Structural basis for proficient incorporation of dTTP opposite O6-methylguanine by human DNA polymerase iota.
Topics: Bacterial Proteins; Base Pairing; Catalytic Domain; Deoxycytosine Nucleotides; DNA; DNA Polymerase beta; DNA Polymerase I; DNA Polymerase iota; DNA-Directed DNA Polymerase; Geobacillus stearothermophilus; Guanine; Humans; Hydrogen Bonding; Kinetics; Structure-Activity Relationship; Sulfolobus; Thymine Nucleotides | 2010 |
Mechanisms of mutagenesis in vivo due to imbalanced dNTP pools.
Topics: Amino Acid Substitution; Amino Acid Transport Systems, Basic; Deoxyadenine Nucleotides; Deoxycytosine Nucleotides; Deoxyguanine Nucleotides; Deoxyribonucleotides; INDEL Mutation; Mutagenesis; Mutation; Ribonucleotide Reductases; Saccharomyces cerevisiae; Saccharomyces cerevisiae Proteins; Thymine Nucleotides | 2011 |
Limited dCTP availability accounts for mitochondrial DNA depletion in mitochondrial neurogastrointestinal encephalomyopathy (MNGIE).
Topics: Animals; Cell Culture Techniques; Deoxycytosine Nucleotides; DNA Replication; DNA, Mitochondrial; Fibroblasts; Humans; Mice; Mitochondria, Liver; Mitochondrial Encephalomyopathies; Thymine Nucleotides | 2011 |
HIV-1 restriction factor SAMHD1 is a deoxynucleoside triphosphate triphosphohydrolase.
Topics: Allosteric Regulation; Biocatalysis; Catalytic Domain; Crystallography, X-Ray; Dendritic Cells; Deoxyadenine Nucleotides; Deoxycytosine Nucleotides; Deoxyguanine Nucleotides; HIV-1; Humans; Hydrolysis; Models, Biological; Models, Molecular; Monomeric GTP-Binding Proteins; Myeloid Cells; Nucleoside-Triphosphatase; Protein Structure, Tertiary; Reverse Transcription; SAM Domain and HD Domain-Containing Protein 1; Thymine Nucleotides; Viral Regulatory and Accessory Proteins; Virus Replication | 2011 |
Gram-scale chemical synthesis of 2'-deoxynucleoside-5'-o-triphosphates.
Topics: Deoxyadenine Nucleotides; Deoxycytosine Nucleotides; Diphosphates; Hydrolysis; Nucleosides; Purine Nucleotides; Pyrimidine Nucleotides; Thymine Nucleotides | 2012 |
Binary and ternary binding affinities between exonuclease-deficient Klenow fragment (Kf-exo(-)) and various arylamine DNA lesions characterized by surface plasmon resonance.
Topics: 2-Acetylaminofluorene; Aminobiphenyl Compounds; Deoxyadenine Nucleotides; Deoxycytosine Nucleotides; Deoxyguanine Nucleotides; DNA; DNA Adducts; DNA Polymerase I; Fluorenes; Kinetics; Surface Plasmon Resonance; Thymine Nucleotides | 2012 |
Replication fork collapse and genome instability in a deoxycytidylate deaminase mutant.
Topics: Cell Cycle; Checkpoint Kinase 1; DCMP Deaminase; Deoxycytosine Nucleotides; DNA Damage; DNA Helicases; DNA Repair; DNA Replication; Genomic Instability; Nucleotidyltransferases; Protein Kinases; Saccharomyces cerevisiae; Saccharomyces cerevisiae Proteins; Schizosaccharomyces; Schizosaccharomyces pombe Proteins; Thymine Nucleotides | 2012 |
The DinB•RecA complex of Escherichia coli mediates an efficient and high-fidelity response to ubiquitous alkylation lesions.
Topics: Adenine; Alkylation; Deoxyadenine Nucleotides; Deoxycytosine Nucleotides; Deoxyguanine Nucleotides; DNA Adducts; DNA Replication; DNA, Bacterial; Escherichia coli; Escherichia coli Proteins; Kinetics; Mutagenesis; Rec A Recombinases; Thymine Nucleotides | 2014 |
Effect of dNTP pool alterations on fidelity of leading and lagging strand DNA replication in E. coli.
Topics: Deoxyadenine Nucleotides; Deoxycytosine Nucleotides; Deoxyguanine Nucleotides; Deoxyribonucleotides; DNA Replication; Escherichia coli; Lac Operon; Thymine Nucleotides | 2014 |
Transition-state destabilization reveals how human DNA polymerase β proceeds across the chemically unstable lesion N7-methylguanine.
Topics: Deoxycytosine Nucleotides; Deoxyguanosine; DNA; DNA Polymerase beta; Guanine; Humans; Kinetics; Manganese; Models, Molecular; Thymine Nucleotides | 2014 |
The first crystal structure of a dTTP-bound deoxycytidylate deaminase validates and details the allosteric-inhibitor binding site.
Topics: Allosteric Regulation; Allosteric Site; Amino Acid Sequence; Bacteriophages; Crystallography, X-Ray; DCMP Deaminase; Deoxycytosine Nucleotides; Enzyme Activation; Enzyme Inhibitors; Escherichia coli; Gene Expression; Hydrogen Bonding; Models, Molecular; Molecular Sequence Data; Recombinant Proteins; Sequence Alignment; Substrate Specificity; Thymine Nucleotides; Tyrosine; Viral Proteins | 2015 |
Increased and imbalanced dNTP pools symmetrically promote both leading and lagging strand replication infidelity.
Topics: Base Pair Mismatch; Base Sequence; Deoxyadenine Nucleotides; Deoxycytosine Nucleotides; Deoxyguanine Nucleotides; DNA Mismatch Repair; DNA Replication; Genomic Instability; Molecular Sequence Data; Mutagenesis; Mutation Rate; Organisms, Genetically Modified; Saccharomyces cerevisiae; Thymine Nucleotides | 2014 |
How Y-Family DNA polymerase IV is more accurate than Dpo4 at dCTP insertion opposite an N2-dG adduct of benzo[a]pyrene.
Topics: Archaeal Proteins; Benzo(a)pyrene; Benzopyrenes; Carcinogens, Environmental; Catalytic Domain; Deoxyadenine Nucleotides; Deoxycytosine Nucleotides; Deoxyguanosine; DNA Polymerase beta; Escherichia coli; Escherichia coli Proteins; Mutagens; Sulfolobus solfataricus; Thymine Nucleotides | 2015 |
Development and validation of an LC-MS/MS quantitative method for endogenous deoxynucleoside triphosphates in cellular lysate.
Topics: Chromatography, Liquid; Deoxyadenine Nucleotides; Deoxycytosine Nucleotides; Tandem Mass Spectrometry; Thymine Nucleotides | 2017 |
Mechanisms of Insertion of dCTP and dTTP Opposite the DNA Lesion O6-Methyl-2'-deoxyguanosine by Human DNA Polymerase η.
Topics: Bacterial Proteins; Crystallography, X-Ray; Deoxycytosine Nucleotides; DNA; DNA Polymerase beta; DNA-Directed DNA Polymerase; Humans; Sulfolobus solfataricus; Thymine Nucleotides | 2016 |
A defective dNTP pool hinders DNA replication in cell cycle-reactivated terminally differentiated muscle cells.
Topics: Animals; Cell Cycle; Cell Differentiation; Cyclin-Dependent Kinase Inhibitor p21; Cyclin-Dependent Kinase Inhibitor p27; Deoxycytosine Nucleotides; DNA Replication; Gene Expression Regulation; Histones; Mice; Muscle Development; Muscle Fibers, Skeletal; Primary Cell Culture; Satellite Cells, Skeletal Muscle; Thymidine; Thymidine Kinase; Thymidine Monophosphate; Thymine Nucleotides | 2017 |
Mechanism of error-free DNA synthesis across N1-methyl-deoxyadenosine by human DNA polymerase-ι.
Topics: Base Pairing; Catalytic Domain; Crystallography, X-Ray; Deoxyadenosines; Deoxycytosine Nucleotides; DNA; DNA Polymerase iota; DNA-Directed DNA Polymerase; Humans; Kinetics; Protein Structure, Quaternary; Thymine Nucleotides | 2017 |
Molecular Insights into the Translesion Synthesis of Benzyl-Guanine from Molecular Dynamics Simulations: Structural Evidence of Mutagenic and Nonmutagenic Replication.
Topics: Benzyl Compounds; Catalytic Domain; Deoxyadenine Nucleotides; Deoxycytosine Nucleotides; Deoxyguanine Nucleotides; DNA Adducts; DNA Damage; DNA Polymerase beta; DNA Repair; DNA Replication; Escherichia coli; Escherichia coli Proteins; Guanine; Hydrogen Bonding; Molecular Dynamics Simulation; Mutagenesis; Protein Structure, Secondary; Protein Structure, Tertiary; Thymine Nucleotides | 2017 |
Metabolic Recruitment and Directed Evolution of Nucleoside Triphosphate Uptake in Escherichia coli.
Topics: Bacterial Outer Membrane Proteins; Decitabine; Deoxycytosine Nucleotides; Deoxyguanine Nucleotides; Deoxyribonucleotides; Directed Molecular Evolution; Escherichia coli; Escherichia coli Proteins; Microalgae; Microorganisms, Genetically-Modified; Mutation Rate; Peptide Hydrolases; Thymidine Kinase; Thymidylate Synthase; Thymine Nucleotides | 2018 |
DCTPP1 prevents a mutator phenotype through the modulation of dCTP, dTTP and dUTP pools.
Topics: Cell Line; Cell Proliferation; Deoxycytosine Nucleotides; Deoxyuracil Nucleotides; DNA Damage; Gene Knockout Techniques; Genomic Instability; Humans; MCF-7 Cells; Mutation; Pyrophosphatases; Thymine Nucleotides | 2020 |
Quantitation of deoxynucleoside triphosphates by click reactions.
Topics: Click Chemistry; Copper; Cycloaddition Reaction; Deoxyadenine Nucleotides; Deoxycytosine Nucleotides; Deoxyguanine Nucleotides; Deoxyribonucleotides; Deoxyuracil Nucleotides; HCT116 Cells; HEK293 Cells; Humans; K562 Cells; Rhodamines; Staining and Labeling; Thymine Nucleotides | 2020 |
Enzymatic Synthesis of Chimeric DNA Oligonucleotides by
Topics: Deoxyadenine Nucleotides; Deoxycytosine Nucleotides; Deoxyguanine Nucleotides; Deoxyribonucleotides; DNA-Directed RNA Polymerases; Fluorine; Substrate Specificity; Synthetic Biology; Thymine Nucleotides; Transcription, Genetic; Viral Proteins | 2021 |