thymic-factor--circulating and interleukin-1beta-(193-195)

thymic-factor--circulating has been researched along with interleukin-1beta-(193-195)* in 1 studies

Other Studies

1 other study(ies) available for thymic-factor--circulating and interleukin-1beta-(193-195)

Article	Year
Hyperalgesia induced by low doses of thymulin injections: possible involvement of prostaglandin E2. Journal of neuroimmunology, 1997, Volume: 73, Issue:1-2 Thymulin injection into rats (20-150 ng) i.p. caused a significant reduction in both mechanical (paw pressure test) and thermal (hot plate and tail flick tests) nociceptive thresholds. Thymulin injection also doubled IL-1beta level in the liver of these animals. Induced hyperalgesia was reversed completely by alpha-MSH related tripeptide, Lys-D-Pro-Val in low doses, which is known to antagonize IL-1beta and PGE2 induced hyperalgesia, but was only partly reversed by IL-1beta related tripeptide, Lys-D-Pro-Thr at high doses, which is known to antagonize IL-1beta induced hyperalgesia only. We conclude from these results that thymulin causes hyperalgesia and that this effect is at least in part mediated via PGE2 and its effectiveness at low concentration implies a physiological role for this thymic hormone. Topics: Animals; Dinoprostone; Dose-Response Relationship, Drug; Foot; Hot Temperature; Hyperalgesia; Injections; Interleukin-1; Interleukin-1beta; Liver; Male; Melanocyte-Stimulating Hormones; Pain Threshold; Peptide Fragments; Pressure; Rats; Rats, Sprague-Dawley; Tail; Thymic Factor, Circulating	1997

Article

Year

Hyperalgesia induced by low doses of thymulin injections: possible involvement of prostaglandin E2.

Journal of neuroimmunology, 1997, Volume: 73, Issue:1-2

Thymulin injection into rats (20-150 ng) i.p. caused a significant reduction in both mechanical (paw pressure test) and thermal (hot plate and tail flick tests) nociceptive thresholds. Thymulin injection also doubled IL-1beta level in the liver of these animals. Induced hyperalgesia was reversed completely by alpha-MSH related tripeptide, Lys-D-Pro-Val in low doses, which is known to antagonize IL-1beta and PGE2 induced hyperalgesia, but was only partly reversed by IL-1beta related tripeptide, Lys-D-Pro-Thr at high doses, which is known to antagonize IL-1beta induced hyperalgesia only. We conclude from these results that thymulin causes hyperalgesia and that this effect is at least in part mediated via PGE2 and its effectiveness at low concentration implies a physiological role for this thymic hormone.

Topics: Animals; Dinoprostone; Dose-Response Relationship, Drug; Foot; Hot Temperature; Hyperalgesia; Injections; Interleukin-1; Interleukin-1beta; Liver; Male; Melanocyte-Stimulating Hormones; Pain Threshold; Peptide Fragments; Pressure; Rats; Rats, Sprague-Dawley; Tail; Thymic Factor, Circulating

1997