thromboxane-b2 and tiaprofenic-acid

IL-1 and prostaglandin (PGE2, PGF2 alpha, TXB2) concentrations, PLA2 activity, neutral protease activity, and collagenase activity specific for types I and II collagen were determined in the SF of patients suffering from RA, before and after treatment with TA. Active and latent forms of protease and collagenases were regularly detected but were unrelated to IL-1, PLA2, and PGE2. TA induced a significant decrease in tested eicosanoids but IL-1, PLA2, and proteases were unchanged.

Topics: Adult; Aged; Cartilage, Articular; Dinoprost; Dinoprostone; Female; Humans; Interleukin-1; Male; Microbial Collagenase; Middle Aged; Peptide Hydrolases; Phospholipases; Phospholipases A; Phospholipases A2; Propionates; Prostaglandins; Rheumatic Diseases; Synovial Fluid; Thromboxane B2

The effects of infusion of the non-steroidal anti-inflammatory drugs (NSAID), tiaprofenic acid (2.2 micrograms/min or 10.0 micrograms/min) and indomethacin (1.0 microgram/min) on the release of leukotriene (LT) C4-like immunoreactivity, thromboxane (TX) B2 and 6-keto-prostaglandin (PG) F1 alpha from isolated perfused anaphylactic guinea-pig hearts were investigated. Tiaprofenic acid at both concentrations used significantly inhibited anaphylactic release of TXB2 and 6-keto-PGF1 alpha as did indomethacin (1.0 microgram/min) which was, however, about ten times more potent in this respect. Release of immunoreactive LTC4-like material was not influenced by the lower concentration of tiaprofenic acid used (2.2 micrograms/min), but significantly enhanced by the higher concentration (10.0 micrograms/min). Thus, the effect of tiaprofenic acid on eicosanoid release by the anaphylactic heart is very similar to that of indomethacin without any differential inhibition of TXB2 or 6-keto-PGF1 alpha formation.

Topics: 6-Ketoprostaglandin F1 alpha; Anaphylaxis; Animals; Anti-Inflammatory Agents; Eicosanoic Acids; Guinea Pigs; In Vitro Techniques; Indomethacin; Male; Myocardium; Propionates; SRS-A; Thromboxane B2