thromboxane-b2 and hesperetin

thromboxane-b2 has been researched along with hesperetin* in 1 studies

Other Studies

1 other study(ies) available for thromboxane-b2 and hesperetin

Article	Year
Effects of continuous ingestion of hesperidin and glucosyl hesperidin on vascular gene expression in spontaneously hypertensive rats. Journal of nutritional science and vitaminology, 2013, Volume: 59, Issue:5 Hesperidin (HES) and glucosyl hesperidin (GHES) have antihypertensive effects. In the present study, to clarify the antihypertensive mechanisms, we compared the effects of continuous ingestion of HES and GHES in spontaneously hypertensive rats (SHRs). HES and GHES ingestion for 8 wk significantly prevented hypertension and suppressed the mRNA expression of NADPH oxidase subunits and thromboxane A2 synthase in SHR aortas. Further, hesperetin, a common metabolite of HES and GHES, reduced thromboxane B2 release from SHR aortas. These findings indicate that continuous ingestion of HES and GHES prevents hypertension via regulating the gene expression related to the modulation of vascular tone. Topics: Animals; Antihypertensive Agents; Aorta, Thoracic; Dietary Supplements; Endothelium, Vascular; Enzyme Repression; Glucosides; Hesperidin; Hypertension; In Vitro Techniques; Male; NADPH Oxidases; Protein Subunits; Random Allocation; Rats; Rats, Inbred SHR; Solubility; Thromboxane B2; Thromboxane-A Synthase; Vascular Resistance	2013

Article

Year

Effects of continuous ingestion of hesperidin and glucosyl hesperidin on vascular gene expression in spontaneously hypertensive rats.

Journal of nutritional science and vitaminology, 2013, Volume: 59, Issue:5

Hesperidin (HES) and glucosyl hesperidin (GHES) have antihypertensive effects. In the present study, to clarify the antihypertensive mechanisms, we compared the effects of continuous ingestion of HES and GHES in spontaneously hypertensive rats (SHRs). HES and GHES ingestion for 8 wk significantly prevented hypertension and suppressed the mRNA expression of NADPH oxidase subunits and thromboxane A2 synthase in SHR aortas. Further, hesperetin, a common metabolite of HES and GHES, reduced thromboxane B2 release from SHR aortas. These findings indicate that continuous ingestion of HES and GHES prevents hypertension via regulating the gene expression related to the modulation of vascular tone.

Topics: Animals; Antihypertensive Agents; Aorta, Thoracic; Dietary Supplements; Endothelium, Vascular; Enzyme Repression; Glucosides; Hesperidin; Hypertension; In Vitro Techniques; Male; NADPH Oxidases; Protein Subunits; Random Allocation; Rats; Rats, Inbred SHR; Solubility; Thromboxane B2; Thromboxane-A Synthase; Vascular Resistance

2013