thromboxane-b2 and cetiedil

thromboxane-b2 has been researched along with cetiedil* in 2 studies

Other Studies

2 other study(ies) available for thromboxane-b2 and cetiedil

Article	Year
Thrombin-induced membrane depolarization of platelets and its inhibition by cetiedil. Journal of biochemistry, 1988, Volume: 103, Issue:5 When 50 microM cetiedil alone was added to a platelet suspension, increase in Na+ content, decrease in K+ content, and depolarization of platelet membrane were observed without change in the intracellular concentration of free Ca2+ ([Ca2+]1) or in the morphology of platelets. The cetiedil-induced depolarization was attenuated by the reduction of extracellular sodium concentration, while sodium transport inhibitors such as procaine and tetrodotoxin failed to modify the depolarization. On the other hand, thrombin caused such changes in platelets as increases in Na+ content, 22Na space and [Ca2+]1, decrease in K+ content, and membrane depolarization. All these changes caused by thrombin were inhibited by cetiedil. It is suggested that cetiedil brought the increased ion transport and subsequent partial depolarization, which might lead to modification of the reaction of platelet membrane induced by thrombin. Topics: Azepines; Blood Platelets; Calcium; Humans; In Vitro Techniques; Membrane Potentials; Microscopy, Electron; Platelet Aggregation Inhibitors; Potassium; Sodium; Thrombin; Thromboxane B2	1988
Effect of cetiedil on platelet aggregation and thromboxane synthesis. Thrombosis research, 1985, Feb-01, Volume: 37, Issue:3 Cetiedil was found to inhibit platelet aggregation and thromboxane synthesis induced by thrombin and arachidonic acid. When platelets were activated by thrombin, half maximal inhibition (ED50 effective dose of cetiedil necessary for 50% inhibition) for platelet aggregation was 100 microM while that for thromboxane B2 (TXB2) production was 50 microM. When arachidonic acid was used, the ED50 for platelet aggregation was 100 microM while that for TXB2 production was 150 microM. The presence of calcium ions did not affect on the inhibitory effects of cetiedil. The cAMP level in platelets did not increase after incubation with cetiedil. Cetiedil appears to inhibit the activation of platelets related to thromboxane synthesis. Topics: Antisickling Agents; Arachidonic Acid; Arachidonic Acids; Azepines; Blood Platelets; Calcium; Cyclic AMP; Humans; L-Lactate Dehydrogenase; Platelet Aggregation; Thrombin; Thromboxane B2; Thromboxanes	1985

Article

Year

Thrombin-induced membrane depolarization of platelets and its inhibition by cetiedil.

Journal of biochemistry, 1988, Volume: 103, Issue:5

When 50 microM cetiedil alone was added to a platelet suspension, increase in Na+ content, decrease in K+ content, and depolarization of platelet membrane were observed without change in the intracellular concentration of free Ca2+ ([Ca2+]1) or in the morphology of platelets. The cetiedil-induced depolarization was attenuated by the reduction of extracellular sodium concentration, while sodium transport inhibitors such as procaine and tetrodotoxin failed to modify the depolarization. On the other hand, thrombin caused such changes in platelets as increases in Na+ content, 22Na space and [Ca2+]1, decrease in K+ content, and membrane depolarization. All these changes caused by thrombin were inhibited by cetiedil. It is suggested that cetiedil brought the increased ion transport and subsequent partial depolarization, which might lead to modification of the reaction of platelet membrane induced by thrombin.

Topics: Azepines; Blood Platelets; Calcium; Humans; In Vitro Techniques; Membrane Potentials; Microscopy, Electron; Platelet Aggregation Inhibitors; Potassium; Sodium; Thrombin; Thromboxane B2

1988

Effect of cetiedil on platelet aggregation and thromboxane synthesis.

Thrombosis research, 1985, Feb-01, Volume: 37, Issue:3

Cetiedil was found to inhibit platelet aggregation and thromboxane synthesis induced by thrombin and arachidonic acid. When platelets were activated by thrombin, half maximal inhibition (ED50 effective dose of cetiedil necessary for 50% inhibition) for platelet aggregation was 100 microM while that for thromboxane B2 (TXB2) production was 50 microM. When arachidonic acid was used, the ED50 for platelet aggregation was 100 microM while that for TXB2 production was 150 microM. The presence of calcium ions did not affect on the inhibitory effects of cetiedil. The cAMP level in platelets did not increase after incubation with cetiedil. Cetiedil appears to inhibit the activation of platelets related to thromboxane synthesis.

Topics: Antisickling Agents; Arachidonic Acid; Arachidonic Acids; Azepines; Blood Platelets; Calcium; Cyclic AMP; Humans; L-Lactate Dehydrogenase; Platelet Aggregation; Thrombin; Thromboxane B2; Thromboxanes

1985