thromboxane-b2 and canadine

thromboxane-b2 has been researched along with canadine* in 1 studies

Other Studies

1 other study(ies) available for thromboxane-b2 and canadine

Article	Year
Inhibitory effect of tetrahydroberberine on platelet aggregation and thrombosis. Zhongguo yao li xue bao = Acta pharmacologica Sinica, 1994, Volume: 15, Issue:2 Tetrahydroberberine (THB), an alkaloid extracted from Corydalis ambigua, inhibited the rabbit platelet aggregation triggered by arachidonic acid (AA), ADP, and collagen with IC50 of 0.86, 1.31, and 1.10 mmol.L-1, respectively. THB reduced the thromboxane B2 (TXB2) generation in rabbit platelet-rich plasma triggered by AA. THB 30 mg.kg-1.d-1 ip for 3 or 5 d restrained the ADP-induced platelet aggregation in rats. THB 30 mg.kg-1.d-1 ip for 1, 3, or 5 d inhibited the AA-induced platelet aggregation in rats. THB 15-30 mg.kg-1 iv showed an inhibition of venous thrombosis in rats. The results show that THB is a potent inhibitor of platelet aggregation in vitro and in vivo and is a promising antithrombotic drug. Topics: Adenosine Diphosphate; Animals; Arachidonic Acids; Berberine; Male; Platelet Aggregation; Platelet Aggregation Inhibitors; Rabbits; Rats; Rats, Sprague-Dawley; Thrombosis; Thromboxane B2	1994

Article

Year

Inhibitory effect of tetrahydroberberine on platelet aggregation and thrombosis.

Zhongguo yao li xue bao = Acta pharmacologica Sinica, 1994, Volume: 15, Issue:2

Tetrahydroberberine (THB), an alkaloid extracted from Corydalis ambigua, inhibited the rabbit platelet aggregation triggered by arachidonic acid (AA), ADP, and collagen with IC50 of 0.86, 1.31, and 1.10 mmol.L-1, respectively. THB reduced the thromboxane B2 (TXB2) generation in rabbit platelet-rich plasma triggered by AA. THB 30 mg.kg-1.d-1 ip for 3 or 5 d restrained the ADP-induced platelet aggregation in rats. THB 30 mg.kg-1.d-1 ip for 1, 3, or 5 d inhibited the AA-induced platelet aggregation in rats. THB 15-30 mg.kg-1 iv showed an inhibition of venous thrombosis in rats. The results show that THB is a potent inhibitor of platelet aggregation in vitro and in vivo and is a promising antithrombotic drug.

Topics: Adenosine Diphosphate; Animals; Arachidonic Acids; Berberine; Male; Platelet Aggregation; Platelet Aggregation Inhibitors; Rabbits; Rats; Rats, Sprague-Dawley; Thrombosis; Thromboxane B2

1994