thromboxane-b2 and calcium-phosphate--dibasic--anhydrous

We have compared the early development (0-4h) of two acute non-specific inflammatory reactions induced by the intrapleural injection of isologous serum or a suspension of CaPP crystals. The intensity of the reactions was assessed in terms of the exudate volume, the number and ratio of pleural cells and different cell functions and secretions. The number of exudative cells elicited by isologous serum was higher than with CaPP but the PMN/Monocytes ratio was the same. The amount of protein in the serum-induced exudate was constant from 1 h to 4 h and was similar in the CaPP-induced pleural exudate at the latter time. The amount of complement increased similarly in the two models. The chemotactic potency of the exudates and cell supernatants following incubation showed similar values in the two models. Eicosanoid levels were higher in CaPP--than in isologous serum-induced exudates. Prostacyclin and peptidoleukotrienes were released in specially large amounts at the very outset of the inflammatory reactions.

Topics: Acute Disease; Animals; Calcium Phosphates; Cells, Cultured; Eicosanoids; Epoprostenol; Leukocytes, Mononuclear; Leukotriene B4; Male; N-Formylmethionine Leucyl-Phenylalanine; Pleurisy; Rats; Rats, Inbred Strains; SRS-A; Thromboxane B2