thromboxane-b2 has been researched along with 9-diazomethylanthracene* in 2 studies
1 trial(s) available for thromboxane-b2 and 9-diazomethylanthracene
| Article | Year |
|---|---|
Plasma prostaglandin levels from bronchial asthmatic patients assayed by 9-anthryldiazomethane-HPLC method.
Plasma prostaglandin (PG) and thromboxane (Tx) levels from bronchial asthmatic patients were assayed by 9-anthryldiazomethane reversed-phase high-performance liquid chromatography method. TxB2 levels from stable bronchial asthmatic patients were significantly higher than those from normal healthy subjects. PGF2 alpha levels were significantly elevated in atopic patients compared with nonatopic ones. PG patterns differed between asthmatic and nonasthmatic conditions in the same patients. PGF2 alpha levels were significantly elevated in the patients with spontaneous attacks compared with those without attacks and 6-keto PGF1 alpha levels were significantly lower in bronchial asthmatic patients having attacks than in the patients without attacks. There were no significant differences of PG levels between mild and moderate asthmatic subjects. Aminophylline injection in patients with mild spontaneous attacks had no significant effects on PG levels which were compared before and after injection. Topics: Adult; Aminophylline; Anthracenes; Asthma; Chromatography, High Pressure Liquid; Female; Fluorescent Dyes; Humans; Male; Middle Aged; Prostaglandins; Thromboxane B2 | 1990 |
1 other study(ies) available for thromboxane-b2 and 9-diazomethylanthracene
| Article | Year |
|---|---|
Procedures for plasma prostaglandins assay from bronchial asthmatic patients using 9-anthryldiazomethane-HPLC method.
We report here an efficient method for simultaneous and quantitative determinations of plasma prostaglandins (PGs) from asthmatic patients using 9-anthryldiazomethane-reversed-phase high performance liquid chromatography (HPLC). Detection and simultaneous quantitation of 20 pg PGE1, PGE2, PGF2 alpha and 100 pg 6-keto PGF1 alpha, thromboxane B2 (TXB2) was possible by the present method. Preliminary studies showed that plasma TXB2 levels from stable asthmatic patients were elevated compared with normal healthy subjects, suggesting pathophysiologic implications regarding PGs and TXB2 in asthma may be elicited by the present HPLC method. Topics: Anthracenes; Asthma; Chromatography, High Pressure Liquid; Dinoprost; Dinoprostone; Fluorometry; Humans; Microchemistry; Prostaglandins; Radioimmunoassay; Thromboxane B2; Time Factors | 1990 |