thromboxane-b2 and 1-1-3-3-tetramethylurea

thromboxane-b2 has been researched along with 1-1-3-3-tetramethylurea* in 1 studies

Other Studies

1 other study(ies) available for thromboxane-b2 and 1-1-3-3-tetramethylurea

Article	Year
Influence of hydroxyl radical scavengers on platelet function. Haemostasis, 1988, Volume: 18, Issue:2 The influence of four hydroxil radical (OH.) scavengers on platelet function was investigated. OH. scavengers inhibited ADP, collagen, arachidonic acid, PAF-induced platelet aggregation, and platelet cyclooxygenase pathway activation, which was studied by evaluating platelet malondialdehyde and serum thromboxane A2 formation. The latter was not affected by superoxide dismutase, catalase, or metal ion chelants such as desferioxamine or DETAPAC. The detection of deoxyribose degradation by stimulated platelets suggested that platelets produce OH.. This study shows that activated platelets produce free radicals and that antioxidant agents such as OH. scavengers inhibit platelet function. Topics: Adult; Blood Platelets; Catalase; Chelating Agents; Dimethyl Sulfoxide; Ethylene Glycols; Female; Free Radicals; Humans; Hydroxides; Hydroxyl Radical; Male; Malondialdehyde; Methylurea Compounds; Platelet Aggregation Inhibitors; Platelet Function Tests; Prostaglandin-Endoperoxide Synthases; Superoxide Dismutase; Thiourea; Thromboxane B2	1988

Article

Year

Influence of hydroxyl radical scavengers on platelet function.

Haemostasis, 1988, Volume: 18, Issue:2

The influence of four hydroxil radical (OH.) scavengers on platelet function was investigated. OH. scavengers inhibited ADP, collagen, arachidonic acid, PAF-induced platelet aggregation, and platelet cyclooxygenase pathway activation, which was studied by evaluating platelet malondialdehyde and serum thromboxane A2 formation. The latter was not affected by superoxide dismutase, catalase, or metal ion chelants such as desferioxamine or DETAPAC. The detection of deoxyribose degradation by stimulated platelets suggested that platelets produce OH.. This study shows that activated platelets produce free radicals and that antioxidant agents such as OH. scavengers inhibit platelet function.

Topics: Adult; Blood Platelets; Catalase; Chelating Agents; Dimethyl Sulfoxide; Ethylene Glycols; Female; Free Radicals; Humans; Hydroxides; Hydroxyl Radical; Male; Malondialdehyde; Methylurea Compounds; Platelet Aggregation Inhibitors; Platelet Function Tests; Prostaglandin-Endoperoxide Synthases; Superoxide Dismutase; Thiourea; Thromboxane B2

1988