thromboxane-a2 and vitexin

thromboxane-a2 has been researched along with vitexin* in 2 studies

Other Studies

2 other study(ies) available for thromboxane-a2 and vitexin

Article	Year
The inhibitory effect of vitexin on the agonist-induced regulation of vascular contractility. Die Pharmazie, 2014, Volume: 69, Issue:3 The present study was undertaken to investigate the influence of vitexin on vascular smooth muscle contractility and to determine the mechanism involved. Intact or denuded aortic rings from male rats were used and isometric contractions were recorded and combined with molecular experiments. Vitexin more significantly relaxed phorbol ester-induced vascular contraction than thromboxane A2 or fluoride-induced contraction suggesting as a possible anti-hypertensive on the agonist-induced vascular contraction regardless of endothelial nitric oxide synthesis. Furthermore, vitexin significantly inhibited phorbol ester-induced increases in pERK1/2 levels. On the other hand, it did not significantly inhibit thromboxane A2-induced increases in pMYPT1 levels suggesting the mechanism involving the primarily inhibition of MEK activity and the subsequent phosphorylation of ERK1/2. This study provides evidence regarding the mechanism underlying the relaxation effect of vitexin on agonist-induced vascular contraction regardless of endothelial function. Topics: Animals; Aorta, Thoracic; Apigenin; Blotting, Western; Enzyme Activators; Male; MAP Kinase Signaling System; Mitogen-Activated Protein Kinases; Muscle Contraction; Muscle, Smooth, Vascular; Phorbol Esters; Protein Phosphatase 1; Rats; Rats, Sprague-Dawley; rho-Associated Kinases; Sodium Fluoride; Thromboxane A2	2014
Inhibition of thromboxane A2 biosynthesis in vitro by the main components of Crataegus oxyacantha (Hawthorn) flower heads. Prostaglandins, leukotrienes, and essential fatty acids, 1994, Volume: 50, Issue:4 A hydro-alcoholic extract from Crataegus o. (Co) flower heads inhibited thromboxane A2 (TXA2) biosynthesis in vitro. This present study aims to find out which are the active principles. The main components, as revealed by chromatography, were tested. We also took into consideration catechin and epicatechin: although they do not appear as such with chromatography because of their polymerisation or-and condensed structure, these two proanthocyanidins seem to play a major role in the mentioned activity of the plant. Topics: Animals; Apigenin; Blood Platelets; Catechin; Flavonoids; Horses; Hydrolysis; Microsomes; Plant Extracts; Plants, Medicinal; Quercetin; Thromboxane A2	1994

Article

Year

The inhibitory effect of vitexin on the agonist-induced regulation of vascular contractility.

Die Pharmazie, 2014, Volume: 69, Issue:3

The present study was undertaken to investigate the influence of vitexin on vascular smooth muscle contractility and to determine the mechanism involved. Intact or denuded aortic rings from male rats were used and isometric contractions were recorded and combined with molecular experiments. Vitexin more significantly relaxed phorbol ester-induced vascular contraction than thromboxane A2 or fluoride-induced contraction suggesting as a possible anti-hypertensive on the agonist-induced vascular contraction regardless of endothelial nitric oxide synthesis. Furthermore, vitexin significantly inhibited phorbol ester-induced increases in pERK1/2 levels. On the other hand, it did not significantly inhibit thromboxane A2-induced increases in pMYPT1 levels suggesting the mechanism involving the primarily inhibition of MEK activity and the subsequent phosphorylation of ERK1/2. This study provides evidence regarding the mechanism underlying the relaxation effect of vitexin on agonist-induced vascular contraction regardless of endothelial function.

Topics: Animals; Aorta, Thoracic; Apigenin; Blotting, Western; Enzyme Activators; Male; MAP Kinase Signaling System; Mitogen-Activated Protein Kinases; Muscle Contraction; Muscle, Smooth, Vascular; Phorbol Esters; Protein Phosphatase 1; Rats; Rats, Sprague-Dawley; rho-Associated Kinases; Sodium Fluoride; Thromboxane A2

2014

Inhibition of thromboxane A2 biosynthesis in vitro by the main components of Crataegus oxyacantha (Hawthorn) flower heads.

Prostaglandins, leukotrienes, and essential fatty acids, 1994, Volume: 50, Issue:4

A hydro-alcoholic extract from Crataegus o. (Co) flower heads inhibited thromboxane A2 (TXA2) biosynthesis in vitro. This present study aims to find out which are the active principles. The main components, as revealed by chromatography, were tested. We also took into consideration catechin and epicatechin: although they do not appear as such with chromatography because of their polymerisation or-and condensed structure, these two proanthocyanidins seem to play a major role in the mentioned activity of the plant.

Topics: Animals; Apigenin; Blood Platelets; Catechin; Flavonoids; Horses; Hydrolysis; Microsomes; Plant Extracts; Plants, Medicinal; Quercetin; Thromboxane A2

1994