thromboxane-a2 has been researched along with phosphatidylethanol* in 1 studies
1 other study(ies) available for thromboxane-a2 and phosphatidylethanol
| Article | Year |
|---|---|
Thromboxane A2-induced phosphatidylcholine hydrolysis in porcine vascular smooth muscle cells.
The effect of 9,11-epithio-11,12-methanothromboxane A2 (STA2), a thromboxane A2 receptor agonist, on phosphatidylcholine hydrolysis was examined in porcine vascular smooth muscle cells. Although STA2 stimulated diacylglycerol production in a concentration-dependent manner, it only caused a slight accumulation of [3H]phosphatidylethanol in the presence of 0.5% ethanol, reflecting its weak stimulation of phosphatidylcholine-specific phospholipase D. STA2-induced diacylglycerol production was potently and concentration dependently inhibited by potassium tricyclo-[5.2.1.0(2.6)]-decyl-(9[8])-xanthogenate (D609), an inhibitor of phosphatidylcholine-specific phospholipase C. These results suggest that the thromboxane A2 receptor in vascular smooth muscles is functionally coupled to phosphatidylcholine-specific phospholipase C to yield diacylglycerol. Topics: Animals; Bridged-Ring Compounds; Cells, Cultured; Diglycerides; Glycerophospholipids; Hydrolysis; Muscle, Smooth, Vascular; Norbornanes; Phosphatidylcholines; Receptors, Thromboxane; Swine; Thiocarbamates; Thiones; Thromboxane A2 | 1999 |