thromboxane-a2 and morin

thromboxane-a2 has been researched along with morin* in 2 studies

Other Studies

2 other study(ies) available for thromboxane-a2 and morin

ArticleYear
Morin hydrate inhibits platelet activation and clot retraction by regulating integrin α
    European journal of pharmacology, 2019, Dec-15, Volume: 865

    Morin hydrate is an active constituent of Morus alba L, Prunus dulcis, and Cudrania tricuspidata and has been reported to inhibit platelet activation in vivo and in vitro, but no reports have been issued on its regulation of α

    Topics: Blood Coagulation; Clot Retraction; Collagen; Cyclic AMP; Flavonoids; Humans; Inositol 1,4,5-Trisphosphate Receptors; Phosphorylation; Platelet Activation; Platelet Aggregation; Platelet Glycoprotein GPIIb-IIIa Complex; Thrombin; Thromboxane A2

2019
Effect of short-term polyphenol treatment on endothelial dysfunction and thromboxane A2 levels in streptozotocin-induced diabetic mice.
    Biological & pharmaceutical bulletin, 2014, Volume: 37, Issue:6

    Diabetes is characterized by the development of endothelial dysfunction, which affects both nitric oxide (NO)-mediated relaxation and endothelium-derived contracting factors, associated with vascular oxidative stress. There is a growing body of evidence suggesting that polyphenols have several beneficial effects, such as antioxidant and anti-inflammatory activities. This study investigated whether short-term treatment with polyphenols (chlorogenic acid (CA), morin (MO), resveratrol (RV)) can improve endothelial dysfunction related to diabetes. Aorta reactivity was determined in organ chambers, and we measured NO production and thromboxane B2 (TXB2; a metabolite of TXA2) from aortas in response to acetylcholine (ACh). Streptozotocin (STZ)-induced diabetic mice (16 weeks) were injected with solvent (ethanol, 10% v/v; intraperitoneally (i.p.)), CA (0.03 mmol/kg/d), MO (0.03 mmol/kg/d), and RV (0.03 mmol/kg/d) for 5 d. The ACh-induced endothelium-dependent relaxation was markedly reduced in rings of STZ-induced diabetic mice compared to controls. The treatment with polyphenols (significantly: MO, tendency: CA and RV) for only 5 d improved the NO components of relaxation, but did not normalize ACh-stimulated NO production. However, polyphenol treatment suppressed the ACh-stimulated level of TXB2 in aortas from STZ-induced diabetic mice. Thus, treatment with polyphenols caused basal NO production and a prompt improvement of the endothelial function in diabetic mice, and this may involve the normalization of TXA2 levels, not NO production, under ACh stimulation.

    Topics: Animals; Antioxidants; Aorta, Thoracic; Chlorogenic Acid; Diabetes Mellitus, Experimental; Endothelium-Dependent Relaxing Factors; Endothelium, Vascular; Flavonoids; Isometric Contraction; Male; Mice, Inbred ICR; Muscle, Smooth, Vascular; Nitric Oxide; Oxidative Stress; Polyphenols; Resveratrol; Stilbenes; Streptozocin; Thromboxane A2

2014