thromboxane-a2 and imidapril

thromboxane-a2 has been researched along with imidapril* in 1 studies

Other Studies

1 other study(ies) available for thromboxane-a2 and imidapril

Article	Year
Altered prostaglandin metabolism induced by angiotensin-converting enzyme inhibitors in broncho-alveolar lavage fluid of the guinea pig. Japanese journal of pharmacology, 1996, Volume: 72, Issue:1 The aim of this study was to investigate if prostaglandin (PG) metabolism is altered by angiotensin-converting enzyme (ACE) inhibitors as determined in the broncho-alveolar lavage fluid (BALF) of the guinea pig. Enalapril or imidapril was orally administered once a day for 2 weeks to Hartley male guinea pigs. Twenty-four hours after the last treatment, BALF was collected and the concentrations of PGI2, thromboxane A2 (TXA2) and PGE2 were measured by enzyme immunoassay. Enalapril significanlty P < 0.05) increased the TXA2 content, which was inhibited by indomethacin treatment and significantly (P < 0.05) decreased the PGI2 content. Imidapril, however, did not affect TXA2 or PGI2 generation. These findings suggest that altered PG metabolism may be associated with coughing as a side effect of enalapril. Topics: Analysis of Variance; Angiotensin-Converting Enzyme Inhibitors; Animals; Antihypertensive Agents; Blood Pressure; Bronchoalveolar Lavage Fluid; Dinoprostone; Dose-Response Relationship, Drug; Enalapril; Epoprostenol; Guinea Pigs; Heart Rate; Imidazoles; Imidazolidines; Immunoenzyme Techniques; Male; Oxytocics; Thromboxane A2	1996

Article

Year

Altered prostaglandin metabolism induced by angiotensin-converting enzyme inhibitors in broncho-alveolar lavage fluid of the guinea pig.

Japanese journal of pharmacology, 1996, Volume: 72, Issue:1

The aim of this study was to investigate if prostaglandin (PG) metabolism is altered by angiotensin-converting enzyme (ACE) inhibitors as determined in the broncho-alveolar lavage fluid (BALF) of the guinea pig. Enalapril or imidapril was orally administered once a day for 2 weeks to Hartley male guinea pigs. Twenty-four hours after the last treatment, BALF was collected and the concentrations of PGI2, thromboxane A2 (TXA2) and PGE2 were measured by enzyme immunoassay. Enalapril significanlty P < 0.05) increased the TXA2 content, which was inhibited by indomethacin treatment and significantly (P < 0.05) decreased the PGI2 content. Imidapril, however, did not affect TXA2 or PGI2 generation. These findings suggest that altered PG metabolism may be associated with coughing as a side effect of enalapril.

Topics: Analysis of Variance; Angiotensin-Converting Enzyme Inhibitors; Animals; Antihypertensive Agents; Blood Pressure; Bronchoalveolar Lavage Fluid; Dinoprostone; Dose-Response Relationship, Drug; Enalapril; Epoprostenol; Guinea Pigs; Heart Rate; Imidazoles; Imidazolidines; Immunoenzyme Techniques; Male; Oxytocics; Thromboxane A2

1996