thromboxane-a2 has been researched along with allicin* in 1 studies
1 other study(ies) available for thromboxane-a2 and allicin
| Article | Year |
|---|---|
Lead compound design for TPR/COX dual inhibition.
The modes of action of TxA2 antagonists and COX-2 inhibitors were studied utilizing flexible ligand docking with postdocking minimization and ab initio interaction energy calculations. The resulting increased understanding of their binding interactions led to the design of a lead compound with chemical moieties that allowed efficient binding to both the thromboxane receptor and the COX-2 enzyme. This compound is derived from allicin, a natural component of garlic, and is a good starting point for the development of anti-inflammatory drugs with fewer side effects or improved cardiovascular drugs. Topics: Cyclooxygenase 2; Cyclooxygenase Inhibitors; Disulfides; Drug Design; Humans; Ligands; Molecular Docking Simulation; Protein Conformation; Receptors, Thromboxane; Sulfinic Acids; Thermodynamics; Thromboxane A2 | 2012 |