thromboxane-a2 and 3-4-dihydroxyacetophenone

Through systematic experimental and clinical studies, the physiological regulation of utero-placental circulation and the relation of the disturbance in this acirculation to pathogenic mechanisms of high risk pregnancies-Intrauterine Growth Retardation (IUGR) and Pregnancy-induced hypertension (PIH) were explored. The pharmacological effects and mechanism of a Chinese herbal medicine-Qingxintong in improving, the utero-placental circulation and the therapeutic efficacy in treatment of IUGR and PIH, both accompanied by disturbance of utero-placental circulation, were investigated as well.

Topics: Acetophenones; Drugs, Chinese Herbal; Epoprostenol; Female; Fetal Growth Retardation; Humans; Placental Circulation; Platelet Aggregation Inhibitors; Pre-Eclampsia; Pregnancy; Pregnancy, High-Risk; Thromboxane A2

In this paper, the effects of 3,4-dihydroxyacetophenone, DHAP (Qingxintong), an active constituent of traditional Chinese medicine, on the biosynthesis of TXA2 and PGI2 in human placental villi and umbilical artery segments of normal term pregnancy in vitro were studied by a perifusion technique. The collected fractions were assayed by radioimmunoassay for TXB2 and 6-keto-PGF1 alpha. The results showed that DHAP inhibited TXA2 and PGI2 production by umbilical artery segments in a dose dependent fashion and in both tissues TXA2 was more sensitive to inhibition than was 6-keto-PGF1 alpha. According to these data it is suggested that DHAP might be useful in treatment of pathologic pregnancies with chronic defective utero-placental circulation such as PIH and IUGR to improve this circulation.

Topics: 6-Ketoprostaglandin F1 alpha; Acetophenones; Chorionic Villi; Epoprostenol; Female; Humans; In Vitro Techniques; Medicine, Chinese Traditional; Perfusion; Pregnancy; Radioimmunoassay; Thromboxane A2; Thromboxane B2; Umbilical Arteries

Topics: Acetophenones; Animals; Anti-Arrhythmia Agents; Biological Assay; Blood Platelets; Platelet Aggregation; Rabbits; Radioimmunoassay; Thromboxane A2; Thromboxane B2