thromboplastin has been researched along with varespladib* in 1 studies
1 other study(ies) available for thromboplastin and varespladib
Article | Year |
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Anticoagulant Micrurus venoms: Targets and neutralization.
Snakebite is a neglected tropical disease with a massive global burden of injury and death. The best current treatments, antivenoms, are plagued by a number of logistical issues that limit supply and access in remote or poor regions. We explore the anticoagulant properties of venoms from the genus Micrurus (coral snakes), which have been largely unstudied, as well as the effectiveness of antivenom and a small-molecule phospholipase inhibitor-varespladib-at counteracting these effects. Our in vitro results suggest that these venoms likely interfere with the formation or function of the prothrombinase complex. We find that the anticoagulant potency varies widely across the genus and is especially pronounced in M. laticollaris. This variation does not appear to correspond to previously described patterns regarding the relative expression of the three-finger toxin and phospholipase A Topics: Acetates; Animals; Anticoagulants; Blood Coagulation; Coral Snakes; Elapid Venoms; Humans; Indoles; Keto Acids; Mice; Phospholipase A2 Inhibitors; Receptors, Phospholipase A2; Snake Bites; Species Specificity; Thromboplastin; Whole Blood Coagulation Time | 2021 |