thromboplastin and phenylglycinamide

thromboplastin has been researched along with phenylglycinamide* in 1 studies

Other Studies

1 other study(ies) available for thromboplastin and phenylglycinamide

Article	Year
Design of selective phenylglycine amide tissue factor/factor VIIa inhibitors. Bioorganic & medicinal chemistry letters, 2005, Feb-01, Volume: 15, Issue:3 Proof of concept experiments have shown that tissue factor/factor VIIa inhibitors have antithrombotic activity without enhancing bleeding propensity. Starting from lead compounds generated by a biased combinatorial approach, phenylglycine amide tissue factor/factor VIIa inhibitors with low nanomolar affinity and good selectivity against other serine proteases of the coagulation cascade were designed, using the guidance of X-ray structural analysis and molecular modelling. Topics: Drug Design; Factor VIIa; Fibrinolytic Agents; Glycine; Humans; Kinetics; Models, Molecular; Molecular Structure; Serine Proteinase Inhibitors; Structure-Activity Relationship; Thromboplastin	2005

Article

Year

Design of selective phenylglycine amide tissue factor/factor VIIa inhibitors.

Bioorganic & medicinal chemistry letters, 2005, Feb-01, Volume: 15, Issue:3

Proof of concept experiments have shown that tissue factor/factor VIIa inhibitors have antithrombotic activity without enhancing bleeding propensity. Starting from lead compounds generated by a biased combinatorial approach, phenylglycine amide tissue factor/factor VIIa inhibitors with low nanomolar affinity and good selectivity against other serine proteases of the coagulation cascade were designed, using the guidance of X-ray structural analysis and molecular modelling.

Topics: Drug Design; Factor VIIa; Fibrinolytic Agents; Glycine; Humans; Kinetics; Models, Molecular; Molecular Structure; Serine Proteinase Inhibitors; Structure-Activity Relationship; Thromboplastin

2005