thromboplastin and methyl-3-methoxy-4-hydroxystyryl-ketone

Atherosclerosis is characterized by endothelial dysfunction, mainly induced by inflammation and oxidative stress. Increased reactive oxygen species (ROS) production together with increased adhesion molecules and thrombogenic tissue factor (TF) expression on endothelial cells has a key role in proatherogenic mechanisms. Therefore downmodulation of these molecules could be useful for reducing the severity of inflammation and atherosclerosis progression. Dehydrozingerone (DHZ) is a nutraceutical compound with anti-inflammatory and antioxidant activities. In this study we evaluated the ability of DHZ and its symmetric dimer to modulate hydrogen peroxide- (H

Topics: Atherosclerosis; Cell Adhesion; Cell Survival; Dietary Supplements; Dimerization; Fluorometry; Gene Expression Regulation; Human Umbilical Vein Endothelial Cells; Humans; Inflammation; Intercellular Adhesion Molecule-1; Intracellular Space; NF-kappa B; Oxidative Stress; Reactive Oxygen Species; Solubility; Styrenes; Thromboplastin; Vascular Cell Adhesion Molecule-1