thromboplastin has been researched along with diallyl-trisulfide* in 1 studies
1 other study(ies) available for thromboplastin and diallyl-trisulfide
| Article | Year |
|---|---|
The garlic-derived organosulfur compound diallyl trisulphide suppresses tissue factor function.
Tissue factor (TF) is a critical initiator of extrinsic coagulation that sometimes causes thromboembolism. Diallyl trisulphide (DATS) is a secondary metabolite of allicin generated in crushed garlic, with various pharmacological effects. This study aimed to clarify the effect of DATS on the extrinsic coagulation elicited by TF and arteriosclerosis. TF activity was measured using a clotting assay in TF-expressing HL60 cells. DATS inhibited TF activity in a dose-dependent manner. TF expression in TNF-α-stimulated human umbilical vein endothelial cells was examined using real-time PCR and western blotting. DATS inhibited TF mRNA and protein expression induced by TNF-α Topics: Allyl Compounds; Animals; Antioxidants; Apoptosis; Disease Models, Animal; Garlic; Male; Mice; Sulfides; Thromboplastin | 2022 |