thromboplastin and 8-bromoguanosino-3--5--cyclic-monophosphorothioate

thromboplastin has been researched along with 8-bromoguanosino-3--5--cyclic-monophosphorothioate* in 1 studies

Other Studies

1 other study(ies) available for thromboplastin and 8-bromoguanosino-3--5--cyclic-monophosphorothioate

Article	Year
Natriuretic peptides regulate the expression of tissue factor and PAI-1 in endothelial cells. Thrombosis and haemostasis, 1999, Volume: 82, Issue:5 In the present study, we demonstrate that brain natriuretic peptide (BNP) and C-type natriuretic peptide (CNP) interact with angiotensin II (Ang II) in regulative blood coagulation and fibrinolysis by suppressing the expressions of both tissue factor (TF) and plasminogen activator inhibitor-1 (PAI-1) induced by Ang II. The expressions of TF and PAI-1 mRNA were analyzed by northern blotting methods, and the activities of TF on the surface of rat aortic endothelial cells (RAECs) and PAI-1 in the culture media were respectively measured by chromogenic assay. Both BNP and CNP suppressed the expressions of TF and PAI-1 mRNA induced by Ang II in a time- and concentration-dependent manner via cGMP cascade, which suppressions were accompanied by respective decrease in activities of TF and PAI-1. However, neither the expression of tissue factor pathway inhibitor (TFPI) nor tissue-type plasminogen activator (TPA) mRNA was affected by the treatment of BNP and CNP. Topics: Angiotensin II; Animals; Blotting, Northern; Cells, Cultured; Culture Media, Conditioned; Cyclic GMP; Endothelium, Vascular; Gene Expression Regulation; Lipopolysaccharides; Lipoproteins; Male; Natriuretic Peptide, Brain; Natriuretic Peptide, C-Type; Plasminogen Activator Inhibitor 1; Rats; Rats, Sprague-Dawley; RNA, Messenger; Second Messenger Systems; Thionucleotides; Thrombin; Thromboplastin; Tissue Plasminogen Activator	1999

Article

Year

Natriuretic peptides regulate the expression of tissue factor and PAI-1 in endothelial cells.

Thrombosis and haemostasis, 1999, Volume: 82, Issue:5

In the present study, we demonstrate that brain natriuretic peptide (BNP) and C-type natriuretic peptide (CNP) interact with angiotensin II (Ang II) in regulative blood coagulation and fibrinolysis by suppressing the expressions of both tissue factor (TF) and plasminogen activator inhibitor-1 (PAI-1) induced by Ang II. The expressions of TF and PAI-1 mRNA were analyzed by northern blotting methods, and the activities of TF on the surface of rat aortic endothelial cells (RAECs) and PAI-1 in the culture media were respectively measured by chromogenic assay. Both BNP and CNP suppressed the expressions of TF and PAI-1 mRNA induced by Ang II in a time- and concentration-dependent manner via cGMP cascade, which suppressions were accompanied by respective decrease in activities of TF and PAI-1. However, neither the expression of tissue factor pathway inhibitor (TFPI) nor tissue-type plasminogen activator (TPA) mRNA was affected by the treatment of BNP and CNP.

Topics: Angiotensin II; Animals; Blotting, Northern; Cells, Cultured; Culture Media, Conditioned; Cyclic GMP; Endothelium, Vascular; Gene Expression Regulation; Lipopolysaccharides; Lipoproteins; Male; Natriuretic Peptide, Brain; Natriuretic Peptide, C-Type; Plasminogen Activator Inhibitor 1; Rats; Rats, Sprague-Dawley; RNA, Messenger; Second Messenger Systems; Thionucleotides; Thrombin; Thromboplastin; Tissue Plasminogen Activator

1999