thromboplastin and 1-5-benzothiazepine

thromboplastin has been researched along with 1-5-benzothiazepine* in 1 studies

Other Studies

1 other study(ies) available for thromboplastin and 1-5-benzothiazepine

Article	Year
Design, synthesis, and biological evaluation of 1,5-benzothiazepine-4-one derivatives targeting factor VIIa/tissue factor. Bioorganic & medicinal chemistry letters, 2009, Mar-01, Volume: 19, Issue:5 The 1,5-benzothiazepine-4-one scaffold was earlier shown to provide efficient protease inhibitors. In this contribution, we describe its use in the design of factor VIIa/tissue factor inhibitors. A series containing a scaffold non-substituted on its aryl part led to compound 20 with an IC(50) of 2.16 microM. Following molecular modelling studies of this compound, a second series was prepared, which necessitated the synthesis of protected 7- or 8-substituted 1,5-benzothiazepine-4-one derivatives. Topics: Drug Delivery Systems; Drug Design; Drug Evaluation, Preclinical; Factor VIIa; Humans; Thiazepines; Thromboplastin	2009

Article

Year

Design, synthesis, and biological evaluation of 1,5-benzothiazepine-4-one derivatives targeting factor VIIa/tissue factor.

Bioorganic & medicinal chemistry letters, 2009, Mar-01, Volume: 19, Issue:5

The 1,5-benzothiazepine-4-one scaffold was earlier shown to provide efficient protease inhibitors. In this contribution, we describe its use in the design of factor VIIa/tissue factor inhibitors. A series containing a scaffold non-substituted on its aryl part led to compound 20 with an IC(50) of 2.16 microM. Following molecular modelling studies of this compound, a second series was prepared, which necessitated the synthesis of protected 7- or 8-substituted 1,5-benzothiazepine-4-one derivatives.

Topics: Drug Delivery Systems; Drug Design; Drug Evaluation, Preclinical; Factor VIIa; Humans; Thiazepines; Thromboplastin

2009