threoninol and pyrimidine

threoninol has been researched along with pyrimidine* in 2 studies

Other Studies

2 other study(ies) available for threoninol and pyrimidine

ArticleYear
Highly stable triple helix formation by homopyrimidine (L)-acyclic threoninol nucleic acids with single stranded DNA and RNA.
    Organic & biomolecular chemistry, 2015, Feb-28, Volume: 13, Issue:8

    Acyclic (L)-threoninol nucleic acid (aTNA) containing thymine, cytosine and adenine nucleobases were synthesized and shown to form surprisingly stable triplexes with complementary single stranded homopurine DNA or RNA targets. The triplex structures consist of two (L)-aTNA strands and one DNA or RNA, and these triplexes are significantly stronger than the corresponding DNA or RNA duplexes as shown in competition experiments. As a unique property the (L)-aTNAs exclusively form triplex structures with DNA and RNA and no duplex structures are observed by gel electrophoresis. The results were compared to the known enantiomer (D)-aTNA, which forms much weaker triplexes depending upon temperature and time. It was demonstrated that (L)-aTNA triplexes are able to stop primer extension on a DNA template, showing the potential of (L)-aTNA for antisense applications.

    Topics: Amino Alcohols; Butylene Glycols; DNA, Single-Stranded; Molecular Conformation; Nucleic Acids; Pyrimidines; RNA; Temperature

2015
DNA photo-cross-linking using 3-cyanovinylcarbazole modified oligonucleotide with threoninol linker.
    Organic letters, 2015, Feb-20, Volume: 17, Issue:4

    3-Cyanovinylcarbazole modified D-threoninol ((CNV)D) was incorporated in oligodeoxyribonucleotide and tested for a photo-cross-linking reaction with complementary oligodeoxyribonucleotide. The photoreactivity was 1.8- to 8-fold greater than that of 3-cyanovinylcarbazole modified deoxyribose ((CNV)K) previously reported. From the results of melting analysis and circular dichroism spectroscopy of the duplexes, the relatively flexible structure of (CNV)D compared with (CNV)K might be advantageous for [2 + 2] photocycloaddition between the cyanovinyl group on the (CNV)D and pyrimidine base in the complementary strand.

    Topics: Amino Alcohols; Butylene Glycols; Carbazoles; Cross-Linking Reagents; DNA; Molecular Structure; Oligodeoxyribonucleotides; Photochemical Processes; Pyrimidines

2015