threoninol has been researched along with pyrimidine* in 2 studies
2 other study(ies) available for threoninol and pyrimidine
Article | Year |
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Highly stable triple helix formation by homopyrimidine (L)-acyclic threoninol nucleic acids with single stranded DNA and RNA.
Acyclic (L)-threoninol nucleic acid (aTNA) containing thymine, cytosine and adenine nucleobases were synthesized and shown to form surprisingly stable triplexes with complementary single stranded homopurine DNA or RNA targets. The triplex structures consist of two (L)-aTNA strands and one DNA or RNA, and these triplexes are significantly stronger than the corresponding DNA or RNA duplexes as shown in competition experiments. As a unique property the (L)-aTNAs exclusively form triplex structures with DNA and RNA and no duplex structures are observed by gel electrophoresis. The results were compared to the known enantiomer (D)-aTNA, which forms much weaker triplexes depending upon temperature and time. It was demonstrated that (L)-aTNA triplexes are able to stop primer extension on a DNA template, showing the potential of (L)-aTNA for antisense applications. Topics: Amino Alcohols; Butylene Glycols; DNA, Single-Stranded; Molecular Conformation; Nucleic Acids; Pyrimidines; RNA; Temperature | 2015 |
DNA photo-cross-linking using 3-cyanovinylcarbazole modified oligonucleotide with threoninol linker.
3-Cyanovinylcarbazole modified D-threoninol ((CNV)D) was incorporated in oligodeoxyribonucleotide and tested for a photo-cross-linking reaction with complementary oligodeoxyribonucleotide. The photoreactivity was 1.8- to 8-fold greater than that of 3-cyanovinylcarbazole modified deoxyribose ((CNV)K) previously reported. From the results of melting analysis and circular dichroism spectroscopy of the duplexes, the relatively flexible structure of (CNV)D compared with (CNV)K might be advantageous for [2 + 2] photocycloaddition between the cyanovinyl group on the (CNV)D and pyrimidine base in the complementary strand. Topics: Amino Alcohols; Butylene Glycols; Carbazoles; Cross-Linking Reagents; DNA; Molecular Structure; Oligodeoxyribonucleotides; Photochemical Processes; Pyrimidines | 2015 |