threonine has been researched along with wortmannin in 26 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 3 (11.54) | 18.2507 |
| 2000's | 20 (76.92) | 29.6817 |
| 2010's | 3 (11.54) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Accili, D; Nakae, J; Park, BC | 1 |
| Cichy, SC; Cohen, P; Guo, S; Rena, G; Unterman, TG | 1 |
| Bandyopadhyay, G; Burke, TR; Farese, RV; Quon, MJ; Sajan, MP; Standaert, ML | 1 |
| Kar, S; Quirion, R; Zheng, WH | 1 |
| Kramer, DL; Pederson, TM; Rondinone, CM | 1 |
| Lai, MT; Vlahos, CJ; Zinda, MJ | 1 |
| Alt, A; Herschkovitz, A; Kuroki, T; LeRoith, D; Liu, YF; Ohba, M; Paz, K; Sampson, SR; Tennenbaum, T; Zick, Y | 1 |
| Badorff, C; Dimmeler, S; Holzmann, Y; Rössig, L; Zeiher, AM | 1 |
| Aschenbach, WG; Goodyear, LJ; Hirshman, MF; Sakamoto, K | 1 |
| Brennan, P; Cantrell, D; Dennis, PB; Pullen, N; Saitoh, M; Thomas, G | 1 |
| Hresko, RC; Mueckler, M; Murata, H | 1 |
| Kupferwasser, D; Lam, J; Lee-Fruman, KK; Phin, S | 1 |
| Bijur, GN; Jope, RS | 1 |
| Kojima, Y; Sakurai, H; Ueda, E; Yoshikawa, Y | 1 |
| Douglas, P; Kurz, EU; Lees-Miller, SP | 1 |
| Bernd, A; Guschel, M; Kaufmann, R; Kippenberger, S; Knies, Y; Loitsch, S; Müller, J | 1 |
| Juhnn, YS; Kang, UG; Kim, SY; Kim, Y; Kim, YS; Lee, YI; Seo, M | 1 |
| Blenis, J; Holz, MK | 1 |
| Brennesvik, EO; Jebens, E; Jensen, J; Ktori, C; Ruzzin, J; Shepherd, PR | 1 |
| Misra, UK; Pizzo, SV | 1 |
| Blaser, N; Gutjahr, MC; Niggli, V; Rossy, J; Schlicht, D | 1 |
| Bahr, SM; Brat, D; Gutmann, DH; Jang, SW; Liu, Z; Sun, SY; Tang, X; Wang, X; Ye, K | 1 |
| Cao, J; Chen, W; Dai, B; Lin, D; Liu, L; Liu, Y; Ma, D; Sun, Y; Yu, H | 1 |
| Diamant, M; Guigas, B; Jazet, IM; Kriek, J; Maassen, JA; Nascimento, EB; Ouwens, DM; Snel, M; van der Zon, GC | 1 |
| Guo, QL; Ha, J; Hu, R; Lu, N; Qi, Q; Rong, JJ; Song, XM; Tao, L; You, QD | 1 |
| Kanno, T; Nishizaki, T; Tsuchiya, A | 1 |
26 other study(ies) available for threonine and wortmannin
| Article | Year |
|---|---|
Insulin stimulates phosphorylation of the forkhead transcription factor FKHR on serine 253 through a Wortmannin-sensitive pathway.
Topics: Amino Acid Substitution; Androstadienes; Animals; Blood Proteins; Cell Cycle Proteins; Cells, Cultured; Consensus Sequence; Enzyme Inhibitors; Forkhead Transcription Factors; Gene Expression Regulation; Humans; Insulin; Liver; Mice; Molecular Sequence Data; Mutagenesis, Site-Directed; Phosphatidylinositol 3-Kinases; Phosphorylation; Protein Serine-Threonine Kinases; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-akt; Serine; Simian virus 40; Structure-Activity Relationship; Threonine; Transcription Factors; Wortmannin | 1999 |
Phosphorylation of the transcription factor forkhead family member FKHR by protein kinase B.
Topics: 3-Phosphoinositide-Dependent Protein Kinases; Amino Acid Sequence; Androstadienes; Antibody Specificity; bcl-Associated Death Protein; Caenorhabditis elegans Proteins; Carrier Proteins; Consensus Sequence; DNA-Binding Proteins; Enzyme Activation; Forkhead Box Protein O1; Forkhead Transcription Factors; Humans; Insulin-Like Growth Factor I; Molecular Sequence Data; Phosphoinositide-3 Kinase Inhibitors; Phosphorylation; Phosphoserine; Phosphothreonine; Protein Processing, Post-Translational; Protein Serine-Threonine Kinases; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-akt; Recombinant Proteins; Serine; Signal Transduction; Sirolimus; Threonine; Transcription Factors; Wortmannin | 1999 |
Protein kinase C-zeta and phosphoinositide-dependent protein kinase-1 are required for insulin-induced activation of ERK in rat adipocytes.
Topics: 3-Phosphoinositide-Dependent Protein Kinases; Adipocytes; Amino Acid Substitution; Androstadienes; Animals; Chromones; Enzyme Activation; Enzyme Inhibitors; Epididymis; Flavonoids; Genistein; Insulin; Kinetics; Male; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Mitogen-Activated Protein Kinases; Morpholines; Mutagenesis, Site-Directed; Phosphatidylinositol 3-Kinases; Protein Kinase C; Protein Serine-Threonine Kinases; Rats; Rats, Sprague-Dawley; Receptor, Insulin; Recombinant Proteins; Signal Transduction; src Homology Domains; Threonine; Wortmannin | 1999 |
Insulin-like growth factor-1-induced phosphorylation of the forkhead family transcription factor FKHRL1 is mediated by Akt kinase in PC12 cells.
Topics: 3T3 Cells; Androstadienes; Animals; Apoptosis; Blotting, Western; Cell Line; Cells, Cultured; Cerebellum; Cerebral Cortex; DNA-Binding Proteins; Dose-Response Relationship, Drug; Enzyme Inhibitors; Flavonoids; Forkhead Box Protein O1; Forkhead Box Protein O3; Forkhead Transcription Factors; Humans; Insulin-Like Growth Factor I; Mice; Mutagenesis; Myristic Acid; Nerve Tissue Proteins; Neurons; PC12 Cells; Phosphatidylinositol 3-Kinases; Phosphoinositide-3 Kinase Inhibitors; Phosphorylation; Precipitin Tests; Protein Serine-Threonine Kinases; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-akt; Rats; Rats, Sprague-Dawley; Ribosomal Protein S6 Kinases; Serine; Sirolimus; Threonine; Transcription Factors; Transfection; Vanadates; Wortmannin | 2000 |
Serine/threonine phosphorylation of IRS-1 triggers its degradation: possible regulation by tyrosine phosphorylation.
Topics: 3T3 Cells; Androstadienes; Animals; Cysteine Endopeptidases; Enzyme Inhibitors; Insulin; Insulin Receptor Substrate Proteins; Mice; Multienzyme Complexes; Okadaic Acid; Phosphoproteins; Phosphorylation; Proteasome Endopeptidase Complex; Protein Kinase Inhibitors; Serine; Sirolimus; Threonine; Time Factors; Tyrosine; Vanadates; Wortmannin | 2001 |
Ceramide induces the dephosphorylation and inhibition of constitutively activated Akt in PTEN negative U87mg cells.
Topics: Androstadienes; Blotting, Western; Chromatography, High Pressure Liquid; Dose-Response Relationship, Drug; Electrophoresis, Polyacrylamide Gel; Enzyme Inhibitors; Humans; Marine Toxins; Okadaic Acid; Oxazoles; Phosphatidylinositol Phosphates; Phosphatidylinositols; Phosphoric Monoester Hydrolases; Phosphorylation; Precipitin Tests; Protein Serine-Threonine Kinases; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-akt; PTEN Phosphohydrolase; Serine; Sphingosine; Threonine; Time Factors; Tumor Cells, Cultured; Tumor Suppressor Proteins; Wortmannin | 2001 |
Insulin stimulates PKCzeta -mediated phosphorylation of insulin receptor substrate-1 (IRS-1). A self-attenuated mechanism to negatively regulate the function of IRS proteins.
Topics: Adenoviridae; Androstadienes; Animals; Carcinoma, Hepatocellular; Cell Line; Dose-Response Relationship, Drug; Enzyme Inhibitors; Gene Expression Regulation; Humans; Insulin; Insulin Receptor Substrate Proteins; Liver Neoplasms; Phosphoinositide-3 Kinase Inhibitors; Phosphoproteins; Phosphorylation; Precipitin Tests; Protein Isoforms; Protein Kinase C; Rats; Receptor, Insulin; Recombinant Proteins; Serine; Threonine; Time Factors; Tumor Necrosis Factor-alpha; Tyrosine; Wortmannin | 2001 |
Glycogen synthase kinase-3 couples AKT-dependent signaling to the regulation of p21Cip1 degradation.
Topics: Adjuvants, Immunologic; Androstadienes; Animals; Blotting, Western; Bromodeoxyuridine; Calcium-Calmodulin-Dependent Protein Kinases; Cell Cycle; Cell Division; Cell Survival; Cells, Cultured; Chromones; COS Cells; Cyclin-Dependent Kinase Inhibitor p21; Cyclins; Dose-Response Relationship, Drug; Endothelium, Vascular; Enzyme Inhibitors; Glycogen Synthase Kinase 3; Glycogen Synthase Kinases; Humans; Immunoblotting; Lithium Chloride; Morpholines; Mutagenesis, Site-Directed; Phosphorylation; Protein Binding; Protein Serine-Threonine Kinases; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-akt; Serine; Signal Transduction; Threonine; Time Factors; Transfection; Umbilical Veins; Wortmannin | 2002 |
Contraction regulation of Akt in rat skeletal muscle.
Topics: Androstadienes; Animals; Calcium-Calmodulin-Dependent Protein Kinases; Chromones; Electrophoresis, Polyacrylamide Gel; Enzyme Inhibitors; Glycogen Synthase; Glycogen Synthase Kinase 3; Glycogen Synthase Kinases; Insulin; Morpholines; Muscle Contraction; Muscle, Skeletal; Phosphorylation; Protein Binding; Protein Isoforms; Protein Serine-Threonine Kinases; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-akt; Rats; Serine; Signal Transduction; Threonine; Time Factors; Tyrosine; Wortmannin | 2002 |
Regulation of an activated S6 kinase 1 variant reveals a novel mammalian target of rapamycin phosphorylation site.
Topics: Androstadienes; Animals; Antibiotics, Antineoplastic; Binding Sites; Cell Line; Enzyme Inhibitors; Genes, Dominant; Glutathione Transferase; Humans; Immunoblotting; Insulin; Phosphorylation; Plasmids; Precipitin Tests; Protein Binding; Protein Structure, Tertiary; Recombinant Fusion Proteins; Ribosomal Protein S6 Kinases; Serine; Sirolimus; Threonine; Transfection; Wortmannin | 2002 |
Reconstitution of phosphoinositide 3-kinase-dependent insulin signaling in a cell-free system.
Topics: 3T3 Cells; Adipocytes; Androstadienes; Animals; Cell Membrane; Cell-Free System; Cytosol; Glutathione Transferase; Immunoblotting; Insulin; Insulin Receptor Substrate Proteins; Intracellular Signaling Peptides and Proteins; Mice; Phosphatidylinositol 3-Kinases; Phosphoproteins; Phosphorylation; Precipitin Tests; Recombinant Fusion Proteins; Serine; Signal Transduction; Subcellular Fractions; Threonine; Time Factors; Wortmannin | 2003 |
Mutational analysis of ribosomal S6 kinase 2 shows differential regulation of its kinase activity from that of ribosomal S6 kinase 1.
Topics: 3-Phosphoinositide-Dependent Protein Kinases; Androstadienes; Antineoplastic Agents; Cells, Cultured; Humans; Immunosuppressive Agents; MAP Kinase Signaling System; Mitogen-Activated Protein Kinase Kinases; Mitogen-Activated Protein Kinases; Mutagenesis, Site-Directed; Mutation; Phosphoinositide-3 Kinase Inhibitors; Phosphorylation; Precipitin Tests; Proline; Protein Serine-Threonine Kinases; Ribosomal Protein S6 Kinases, 90-kDa; Serine; Signal Transduction; Sirolimus; Threonine; Transfection; Wortmannin | 2003 |
Rapid accumulation of Akt in mitochondria following phosphatidylinositol 3-kinase activation.
Topics: Androstadienes; Brain Neoplasms; Carbonyl Cyanide m-Chlorophenyl Hydrazone; Cell Fractionation; Cell Line; Cell Membrane; Cell Nucleus; Cytochromes c; Cytosol; Drug Interactions; Electron Transport Complex IV; Embryo, Mammalian; Enzyme Activation; Enzyme Inhibitors; Glycogen Synthase Kinase 3; Glycogen Synthase Kinase 3 beta; Humans; Immunoblotting; Insulin-Like Growth Factor I; Ionophores; Kidney; Mitochondria; Mitochondrial Proton-Translocating ATPases; Neuroblastoma; Phosphatidylinositol 3-Kinases; Phosphorylation; Porins; Precipitin Tests; Protein Serine-Threonine Kinases; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-akt; Serine; Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization; Superoxide Dismutase; Threonine; Time Factors; Voltage-Dependent Anion Channel 1; Wortmannin | 2003 |
The action mechanism of zinc(II) complexes with insulinomimetic activity in rat adipocytes.
Topics: Adipocytes; Androstadienes; Animals; Cells, Cultured; Dose-Response Relationship, Drug; Enzyme Inhibitors; Epinephrine; Fatty Acids, Nonesterified; Insulin; Male; Maltose; Organometallic Compounds; Picolinic Acids; Quinolones; Rats; Rats, Wistar; Sulfates; Threonine; Wortmannin; Zinc | 2004 |
Doxorubicin activates ATM-dependent phosphorylation of multiple downstream targets in part through the generation of reactive oxygen species.
Topics: Acetylcysteine; Androstadienes; Antibiotics, Antineoplastic; Antineoplastic Agents; Ascorbic Acid; Ataxia Telangiectasia Mutated Proteins; Binding Sites; Cell Cycle Proteins; Cell Line; Cell Line, Tumor; Cell Nucleus; DNA; DNA Damage; DNA-Binding Proteins; Dose-Response Relationship, Drug; Doxorubicin; Enzyme Inhibitors; Histones; Humans; Hydroxyl Radical; Image Processing, Computer-Assisted; Immunoblotting; Immunoprecipitation; Microscopy, Fluorescence; Oligonucleotides; Phosphorylation; Protein Binding; Protein Serine-Threonine Kinases; Radiation, Ionizing; Reactive Oxygen Species; Serine; Signal Transduction; Threonine; Time Factors; Transcription, Genetic; Tumor Suppressor Protein p53; Tumor Suppressor Proteins; Wortmannin | 2004 |
Mechanical stretch stimulates protein kinase B/Akt phosphorylation in epidermal cells via angiotensin II type 1 receptor and epidermal growth factor receptor.
Topics: Androstadienes; Apoptosis; Caspase 3; Caspase 8; Caspases; Cell Line; Cell Membrane; Cell Proliferation; Chromones; Dose-Response Relationship, Drug; Enzyme Activation; Enzyme Inhibitors; Epidermal Cells; Epidermis; Epithelial Cells; ErbB Receptors; Genes, Dominant; Humans; Immunoblotting; Microscopy, Confocal; Morpholines; Pertussis Toxin; Phosphatidylinositol 3-Kinases; Phosphorylation; Protein Serine-Threonine Kinases; Proto-Oncogene Mas; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-akt; Quinazolines; Receptor, Angiotensin, Type 1; Signal Transduction; Threonine; Time Factors; Tyrphostins; Wortmannin | 2005 |
Membrane depolarization induces the undulating phosphorylation/dephosphorylation of glycogen synthase kinase 3beta, and this dephosphorylation involves protein phosphatases 2A and 2B in SH-SY5Y human neuroblastoma cells.
Topics: Androstadienes; Animals; Calcineurin; Calcium; Cell Line; Cell Line, Tumor; Cell Membrane; Enzyme Inhibitors; Glioblastoma; Glycogen Synthase Kinase 3; Glycogen Synthase Kinase 3 beta; Hippocampus; Humans; Immunoblotting; Immunoprecipitation; Microscopy, Confocal; Naphthalenes; PC12 Cells; Phosphoprotein Phosphatases; Phosphorylation; Potassium Chloride; Rats; Serine; Threonine; Time Factors; Transfection; Wortmannin | 2005 |
Identification of S6 kinase 1 as a novel mammalian target of rapamycin (mTOR)-phosphorylating kinase.
Topics: Alleles; Androstadienes; Cell Line; Cell Line, Tumor; Culture Media, Serum-Free; Enzyme Inhibitors; Genetic Vectors; Humans; Immunoblotting; Immunoprecipitation; Insulin; Models, Biological; Phorbol Esters; Phosphatidylinositol 3-Kinases; Phosphorylation; Protein Kinases; Protein Structure, Tertiary; Ribosomal Protein S6 Kinases, 90-kDa; RNA, Messenger; RNA, Small Interfering; Serine; Signal Transduction; Sirolimus; Threonine; Time Factors; TOR Serine-Threonine Kinases; Wortmannin | 2005 |
Adrenaline potentiates insulin-stimulated PKB activation via cAMP and Epac: implications for cross talk between insulin and adrenaline.
Topics: Androstadienes; Animals; Cyclic AMP; Drug Synergism; Epinephrine; Glycogen Phosphorylase; Guanine Nucleotide Exchange Factors; Insulin; Male; Muscle, Skeletal; Phosphoinositide-3 Kinase Inhibitors; Phosphorylation; Protein Serine-Threonine Kinases; Rats; Rats, Wistar; Receptors, Adrenergic, beta; Serine; Signal Transduction; Threonine; Wortmannin | 2005 |
Coordinate regulation of forskolin-induced cellular proliferation in macrophages by protein kinase A/cAMP-response element-binding protein (CREB) and Epac1-Rap1 signaling: effects of silencing CREB gene expression on Akt activation.
Topics: Androstadienes; Animals; bcl-Associated Death Protein; Blotting, Western; Cell Count; Cell Proliferation; Chromones; Colforsin; Cyclic AMP; Cyclic AMP Response Element-Binding Protein; Cyclic AMP-Dependent Protein Kinases; Cyclin D1; Dose-Response Relationship, Drug; Enzyme Activation; Enzyme Inhibitors; Forkhead Box Protein O1; Forkhead Transcription Factors; Gene Expression Regulation; Gene Silencing; Guanine Nucleotide Exchange Factors; Guanosine Triphosphate; Immunoprecipitation; Isoquinolines; Macrophages; Mice; Mice, Inbred C57BL; Morpholines; Phosphatidylinositol 3-Kinases; Phosphorylation; Protein Structure, Tertiary; Proto-Oncogene Proteins c-akt; Proto-Oncogene Proteins c-bcl-2; rap1 GTP-Binding Proteins; RNA Interference; RNA, Double-Stranded; Serine; Signal Transduction; Sulfonamides; Threonine; Thymidine; Time Factors; Up-Regulation; Wortmannin; X-Linked Inhibitor of Apoptosis Protein | 2005 |
Ezrin/moesin in motile Walker 256 carcinosarcoma cells: signal-dependent relocalization and role in migration.
Topics: Androstadienes; Animals; Carcinogens; Carcinoma 256, Walker; Cell Movement; Cell Polarity; Cytoskeletal Proteins; Down-Regulation; Enzyme Activation; Intracellular Signaling Peptides and Proteins; Membrane Proteins; Microfilament Proteins; Phosphatidylinositol 3-Kinases; Phosphorylation; Protein Serine-Threonine Kinases; Protein Transport; rac1 GTP-Binding Protein; Rats; rho GTP-Binding Proteins; rho-Associated Kinases; RNA, Small Interfering; Signal Transduction; Tetradecanoylphorbol Acetate; Threonine; Transfection; Wortmannin | 2007 |
Akt phosphorylation regulates the tumour-suppressor merlin through ubiquitination and degradation.
Topics: Androstadienes; Animals; Blotting, Western; Cell Line, Tumor; Immunohistochemistry; Immunoprecipitation; Mutation; Neurofibromin 2; Phosphorylation; Protein Binding; Protein Kinase Inhibitors; Protein Processing, Post-Translational; Proto-Oncogene Proteins c-akt; Serine; Threonine; Ubiquitins; Wortmannin | 2007 |
S6K1 is involved in polyploidization through its phosphorylation at Thr421/Ser424.
Topics: Adaptor Proteins, Signal Transducing; Androstadienes; Animals; Antineoplastic Agents; Carcinogens; Cell Cycle; Cell Cycle Proteins; Cell Line, Tumor; Chromones; Cyclin B; Enzyme Inhibitors; Humans; Megakaryocytes; Morpholines; Nocodazole; Phosphoproteins; Phosphorylation; Polyploidy; Protein Kinases; Ribosomal Protein S6 Kinases, 90-kDa; Serine; Sirolimus; Tetradecanoylphorbol Acetate; Threonine; TOR Serine-Threonine Kinases; Wortmannin | 2009 |
Phosphorylation of PRAS40 on Thr246 by PKB/AKT facilitates efficient phosphorylation of Ser183 by mTORC1.
Topics: Adaptor Proteins, Signal Transducing; Androstadienes; Animals; Cell Line; Enzyme Inhibitors; Humans; Insulin; Insulin Resistance; Mice; Muscle, Skeletal; NIH 3T3 Cells; Phosphoproteins; Phosphorylation; Proto-Oncogene Proteins c-akt; Rats; Serine; Sirolimus; Threonine; Transcription Factors; Wortmannin | 2010 |
Gambogic acid triggers DNA damage signaling that induces p53/p21(Waf1/CIP1) activation through the ATR-Chk1 pathway.
Topics: Androstadienes; Antineoplastic Agents; Bone Neoplasms; Caffeine; CDC2 Protein Kinase; Cell Cycle; Cell Line, Tumor; Comet Assay; Cyclin-Dependent Kinase Inhibitor p21; DNA Damage; Down-Regulation; Doxorubicin; Hep G2 Cells; Humans; Osteosarcoma; Phosphorylation; Phosphothreonine; Signal Transduction; Threonine; Tumor Suppressor Protein p53; Wortmannin; Xanthones | 2010 |
PI3 kinase directly phosphorylates Akt1/2 at Ser473/474 in the insulin signal transduction pathway.
Topics: 3T3-L1 Cells; Adipocytes; Androstadienes; Animals; Blotting, Western; Glucose; Glucose Transporter Type 4; Heterocyclic Compounds, 3-Ring; Hypoglycemic Agents; Insulin; Mice; Phosphatidylinositol 3-Kinases; Phosphoinositide-3 Kinase Inhibitors; Phosphorylation; Protein Kinase Inhibitors; Protein Serine-Threonine Kinases; Protein Transport; Proto-Oncogene Proteins c-akt; Pyruvate Dehydrogenase Acetyl-Transferring Kinase; RNA Interference; Serine; Signal Transduction; Threonine; Wortmannin | 2014 |