threonine has been researched along with sirolimus in 46 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 5 (10.87) | 18.2507 |
| 2000's | 28 (60.87) | 29.6817 |
| 2010's | 10 (21.74) | 24.3611 |
| 2020's | 3 (6.52) | 2.80 |
| Authors | Studies |
|---|---|
| Arora, S; Chaturvedi, A; Heuser, M; Joshi, G; Kumar, R; Patil, S | 1 |
| Gelfand, EW; Papst, P; Sugiyama, H; Terada, N | 1 |
| Brunn, GJ; Fadden, P; Haystead, TA; Lawrence, JC | 1 |
| Cichy, SC; Cohen, P; Guo, S; Rena, G; Unterman, TG | 1 |
| Abraham, RT; Aebersold, R; Gingras, AC; Gygi, SP; Hoekstra, MF; Polakiewicz, RD; Raught, B; Sonenberg, N | 1 |
| Hara, K; Parekh, D; Parker, PJ; Yonezawa, K; Ziegler, W | 1 |
| Fadden, P; Haystead, TA; Lawrence, JC; Mothe-Satney, I; Yang, D | 1 |
| Baserga, R; Edmonds, P; McCormick, J; Morrione, A; Navarro, M; Reiss, K; Romano, G; Sacchi, A; Valentinis, B; Zanocco-Marani, T | 1 |
| Kar, S; Quirion, R; Zheng, WH | 1 |
| Kramer, DL; Pederson, TM; Rondinone, CM | 1 |
| Khan, A; Pepio, AM; Sossin, WS | 1 |
| Haruta, T; Iwata, M; Kawahara, J; Kobayashi, M; Takano, A; Uno, T; Usui, I | 1 |
| Aebersold, R; Burley, SK; Gingras, AC; Gygi, SP; Miron, M; Niedzwiecka, A; Polakiewicz, RD; Raught, B; Sonenberg, N; Wyslouch-Cieszynska, A | 1 |
| Cox, TC; Hopwood, B; Short, KM; Yi, Z | 1 |
| Brennan, P; Cantrell, D; Dennis, PB; Pullen, N; Saitoh, M; Thomas, G | 1 |
| Iijima, Y; Kuppuswamy, D; Laser, M; McDermott, PJ; Shiraishi, H; Sundaravadivel, B; Willey, CD; Xu, L | 1 |
| Abraham, RT; Choi, KM; Lawrence, JC; Lin, TA; McMahon, LP | 1 |
| Kupferwasser, D; Lam, J; Lee-Fruman, KK; Phin, S | 1 |
| Calvo, V; Gomez-Cambronero, J; Lehman, JA | 1 |
| Ferguson, G; Lawrence, JC; Mothe-Satney, I | 1 |
| Aguilar, R; Reyes de la Cruz, H; Sánchez de Jiménez, E | 1 |
| Carling, D; Cheng, SW; Fryer, LG; Shepherd, PR | 1 |
| Gautier, N; Hinault, C; Lawrence, JC; Mothe-Satney, I; Van Obberghen, E | 1 |
| Brattain, MG; Cookson, MM; Hauser, J; Sawhney, RS; Sharma, B | 1 |
| Carroll, M; Fan, X; Sossin, WS; Warren, O | 1 |
| Beugnet, A; Murakami, M; Proud, CG; Wang, X; Yamanaka, S | 1 |
| Crépieux, P; Fontaine, I; Gauthier, C; Guillou, F; Kara, E; Lécureuil, C; Martinat, N; Reiter, E; Sow, A; Tesseraud, S | 1 |
| Blenis, J; Holz, MK | 1 |
| Inamura, N; Nawa, H; Takei, N | 1 |
| Cook, LG; Hamilton, SL; Long, C; Mitchell, BM; Wu, GY | 1 |
| Chien, S; Hornberger, TA; Sukhija, KB; Wang, XR | 1 |
| Al-Younes, H; Braun, PR; Gussmann, J; Klein, J; Meyer, TF; Schneider, E | 1 |
| Cao, J; Chen, W; Dai, B; Lin, D; Liu, L; Liu, Y; Ma, D; Sun, Y; Yu, H | 1 |
| Albert, L; Gulati, N; Jhanwar-Uniyal, M; Karsy, M; Murali, R | 1 |
| Carvalheira, JB; Carvalho, HF; Clemente, CF; Dalla Costa, AP; Franchini, KG; Nadruz, W | 1 |
| Diamant, M; Guigas, B; Jazet, IM; Kriek, J; Maassen, JA; Nascimento, EB; Ouwens, DM; Snel, M; van der Zon, GC | 1 |
| Han, HJ; Ryu, JM | 1 |
| Crespo, JL; Díaz-Troya, S; Florencio, FJ; Jeno, P; Moes, S; Pérez-Martín, M; Pérez-Pérez, ME | 1 |
| Cinar, B; Collak, FK; Erkaya, B; Luthringer, DJ; Yagiz, K | 1 |
| Arriola Apelo, SI; Hanigan, MD; Lin, XY; McGilliard, ML; Singer, LM; St-Pierre, NR | 1 |
| Albac, C; Allinquant, B; Dorard, E; Gorisse-Hussonnois, L; Guihenneuc-Jouyaux, C; Potier, MC | 1 |
| Dong, X; Helmbrecht, A; Loor, JJ; Saremi, B; Wang, Z; Zhou, Z | 1 |
| Dong, X; Helmbrecht, A; Loor, JJ; Saremi, B; Wang, L; Wang, Z; Zhou, Z | 1 |
| Belova, SP; Mirzoev, TM; Mochalova, EP; Nemirovskaya, TL; Shenkman, BS; Vilchinskaya, NA | 1 |
| Alain, T; Anton, L; Berman, AJ; Celucci, G; Chaker-Margot, M; Dajadian, C; Damgaard, CK; Fonseca, BD; Graber, TE; Hearnden, J; Hoang, HD; Hollensen, AK; Jia, JJ; Lahr, RM; Livingstone, M; Maier, T; Moraes, BJ; Niklaus, MR; Pena, IA; Pointet, R; Smith, EM; Solgaard, MT; Wang, XD; Yang, AD; Yu, Y | 1 |
| Ma, N; Ma, X; Tan, P; Tang, Q | 1 |
1 review(s) available for threonine and sirolimus
| Article | Year |
|---|---|
Physiological Functions of Threonine in Animals: Beyond Nutrition Metabolism.
Topics: Amino Acids; Animals; Diet; Energy Metabolism; Gastrointestinal Tract; Metabolic Networks and Pathways; Mitogen-Activated Protein Kinases; Mucins; Nutritional Status; Sirolimus; Stem Cells; Swine; Threonine | 2021 |
45 other study(ies) available for threonine and sirolimus
| Article | Year |
|---|---|
A Perspective on Medicinal Chemistry Approaches for Targeting Pyruvate Kinase M2.
Topics: Allosteric Regulation; Allosteric Site; Carrier Proteins; Chemistry, Pharmaceutical; Glycolysis; Humans; Membrane Proteins; Protein Kinase Inhibitors; Thyroid Hormone-Binding Proteins; Thyroid Hormones | 2022 |
p70 S6 kinase sensitivity to rapamycin is eliminated by amino acid substitution of Thr229.
Topics: 3T3 Cells; Amino Acid Sequence; Animals; Base Sequence; Conserved Sequence; Drug Resistance; Enzyme Activation; Mice; Molecular Sequence Data; Mutagenesis, Site-Directed; Phosphorylation; Polyenes; Protein Serine-Threonine Kinases; Rats; Ribosomal Protein S6 Kinases; Sirolimus; Threonine | 1996 |
The mammalian target of rapamycin phosphorylates sites having a (Ser/Thr)-Pro motif and is activated by antibodies to a region near its COOH terminus.
Topics: Amino Acid Sequence; Animals; Antibodies; Binding Sites; Carrier Proteins; Intracellular Signaling Peptides and Proteins; Molecular Sequence Data; Phosphoproteins; Phosphorylation; Polyenes; Proline; Rats; Serine; Sirolimus; Substrate Specificity; Threonine | 1997 |
Phosphorylation of the transcription factor forkhead family member FKHR by protein kinase B.
Topics: 3-Phosphoinositide-Dependent Protein Kinases; Amino Acid Sequence; Androstadienes; Antibody Specificity; bcl-Associated Death Protein; Caenorhabditis elegans Proteins; Carrier Proteins; Consensus Sequence; DNA-Binding Proteins; Enzyme Activation; Forkhead Box Protein O1; Forkhead Transcription Factors; Humans; Insulin-Like Growth Factor I; Molecular Sequence Data; Phosphoinositide-3 Kinase Inhibitors; Phosphorylation; Phosphoserine; Phosphothreonine; Protein Processing, Post-Translational; Protein Serine-Threonine Kinases; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-akt; Recombinant Proteins; Serine; Signal Transduction; Sirolimus; Threonine; Transcription Factors; Wortmannin | 1999 |
Regulation of 4E-BP1 phosphorylation: a novel two-step mechanism.
Topics: Adaptor Proteins, Signal Transducing; Amino Acid Sequence; Antigen-Antibody Complex; Binding Sites; Carrier Proteins; Cell Cycle Proteins; Cell Line; Chromones; Culture Media, Serum-Free; Eukaryotic Initiation Factor-4E; Humans; Immunophilins; Molecular Sequence Data; Morpholines; Peptide Initiation Factors; Phosphoproteins; Phosphorylation; Phosphotransferases (Alcohol Group Acceptor); Protein Isoforms; Protein Kinases; Recombinant Fusion Proteins; Sirolimus; Threonine; TOR Serine-Threonine Kinases | 1999 |
Mammalian TOR controls one of two kinase pathways acting upon nPKCdelta and nPKCepsilon.
Topics: Allosteric Regulation; Amino Acids; Cell Line; Chromones; Dose-Response Relationship, Drug; Enzyme Inhibitors; Humans; Isoenzymes; Leucine; Morpholines; Naphthalenes; Phosphorylation; Phosphotransferases (Alcohol Group Acceptor); Precipitin Tests; Protein Kinase C; Protein Kinase C-delta; Protein Kinase C-epsilon; Protein Kinases; Serine; Signal Transduction; Sirolimus; Threonine; TOR Serine-Threonine Kinases; Transfection | 1999 |
Multiple mechanisms control phosphorylation of PHAS-I in five (S/T)P sites that govern translational repression.
Topics: Amino Acids; Carrier Proteins; Eukaryotic Initiation Factor-4E; Insulin; Mutation; Peptide Initiation Factors; Phosphoproteins; Phosphorylation; Protein Biosynthesis; Repressor Proteins; RNA Caps; Serine; Sirolimus; Threonine | 2000 |
Insulin receptor substrate-1, p70S6K, and cell size in transformation and differentiation of hemopoietic cells.
Topics: Animals; Antibiotics, Antineoplastic; Cell Cycle; Cell Differentiation; Cell Division; Cell Size; Cell Transformation, Neoplastic; Culture Media, Serum-Free; Enzyme Activation; Enzyme Inhibitors; Hematopoietic Stem Cells; Humans; Insulin Receptor Substrate Proteins; Interleukin-3; Liver; Mice; Mice, Nude; Neoplasm Transplantation; Neoplasms, Experimental; Okadaic Acid; Peroxidase; Phenotype; Phosphoproteins; Phosphorylation; Ribosomal Protein S6 Kinases; RNA, Messenger; Sirolimus; Spleen; Threonine; Time Factors; Transfection; Tumor Cells, Cultured | 2000 |
Insulin-like growth factor-1-induced phosphorylation of the forkhead family transcription factor FKHRL1 is mediated by Akt kinase in PC12 cells.
Topics: 3T3 Cells; Androstadienes; Animals; Apoptosis; Blotting, Western; Cell Line; Cells, Cultured; Cerebellum; Cerebral Cortex; DNA-Binding Proteins; Dose-Response Relationship, Drug; Enzyme Inhibitors; Flavonoids; Forkhead Box Protein O1; Forkhead Box Protein O3; Forkhead Transcription Factors; Humans; Insulin-Like Growth Factor I; Mice; Mutagenesis; Myristic Acid; Nerve Tissue Proteins; Neurons; PC12 Cells; Phosphatidylinositol 3-Kinases; Phosphoinositide-3 Kinase Inhibitors; Phosphorylation; Precipitin Tests; Protein Serine-Threonine Kinases; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-akt; Rats; Rats, Sprague-Dawley; Ribosomal Protein S6 Kinases; Serine; Sirolimus; Threonine; Transcription Factors; Transfection; Vanadates; Wortmannin | 2000 |
Serine/threonine phosphorylation of IRS-1 triggers its degradation: possible regulation by tyrosine phosphorylation.
Topics: 3T3 Cells; Androstadienes; Animals; Cysteine Endopeptidases; Enzyme Inhibitors; Insulin; Insulin Receptor Substrate Proteins; Mice; Multienzyme Complexes; Okadaic Acid; Phosphoproteins; Phosphorylation; Proteasome Endopeptidase Complex; Protein Kinase Inhibitors; Serine; Sirolimus; Threonine; Time Factors; Tyrosine; Vanadates; Wortmannin | 2001 |
Serotonin activates S6 kinase in a rapamycin-sensitive manner in Aplysia synaptosomes.
Topics: 3-Phosphoinositide-Dependent Protein Kinases; Animals; Anti-Bacterial Agents; Aplysia; Binding Sites; Cell Line; Enzyme Inhibitors; Long-Term Potentiation; Marine Toxins; Molecular Sequence Data; Neuronal Plasticity; Oxazoles; Phosphoinositide-3 Kinase Inhibitors; Phosphorylation; Protein Serine-Threonine Kinases; Ribosomal Protein S6; Ribosomal Protein S6 Kinases; Ribosomal Proteins; Serotonin; Sirolimus; Spodoptera; Synapses; Synaptosomes; Threonine | 2001 |
Mammalian target of rapamycin pathway regulates insulin signaling via subcellular redistribution of insulin receptor substrate 1 and integrates nutritional signals and metabolic signals of insulin.
Topics: Acetylcysteine; Adaptor Proteins, Signal Transducing; Adenoviridae; Amino Acids; Animals; Biological Transport; Carrier Proteins; Cell Cycle Proteins; Cell Line; Cysteine Endopeptidases; Cytosol; Deoxyglucose; Down-Regulation; Enzyme Inhibitors; Eukaryotic Initiation Factors; Glucose; Humans; Immunoblotting; Insulin; Insulin Receptor Substrate Proteins; Mice; Multienzyme Complexes; Phosphoproteins; Phosphorylation; Precipitin Tests; Proteasome Endopeptidase Complex; Protein Binding; Protein Kinases; Protein Serine-Threonine Kinases; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-akt; Ribosomal Protein S6 Kinases; Serine; Signal Transduction; Sirolimus; Subcellular Fractions; Threonine; Time Factors; TOR Serine-Threonine Kinases; Tyrosine | 2001 |
Hierarchical phosphorylation of the translation inhibitor 4E-BP1.
Topics: Adaptor Proteins, Signal Transducing; Amino Acid Sequence; Blotting, Western; Carrier Proteins; Cell Cycle Proteins; Cell Line; DNA Mutational Analysis; Dose-Response Relationship, Drug; Electrophoresis, Polyacrylamide Gel; Enzyme Inhibitors; Humans; Isoelectric Focusing; Mass Spectrometry; Molecular Sequence Data; Mutation; Peptide Mapping; Phosphoproteins; Phosphorylation; Protein Biosynthesis; Ribosomes; RNA, Messenger; Sequence Homology, Amino Acid; Serine; Sirolimus; Spectrometry, Fluorescence; Threonine; Transfection | 2001 |
MID1 and MID2 homo- and heterodimerise to tether the rapamycin-sensitive PP2A regulatory subunit, alpha 4, to microtubules: implications for the clinical variability of X-linked Opitz GBBB syndrome and other developmental disorders.
Topics: Amino Acid Motifs; Binding Sites; Dimerization; Genetic Diseases, X-Linked; Humans; Ligases; Microtubule Proteins; Microtubule-Associated Proteins; Microtubules; Nuclear Proteins; Phosphoprotein Phosphatases; Phosphorylation; Protein Binding; Protein Subunits; Regulatory Sequences, Nucleic Acid; Sequence Deletion; Serine; Signal Transduction; Sirolimus; Smith-Lemli-Opitz Syndrome; Threonine; Transcription Factors; Two-Hybrid System Techniques; Ubiquitin-Protein Ligases | 2002 |
Regulation of an activated S6 kinase 1 variant reveals a novel mammalian target of rapamycin phosphorylation site.
Topics: Androstadienes; Animals; Antibiotics, Antineoplastic; Binding Sites; Cell Line; Enzyme Inhibitors; Genes, Dominant; Glutathione Transferase; Humans; Immunoblotting; Insulin; Phosphorylation; Plasmids; Precipitin Tests; Protein Binding; Protein Structure, Tertiary; Recombinant Fusion Proteins; Ribosomal Protein S6 Kinases; Serine; Sirolimus; Threonine; Transfection; Wortmannin | 2002 |
c-Raf/MEK/ERK pathway controls protein kinase C-mediated p70S6K activation in adult cardiac muscle cells.
Topics: Adenoviridae; Animals; Blotting, Western; Butadienes; Cats; Cells, Cultured; Cyclic AMP-Dependent Protein Kinases; Detergents; Dose-Response Relationship, Drug; Dual Specificity Phosphatase 1; Electrophoresis, Polyacrylamide Gel; Enzyme Activation; Enzyme Inhibitors; Genes, Dominant; Insulin; MAP Kinase Kinase 1; MAP Kinase Kinase 2; Mitogen-Activated Protein Kinase Kinases; Mitogen-Activated Protein Kinases; Myocardium; Nitriles; Phosphatidylinositol 3-Kinases; Phosphorylation; Protein Binding; Protein Isoforms; Protein Kinase C; Protein Phosphatase 1; Protein Serine-Threonine Kinases; Protein Tyrosine Phosphatases; Protein-Tyrosine Kinases; Proto-Oncogene Proteins c-raf; Ribosomal Protein S6 Kinases; Signal Transduction; Sirolimus; Tetradecanoylphorbol Acetate; Threonine; Time Factors | 2002 |
The rapamycin-binding domain governs substrate selectivity by the mammalian target of rapamycin.
Topics: Adaptor Proteins, Signal Transducing; Antibiotics, Antineoplastic; Binding Sites; Carrier Proteins; Cell Cycle Proteins; Cell Line; DNA, Complementary; Dose-Response Relationship, Drug; Humans; Kinetics; Models, Biological; Mutagenesis, Site-Directed; Mutation; Phosphoproteins; Phosphorylation; Protein Binding; Protein Kinases; Protein Structure, Tertiary; Recombinant Proteins; Ribosomal Protein S6 Kinases, 70-kDa; Serine; Sirolimus; Substrate Specificity; Threonine; Time Factors; TOR Serine-Threonine Kinases; Transfection | 2002 |
Mutational analysis of ribosomal S6 kinase 2 shows differential regulation of its kinase activity from that of ribosomal S6 kinase 1.
Topics: 3-Phosphoinositide-Dependent Protein Kinases; Androstadienes; Antineoplastic Agents; Cells, Cultured; Humans; Immunosuppressive Agents; MAP Kinase Signaling System; Mitogen-Activated Protein Kinase Kinases; Mitogen-Activated Protein Kinases; Mutagenesis, Site-Directed; Mutation; Phosphoinositide-3 Kinase Inhibitors; Phosphorylation; Precipitin Tests; Proline; Protein Serine-Threonine Kinases; Ribosomal Protein S6 Kinases, 90-kDa; Serine; Signal Transduction; Sirolimus; Threonine; Transfection; Wortmannin | 2003 |
Mechanism of ribosomal p70S6 kinase activation by granulocyte macrophage colony-stimulating factor in neutrophils: cooperation of a MEK-related, THR421/SER424 kinase and a rapamycin-sensitive, m-TOR-related THR389 kinase.
Topics: 3T3 Cells; Alkaline Phosphatase; Animals; Blotting, Western; Dose-Response Relationship, Drug; Enzyme Activation; Enzyme Inhibitors; Flavonoids; Granulocyte-Macrophage Colony-Stimulating Factor; Immunosuppressive Agents; Inhibitory Concentration 50; Kinetics; MAP Kinase Signaling System; Mice; Models, Biological; Neutrophils; Phosphorylation; Precipitin Tests; Protein Kinases; Ribosomal Protein S6 Kinases, 70-kDa; Ribosomes; Sirolimus; Threonine; Time Factors; TOR Serine-Threonine Kinases | 2003 |
Ser-64 and Ser-111 in PHAS-I are dispensable for insulin-stimulated dissociation from eIF4E.
Topics: Adaptor Proteins, Signal Transducing; Alanine; Binding Sites; Carrier Proteins; Cell Cycle Proteins; Cell Line; DNA, Complementary; Eukaryotic Initiation Factor-4E; Eukaryotic Initiation Factors; Genetic Vectors; Humans; Insulin; Mutation; Phosphoproteins; Phosphorylation; Precipitin Tests; Protein Binding; Protein Biosynthesis; Protein Isoforms; Protein Structure, Tertiary; Serine; Sirolimus; Threonine; Transfection | 2003 |
Functional characterization of a maize ribosomal S6 protein kinase (ZmS6K), a plant ortholog of metazoan p70(S6K).
Topics: Animals; Antigen-Antibody Reactions; DNA, Complementary; Enzyme Activation; Germination; Humans; Immune Sera; Insulin; Molecular Weight; Phosphorylation; Plant Proteins; Precipitin Tests; Ribosomal Protein S6 Kinases; Ribosomal Protein S6 Kinases, 70-kDa; Sequence Homology, Amino Acid; Sirolimus; Threonine; Zea mays | 2004 |
Thr2446 is a novel mammalian target of rapamycin (mTOR) phosphorylation site regulated by nutrient status.
Topics: Aminoimidazole Carboxamide; AMP-Activated Protein Kinases; Animals; CHO Cells; Cricetinae; Dinitrophenols; Enzyme Activation; Humans; Insulin; Mice; Multienzyme Complexes; Phosphorylation; Protein Biosynthesis; Protein Kinases; Protein Serine-Threonine Kinases; Ribonucleotides; Signal Transduction; Sirolimus; Threonine; TOR Serine-Threonine Kinases | 2004 |
In rat hepatocytes glucagon increases mammalian target of rapamycin phosphorylation on serine 2448 but antagonizes the phosphorylation of its downstream targets induced by insulin and amino acids.
Topics: Amino Acids; Animals; Binding Sites; Biological Transport; Blotting, Western; Carrier Proteins; Cells, Cultured; Cyclic AMP; Dose-Response Relationship, Drug; Electrophoresis, Polyacrylamide Gel; Glucagon; Hepatocytes; Immunoprecipitation; Insulin; Intracellular Signaling Peptides and Proteins; Male; Okadaic Acid; Phosphoproteins; Phosphorylation; Protein Kinases; Protein Serine-Threonine Kinases; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-akt; Rats; Rats, Wistar; Recombinant Proteins; Serine; Sirolimus; Threonine; Time Factors; TOR Serine-Threonine Kinases | 2004 |
Autocrine transforming growth factor alpha regulates cell adhesion by multiple signaling via specific phosphorylation sites of p70S6 kinase in colon cancer cells.
Topics: Autocrine Communication; Binding Sites; Biotinylation; Blotting, Western; Cell Adhesion; Cell Culture Techniques; Cell Line, Tumor; Cell Movement; Colonic Neoplasms; Dose-Response Relationship, Drug; Enzyme Activation; Enzyme Inhibitors; Gene Expression Regulation; Genes, Dominant; Humans; Immunoblotting; Indoles; Integrin alpha2; Maleimides; Mitogen-Activated Protein Kinase Kinases; Mutation; Phosphorylation; Plasmids; Protein Kinase C; Ribosomal Protein S6 Kinases, 70-kDa; Serine; Signal Transduction; Sirolimus; Threonine; Time Factors; Transfection; Transforming Growth Factor alpha | 2004 |
5-HT stimulates eEF2 dephosphorylation in a rapamycin-sensitive manner in Aplysia neurites.
Topics: Amino Acid Sequence; Animals; Aplysia; Axotomy; Base Sequence; Blotting, Western; Cells, Cultured; Cloning, Molecular; Drug Interactions; Enzyme Inhibitors; Fluorescence Recovery After Photobleaching; Gene Expression Regulation; Immunohistochemistry; Models, Neurological; Neurites; Neurons; Peptide Elongation Factor 2; Phosphorylation; Potassium Chloride; Serotonin; Sirolimus; Synaptosomes; Tacrolimus Binding Protein 1A; Threonine; Time Factors | 2004 |
Distinct signaling events downstream of mTOR cooperate to mediate the effects of amino acids and insulin on initiation factor 4E-binding proteins.
Topics: Adaptor Proteins, Signal Transducing; Amino Acid Sequence; Amino Acids; Animals; Carrier Proteins; Cell Cycle Proteins; Cell Line; Chromones; Cricetinae; Eukaryotic Initiation Factor-4E; Humans; Insulin; Intracellular Signaling Peptides and Proteins; Molecular Sequence Data; Morpholines; Phosphoproteins; Phosphorylation; Protein Binding; Protein Kinases; Rats; Ribosomal Protein S6 Kinases; Sequence Alignment; Serine; Signal Transduction; Sirolimus; Threonine; TOR Serine-Threonine Kinases | 2005 |
Follicle-stimulating hormone activates p70 ribosomal protein S6 kinase by protein kinase A-mediated dephosphorylation of Thr 421/Ser 424 in primary Sertoli cells.
Topics: Animals; Cyclic AMP-Dependent Protein Kinases; Enzyme Activation; Follicle Stimulating Hormone; Male; Phosphoinositide-3 Kinase Inhibitors; Phosphorylation; Protein Kinases; Rats; Ribosomal Protein S6 Kinases, 70-kDa; Serine; Sertoli Cells; Sirolimus; Threonine; TOR Serine-Threonine Kinases | 2005 |
Identification of S6 kinase 1 as a novel mammalian target of rapamycin (mTOR)-phosphorylating kinase.
Topics: Alleles; Androstadienes; Cell Line; Cell Line, Tumor; Culture Media, Serum-Free; Enzyme Inhibitors; Genetic Vectors; Humans; Immunoblotting; Immunoprecipitation; Insulin; Models, Biological; Phorbol Esters; Phosphatidylinositol 3-Kinases; Phosphorylation; Protein Kinases; Protein Structure, Tertiary; Ribosomal Protein S6 Kinases, 90-kDa; RNA, Messenger; RNA, Small Interfering; Serine; Signal Transduction; Sirolimus; Threonine; Time Factors; TOR Serine-Threonine Kinases; Wortmannin | 2005 |
Enhancement of translation elongation in neurons by brain-derived neurotrophic factor: implications for mammalian target of rapamycin signaling.
Topics: Animals; Blotting, Western; Brain-Derived Neurotrophic Factor; Calcium-Calmodulin-Dependent Protein Kinases; Cells, Cultured; Cerebral Cortex; Drug Interactions; Elongation Factor 2 Kinase; Flavonoids; Gene Expression Regulation; Immunohistochemistry; Microtubule-Associated Proteins; Neurons; Peptide Elongation Factor 1; Phosphorus Isotopes; Phosphorylation; Protein Biosynthesis; Protein Kinases; Rats; Ribosomes; RNA, Double-Stranded; Signal Transduction; Sirolimus; Threonine; Time Factors; TOR Serine-Threonine Kinases | 2005 |
FK506 binding protein 12/12.6 depletion increases endothelial nitric oxide synthase threonine 495 phosphorylation and blood pressure.
Topics: Animals; Blood Pressure; Calcium; Endothelium, Vascular; Hypertension; Immunosuppressive Agents; Male; Mice; Mice, Inbred C57BL; Nitric Oxide Synthase Type III; Phosphorylation; Protein Isoforms; Ryanodine Receptor Calcium Release Channel; Sirolimus; Tacrolimus Binding Proteins; Threonine | 2007 |
mTOR is the rapamycin-sensitive kinase that confers mechanically-induced phosphorylation of the hydrophobic motif site Thr(389) in p70(S6k).
Topics: Animals; Cell Line; Hydrophobic and Hydrophilic Interactions; Mice; Phosphorylation; Protein Kinases; Ribosomal Protein S6 Kinases, 70-kDa; Signal Transduction; Sirolimus; Threonine; Time Factors; TOR Serine-Threonine Kinases | 2007 |
Competitive inhibition of amino acid uptake suppresses chlamydial growth: involvement of the chlamydial amino acid transporter BrnQ.
Topics: Amino Acid Transport Systems; Amino Acids; Bacterial Proteins; Biological Transport; Cell Survival; Chlamydia; Chromatography, High Pressure Liquid; Cycloheximide; Electrophoresis, Gel, Two-Dimensional; Gene Expression Regulation, Bacterial; Genetic Complementation Test; Glycine; HeLa Cells; Humans; Isoleucine; Leucine; Methionine; Microscopy, Confocal; Microscopy, Electron, Transmission; Oligonucleotide Array Sequence Analysis; Phenylalanine; Reverse Transcriptase Polymerase Chain Reaction; Serine; Sirolimus; Threonine | 2008 |
S6K1 is involved in polyploidization through its phosphorylation at Thr421/Ser424.
Topics: Adaptor Proteins, Signal Transducing; Androstadienes; Animals; Antineoplastic Agents; Carcinogens; Cell Cycle; Cell Cycle Proteins; Cell Line, Tumor; Chromones; Cyclin B; Enzyme Inhibitors; Humans; Megakaryocytes; Morpholines; Nocodazole; Phosphoproteins; Phosphorylation; Polyploidy; Protein Kinases; Ribosomal Protein S6 Kinases, 90-kDa; Serine; Sirolimus; Tetradecanoylphorbol Acetate; Threonine; TOR Serine-Threonine Kinases; Wortmannin | 2009 |
Involvement of mTORC1 and mTORC2 in regulation of glioblastoma multiforme growth and motility.
Topics: Active Transport, Cell Nucleus; Adaptor Proteins, Signal Transducing; Antibiotics, Antineoplastic; Carrier Proteins; Cell Line, Tumor; Cell Movement; Cell Proliferation; Chromones; Enzyme Activation; Fibronectins; Glioblastoma; Humans; Morpholines; Multiprotein Complexes; Neoplasm Invasiveness; Phosphatidylinositol 3-Kinases; Phosphoinositide-3 Kinase Inhibitors; Phosphorylation; Platelet-Derived Growth Factor; Protein Kinase Inhibitors; Protein Kinases; Proteins; Proto-Oncogene Proteins c-akt; Rapamycin-Insensitive Companion of mTOR Protein; Regulatory-Associated Protein of mTOR; Ribosomal Protein S6 Kinases, 70-kDa; RNA Interference; Serine; Signal Transduction; Sirolimus; STAT3 Transcription Factor; Threonine; Time Factors; TOR Serine-Threonine Kinases | 2009 |
FAK mediates the activation of cardiac fibroblasts induced by mechanical stress through regulation of the mTOR complex.
Topics: Actins; Animals; Animals, Newborn; Apoptosis; Cell Differentiation; Cell Proliferation; Cells, Cultured; Collagen Type I; Enzyme Activation; Fibroblasts; Focal Adhesion Kinase 1; Intracellular Signaling Peptides and Proteins; Leucine; Matrix Metalloproteinase 2; Mechanotransduction, Cellular; Myocardium; Oligopeptides; Phosphorylation; Protein Serine-Threonine Kinases; Proto-Oncogene Proteins c-akt; Rats; Rats, Wistar; Ribosomal Protein S6 Kinases; RNA Interference; Serine; Sirolimus; Stress, Mechanical; Threonine; Time Factors; TOR Serine-Threonine Kinases; Tuberous Sclerosis Complex 2 Protein; Tumor Suppressor Proteins; Tyrosine | 2010 |
Phosphorylation of PRAS40 on Thr246 by PKB/AKT facilitates efficient phosphorylation of Ser183 by mTORC1.
Topics: Adaptor Proteins, Signal Transducing; Androstadienes; Animals; Cell Line; Enzyme Inhibitors; Humans; Insulin; Insulin Resistance; Mice; Muscle, Skeletal; NIH 3T3 Cells; Phosphoproteins; Phosphorylation; Proto-Oncogene Proteins c-akt; Rats; Serine; Sirolimus; Threonine; Transcription Factors; Wortmannin | 2010 |
L-threonine regulates G1/S phase transition of mouse embryonic stem cells via PI3K/Akt, MAPKs, and mTORC pathways.
Topics: Adaptor Proteins, Signal Transducing; Animals; Anti-Bacterial Agents; beta-Cyclodextrins; Carrier Proteins; Caveolae; Caveolin 1; Cell Cycle Proteins; Cell Line; Cyclins; Embryonic Stem Cells; Eukaryotic Initiation Factors; G1 Phase; Mice; Mitogen-Activated Protein Kinase Kinases; Octamer Transcription Factor-3; Phosphatidylinositol 3-Kinases; Phosphoinositide-3 Kinase Inhibitors; Phosphoproteins; Protein Kinase Inhibitors; Proto-Oncogene Proteins c-akt; Proto-Oncogene Proteins c-myc; Ribosomal Protein S6 Kinases, 70-kDa; RNA, Small Interfering; S Phase; Sirolimus; Threonine; TOR Serine-Threonine Kinases | 2011 |
Inhibition of protein synthesis by TOR inactivation revealed a conserved regulatory mechanism of the BiP chaperone in Chlamydomonas.
Topics: Binding Sites; Chlamydomonas reinhardtii; Cycloheximide; Endoplasmic Reticulum Chaperone BiP; Glycosylation; Heat-Shock Proteins; Heat-Shock Response; Phosphorylation; Protein Biosynthesis; Protein Synthesis Inhibitors; Sirolimus; Threonine; TOR Serine-Threonine Kinases; Tunicamycin | 2011 |
Threonine-120 phosphorylation regulated by phosphoinositide-3-kinase/Akt and mammalian target of rapamycin pathway signaling limits the antitumor activity of mammalian sterile 20-like kinase 1.
Topics: Animals; Blotting, Western; Cell Line, Tumor; Cell Nucleus; Chromones; HEK293 Cells; HeLa Cells; Humans; Intracellular Signaling Peptides and Proteins; Male; Mice; Mice, Nude; Morpholines; Neoplasms, Experimental; Phosphatidylinositol 3-Kinases; Phosphoinositide-3 Kinase Inhibitors; Phosphorylation; Prostatic Neoplasms; Protein Serine-Threonine Kinases; Proto-Oncogene Proteins c-akt; Pyrimidines; RNA Interference; Signal Transduction; Sirolimus; Threonine; TOR Serine-Threonine Kinases; Transplantation, Heterologous; Tumor Burden | 2012 |
Isoleucine, leucine, methionine, and threonine effects on mammalian target of rapamycin signaling in mammary tissue.
Topics: Animals; Cattle; Epithelial Cells; Female; Isoleucine; Lactation; Leucine; Mammary Glands, Animal; Methionine; Milk; Milk Proteins; Phosphorylation; Protein Biosynthesis; Proteins; Ribosomal Protein S6; Signal Transduction; Sirolimus; Threonine; TOR Serine-Threonine Kinases | 2014 |
Increases of SET level and translocation are correlated with tau hyperphosphorylation at ser202/thr205 in CA1 of Ts65Dn mice.
Topics: Amyloid beta-Protein Precursor; Animals; Brain; CA1 Region, Hippocampal; Cytoplasm; Disease Models, Animal; DNA-Binding Proteins; Down Syndrome; Gene Expression; Histone Chaperones; Male; Mice; Mice, Inbred Strains; Molecular Targeted Therapy; Oncogene Proteins; Phosphorylation; Protein Phosphatase 2; Protein Transport; Serine; Sirolimus; tau Proteins; Threonine | 2016 |
Varying the ratio of Lys:Met while maintaining the ratios of Thr:Phe, Lys:Thr, Lys:His, and Lys:Val alters mammary cellular metabolites, mammalian target of rapamycin signaling, and gene transcription.
Topics: Amino Acid Sequence; Amino Acid Transport Systems; Amino Acids; Animals; Caseins; Cattle; Epithelial Cells; Female; Histidine; Lactation; Lysine; Mammary Glands, Animal; Milk; Milk Proteins; Phenylalanine; Phosphorylation; Protein Biosynthesis; Signal Transduction; Sirolimus; Threonine; TOR Serine-Threonine Kinases; Transcription, Genetic; Valine | 2018 |
Increasing the availability of threonine, isoleucine, valine, and leucine relative to lysine while maintaining an ideal ratio of lysine:methionine alters mammary cellular metabolites, mammalian target of rapamycin signaling, and gene transcription.
Topics: Amino Acid Sequence; Animals; Cattle; Female; Isoleucine; Leucine; Lysine; Mammary Glands, Animal; Methionine; Peptide Fragments; Sirolimus; Threonine; Transcription, Genetic; Valine | 2018 |
Elevated p70S6K phosphorylation in rat soleus muscle during the early stage of unloading: Causes and consequences.
Topics: Aminoimidazole Carboxamide; AMP-Activated Protein Kinases; Animals; Enzyme Activators; Enzyme Inhibitors; Hindlimb Suspension; Histone Deacetylases; Male; Mechanistic Target of Rapamycin Complex 1; Muscle, Skeletal; Phosphorylation; Rats, Wistar; Ribonucleotides; Ribosomal Protein S6 Kinases, 70-kDa; Sirolimus; Threonine; Ubiquitin-Protein Ligases; Up-Regulation | 2019 |
mTORC1 promotes TOP mRNA translation through site-specific phosphorylation of LARP1.
Topics: Amino Acid Motifs; Autoantigens; HEK293 Cells; Humans; Mechanistic Target of Rapamycin Complex 1; Naphthyridines; Phosphorylation; Protein Binding; Protein Biosynthesis; Ribonucleoproteins; Serine; Sirolimus; SS-B Antigen; Threonine; Tyrosine | 2021 |