threonine has been researched along with okadaic acid in 81 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 24 (29.63) | 18.2507 |
| 2000's | 49 (60.49) | 29.6817 |
| 2010's | 8 (9.88) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Capony, JP; Cavadore, JC; Devault, A; Dorée, M; Fesquet, D; Labbé, JC; Le Bouffant, F; Lorca, T | 1 |
| Lerea, KM | 1 |
| Miyasaka, J; Miyasaka, T; Saltiel, AR | 1 |
| Mimnaugh, EG; Neckers, LM; Whitesell, L; Worland, PJ | 1 |
| Bagrodia, S; Chackalaparampil, I; Shalloway, D | 1 |
| Fetz, I; Fölsch, UR; Höcker, M; Kern, HF; Meyer-Alber, A; Schmidt, WE; Waschulewski, IH | 1 |
| Aperia, A; Celsi, G; da Cruz e Silva, EF; Durbeej, M; Ekblom, P; Laestadius, A; Svennilson, J | 1 |
| Gahmberg, CG; Valmu, L | 1 |
| Terrian, DM; Ways, DK | 1 |
| Grémeaux, T; Le Marchand-Brustel, Y; Tanti, JF; van Obberghen, E | 1 |
| Baggio, B; Bordin, L; Clari, G; Gambaro, G; Moret, V | 1 |
| Liauw, S; Steinberg, RA | 1 |
| Mothe, I; Van Obberghen, E | 1 |
| Artçanuthurry, V; Grelac, F; Levy-Tolédano, S; Maclouf, J; Martin-Cramer, E | 1 |
| de Cingolani, GC; Mattiazzi, A; Mundiña-Weilenmann, C; Ortale, M; Vittone, L | 1 |
| Londos, C; Rondinone, CM; Smith, UP; Zarnowski, MJ | 1 |
| da-Costa-Maia, JC; da-Silva, AM; Terenzi, HF; Zapella, PD | 1 |
| Communi, D; Erneux, C; Vanweyenberg, V | 1 |
| Lee, VM; Merrick, SE; Trojanowski, JQ | 1 |
| Ferreri, NR; Mahboubi, K; Young, W | 1 |
| Ha, KS; Jung, HI; Kang, KW; Park, YM; Shin, I | 1 |
| Bize, I; Brugnara, C; Buchbinder, G; Güvenç, B; Robb, A | 1 |
| Ferrell, JE; Sohaskey, ML | 1 |
| Mattiazzi, A; Mundiña-Weilenmann, C; Said, M; Vittone, L | 1 |
| Kanaho, Y; Watanabe, H | 1 |
| Chang, SJ; Chen, JY; Chen, MR; Huang, H | 1 |
| Furukawa, Y; Iwase, S; Kano, Y; Kikuchi, J; Matsuda, M; Nakamura, M; Terui, Y; Yamada, H | 1 |
| Brunati, AM; Donella-Deana, A; Marin, O; Pinna, LA; Ruzzene, M; Sarno, S | 1 |
| Baserga, R; Edmonds, P; McCormick, J; Morrione, A; Navarro, M; Reiss, K; Romano, G; Sacchi, A; Valentinis, B; Zanocco-Marani, T | 1 |
| Chaudhuri, S; Raha, S | 1 |
| Davare, MA; Hell, JW; Horne, MC | 1 |
| Bartel, S; Karczewski, P; Krause, EG; Schlegel, WP; Vetter, D; Wallukat, G | 1 |
| Kramer, DL; Pederson, TM; Rondinone, CM | 1 |
| Lai, MT; Vlahos, CJ; Zinda, MJ | 1 |
| Bennecib, M; Gong, CX; Grundke-Iqbal, I; Iqbal, K | 1 |
| Anguissola, S; Comoglio, PM; Giordano, S; Gual, P; Parker, PJ | 1 |
| Halestrap, AP; Lockyer, PJ; Moule, SK; O'toole, A | 1 |
| Jin, P; Levitan, IB; Weiger, TM; Wu, Y | 1 |
| Bakó, E; Bíró, T; Czifra, G; Felszeghy, S; Gergely, P; Módis, L; Szucs, K; Zákány, R | 1 |
| Cenni, V; Döppler, H; Maraldi, N; Newton, AC; Sonnenburg, ED; Toker, A | 1 |
| Bryckaert, M; Pawlowski, M; Ragab, A; Rosa, JP | 1 |
| Greif, DM; Kou, R; Michel, T | 1 |
| Armstrong, DL; Birnbaumer, L; Darden, T; Erxleben, C; Gomez-Alegria, C; Mori, Y | 1 |
| Baudouin, E; Hirt, H; Jelinek, H; Jonak, C; Liwosz, A; Meskiene, I; Rodriguez, PL; Schweighofer, A | 1 |
| Gahmberg, CG; Hilden, TJ; Kärkkäinen, S; Valmu, L | 1 |
| Holzman, LB; Nihalani, D; Wong, HN | 1 |
| Akkerman, JW; Ferreira, IA; Gorter, G; Relou, IA; van Rijn, HJ | 1 |
| Guthridge, MA; Lindeman, GJ; Lopez, AF; Olayioye, MA; Stomski, FC; Visvader, JE | 1 |
| Griendling, KK; Rocic, P; Seshiah, P | 1 |
| Suzuki, K; Takahashi, K | 1 |
| Ahn, J; Choi, KR; Chun, JS; Kim, SM; Kwon, MS; Park, CS; Song, WK | 1 |
| Donini, M; Dusi, S; Margotto, D; Mazzi, P; Wientjes, F | 1 |
| Craig, RW; Domina, AM; Gregory, MA; Hann, SR; Vrana, JA | 1 |
| Gautier, N; Hinault, C; Lawrence, JC; Mothe-Satney, I; Van Obberghen, E | 1 |
| Hunter, T; Wang, JY; Woodring, PJ | 1 |
| Arora, A; Choe, ES; Fibuch, EE; Liu, Z; Mao, L; Wang, JQ; Yang, L; Zhang, G | 1 |
| Anderson, CW; Appella, E; Chatterjee, DK; Demidov, ON; Durell, SR; Minopoli, G; Yamaguchi, H | 1 |
| Baran, V; Kalous, J; Kubelka, M; Motlik, J; Schultz, RM; Solc, P | 1 |
| Fukazawa, Y; Gao, Y; Hamabe, W; Kishioka, S; Kumamoto, K; Maeda, T; Ozaki, M | 1 |
| Ballard, DW; Carter, RS; Gomez, RJ; Khan, WN; Kray, AE; Llanes, JM; Pennington, KN; Sanders, LE; Wadzinski, BE | 1 |
| Chen, CS; Lin, HP; Tseng, PH; Weng, SC | 1 |
| Hatano, N; Kume, K; Song, T; Sugimoto, K; Tokuda, M; Watanabe, Y; Yamaguchi, F | 1 |
| Bichsel, SJ; Hemmings, BA; Hergovich, A; Stegert, MR; Tamaskovic, R | 1 |
| Blomhoff, HK; Kloster, MM; Låhne, HU; Lefdal, S; Naderi, S | 1 |
| McKeown-Longo, PJ; Zheng, M | 1 |
| Liang, X; Reed, E; Yu, JJ | 1 |
| Bednorz, A; Didié, M; Ditz, D; Dobrev, D; El-Armouche, A; Eschenhagen, T; Pamminger, T | 1 |
| Block, WD; Cui, X; Ding, Q; Douglas, P; Gupta, S; Lees-Miller, SP; Meek, K; Morrice, N; Ye, R; Yu, Y | 1 |
| Ares, IR; Botana, LM; Cagide, E; Louzao, MC; Vieytes, MR; Vilariño, N; Yasumoto, T | 1 |
| Hata, Y; Hidaka, S; Hirabayashi, S; Ikeda, M; Kawai, T; Kawata, A; Nakagawa, K; Ohno, K; Sumita, K | 1 |
| Ito, Y; Nakayama, K; Obara, K; Shimada, H | 1 |
| Chen, C; Freel, CD; Guo, JY; Kornbluth, S; Nairn, AC; Tang, W; Wu, JQ; Yang, CS | 1 |
| Minchin, RF; Mitchell, DJ | 1 |
| Buscemi, G; Carlessi, L; Delia, D; Fontanella, E | 1 |
| Haruta, M; Nakanishi, M; Niida, H; Sawamoto, K; Shimada, M | 1 |
| Hayashi, K; Kinoshita, T; Takahashi, K | 1 |
| Gray, EE; Guglietta, R; Khakh, BS; O'Dell, TJ | 1 |
| Craig, RW; Kasof, G; Nifoussi, SK; Ornstein, DL; Ratcliffe, NR; Strack, S | 1 |
| Hattori, Y; Ikari, A; Noguchi, Y; Sugatani, J; Yamaguchi, M; Yamazaki, Y | 1 |
| Chang, RC; Ho, YS; Huang, C; Irwin, MG; Ng, OT; Wong, GT | 1 |
| An, BC; Ikebe, M; Ikebe, R; Kim, JY; Kishi, H; Kobayashi, S; Komaba, S; Sakai, T | 1 |
81 other study(ies) available for threonine and okadaic acid
| Article | Year |
|---|---|
Dephosphorylation of cdc2 on threonine 161 is required for cdc2 kinase inactivation and normal anaphase.
Topics: Amino Acid Sequence; Anaphase; Animals; Blotting, Western; CDC2 Protein Kinase; Cyclins; Ethers, Cyclic; Humans; Hydrolysis; Maturation-Promoting Factor; Metaphase; Molecular Sequence Data; Okadaic Acid; Peptide Mapping; Phosphoric Monoester Hydrolases; Phosphorylation; Precipitin Tests; Starfish; Threonine; Xenopus | 1992 |
Thrombin-induced effects are selectively inhibited following treatment of intact human platelets with okadaic acid.
Topics: Blood Platelets; Carrier Proteins; Endoribonucleases; Ethers, Cyclic; Humans; Intracellular Signaling Peptides and Proteins; Okadaic Acid; Phosphoprotein Phosphatases; Phosphorylation; Platelet Activation; Proteins; RNA-Binding Proteins; Serine; Serotonin; Threonine; Thrombin | 1991 |
Okadaic acid stimulates the activity of microtubule associated protein kinase in PC-12 pheochromocytoma cells.
Topics: Adrenal Gland Neoplasms; Animals; Brain; Calcium-Calmodulin-Dependent Protein Kinases; Epidermal Growth Factor; Ethers, Cyclic; Nerve Growth Factors; Okadaic Acid; Pheochromocytoma; Phosphorylation; Protein Kinases; Serine; Swine; Threonine; Tumor Cells, Cultured | 1990 |
Possible role for serine/threonine phosphorylation in the regulation of the heteroprotein complex between the hsp90 stress protein and the pp60v-src tyrosine kinase.
Topics: 3T3 Cells; Animals; Cell Line, Transformed; Cell Membrane; Enzyme Inhibitors; Ethers, Cyclic; HSP90 Heat-Shock Proteins; Mice; Okadaic Acid; Oncogene Protein pp60(v-src); Phosphoprotein Phosphatases; Phosphorylation; Protein-Tyrosine Kinases; Serine; Threonine | 1995 |
Tyrosine dephosphorylation of pp60c-src is stimulated by a serine/threonine phosphatase inhibitor.
Topics: 3T3 Cells; Animals; Enzyme Activation; Ethers, Cyclic; Fibroblasts; Mice; Okadaic Acid; Phosphoprotein Phosphatases; Phosphorylation; Proto-Oncogene Proteins pp60(c-src); Serine; Threonine; Tyrosine | 1994 |
Serine/threonine phosphatases play a role in stimulus-secretion coupling in pancreatic acinar cells.
Topics: Amylases; Animals; Culture Techniques; Cyclosporine; Dose-Response Relationship, Drug; Ethers, Cyclic; Male; Marine Toxins; Microscopy, Electron; Okadaic Acid; Oxazoles; Pancreas; Phosphoprotein Phosphatases; Rats; Rats, Wistar; Secretory Rate; Signal Transduction; Threonine | 1994 |
Evidence for a role of protein phosphatases 1 and 2A during early nephrogenesis.
Topics: Animals; Base Sequence; Carrier Proteins; Cell Differentiation; Cell Division; Cells, Cultured; Enzyme Inhibitors; Ethers, Cyclic; Female; Immunoblotting; In Situ Hybridization; Intracellular Signaling Peptides and Proteins; Kidney; Molecular Sequence Data; Morphogenesis; Okadaic Acid; Phosphoprotein Phosphatases; Pregnancy; Proteins; Rats; Rats, Sprague-Dawley; Serine; Threonine | 1995 |
Treatment with okadaic acid reveals strong threonine phosphorylation of CD18 after activation of CD11/CD18 leukocyte integrins with phorbol esters or CD3 antibodies.
Topics: Alkaloids; CD11 Antigens; CD18 Antigens; Cell Aggregation; Ethers, Cyclic; Humans; Muromonab-CD3; Okadaic Acid; Phorbol 12,13-Dibutyrate; Phosphorylation; Phosphothreonine; Protein Kinase C; Protein Processing, Post-Translational; Protein Serine-Threonine Kinases; Staurosporine; T-Lymphocyte Subsets; Threonine | 1995 |
Persistent enhancement of sustained calcium-dependent glutamate release by phorbol esters: role of calmodulin-independent serine/threonine phosphorylation and actin disassembly.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Actins; Alkaloids; Animals; Barium; Calcium; Calcium-Calmodulin-Dependent Protein Kinases; Calmodulin; Cytochalasin D; Ethers, Cyclic; Glutamates; Guinea Pigs; Hippocampus; Isoquinolines; Male; Okadaic Acid; Phorbol 12,13-Dibutyrate; Phorbol Esters; Phosphorylation; Phosphotransferases; Piperazines; Protein Kinase C; Serine; Sphingosine; Staurosporine; Subcellular Fractions; Sulfonamides; Synaptosomes; Threonine | 1995 |
Serine/threonine phosphorylation of insulin receptor substrate 1 modulates insulin receptor signaling.
Topics: 3T3 Cells; Adipocytes; Animals; Electrophoresis, Polyacrylamide Gel; Ethers, Cyclic; Glucose; Insulin; Insulin Receptor Substrate Proteins; Mice; Okadaic Acid; Phosphatidylinositol 3-Kinases; Phosphoproteins; Phosphorylation; Phosphotransferases (Alcohol Group Acceptor); Receptor, Insulin; Serine; Signal Transduction; Threonine; Tyrosine | 1994 |
Functional correlation between the Ser/Thr-phosphorylation of band-3 and band-3-mediated transmembrane anion transport in human erythrocytes.
Topics: Anion Exchange Protein 1, Erythrocyte; Biological Transport; Erythrocytes; Ethers, Cyclic; Humans; Okadaic Acid; Oxalates; Phosphoprotein Phosphatases; Phosphorylation; Serine; Threonine | 1993 |
Dephosphorylation of catalytic subunit of cAMP-dependent protein kinase at Thr-197 by a cellular protein phosphatase and by purified protein phosphatase-2A.
Topics: Animals; Catalysis; Cyclic AMP-Dependent Protein Kinases; Enzyme Inhibitors; Ethers, Cyclic; Mice; Okadaic Acid; Osmolar Concentration; Phosphoprotein Phosphatases; Phosphorylation; Protein Phosphatase 2; Threonine; Tumor Cells, Cultured | 1996 |
Phosphorylation of insulin receptor substrate-1 on multiple serine residues, 612, 632, 662, and 731, modulates insulin action.
Topics: Amino Acid Sequence; Animals; Calcium-Calmodulin-Dependent Protein Kinases; Cell Line; Cloning, Molecular; Enzyme Inhibitors; Ethers, Cyclic; Flavonoids; Humans; Insulin; Insulin Receptor Substrate Proteins; Molecular Sequence Data; Okadaic Acid; Phosphatidylinositol 3-Kinases; Phosphoproteins; Phosphorylation; Phosphotransferases (Alcohol Group Acceptor); Point Mutation; Rats; Recombinant Proteins; Serine; Threonine; Transfection | 1996 |
Serine/threonine dephosphorylation may be involved in tyrosine phosphorylation: a new mode of signal transduction in platelets.
Topics: Blood Platelets; Humans; Okadaic Acid; Phosphorylation; Platelet Aggregation; Serine; Signal Transduction; Threonine; Tyrosine | 1996 |
Immunodetection of phosphorylation sites gives new insights into the mechanisms underlying phospholamban phosphorylation in the intact heart.
Topics: Adenosine Triphosphatases; Animals; Binding Sites; Calcium-Binding Proteins; Calcium-Calmodulin-Dependent Protein Kinases; Dose-Response Relationship, Drug; Isoproterenol; Male; Myocardium; Okadaic Acid; Phosphorylation; Rats; Rats, Wistar; Serine; Threonine | 1996 |
The inhibitory effect of staurosporine on insulin action is prevented by okadaic acid. Evidence for an important role of serine/threonine phosphorylation in eliciting insulin-like effects.
Topics: Animals; Biological Transport; Enzyme Activation; Enzyme Inhibitors; Glucose; Insulin; Insulin Antagonists; Male; Okadaic Acid; Phosphatidylinositol 3-Kinases; Phosphoprotein Phosphatases; Phosphorylation; Phosphotransferases (Alcohol Group Acceptor); Protein Kinases; Protein Phosphatase 1; Rats; Receptor, Insulin; Serine; Staurosporine; Threonine; Tyrosine | 1996 |
Serine/threonine protein phosphatases and a protein phosphatase 1 inhibitor from Neurospora crassa.
Topics: Animals; Chromatography; Neurospora crassa; Okadaic Acid; Phosphoprotein Phosphatases; Protein Phosphatase 1; Rats; Serine; Substrate Specificity; Threonine | 1996 |
D-myo-inositol 1,4,5-trisphosphate 3-kinase A is activated by receptor activation through a calcium:calmodulin-dependent protein kinase II phosphorylation mechanism.
Topics: Animals; Calcium; Calcium-Calmodulin-Dependent Protein Kinase Type 2; Calcium-Calmodulin-Dependent Protein Kinases; Carbachol; Cerebral Cortex; CHO Cells; Cricetinae; Enzyme Activation; Enzyme Inhibitors; Humans; Male; Muscarinic Agonists; Okadaic Acid; Phosphorylation; Phosphotransferases (Alcohol Group Acceptor); Rats; Rats, Sprague-Dawley; Receptors, Purinergic P2; Receptors, Purinergic P2Y2; Threonine; Uridine Triphosphate | 1997 |
Selective destruction of stable microtubules and axons by inhibitors of protein serine/threonine phosphatases in cultured human neurons.
Topics: Axons; Enzyme Inhibitors; Humans; Marine Toxins; Microtubules; Neurons; Okadaic Acid; Oxazoles; Serine; Threonine; Tumor Cells, Cultured | 1997 |
Induction of prostaglandin endoperoxide synthase-2 by serine-threonine phosphatase inhibition.
Topics: Animals; Dose-Response Relationship, Drug; Enzyme Induction; Female; Isoenzymes; Mice; Mice, Inbred C57BL; NF-kappa B; Okadaic Acid; Phosphoprotein Phosphatases; Phosphorylation; Prostaglandin-Endoperoxide Synthases; Proto-Oncogene Proteins; RNA, Messenger; Serine; Threonine; Transcription Factor RelB; Transcription Factors | 1997 |
Colchicine activates actin polymerization by microtubule depolymerization.
Topics: 3T3 Cells; Actins; Animals; Biopolymers; Cell Line; Colchicine; Enzyme Activation; Enzyme Inhibitors; Marine Toxins; Mice; Microtubules; Okadaic Acid; Oxazoles; Phospholipase D; Phosphoprotein Phosphatases; Phosphorylation; Protein Kinase C; Rats; Serine; Threonine; Type C Phospholipases | 1997 |
Serine/threonine protein phosphatases and regulation of K-Cl cotransport in human erythrocytes.
Topics: Anemia, Sickle Cell; Biological Transport; Carrier Proteins; Cell Size; Cytosol; Dehydration; Enzyme Inhibitors; Erythrocytes; Humans; Ionophores; K Cl- Cotransporters; Marine Toxins; Membrane Proteins; Nystatin; Okadaic Acid; Osmolar Concentration; Oxazoles; Phosphoprotein Phosphatases; Serine; Symporters; Threonine; Water-Electrolyte Balance | 1999 |
Distinct, constitutively active MAPK phosphatases function in Xenopus oocytes: implications for p42 MAPK regulation In vivo.
Topics: Animals; Enzyme Activation; Kinetics; MAP Kinase Kinase 1; Meiosis; Microinjections; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase Kinases; Okadaic Acid; Oocytes; Phosphoprotein Phosphatases; Phosphorylation; Protein Phosphatase 2; Protein Serine-Threonine Kinases; Protein Tyrosine Phosphatases; Threonine; Tyrosine; Vanadates; Xenopus | 1999 |
Phosphorylation of the Thr17 residue of phospholamban. New insights into the physiological role of the CaMK-II pathway of phospholamban phosphorylation.
Topics: Animals; Calcium-Binding Proteins; Calcium-Calmodulin-Dependent Protein Kinase Type 2; Calcium-Calmodulin-Dependent Protein Kinases; In Vitro Techniques; Kinetics; Myocardium; Okadaic Acid; Phosphorylation; Phosphothreonine; Rats; Rats, Wistar; Threonine | 1998 |
Inhibition of phosphatidylinositol 4,5-bisphosphate-stimulated phospholipase D2 activity by Ser/Thr phosphorylation.
Topics: Animals; COS Cells; Enzyme Inhibitors; HeLa Cells; Humans; Okadaic Acid; Phosphatidylinositol 4,5-Diphosphate; Phospholipase D; Phosphorylation; Serine; Threonine; Transfection | 2000 |
A protein kinase activity associated with Epstein-Barr virus BGLF4 phosphorylates the viral early antigen EA-D in vitro.
Topics: Amino Acid Sequence; Antigens, Viral; Cloning, Molecular; Cytoplasm; Enzyme Inhibitors; Escherichia coli; Heparin; Herpesvirus 4, Human; Immune Sera; Kinetics; Molecular Sequence Data; Okadaic Acid; Phosphorylation; Protein Kinases; Protein Serine-Threonine Kinases; Sequence Homology, Amino Acid; Serine; Threonine; Viral Proteins | 2000 |
Phosphorylation of Bcl-2 protein by CDC2 kinase during G2/M phases and its role in cell cycle regulation.
Topics: Amino Acid Substitution; CDC2 Protein Kinase; Cell Cycle; Cyclin B; G2 Phase; Genes, bcl-2; HL-60 Cells; Homeostasis; Humans; Kinetics; Mitosis; Mutagenesis, Site-Directed; Okadaic Acid; Peptide Fragments; Phosphopeptides; Phosphorylation; Proto-Oncogene Proteins c-bcl-2; Recombinant Proteins; Threonine; Transfection | 2000 |
Ser/Thr phosphorylation of hematopoietic specific protein 1 (HS1): implication of protein kinase CK2.
Topics: Adaptor Proteins, Signal Transducing; Amino Acid Sequence; Blood Platelets; Blood Proteins; Blotting, Western; Casein Kinase II; Enzyme Inhibitors; Humans; Kinetics; Molecular Sequence Data; Okadaic Acid; Phosphates; Phosphorylation; Polylysine; Precipitin Tests; Protein Serine-Threonine Kinases; Protein-Tyrosine Kinases; Recombinant Proteins; Serine; Threonine | 2000 |
Insulin receptor substrate-1, p70S6K, and cell size in transformation and differentiation of hemopoietic cells.
Topics: Animals; Antibiotics, Antineoplastic; Cell Cycle; Cell Differentiation; Cell Division; Cell Size; Cell Transformation, Neoplastic; Culture Media, Serum-Free; Enzyme Activation; Enzyme Inhibitors; Hematopoietic Stem Cells; Humans; Insulin Receptor Substrate Proteins; Interleukin-3; Liver; Mice; Mice, Nude; Neoplasm Transplantation; Neoplasms, Experimental; Okadaic Acid; Peroxidase; Phenotype; Phosphoproteins; Phosphorylation; Ribosomal Protein S6 Kinases; RNA, Messenger; Sirolimus; Spleen; Threonine; Time Factors; Transfection; Tumor Cells, Cultured | 2000 |
Inhibition and stimulation of growth of Entamoeba histolytica in culture: association with PKC activity and protein phosphorylation.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Animals; Culture Media; Down-Regulation; Entamoeba histolytica; Enzyme Inhibitors; Indoles; Maleimides; Marine Toxins; Okadaic Acid; Oxazoles; Phosphorylation; Protein Kinase C; Tetradecanoylphorbol Acetate; Threonine | 2000 |
Protein phosphatase 2A is associated with class C L-type calcium channels (Cav1.2) and antagonizes channel phosphorylation by cAMP-dependent protein kinase.
Topics: Amino Acids; Animals; Brain; Calcium Channels, L-Type; Catalytic Domain; Cell Line; Cyclic AMP-Dependent Protein Kinases; Enzyme Inhibitors; Escherichia coli; Glutathione Transferase; Humans; Immunoblotting; Inhibitory Concentration 50; Ionophores; Microcystins; Okadaic Acid; Peptides, Cyclic; Phosphoprotein Phosphatases; Phosphorylation; Precipitin Tests; Protein Binding; Protein Kinase C; Protein Phosphatase 2; Protein Structure, Tertiary; Rats; Recombinant Fusion Proteins; Serine; Threonine | 2000 |
Phosphorylation of phospholamban at threonine-17 in the absence and presence of beta-adrenergic stimulation in neonatal rat cardiomyocytes.
Topics: 3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl ester; Adrenergic beta-Agonists; Animals; Animals, Newborn; Blotting, Western; Calcium; Calcium Channel Agonists; Calcium-Binding Proteins; Calcium-Calmodulin-Dependent Protein Kinase Type 2; Calcium-Calmodulin-Dependent Protein Kinases; Cells, Cultured; Cyclic AMP; Dose-Response Relationship, Drug; Enzyme Inhibitors; Ionophores; Isoproterenol; Myocardium; Okadaic Acid; Phosphorylation; Rats; Rats, Wistar; Ryanodine; Sarcoplasmic Reticulum; Serine; Signal Transduction; Thapsigargin; Threonine; Time Factors | 2000 |
Serine/threonine phosphorylation of IRS-1 triggers its degradation: possible regulation by tyrosine phosphorylation.
Topics: 3T3 Cells; Androstadienes; Animals; Cysteine Endopeptidases; Enzyme Inhibitors; Insulin; Insulin Receptor Substrate Proteins; Mice; Multienzyme Complexes; Okadaic Acid; Phosphoproteins; Phosphorylation; Proteasome Endopeptidase Complex; Protein Kinase Inhibitors; Serine; Sirolimus; Threonine; Time Factors; Tyrosine; Vanadates; Wortmannin | 2001 |
Ceramide induces the dephosphorylation and inhibition of constitutively activated Akt in PTEN negative U87mg cells.
Topics: Androstadienes; Blotting, Western; Chromatography, High Pressure Liquid; Dose-Response Relationship, Drug; Electrophoresis, Polyacrylamide Gel; Enzyme Inhibitors; Humans; Marine Toxins; Okadaic Acid; Oxazoles; Phosphatidylinositol Phosphates; Phosphatidylinositols; Phosphoric Monoester Hydrolases; Phosphorylation; Precipitin Tests; Protein Serine-Threonine Kinases; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-akt; PTEN Phosphohydrolase; Serine; Sphingosine; Threonine; Time Factors; Tumor Cells, Cultured; Tumor Suppressor Proteins; Wortmannin | 2001 |
Inhibition of PP-2A upregulates CaMKII in rat forebrain and induces hyperphosphorylation of tau at Ser 262/356.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Animals; Blotting, Western; Calcium-Calmodulin-Dependent Protein Kinase Type 2; Calcium-Calmodulin-Dependent Protein Kinases; Enzyme Inhibitors; Female; Ionophores; Marine Toxins; Okadaic Acid; Oxazoles; Phosphoprotein Phosphatases; Phosphorylation; Prosencephalon; Rats; Rats, Wistar; Serine; tau Proteins; Threonine; Time Factors; Up-Regulation | 2001 |
Gab1 phosphorylation: a novel mechanism for negative regulation of HGF receptor signaling.
Topics: Adaptor Proteins, Signal Transducing; Animals; Cell Communication; Cells, Cultured; Enzyme Activation; Enzyme Inhibitors; Female; Hepatocyte Growth Factor; Humans; Isoenzymes; Okadaic Acid; Phosphoprotein Phosphatases; Phosphoproteins; Phosphorylation; Protein Kinase C; Protein Kinase C beta; Protein Kinase C-alpha; Proto-Oncogene Proteins c-met; Serine; Signal Transduction; src Homology Domains; Staurosporine; Threonine | 2001 |
Tumour necrosis factor-alpha activation of protein kinase B in WEHI-164 cells is accompanied by increased phosphorylation of Ser473, but not Thr308.
Topics: 3-Phosphoinositide-Dependent Protein Kinases; Animals; Antineoplastic Agents; Cell Line; Cell Membrane; Cell Survival; Enzyme Activation; Enzyme Inhibitors; GTPase-Activating Proteins; Humans; Insulin-Like Growth Factor I; Okadaic Acid; Phosphatidylinositol 3-Kinases; Phosphatidylinositol Phosphates; Phosphorylation; Protein Serine-Threonine Kinases; Protein Transport; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-akt; Recombinant Proteins; Serine; Signal Transduction; Threonine; Transfection; Tumor Necrosis Factor-alpha | 2001 |
Phosphorylation-dependent functional coupling of hSlo calcium-dependent potassium channel and its hbeta 4 subunit.
Topics: Animals; Binding Sites; Blotting, Western; Cell Line; CHO Cells; Cricetinae; Electrophysiology; Enzyme Inhibitors; Humans; Kinetics; Large-Conductance Calcium-Activated Potassium Channel alpha Subunits; Large-Conductance Calcium-Activated Potassium Channels; Mutation; Okadaic Acid; Phosphoprotein Phosphatases; Phosphorylation; Potassium Channels; Potassium Channels, Calcium-Activated; Precipitin Tests; Protein Binding; Protein Structure, Tertiary; Serine; Threonine; Time Factors | 2002 |
Protein phosphatase 2A is involved in the regulation of protein kinase A signaling pathway during in vitro chondrogenesis.
Topics: Animals; Cartilage; Cell Differentiation; Cell Division; Cells, Cultured; Chick Embryo; Chondrocytes; Chondrogenesis; Cyclic AMP Response Element-Binding Protein; Cyclic AMP-Dependent Protein Kinases; Dose-Response Relationship, Drug; Enzyme Inhibitors; Isoquinolines; Limb Buds; Okadaic Acid; Phosphoprotein Phosphatases; Phosphorylation; Protein Phosphatase 2; Serine; Signal Transduction; Sulfonamides; Threonine; Time Factors | 2002 |
Regulation of novel protein kinase C epsilon by phosphorylation.
Topics: 3-Phosphoinositide-Dependent Protein Kinases; 3T3 Cells; Amino Acid Sequence; Animals; Enzyme Inhibitors; Humans; Isoenzymes; Mice; Molecular Sequence Data; Okadaic Acid; Phosphorylation; Protein Kinase C; Protein Kinase C-epsilon; Protein Serine-Threonine Kinases; Sequence Alignment; Serine; Threonine | 2002 |
Selective dephosphorylation of the threonine(183) residue of ERK2 upon (alpha)llb(beta)3 engagement in platelets.
Topics: Actins; Animals; Blood Platelets; Cattle; Cytoskeleton; Detergents; Enzyme Activation; Mitogen-Activated Protein Kinase 1; Octoxynol; Okadaic Acid; Phosphoprotein Phosphatases; Phosphorylation; Phosphothreonine; Platelet Glycoprotein GPIIb-IIIa Complex; Protein Phosphatase 1; Solubility; Subcellular Fractions; Threonine; Thrombin | 2002 |
Site-specific dephosphorylation of endothelial nitric oxide synthase by protein phosphatase 2A: evidence for crosstalk between phosphorylation sites.
Topics: Animals; Cattle; Cell Line; COS Cells; Enzyme Activation; Enzyme Inhibitors; Marine Toxins; Mutagenesis, Site-Directed; Nitric Oxide Synthase; Nitric Oxide Synthase Type III; Okadaic Acid; Oxazoles; Phosphates; Phosphoprotein Phosphatases; Phosphorus Radioisotopes; Phosphorylation; Protein Phosphatase 2; Serine; Signal Transduction; Threonine; Transfection | 2002 |
Modulation of cardiac Ca(V)1.2 channels by dihydropyridine and phosphatase inhibitor requires Ser-1142 in the domain III pore loop.
Topics: 3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl ester; Adenosine Triphosphate; Animals; Calcium Channel Agonists; Calcium Channels; Calcium Channels, L-Type; Cell Line; Cell Membrane; Cricetinae; Dihydropyridines; Electrophysiology; Enzyme Inhibitors; Models, Molecular; Mutagenesis, Site-Directed; Mutation; Okadaic Acid; Phosphoric Monoester Hydrolases; Phosphorylation; Protein Binding; Protein Structure, Secondary; Protein Structure, Tertiary; Rabbits; Serine; Threonine; Time Factors; Transfection | 2003 |
Stress-induced protein phosphatase 2C is a negative regulator of a mitogen-activated protein kinase.
Topics: Arabidopsis; Caseins; Cycloheximide; Edetic Acid; Enzyme Activation; Enzyme Inhibitors; Immunosorbent Techniques; Medicago sativa; Mitogen-Activated Protein Kinases; Mutation; Okadaic Acid; Phosphoprotein Phosphatases; Phosphorylation; Plant Extracts; Plant Leaves; Plant Proteins; Protein Phosphatase 2C; Protein Synthesis Inhibitors; Recombinant Proteins; RNA, Messenger; Substrate Specificity; Threonine; Two-Hybrid System Techniques; Vanadates | 2003 |
Threonine phosphorylation sites in the beta 2 and beta 7 leukocyte integrin polypeptides.
Topics: Alanine; Amino Acid Sequence; Animals; CD18 Antigens; Cell Adhesion; Cell Line; Chlorocebus aethiops; COS Cells; Cytoplasm; Humans; Integrin beta Chains; Integrins; Lymphocyte Activation; Mice; Molecular Sequence Data; Mutagenesis, Site-Directed; Okadaic Acid; Peptide Mapping; Phorbol 12,13-Dibutyrate; Phosphopeptides; Phosphorylation; Protein Structure, Tertiary; Receptor-CD3 Complex, Antigen, T-Cell; T-Lymphocyte Subsets; Threonine; Transfection; Tumor Cells, Cultured; Vascular Cell Adhesion Molecule-1 | 2003 |
Recruitment of JNK to JIP1 and JNK-dependent JIP1 phosphorylation regulates JNK module dynamics and activation.
Topics: Adaptor Proteins, Signal Transducing; Animals; Binding Sites; Carrier Proteins; Cell Line; COS Cells; Dimerization; Electrophoresis, Polyacrylamide Gel; Enzyme Activation; Immunosorbent Techniques; JNK Mitogen-Activated Protein Kinases; MAP Kinase Kinase 4; MAP Kinase Kinase Kinases; Mitogen-Activated Protein Kinase Kinases; Neurons; Okadaic Acid; Oligonucleotides, Antisense; Oligopeptides; Peptide Mapping; Peptides; Phosphorylation; Polymerase Chain Reaction; Protein Structure, Quaternary; Rats; Recombinant Fusion Proteins; Threonine; Transfection | 2003 |
Platelet endothelial cell adhesion molecule-1 (PECAM-1) inhibits low density lipoprotein-induced signaling in platelets.
Topics: Amino Acid Motifs; Blood Platelets; Blotting, Western; Cross-Linking Reagents; Cytosol; Down-Regulation; Electrophoresis, Polyacrylamide Gel; Enzyme Activation; Humans; Lipoproteins, LDL; Mitogen-Activated Protein Kinases; Okadaic Acid; p38 Mitogen-Activated Protein Kinases; Peptides; Phospholipases A; Phospholipases A2; Phosphoprotein Phosphatases; Phosphorylation; Platelet Endothelial Cell Adhesion Molecule-1; Signal Transduction; Threonine; Time Factors; Tyrosine; Vanadates | 2003 |
Threonine 391 phosphorylation of the human prolactin receptor mediates a novel interaction with 14-3-3 proteins.
Topics: 14-3-3 Proteins; 3T3 Cells; Amino Acid Motifs; Animals; Cell Line; Cloning, Molecular; DNA-Binding Proteins; Genetic Vectors; Glutathione Transferase; Humans; Ligands; MAP Kinase Signaling System; Mice; Milk Proteins; Mitogen-Activated Protein Kinases; Mutagenesis, Site-Directed; Mutation; Okadaic Acid; Phosphorylation; Phosphoserine; Phosphothreonine; Plasmids; Precipitin Tests; Prolactin; Protein Binding; Protein Isoforms; Protein Serine-Threonine Kinases; Protein Structure, Tertiary; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-akt; Receptors, Prolactin; Recombinant Fusion Proteins; Recombinant Proteins; Signal Transduction; STAT5 Transcription Factor; Threonine; Time Factors; Trans-Activators; Tumor Cells, Cultured; Tumor Suppressor Proteins; Tyrosine; Tyrosine 3-Monooxygenase | 2003 |
Reactive oxygen species sensitivity of angiotensin II-dependent translation initiation in vascular smooth muscle cells.
Topics: Acetylcysteine; Angiotensin II; Animals; Aorta; Azoles; Blotting, Western; Carrier Proteins; Cells, Cultured; Enzyme Inhibitors; Eukaryotic Initiation Factor-4E; Genes, Dominant; Imidazoles; Intracellular Signaling Peptides and Proteins; Isoindoles; Muscle, Smooth, Vascular; Okadaic Acid; Onium Compounds; Organoselenium Compounds; Phosphatidylinositol 3-Kinases; Phosphoprotein Phosphatases; Phosphoproteins; Phosphorylation; Protein Biosynthesis; Protein Phosphatase 2; Pyridines; Rats; Reactive Oxygen Species; Serine; Threonine; Time Factors | 2003 |
Reduced expression of the regulatory A subunit of serine/threonine protein phosphatase 2A in human breast cancer MCF-7 cells.
Topics: Actins; Catalytic Domain; Cell Division; Cell Line, Tumor; Cytoskeleton; Epitopes; Humans; Immunoblotting; Integrin beta1; Microscopy, Fluorescence; Okadaic Acid; Oligopeptides; Peptides; Phosphoprotein Phosphatases; Phosphorylation; Precipitin Tests; Protein Binding; Protein Phosphatase 2; Protein Structure, Tertiary; Threonine | 2003 |
Modulation of Thr phosphorylation of integrin beta1 during muscle differentiation.
Topics: Amino Acid Sequence; Animals; Calcium; Cell Differentiation; Cells, Cultured; Cytoplasm; Cytoskeleton; Cytosol; Extracellular Matrix; Focal Adhesions; Integrin beta1; Microscopy, Confocal; Microscopy, Fluorescence; Molecular Sequence Data; Muscle, Skeletal; Muscles; Mutation; Okadaic Acid; Phosphoprotein Phosphatases; Phosphorylation; Precipitin Tests; Protein Binding; Protein Isoforms; Protein Phosphatase 2; Protein Structure, Tertiary; Rats; Sequence Homology, Amino Acid; Signal Transduction; Threonine; Time Factors | 2004 |
IFN-gamma induces gp91phox expression in human monocytes via protein kinase C-dependent phosphorylation of PU.1.
Topics: Active Transport, Cell Nucleus; Cell Nucleus; Cells, Cultured; Enzyme Activation; Gene Expression Regulation; Humans; Interferon-gamma; Isoenzymes; Membrane Glycoproteins; Monocytes; NADPH Oxidase 2; NADPH Oxidases; Okadaic Acid; Phosphorylation; Promoter Regions, Genetic; Protein Binding; Protein Kinase C; Protein Kinase C beta; Protein Kinase C-alpha; Proto-Oncogene Proteins; Serine; Threonine; Trans-Activators | 2004 |
MCL1 is phosphorylated in the PEST region and stabilized upon ERK activation in viable cells, and at additional sites with cytotoxic okadaic acid or taxol.
Topics: Amino Acid Sequence; Animals; Antineoplastic Agents, Phytogenic; Apoptosis; Binding Sites; Carcinogens; Cell Line, Tumor; Cell Survival; CHO Cells; Cricetinae; Dogs; Dose-Response Relationship, Drug; Enzyme Activation; Enzyme Inhibitors; Humans; MAP Kinase Signaling System; Mice; Mitogen-Activated Protein Kinases; Molecular Sequence Data; Myeloid Cell Leukemia Sequence 1 Protein; Neoplasm Proteins; Okadaic Acid; Paclitaxel; Peptide Mapping; Phosphorylation; Precipitin Tests; Protein Kinase C; Protein Structure, Tertiary; Proto-Oncogene Proteins c-bcl-2; Signal Transduction; Tetradecanoylphorbol Acetate; Threonine; Time Factors; Transfection | 2004 |
In rat hepatocytes glucagon increases mammalian target of rapamycin phosphorylation on serine 2448 but antagonizes the phosphorylation of its downstream targets induced by insulin and amino acids.
Topics: Amino Acids; Animals; Binding Sites; Biological Transport; Blotting, Western; Carrier Proteins; Cells, Cultured; Cyclic AMP; Dose-Response Relationship, Drug; Electrophoresis, Polyacrylamide Gel; Glucagon; Hepatocytes; Immunoprecipitation; Insulin; Intracellular Signaling Peptides and Proteins; Male; Okadaic Acid; Phosphoproteins; Phosphorylation; Protein Kinases; Protein Serine-Threonine Kinases; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-akt; Rats; Rats, Wistar; Recombinant Proteins; Serine; Sirolimus; Threonine; Time Factors; TOR Serine-Threonine Kinases | 2004 |
Mitotic phosphorylation rescues Abl from F-actin-mediated inhibition.
Topics: Actins; Allosteric Site; Amino Acid Sequence; Animals; Aspartic Acid; Cell Line; Enzyme Inhibitors; Fibroblasts; Glutathione Transferase; Immunoprecipitation; Mice; Mitosis; Molecular Sequence Data; Mutation; NIH 3T3 Cells; Okadaic Acid; Peptides; Phalloidine; Phosphorylation; Polymers; Proline; Protein Binding; Protein Conformation; Protein Structure, Tertiary; Proto-Oncogene Proteins c-abl; Recombinant Fusion Proteins; RNA Polymerase II; src Homology Domains; Threonine; Transfection; Trypsin | 2005 |
Role of protein phosphatase 2A in mGluR5-regulated MEK/ERK phosphorylation in neurons.
Topics: Animals; Blotting, Western; Brain; Cell Survival; Cells, Cultured; Dose-Response Relationship, Drug; Excitatory Amino Acid Agonists; Glycine; Immunoprecipitation; MAP Kinase Kinase 1; Marine Toxins; Microscopy, Confocal; Microscopy, Fluorescence; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Neurons; Okadaic Acid; Oxazoles; Peptides; Phenylacetates; Phosphoprotein Phosphatases; Phosphorylation; Protein Phosphatase 2; Protein Structure, Tertiary; Protein-Tyrosine Kinases; Rats; Receptor, Metabotropic Glutamate 5; Receptors, Metabotropic Glutamate; Resorcinols; Serine; Signal Transduction; Threonine; Time Factors; Up-Regulation | 2005 |
Substrate specificity of the human protein phosphatase 2Cdelta, Wip1.
Topics: Amino Acid Sequence; Base Sequence; Catalytic Domain; DNA Primers; Enzyme Inhibitors; Humans; Kinetics; Molecular Sequence Data; Neoplasm Proteins; Okadaic Acid; Phosphoprotein Phosphatases; Phosphorylation; Protein Phosphatase 2C; Sequence Homology, Amino Acid; Substrate Specificity; Threonine | 2005 |
PKB/AKT is involved in resumption of meiosis in mouse oocytes.
Topics: 4-Butyrolactone; Animals; CDC2 Protein Kinase; Centrosome; Chromones; Enzyme Activation; Female; In Vitro Techniques; Meiosis; Mice; Morpholines; Nuclear Envelope; Okadaic Acid; Oocytes; Phosphorylation; Protein Transport; Proto-Oncogene Proteins c-akt; Serine; Threonine | 2006 |
Morphine has an antinociceptive effect through activation of the okadaic-acid-sensitive Ser/Thr protein phosphatases PP 2 A and PP5 estimated by tail-pinch test in mice.
Topics: Animals; Area Under Curve; Blotting, Western; Brain; Dose-Response Relationship, Drug; Drug Administration Routes; Drug Interactions; Enzyme Activation; Enzyme Inhibitors; Male; Mice; Mice, Inbred ICR; Morphine; Naloxone; Narcotics; Nuclear Proteins; Okadaic Acid; Pain; Phosphoprotein Phosphatases; Phosphorylation; Serine; Threonine; Time Factors | 2005 |
Positive regulation of IkappaB kinase signaling by protein serine/threonine phosphatase 2A.
Topics: Active Transport, Cell Nucleus; Adenosine Triphosphate; Alkenes; Animals; B-Lymphocytes; Catalysis; Cell Line; Chromatography, Liquid; Cytoplasm; Enzyme Activation; Enzyme Inhibitors; Fibroblasts; Gene Deletion; Humans; I-kappa B Kinase; Immunoblotting; Immunoprecipitation; Inflammation; Jurkat Cells; Mice; Mice, Inbred C57BL; Mutation; Okadaic Acid; Phosphoprotein Phosphatases; Phosphorylation; Polyenes; Protein Phosphatase 2; Pyrones; Sepharose; Serine; Signal Transduction; Spleen; Threonine; Time Factors; Transfection; Tumor Necrosis Factor-alpha | 2005 |
Histone acetylation-independent effect of histone deacetylase inhibitors on Akt through the reshuffling of protein phosphatase 1 complexes.
Topics: Apoptosis; Cell Cycle; Cell Line, Tumor; Cell Survival; Dose-Response Relationship, Drug; Down-Regulation; Enzyme Inhibitors; Histone Deacetylase Inhibitors; Histones; Humans; Hydroxamic Acids; Immunoblotting; Immunohistochemistry; Immunoprecipitation; Marine Toxins; Okadaic Acid; Oxazoles; Phosphatidylinositols; Phosphoprotein Phosphatases; Phosphorylation; Protein Binding; Protein Isoforms; Protein Phosphatase 1; Protein Phosphatase 2; Protein Structure, Tertiary; Proto-Oncogene Proteins c-akt; Pyrans; RNA, Small Interfering; Serine; Signal Transduction; Spiro Compounds; Subcellular Fractions; Threonine; Time Factors | 2005 |
Inhibition of neuronal nitric-oxide synthase by phosphorylation at Threonine1296 in NG108-15 neuronal cells.
Topics: Animals; Enzyme Inhibitors; Marine Toxins; Mutation; NADP; Neurons; Nitric Oxide; Nitric Oxide Synthase Type I; Okadaic Acid; Oxazoles; Phosphorylation; Rats; Threonine | 2005 |
Regulation of NDR protein kinase by hydrophobic motif phosphorylation mediated by the mammalian Ste20-like kinase MST3.
Topics: Adaptor Proteins, Signal Transducing; Amino Acid Motifs; Animals; Carrier Proteins; Catalytic Domain; Chlorocebus aethiops; COS Cells; Cytoplasm; Enzyme Activation; Humans; Hydrophobic and Hydrophilic Interactions; Intracellular Signaling Peptides and Proteins; Okadaic Acid; Phosphorylation; Protein Serine-Threonine Kinases; Threonine | 2005 |
Degradation of cyclin D3 independent of Thr-283 phosphorylation.
Topics: Amino Acid Sequence; B-Lymphocytes; Cyclin D3; Cyclins; Enzyme Inhibitors; Glycogen Synthase Kinase 3; Glycogen Synthase Kinase 3 beta; Humans; Leukemia, Lymphoid; Molecular Sequence Data; Okadaic Acid; Phosphoprotein Phosphatases; Phosphorylation; Proteasome Endopeptidase Complex; Threonine; Tumor Cells, Cultured | 2006 |
Cell adhesion regulates Ser/Thr phosphorylation and proteasomal degradation of HEF1.
Topics: Actin Cytoskeleton; Actins; Adaptor Proteins, Signal Transducing; Antineoplastic Agents; Cell Adhesion; Cell Line; Colchicine; Cytochalasin D; Enzyme Inhibitors; Humans; Intermediate Filaments; Marine Toxins; Microtubules; Nocodazole; Nucleic Acid Synthesis Inhibitors; Okadaic Acid; Oxazoles; Phosphoprotein Phosphatases; Phosphoproteins; Phosphorylation; Proteasome Endopeptidase Complex; Proteasome Inhibitors; Protein Isoforms; Protein Phosphatase 2; Pyrans; Serine; Signal Transduction; Spiro Compounds; Threonine; Tubulin Modulators | 2006 |
Protein phosphatase 2A interacts with Chk2 and regulates phosphorylation at Thr-68 after cisplatin treatment of human ovarian cancer cells.
Topics: Antineoplastic Agents; Blotting, Western; Cell Line, Tumor; Checkpoint Kinase 2; Cisplatin; Enzyme Inhibitors; Female; Humans; Immunoprecipitation; Okadaic Acid; Ovarian Neoplasms; Phosphoprotein Phosphatases; Phosphorylation; Protein Binding; Protein Phosphatase 2; Protein Serine-Threonine Kinases; RNA Interference; RNA, Small Interfering; Threonine; Time Factors; Tumor Suppressor Protein p53 | 2006 |
Role of calcineurin and protein phosphatase-2A in the regulation of phosphatase inhibitor-1 in cardiac myocytes.
Topics: Animals; Animals, Newborn; Calcineurin; Cells, Cultured; Cyclosporine; Gene Expression Regulation; Intracellular Signaling Peptides and Proteins; Myocytes, Cardiac; Okadaic Acid; Phosphoprotein Phosphatases; Phosphorylation; Protein Phosphatase 1; Protein Phosphatase 2; Rats; Serine; Threonine | 2006 |
The DNA-dependent protein kinase catalytic subunit is phosphorylated in vivo on threonine 3950, a highly conserved amino acid in the protein kinase domain.
Topics: Amino Acid Motifs; Amino Acid Sequence; Catalytic Domain; Cell Line; Cell Line, Tumor; Conserved Sequence; DNA-Activated Protein Kinase; Enzyme Inhibitors; Humans; Molecular Sequence Data; Okadaic Acid; Phosphorylation; Protein Kinases; Protein Structure, Secondary; Protein Structure, Tertiary; Radiation, Ionizing; Recombinant Proteins; Sequence Homology, Amino Acid; Threonine | 2007 |
Induction of actin cytoskeleton rearrangement by methyl okadaate--comparison with okadaic acid.
Topics: Actins; Calcium; Cell Line; Cytoskeleton; Cytosol; Ethers, Cyclic; Humans; Membrane Potentials; Okadaic Acid; Phosphorylation; Protein Phosphatase 1; Protein Phosphatase 2; Serine; Threonine | 2008 |
Threonine 74 of MOB1 is a putative key phosphorylation site by MST2 to form the scaffold to activate nuclear Dbf2-related kinase 1.
Topics: Apoptosis; Cell Line; Cell Proliferation; Chemokine CXCL10; Enzyme Activation; Gene Expression Regulation, Enzymologic; Gene Expression Regulation, Neoplastic; HeLa Cells; Humans; Okadaic Acid; Phosphorylation; Protein Serine-Threonine Kinases; Serine-Threonine Kinase 3; Subcellular Fractions; Threonine | 2008 |
The relaxant effect of okadaic acid on canine basilar artery involves activation of PKCalpha and phosphorylation of the myosin light chain at Thr-9.
Topics: Animals; Basilar Artery; Blotting, Western; Carbazoles; Dogs; Enzyme Activation; Enzyme Inhibitors; Female; Isometric Contraction; Male; Muscle Relaxation; Myosin Light Chains; Naphthalenes; Okadaic Acid; Peptide Mapping; Phosphorylation; Potassium Chloride; Protein Kinase C-alpha; Threonine | 2008 |
PP1-mediated dephosphorylation of phosphoproteins at mitotic exit is controlled by inhibitor-1 and PP1 phosphorylation.
Topics: 8-Bromo Cyclic Adenosine Monophosphate; Animals; CDC2 Protein Kinase; Cell Cycle; Cell Cycle Proteins; Cyclic AMP-Dependent Protein Kinases; Cyclin B; Cyclin-Dependent Kinases; HeLa Cells; Humans; Mitosis; Models, Biological; Okadaic Acid; Oocytes; Phosphoproteins; Phosphorylation; Protein Binding; Protein Kinase Inhibitors; Protein Kinases; Protein Phosphatase 1; Proteins; Purines; Roscovitine; Threonine; Xenopus laevis; Xenopus Proteins | 2009 |
Cytosolic Aryl sulfotransferase 4A1 interacts with the peptidyl prolyl cis-trans isomerase Pin1.
Topics: Amino Acid Motifs; Amino Acid Sequence; Binding Sites; Calpain; Cysteine Proteinase Inhibitors; Cytosol; Escherichia coli; Escherichia coli Proteins; Glutathione Transferase; Half-Life; HeLa Cells; Humans; Leupeptins; Molecular Sequence Data; NIMA-Interacting Peptidylprolyl Isomerase; Okadaic Acid; Peptidylprolyl Isomerase; Phosphorylation; Proline; Protein Binding; Recombinant Proteins; Serine; Sulfotransferases; Threonine; Transfection; Two-Hybrid System Techniques | 2009 |
A protein phosphatase feedback mechanism regulates the basal phosphorylation of Chk2 kinase in the absence of DNA damage.
Topics: Ataxia Telangiectasia Mutated Proteins; Blotting, Western; Cell Cycle Proteins; Cell Line; Cell Line, Tumor; Checkpoint Kinase 2; DNA Damage; DNA-Binding Proteins; Enzyme Inhibitors; Feedback, Physiological; Humans; Models, Biological; Okadaic Acid; Phosphoprotein Phosphatases; Phosphorylation; Protein Phosphatase 1; Protein Phosphatase 2; Protein Phosphatase 2C; Protein Serine-Threonine Kinases; RNA Interference; Thiazoles; Threonine; Tumor Suppressor Proteins | 2010 |
Protein phosphatase 1γ is responsible for dephosphorylation of histone H3 at Thr 11 after DNA damage.
Topics: Animals; Ataxia Telangiectasia Mutated Proteins; Cell Cycle Proteins; Checkpoint Kinase 1; Chromatin; DNA Damage; HCT116 Cells; HeLa Cells; Histones; Humans; Mice; Models, Biological; Okadaic Acid; Phosphorylation; Protein Kinases; Protein Phosphatase 1; Protein Serine-Threonine Kinases; Threonine; Transcription, Genetic | 2010 |
Auxin activates the plasma membrane H+-ATPase by phosphorylation during hypocotyl elongation in Arabidopsis.
Topics: Arabidopsis; Arabidopsis Proteins; Cell Membrane; Enzyme Activation; F-Box Proteins; Gene Expression Regulation, Enzymologic; Gene Expression Regulation, Plant; Hypocotyl; Indoleacetic Acids; Leupeptins; Marine Toxins; Okadaic Acid; Oxazoles; Phosphorylation; Proteasome Endopeptidase Complex; Proton-Translocating ATPases; Receptors, Cell Surface; Signal Transduction; Threonine; Time Factors; Transcription, Genetic | 2012 |
Inhibitory interactions between phosphorylation sites in the C terminus of α-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid-type glutamate receptor GluA1 subunits.
Topics: Animals; Binding Sites; Blotting, Western; Calcium; Calcium Channels; Cyclic AMP-Dependent Protein Kinases; HEK293 Cells; Hippocampus; Humans; Male; Marine Toxins; Membrane Potentials; Mice; Mice, Inbred C57BL; Neurons; Okadaic Acid; Oxazoles; Phosphorylation; Protein Kinase C; Protein Phosphatase 1; Protein Phosphatase 2; Protein Subunits; Receptors, AMPA; Serine; Threonine | 2014 |
Inhibition of protein phosphatase 2A (PP2A) prevents Mcl-1 protein dephosphorylation at the Thr-163/Ser-159 phosphodegron, dramatically reducing expression in Mcl-1-amplified lymphoma cells.
Topics: Binding Sites; Burkitt Lymphoma; Cell Line, Tumor; Drug Resistance, Neoplasm; Enzyme Inhibitors; Gene Expression; Gene Knockdown Techniques; Humans; MAP Kinase Signaling System; Marine Toxins; Myeloid Cell Leukemia Sequence 1 Protein; Okadaic Acid; Oxazoles; Phosphorylation; Protein Phosphatase 2; Proteolysis; Serine; Tetradecanoylphorbol Acetate; Threonine | 2014 |
Threonine-290 regulates nuclear translocation of the human pregnane X receptor through its phosphorylation/dephosphorylation by Ca2+/calmodulin-dependent protein kinase II and protein phosphatase 1.
Topics: Animals; Benzylamines; Calcium-Calmodulin-Dependent Protein Kinase Type 2; Cell Line; Cell Nucleus; Gene Expression Regulation, Enzymologic; Glucuronosyltransferase; HSP90 Heat-Shock Proteins; Humans; Liver; Mice; Mutation; Okadaic Acid; Phosphorylation; Pregnane X Receptor; Protein Phosphatase 1; Protein Transport; Purines; Receptors, Steroid; Rifampin; RNA, Small Interfering; Roscovitine; Sulfonamides; Threonine | 2014 |
Dexmedetomidine directly increases tau phosphorylation.
Topics: Analgesics, Non-Narcotic; Analysis of Variance; Animals; Brain; Cells, Cultured; Cerebral Cortex; Dexmedetomidine; Dose-Response Relationship, Drug; Embryo, Mammalian; Enzyme Inhibitors; Glycogen Synthase Kinase 3; Male; Neurons; Okadaic Acid; Phosphorylation; Rats; Rats, Sprague-Dawley; Serine; tau Proteins; Threonine; Time Factors | 2015 |
Phosphorylation of the kinase domain regulates autophosphorylation of myosin IIIA and its translocation in microvilli.
Topics: Actin Cytoskeleton; Amino Acid Substitution; Animals; Caco-2 Cells; Catalytic Domain; Enterocytes; Enzyme Inhibitors; Furans; Humans; Lipids; Microvilli; Models, Molecular; Mutant Proteins; Myosin Heavy Chains; Myosin Type III; Okadaic Acid; Phosphorylation; Protein Interaction Domains and Motifs; Protein Processing, Post-Translational; Protein Stability; Protein Transport; Rabbits; Recombinant Proteins; Threonine | 2014 |