threonine has been researched along with enkephalin, ala(2)-mephe(4)-gly(5)- in 7 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 4 (57.14) | 18.2507 |
| 2000's | 3 (42.86) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| George, SR; O'Dowd, BF; Pak, Y | 1 |
| Bertin, B; Capeyrou, R; Corbani, M; Emorine, LJ; Lepage, JF; Riond, J | 1 |
| Bühling, F; Höllt, V; Klutzny, M; Koch, T; Raulf, E; Schröder, H; Schulz, S; Wolf, R | 1 |
| George, SR; O'Dowd, BF; Pak, Y; Wang, JB | 1 |
| Wang, HL | 1 |
| Burd, AL; Chang, CY; El Kouhen, R; Erickson-Herbrandson, LJ; Law, PY; Loh, HH | 1 |
| Celver, JP; Chavkin, C; Gurevich, VV; Lowe, JD | 1 |
7 other study(ies) available for threonine and enkephalin, ala(2)-mephe(4)-gly(5)-
| Article | Year |
|---|---|
Agonist-induced desensitization of the mu opioid receptor is determined by threonine 394 preceded by acidic amino acids in the COOH-terminal tail.
Topics: Alanine; Amino Acid Sequence; Animals; Binding, Competitive; CHO Cells; Cricetinae; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalins; Kinetics; Molecular Sequence Data; Mutagenesis, Site-Directed; Naloxone; Point Mutation; Rats; Receptors, Opioid, mu; Recombinant Proteins; Serine; Threonine; Transfection | 1997 |
Agonist-induced signaling and trafficking of the mu-opioid receptor: role of serine and threonine residues in the third cytoplasmic loop and C-terminal domain.
Topics: Adenylyl Cyclases; Animals; Cell Membrane; CHO Cells; Colforsin; Cricetinae; Cyclic AMP; Diprenorphine; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalins; Enzyme Activation; Etorphine; GTP-Binding Proteins; Guanylyl Imidodiphosphate; Humans; Morphine; Mutagenesis, Site-Directed; Receptors, Opioid, mu; Serine; Signal Transduction; Threonine | 1997 |
Replacement of threonine 394 by alanine facilitates internalization and resensitization of the rat mu opioid receptor.
Topics: Alanine; Amino Acid Substitution; Analgesics, Opioid; Animals; Cyclic AMP; Endocytosis; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalins; Gene Expression Regulation, Neoplastic; Mutation; Rats; Receptors, Cell Surface; Receptors, Opioid, mu; Threonine; Tumor Cells, Cultured | 1999 |
Agonist-induced, G protein-dependent and -independent down-regulation of the mu opioid receptor. The receptor is a direct substrate for protein-tyrosine kinase.
Topics: Amino Acid Sequence; Amino Acid Substitution; Animals; Cell Line; CHO Cells; Cricetinae; Cyclic AMP-Dependent Protein Kinases; Down-Regulation; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enzyme Inhibitors; GTP-Binding Proteins; Molecular Sequence Data; Mutagenesis, Site-Directed; Naloxone; Pertussis Toxin; Phosphorylation; Protein Kinases; Protein-Tyrosine Kinases; Rats; Receptors, Opioid, mu; Recombinant Proteins; Threonine; Transfection; Virulence Factors, Bordetella | 1999 |
A cluster of Ser/Thr residues at the C-terminus of mu-opioid receptor is required for G protein-coupled receptor kinase 2-mediated desensitization.
Topics: Analgesics, Opioid; Animals; beta-Adrenergic Receptor Kinases; Cell Line; Cyclic AMP-Dependent Protein Kinases; Drug Tolerance; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; G-Protein-Coupled Receptor Kinase 2; Humans; Naloxone; Narcotic Antagonists; Rats; Receptors, Opioid, mu; Serine; Threonine; Transfection | 2000 |
Phosphorylation of Ser363, Thr370, and Ser375 residues within the carboxyl tail differentially regulates mu-opioid receptor internalization.
Topics: Alanine; Amino Acid Sequence; Amino Acid Substitution; Animals; Cell Line; Diprenorphine; Endocytosis; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Humans; Kinetics; Molecular Sequence Data; Mutagenesis, Site-Directed; Phosphates; Phosphorylation; Phosphoserine; Phosphothreonine; Rats; Receptors, Opioid, mu; Recombinant Proteins; Serine; Threonine; Transfection | 2001 |
mu-Opioid receptors desensitize less rapidly than delta-opioid receptors due to less efficient activation of arrestin.
Topics: Amino Acid Sequence; Amino Acid Substitution; Animals; Arrestin; Arrestins; Cloning, Molecular; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, D-Penicillamine (2,5)-; G-Protein-Coupled Receptor Kinase 3; GTP-Binding Proteins; Kinetics; Mice; Models, Molecular; Mutagenesis, Site-Directed; Oocytes; Phosphoproteins; Phosphorylation; Protein Conformation; Protein Serine-Threonine Kinases; Receptors, Opioid, delta; Receptors, Opioid, mu; Recombinant Proteins; Threonine; Xenopus laevis | 2002 |