Compounds > threonine

threonine and cyclin d1

threonine has been researched along with cyclin d1 in 41 studies

Research

Studies (41)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's4 (9.76)18.2507
2000's21 (51.22)29.6817
2010's14 (34.15)24.3611
2020's2 (4.88)2.80

Authors

AuthorsStudies
Diehl, JA; Sherr, CJ; Zindy, F1
Kato, A; Matsushime, H; Takahashi, H; Takahashi, Y1
Ando, A; Fujimoto, A; Ikeda, K; Morisaki, H; Nagata, Y; Nakanishi, M1
Grafstrom, RH; Hoess, RH; Pan, W1
Germain, D; Hendley, J; Russell, A; Thompson, A1
Agell, N; Bachs, O; Casanovas, O; Estanyol, JM; Itarte, E; Miró, F1
Alt, JR; Cleveland, JL; Diehl, JA; Hannink, M1
Carrano, AC; Pagano, M1
Alt, JR; Diehl, JA; Gladden, AB1
Bangash, S; Lopatka, K; Paller, AS; Sun, P; Wang, XQ1
Baldassare, JJ; Bellone, C; Keenan, SM; Lents, NH1
Conti, CJ; Fox, SR; Giesting, S; Knudsen, ES; Lambeck, TC; Lan, Z; Senderowicz, AM; Solomon, DA; Wang, Y1
Desai, NB; Dmitrovsky, E; Dragnev, KH; Freemantle, SJ; Ma, Y; Murphy, B; Petty, WJ; Pitha-Rowe, I; Rendi, M; Sekula, D; Sporn, MB; Suh, N1
Deng, X; Ewton, DZ; Friedman, E; Mercer, SE; Zou, Y1
Benzeno, S; Diehl, JA1
Garrett, MD; Guo, Y; Harwalkar, J; Hitomi, M; Mason, DR; Nye, JM; Stacey, DW; Yang, K1
Behring, A; Goyal, P; Pandey, D; Siess, W1
Claret, FX; Johnson, TJ; Korapati, AL; Mansouri, A; Tian, L; Zhang, Q1
Hirata, M; Miwa, Y; Mori, J; Morimoto, S; Sasaguri, T; Shirasuna, K; Takahashi-Yanaga, F; Watanabe, Y1
Misra, UK; Pizzo, SV1
Berndt, N; Liu, CW; Wang, RH1
Albertson, DG; Lee, SH; McCormick, F; Okabe, H; Phuchareon, J; Tetsu, O1
Grøsvik, H; Huitfeldt, HS; Lindeman, B; Oksvold, MP; Rosseland, CM; Skarpen, E; Wierød, L1
Da Silva, T; Dumont, D; Han, K; Hong, F; Larrea, MD; Liang, J; Shao, SH; Slingerland, JM1
Moir, RD; Myre, MA; Tanzi, RE; Tesco, G; Wasco, W; Washicosky, K1
Heese, K; Sim, PL1
Biggar, KK; Storey, KB1
Ashford, AL; Cook, SJ; Guichard, S; Hudson, K; Kettle, J; Lochhead, PA; Oxley, D1
Becker, W; Florencio Ortiz, V; Pasqualon, T; Schumacher, J; Soppa, U; Tejedor, FJ1
Eo, HJ; Jeong, JB; Kim, MK; Koo, JS; Lee, JR; Lee, JW; Lee, MH; Park, GH; Song, HM1
Brock, A; Fedarovich, A; Fedarovich, D; Heise, T; Kuehnert, J; Sommer, G; Zierk, AW1
Gillam, T; Lam, F; Sykes, MJ; Teo, T; Wang, S; Yang, Y; Yu, M1
Eo, HJ; Jeong, JB; Park, GH1
Ali, SM; Busaidy, NL; Chmielecki, J; Elvin, JA; Erlich, RL; Heilmann, AM; Khan, SA; Lipson, D; Miller, VA; Murthy, R; Nangia, C; Ross, JS; Shah, MH; Sherman, SI; Stephens, PJ; Subbiah, I; Subbiah, V; Sun, JX; Vergilio, JA; Wang, K; Yelensky, R1
Jeong, JB; Park, GH; Song, HM1
Cai, X; Chu, Y; Fan, D; Fan, X; Horvath, T; Jiang, M; Li, X; Liang, J; Nie, Y; Qiu, Z; Wang, W; Wu, K; Xu, B; Yang, X; Zhang, S; Zhang, X; Zhou, J1
Aburatani, H; Aihara, H; Cheung, E; Doiguchi, M; Hayashi, T; Higashi, M; Ikura, T; Imamura, Y; Inoue, S; Ito, T; Kato, M; Kodama, Y; Koseki, H; Mizusaki, H; Nakagawa, T; Nakayama, T; Oki, M; Takayama, KI; Takeshima, Y; Yoneda, M1
Jeon, Y; Jeong, HJ; Jeong, JB; Kim, YS; Koo, JS; Park, GH; Song, HM1
Chen, L; Chen, X; Gilbert, MTP; Heller, R; Li, G; Li, Z; Lin, Z; Liu, C; Liu, X; Qiu, Q; Røed, KH; Sternang Kvie, K; Wang, H; Wang, K; Wang, W; Wei, H; Xia, W; Xiao, W; Yan, B; Yang, Y; Zhong, Y; Zhu, W1
Avril, S; Diehl, JA; Koivisto, C; Leone, G; Phillips-Mason, P; Tarallo, V; Yoshida, A1
Bi, H; Fan, S; Gao, Y; Huang, M; Li, X; Liang, H; Qu, X; Tian, J; Wang, R; Yang, J; Yang, X; Zhang, S; Zhang, Y1

Other Studies

41 other study(ies) available for threonine and cyclin d1

ArticleYear
Inhibition of cyclin D1 phosphorylation on threonine-286 prevents its rapid degradation via the ubiquitin-proteasome pathway.
    Genes & development, 1997, Apr-15, Volume: 11, Issue:8

    Topics: 3T3 Cells; Animals; Cell Line; Cyclin D1; Cyclin-Dependent Kinase 4; Cyclin-Dependent Kinases; Cyclins; Cysteine Endopeptidases; Mice; Multienzyme Complexes; Mutation; Oncogene Proteins; Phosphopeptides; Phosphorylation; Proteasome Endopeptidase Complex; Proto-Oncogene Proteins; Recombinant Fusion Proteins; Retinoblastoma Protein; Spodoptera; Threonine; Ubiquitins

1997
Contact inhibition-induced inactivation of the cyclin D-dependent kinase in rat fibroblast cell line, 3Y1.
    Leukemia, 1997, Volume: 11 Suppl 3

    Topics: Animals; Cell Cycle; Cell Cycle Proteins; Cell Line; Contact Inhibition; Cyclin D1; Cyclin H; Cyclin-Dependent Kinase 4; Cyclin-Dependent Kinase Inhibitor p27; Cyclin-Dependent Kinase-Activating Kinase; Cyclin-Dependent Kinases; Cyclins; Enzyme Inhibitors; Fibroblasts; Microtubule-Associated Proteins; Oncogene Proteins; Phosphorylation; Protein Serine-Threonine Kinases; Proto-Oncogene Proteins; Rats; Recombinant Proteins; Spodoptera; Threonine; Transfection; Tumor Suppressor Proteins

1997
Cell cycle-dependent phosphorylation of p27 cyclin-dependent kinase (Cdk) inhibitor by cyclin E/Cdk2.
    Biochemical and biophysical research communications, 1997, Nov-17, Volume: 240, Issue:2

    Topics: Amino Acid Substitution; Animals; CDC2-CDC28 Kinases; Cell Cycle; Cell Cycle Proteins; Cell Line; Cyclin D1; Cyclin E; Cyclin-Dependent Kinase 2; Cyclin-Dependent Kinase Inhibitor p27; Cyclin-Dependent Kinases; DNA Primers; Fibroblasts; G1 Phase; Glutathione Transferase; Humans; Kinetics; Microtubule-Associated Proteins; Mutagenesis, Site-Directed; Phosphorylation; Polymerase Chain Reaction; Protein Serine-Threonine Kinases; Recombinant Fusion Proteins; Skin; Spodoptera; Threonine; Transfection; Tumor Suppressor Proteins

1997
Defining the substrate specificity of cdk4 kinase-cyclin D1 complex.
    Carcinogenesis, 1999, Volume: 20, Issue:2

    Topics: Amino Acid Sequence; Amino Acid Substitution; Arginine; Binding Sites; Conserved Sequence; Cyclin D1; Cyclin-Dependent Kinase 4; Cyclin-Dependent Kinases; HeLa Cells; Humans; Nuclear Proteins; Phosphorylation; Proto-Oncogene Proteins; Retinoblastoma Protein; Retinoblastoma-Like Protein p107; Serine; Substrate Specificity; Threonine

1999
Ubiquitination of free cyclin D1 is independent of phosphorylation on threonine 286.
    The Journal of biological chemistry, 2000, Apr-21, Volume: 275, Issue:16

    Topics: Animals; Cells, Cultured; Cyclin D1; Electrophoresis, Polyacrylamide Gel; G1 Phase; Humans; Mice; Peptide Hydrolases; Phosphorylation; Proteasome Endopeptidase Complex; S Phase; Structure-Activity Relationship; Threonine; Ubiquitins

2000
Osmotic stress regulates the stability of cyclin D1 in a p38SAPK2-dependent manner.
    The Journal of biological chemistry, 2000, Nov-10, Volume: 275, Issue:45

    Topics: Arsenites; Blotting, Western; Calcium Chloride; Cell Division; Cell Line; Cyclin D1; Cysteine Endopeptidases; Down-Regulation; Enzyme Inhibitors; Escherichia coli; Glutathione Transferase; Humans; Hydrogen Peroxide; Imidazoles; Kinetics; Magnesium Chloride; MAP Kinase Signaling System; Mitogen-Activated Protein Kinases; Multienzyme Complexes; Osmosis; Oxidative Stress; p38 Mitogen-Activated Protein Kinases; Phosphorylation; Point Mutation; Precipitin Tests; Proteasome Endopeptidase Complex; Pyridines; Pyrimidines; Recombinant Fusion Proteins; RNA Processing, Post-Transcriptional; Sodium Chloride; Threonine; Time Factors; Tumor Cells, Cultured; Ubiquitins

2000
Phosphorylation-dependent regulation of cyclin D1 nuclear export and cyclin D1-dependent cellular transformation.
    Genes & development, 2000, Dec-15, Volume: 14, Issue:24

    Topics: Active Transport, Cell Nucleus; Animals; Calcium-Calmodulin-Dependent Protein Kinases; Carcinogenicity Tests; Carrier Proteins; Cell Nucleus; Cell Transformation, Neoplastic; Cyclin D1; Cytoplasm; Exportin 1 Protein; Fatty Acids, Unsaturated; Fibroblasts; Glycogen Synthase Kinase 3; Humans; Karyopherins; Male; Mice; Mice, SCID; Phosphorylation; Receptors, Cytoplasmic and Nuclear; S Phase; Threonine

2000
Role of the F-box protein Skp2 in adhesion-dependent cell cycle progression.
    The Journal of cell biology, 2001, Jun-25, Volume: 153, Issue:7

    Topics: Animals; Cell Adhesion; Cell Cycle; Cell Cycle Proteins; Cell Division; Cell Line; Cyclin D1; Cyclin E; Cyclin-Dependent Kinase Inhibitor p27; Down-Regulation; Extracellular Matrix; Fibroblasts; Gene Expression Regulation; Humans; Ligases; Macromolecular Substances; Microtubule-Associated Proteins; Phosphorylation; Protein Subunits; Rats; RNA, Messenger; Signal Transduction; Threonine; Tumor Suppressor Proteins; Ubiquitin-Protein Ligases

2001
p21(Cip1) Promotes cyclin D1 nuclear accumulation via direct inhibition of nuclear export.
    The Journal of biological chemistry, 2002, Mar-08, Volume: 277, Issue:10

    Topics: 3T3 Cells; Active Transport, Cell Nucleus; Animals; Calcium-Calmodulin-Dependent Protein Kinases; Cell Cycle Proteins; Cell Division; Cell Line; Cell Nucleus; Cyclin D1; Cyclin-Dependent Kinase Inhibitor p21; Cyclin-Dependent Kinase Inhibitor p27; Cyclins; Cytoplasm; Glycogen Synthase Kinase 3; Glycogen Synthase Kinases; Humans; Immunoblotting; Insecta; Mice; Microscopy, Fluorescence; Phosphorylation; Protein Binding; Threonine; Transfection; Tumor Suppressor Proteins

2002
Ganglioside loss promotes survival primarily by activating integrin-linked kinase/Akt without phosphoinositide 3-OH kinase signaling.
    The Journal of investigative dermatology, 2002, Volume: 119, Issue:1

    Topics: Apoptosis; bcl-Associated Death Protein; Carcinoma, Squamous Cell; Carrier Proteins; Caspase 9; Caspases; Cell Survival; Cyclin D1; Cyclin E; DNA, Complementary; Fibronectins; G1 Phase; Gangliosides; Humans; Integrin beta1; Keratinocytes; Neuraminidase; Phosphatidylinositol 3-Kinases; Phosphorylation; Protein Serine-Threonine Kinases; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-akt; S Phase; Serine; Signal Transduction; Skin Neoplasms; Threonine; Transfection; Tumor Cells, Cultured

2002
Stimulation of the Raf/MEK/ERK cascade is necessary and sufficient for activation and Thr-160 phosphorylation of a nuclear-targeted CDK2.
    The Journal of biological chemistry, 2002, Dec-06, Volume: 277, Issue:49

    Topics: Active Transport, Cell Nucleus; Animals; Blotting, Western; Butadienes; CDC2-CDC28 Kinases; Cell Cycle Proteins; Cell Line; Cell Nucleus; Cricetinae; Cyclin D1; Cyclin E; Cyclin-Dependent Kinase 2; Cyclin-Dependent Kinase Inhibitor p27; Cyclin-Dependent Kinases; DNA, Complementary; Enzyme Activation; Enzyme Inhibitors; Humans; Immunohistochemistry; Microscopy, Fluorescence; Mitogen-Activated Protein Kinase Kinases; Mitogen-Activated Protein Kinases; Models, Biological; Models, Genetic; Nitriles; Phosphorylation; Plasmids; Precipitin Tests; Protein Binding; Protein Serine-Threonine Kinases; Proto-Oncogene Proteins c-raf; Retinoblastoma Protein; Signal Transduction; Threonine; Time Factors; Transfection; Tumor Suppressor Proteins; Up-Regulation

2002
Cyclin D1 splice variants. Differential effects on localization, RB phosphorylation, and cellular transformation.
    The Journal of biological chemistry, 2003, Aug-08, Volume: 278, Issue:32

    Topics: 3T3 Cells; Alleles; Alternative Splicing; Animals; Binding Sites; Cell Cycle; Cell Nucleus; Cell Transformation, Neoplastic; Cyclin D1; Cyclin-Dependent Kinase 4; Cyclin-Dependent Kinases; Cytoplasm; DNA; Flow Cytometry; Green Fluorescent Proteins; Humans; Immunoblotting; Luminescent Proteins; Mice; Microscopy, Fluorescence; Models, Genetic; Neoplasms; Phosphorylation; Plasmids; Polymorphism, Genetic; Precipitin Tests; Protein Binding; Protein Structure, Tertiary; Proto-Oncogene Mas; Proto-Oncogene Proteins; Retinoblastoma Protein; Threonine; Time Factors; Transcription, Genetic; Transfection; Tumor Cells, Cultured

2003
Specific chemopreventive agents trigger proteasomal degradation of G1 cyclins: implications for combination therapy.
    Clinical cancer research : an official journal of the American Association for Cancer Research, 2004, Apr-01, Volume: 10, Issue:7

    Topics: Anticarcinogenic Agents; Antineoplastic Combined Chemotherapy Protocols; Bronchi; Cell Culture Techniques; Cell Division; Cell Line; Cyclin D1; Cyclin E; Cyclin G; Cyclin G1; Cyclins; DNA Damage; Dose-Response Relationship, Drug; Epithelial Cells; G1 Phase; Humans; Immunoblotting; Leupeptins; Mutation; Proteasome Endopeptidase Complex; Proteasome Inhibitors; Retinoids; Reverse Transcriptase Polymerase Chain Reaction; Threonine; Transcription, Genetic; Transfection; Tretinoin

2004
Mirk/dyrk1B kinase destabilizes cyclin D1 by phosphorylation at threonine 288.
    The Journal of biological chemistry, 2004, Jun-25, Volume: 279, Issue:26

    Topics: Animals; Cell Division; Cell Line; Cyclin D1; Cycloheximide; Dyrk Kinases; Enzyme Induction; Epithelial Cells; Glycogen Synthase Kinase 3; Isopropyl Thiogalactoside; Lung; Mice; Mink; Mitogen-Activated Protein Kinases; Myoblasts; Phosphorylation; Protein Serine-Threonine Kinases; Protein-Tyrosine Kinases; Recombinant Proteins; RNA Interference; S Phase; Threonine; Transcription Factors

2004
C-terminal sequences direct cyclin D1-CRM1 binding.
    The Journal of biological chemistry, 2004, Dec-31, Volume: 279, Issue:53

    Topics: Active Transport, Cell Nucleus; Amino Acid Sequence; Animals; Cell Proliferation; Cyclin D1; Epitopes; Exportin 1 Protein; Fibroblasts; Humans; Immunoblotting; Karyopherins; Mice; Microscopy, Fluorescence; Models, Biological; Molecular Sequence Data; Neoplasms; NIH 3T3 Cells; Phosphorylation; Protein Binding; Protein Structure, Tertiary; Receptors, Cytoplasmic and Nuclear; Threonine; Time Factors

2004
Phosphorylation of cyclin D1 at Thr 286 during S phase leads to its proteasomal degradation and allows efficient DNA synthesis.
    Oncogene, 2005, Apr-14, Volume: 24, Issue:16

    Topics: Animals; Cell Proliferation; Cyclin D1; DNA; Humans; Kinetics; Mice; Models, Biological; Models, Theoretical; NIH 3T3 Cells; Phosphorylation; Proteasome Endopeptidase Complex; S Phase; Threonine

2005
Inhibition of nuclear import of LIMK2 in endothelial cells by protein kinase C-dependent phosphorylation at Ser-283.
    The Journal of biological chemistry, 2005, Jul-29, Volume: 280, Issue:30

    Topics: Active Transport, Cell Nucleus; Binding Sites; Cell Nucleus; Cells, Cultured; Cyclin D1; Cytoplasm; DNA-Binding Proteins; Endothelium, Vascular; Enzyme Activation; Fatty Acids, Unsaturated; Fluorescence Recovery After Photobleaching; G1 Phase; Humans; Immunoprecipitation; Lim Kinases; Microscopy, Fluorescence; Mutation; Phosphorylation; Pichia; Plasmids; Protein Binding; Protein Isoforms; Protein Kinase C; Protein Serine-Threonine Kinases; Protein Structure, Tertiary; Recombinant Proteins; Resting Phase, Cell Cycle; S Phase; Serine; Threonine; Time Factors; Transfection; Umbilical Veins

2005
Inducible expression of a degradation-resistant form of p27Kip1 causes growth arrest and apoptosis in breast cancer cells.
    FEBS letters, 2005, Jul-18, Volume: 579, Issue:18

    Topics: Adenoviridae; Alanine; Annexin A5; Apoptosis; Biomarkers, Tumor; Breast Neoplasms; CDC2-CDC28 Kinases; Cell Cycle; Cell Cycle Proteins; Cell Line; Cell Line, Tumor; Cell Proliferation; Cyclin D1; Cyclin E; Cyclin-Dependent Kinase 2; Cyclin-Dependent Kinase Inhibitor p27; Doxycycline; Ecdysterone; Humans; Immunoblotting; Mutagenesis, Site-Directed; Mutation; Phosphorylation; Prognosis; Proteasome Endopeptidase Complex; Proteins; S Phase; Threonine; Time Factors; Tumor Suppressor Proteins; Ubiquitin

2005
Differentiation-inducing factor-1 induces cyclin D1 degradation through the phosphorylation of Thr286 in squamous cell carcinoma.
    Experimental cell research, 2005, Nov-01, Volume: 310, Issue:2

    Topics: Antineoplastic Agents; Carcinoma, Squamous Cell; Cell Cycle; Cell Nucleus; Cyclin D1; Glycogen Synthase Kinase 3; Glycogen Synthase Kinase 3 beta; Hexanones; Humans; Hydrocarbons, Chlorinated; Mouth Neoplasms; Mutation; Phosphorylation; Protein Transport; RNA Interference; Threonine

2005
Coordinate regulation of forskolin-induced cellular proliferation in macrophages by protein kinase A/cAMP-response element-binding protein (CREB) and Epac1-Rap1 signaling: effects of silencing CREB gene expression on Akt activation.
    The Journal of biological chemistry, 2005, Nov-18, Volume: 280, Issue:46

    Topics: Androstadienes; Animals; bcl-Associated Death Protein; Blotting, Western; Cell Count; Cell Proliferation; Chromones; Colforsin; Cyclic AMP; Cyclic AMP Response Element-Binding Protein; Cyclic AMP-Dependent Protein Kinases; Cyclin D1; Dose-Response Relationship, Drug; Enzyme Activation; Enzyme Inhibitors; Forkhead Box Protein O1; Forkhead Transcription Factors; Gene Expression Regulation; Gene Silencing; Guanine Nucleotide Exchange Factors; Guanosine Triphosphate; Immunoprecipitation; Isoquinolines; Macrophages; Mice; Mice, Inbred C57BL; Morpholines; Phosphatidylinositol 3-Kinases; Phosphorylation; Protein Structure, Tertiary; Proto-Oncogene Proteins c-akt; Proto-Oncogene Proteins c-bcl-2; rap1 GTP-Binding Proteins; RNA Interference; RNA, Double-Stranded; Serine; Signal Transduction; Sulfonamides; Threonine; Thymidine; Time Factors; Up-Regulation; Wortmannin; X-Linked Inhibitor of Apoptosis Protein

2005
Protein phosphatase 1alpha activity prevents oncogenic transformation.
    Molecular carcinogenesis, 2006, Volume: 45, Issue:9

    Topics: Animals; Apoptosis; Caspases; Cell Transformation, Neoplastic; Cyclin D1; Humans; Mice; Mutation; Phosphoprotein Phosphatases; Phosphorylation; ras Proteins; Retinoblastoma Protein; Threonine; Transfection; Tumor Suppressor Proteins

2006
A critical role for FBXW8 and MAPK in cyclin D1 degradation and cancer cell proliferation.
    PloS one, 2006, Dec-27, Volume: 1

    Topics: Amino Acid Sequence; Amino Acid Substitution; Animals; Base Sequence; Binding Sites; Cell Cycle; Cell Line, Tumor; Cell Proliferation; Cyclin D1; F-Box Proteins; Humans; In Vitro Techniques; MAP Kinase Signaling System; Mice; Multiprotein Complexes; Mutagenesis, Site-Directed; NIH 3T3 Cells; Proteasome Endopeptidase Complex; Protein Stability; Protein Structure, Tertiary; Recombinant Fusion Proteins; RNA, Small Interfering; Threonine; Ubiquitin

2006
CDK2 regulation through PI3K and CDK4 is necessary for cell cycle progression of primary rat hepatocytes.
    Cell proliferation, 2007, Volume: 40, Issue:4

    Topics: Active Transport, Cell Nucleus; Animals; Cell Cycle; Cell Nucleus; Cell Proliferation; Cells, Cultured; Cyclin D1; Cyclin E; Cyclin-Dependent Kinase 2; Cyclin-Dependent Kinase 4; Epidermal Growth Factor; Hepatocytes; Male; Phosphatidylinositol 3-Kinases; Rats; Rats, Wistar; Threonine

2007
Phosphorylation of p27Kip1 regulates assembly and activation of cyclin D1-Cdk4.
    Molecular and cellular biology, 2008, Volume: 28, Issue:20

    Topics: Amino Acid Substitution; Catalysis; Cell Line, Tumor; Cyclin D1; Cyclin-Dependent Kinase 2; Cyclin-Dependent Kinase 4; Cyclin-Dependent Kinase Inhibitor p27; Enzyme Activation; G1 Phase; Humans; Phosphoinositide-3 Kinase Inhibitors; Phosphorylation; Phosphotyrosine; Protein Binding; Protein Kinase Inhibitors; Proto-Oncogene Proteins c-akt; Threonine

2008
Reduced amyloidogenic processing of the amyloid beta-protein precursor by the small-molecule Differentiation Inducing Factor-1.
    Cellular signalling, 2009, Volume: 21, Issue:4

    Topics: Acetylcysteine; Amyloid beta-Peptides; Amyloid beta-Protein Precursor; Animals; Benzazepines; Cell Line; Cell Line, Tumor; CHO Cells; Cricetinae; Cricetulus; Cyclin D1; Fibroblasts; Glioma; Hexanones; Humans; Hydrocarbons, Chlorinated; Indoles; Leupeptins; Mice; Peptide Fragments; Proteasome Inhibitors; Purines; Recombinant Fusion Proteins; Roscovitine; Threonine

2009
Ligand-dependent activation of the chimeric tumor necrosis factor receptor-amyloid precursor protein (APP) reveals increased APP processing and suppressed neuronal differentiation.
    Neuro-Signals, 2010, Volume: 18, Issue:1

    Topics: Amyloid beta-Protein Precursor; Animals; Cell Differentiation; Cyclin D1; Dose-Response Relationship, Drug; Enzyme Activation; Enzyme Inhibitors; Enzyme-Linked Immunosorbent Assay; Gene Expression Regulation, Enzymologic; Green Fluorescent Proteins; Humans; Ligands; Nerve Growth Factor; Neurites; PC12 Cells; Phosphorylation; Protein Isoforms; Protein Structure, Tertiary; Protein Transport; Rats; Receptor, trkA; Receptors, Tumor Necrosis Factor; Recombinant Fusion Proteins; Threonine; Time Factors; Transfection; Tumor Suppressor Protein p53

2010
Evidence for cell cycle suppression and microRNA regulation of cyclin D1 during anoxia exposure in turtles.
    Cell cycle (Georgetown, Tex.), 2012, May-01, Volume: 11, Issue:9

    Topics: 3' Untranslated Regions; Anaerobiosis; Animals; Cell Cycle Checkpoints; Cell Proliferation; Cyclin D1; Hypoxia; Kidney; Liver; MicroRNAs; Oxygen; Phosphorylation; Proteasome Endopeptidase Complex; Protein Processing, Post-Translational; Proteolysis; Regulatory Elements, Transcriptional; RNA, Messenger; Threonine; Turtles

2012
A novel DYRK1B inhibitor AZ191 demonstrates that DYRK1B acts independently of GSK3β to phosphorylate cyclin D1 at Thr(286), not Thr(288).
    The Biochemical journal, 2014, Jan-01, Volume: 457, Issue:1

    Topics: Cells, Cultured; Cyclin D1; Dyrk Kinases; G1 Phase Cell Cycle Checkpoints; Glycogen Synthase Kinase 3; Glycogen Synthase Kinase 3 beta; HEK293 Cells; Heterocyclic Compounds, 2-Ring; Humans; Phosphorylation; Protein Interaction Domains and Motifs; Protein Kinase Inhibitors; Protein Serine-Threonine Kinases; Protein-Tyrosine Kinases; Proteolysis; Pyrimidines; Substrate Specificity; Threonine

2014
The Down syndrome-related protein kinase DYRK1A phosphorylates p27(Kip1) and Cyclin D1 and induces cell cycle exit and neuronal differentiation.
    Cell cycle (Georgetown, Tex.), 2014, Volume: 13, Issue:13

    Topics: Animals; Brain; Cell Cycle; Cell Differentiation; Cell Line; Cyclin D1; Cyclin-Dependent Kinase Inhibitor p27; Down Syndrome; Dyrk Kinases; Humans; Mice, Inbred ICR; Neurogenesis; Neurons; Phosphorylation; Primary Cell Culture; Protein Serine-Threonine Kinases; Protein-Tyrosine Kinases; Serine; Threonine

2014
Silymarin induces cyclin D1 proteasomal degradation via its phosphorylation of threonine-286 in human colorectal cancer cells.
    International immunopharmacology, 2015, Volume: 24, Issue:1

    Topics: Antineoplastic Agents; Cell Cycle; Cell Proliferation; Colorectal Neoplasms; Cyclin D1; HCT116 Cells; Humans; Leupeptins; NF-kappa B; Nitriles; Phosphorylation; Point Mutation; Proteasome Endopeptidase Complex; Proteolysis; Silybum marianum; Silymarin; Sulfones; Threonine

2015
Novel RNA chaperone domain of RNA-binding protein La is regulated by AKT phosphorylation.
    Nucleic acids research, 2015, Volume: 43, Issue:1

    Topics: 5' Untranslated Regions; Amino Acid Motifs; Autoantigens; Binding Sites; Codon, Initiator; Cyclin D1; HEK293 Cells; Humans; Phosphorylation; Protein Biosynthesis; Protein Structure, Tertiary; Proto-Oncogene Proteins c-akt; Ribonucleoproteins; RNA; SS-B Antigen; Threonine

2015
Pharmacologic co-inhibition of Mnks and mTORC1 synergistically suppresses proliferation and perturbs cell cycle progression in blast crisis-chronic myeloid leukemia cells.
    Cancer letters, 2015, Feb-28, Volume: 357, Issue:2

    Topics: Adaptor Proteins, Signal Transducing; Apoptosis; Blast Crisis; Blotting, Western; Cell Cycle Proteins; Cell Line, Tumor; Cell Proliferation; Cell Survival; Cyclin D1; Drug Synergism; Enzyme Inhibitors; Flow Cytometry; G1 Phase Cell Cycle Checkpoints; HCT116 Cells; HT29 Cells; Humans; Intracellular Signaling Peptides and Proteins; K562 Cells; MCF-7 Cells; Mechanistic Target of Rapamycin Complex 1; Molecular Structure; Multiprotein Complexes; Phosphoproteins; Phosphorylation; Protein Serine-Threonine Kinases; Reverse Transcriptase Polymerase Chain Reaction; Threonine; TOR Serine-Threonine Kinases; U937 Cells

2015
The involvement of cyclin D1 degradation through GSK3β-mediated threonine-286 phosphorylation-dependent nuclear export in anti-cancer activity of mulberry root bark extracts.
    Phytomedicine : international journal of phytotherapy and phytopharmacology, 2016, Feb-15, Volume: 23, Issue:2

    Topics: Active Transport, Cell Nucleus; Cell Line, Tumor; Cell Proliferation; Cyclin D1; Down-Regulation; Glycogen Synthase Kinase 3; Glycogen Synthase Kinase 3 beta; Half-Life; Humans; Leupeptins; Morus; Phosphorylation; Plant Bark; Plant Extracts; Proteolysis; Threonine

2016
Comprehensive Genomic Profiling of Clinically Advanced Medullary Thyroid Carcinoma.
    Oncology, 2016, Volume: 90, Issue:6

    Topics: Aged; Anilides; Antineoplastic Combined Chemotherapy Protocols; Carcinoma, Neuroendocrine; Cyclin D1; Cyclin-Dependent Kinase Inhibitor p16; Drug Resistance, Neoplasm; Everolimus; Female; Fibroblast Growth Factor 3; Fibroblast Growth Factors; Gene Amplification; Gene Expression Profiling; Gene Expression Regulation, Neoplastic; Humans; Male; Methionine; Middle Aged; Molecular Targeted Therapy; Mutation; Piperidines; Proto-Oncogene Proteins c-ret; Proto-Oncogene Proteins p21(ras); Pyridines; Quinazolines; Threonine; Thyroid Neoplasms

2016
The coffee diterpene kahweol suppresses the cell proliferation by inducing cyclin D1 proteasomal degradation via ERK1/2, JNK and GKS3β-dependent threonine-286 phosphorylation in human colorectal cancer cells.
    Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association, 2016, Volume: 95

    Topics: Antineoplastic Agents; Blotting, Western; Cell Proliferation; Coffee; Colorectal Neoplasms; Cyclin D1; Diterpenes; Glycogen Synthase Kinase 3 beta; Humans; MAP Kinase Kinase 4; MAP Kinase Signaling System; Phosphorylation; Proteasome Endopeptidase Complex; Proteolysis; Real-Time Polymerase Chain Reaction; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Threonine; Tumor Cells, Cultured

2016
Elevated O-GlcNAcylation promotes gastric cancer cells proliferation by modulating cell cycle related proteins and ERK 1/2 signaling.
    Oncotarget, 2016, Sep-20, Volume: 7, Issue:38

    Topics: Acetylglucosamine; Animals; Cell Cycle; Cell Line, Tumor; Cell Proliferation; Cyclin D1; Cyclin-Dependent Kinase 2; Down-Regulation; Female; Gene Knockdown Techniques; Humans; Male; MAP Kinase Signaling System; Mice; Mice, Inbred BALB C; Mice, Nude; Middle Aged; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; N-Acetylglucosaminyltransferases; Phosphorylation; Protein Processing, Post-Translational; RNA Interference; RNA, Small Interfering; Serine; Stomach Neoplasms; Threonine; Up-Regulation; Xenograft Model Antitumor Assays

2016
Histone H2A T120 Phosphorylation Promotes Oncogenic Transformation via Upregulation of Cyclin D1.
    Molecular cell, 2016, 10-06, Volume: 64, Issue:1

    Topics: Amino Acid Sequence; Animals; Cell Line, Tumor; Cell Transformation, Neoplastic; Chromatin; Cyclin D1; Drosophila melanogaster; Drosophila Proteins; Gene Expression Regulation, Neoplastic; HeLa Cells; Histones; Humans; Intracellular Signaling Peptides and Proteins; Methylation; Mice; Oligopeptides; Phosphorylation; Protamine Kinase; Protein Processing, Post-Translational; Protein Serine-Threonine Kinases; Sequence Alignment; Sequence Homology, Amino Acid; Signal Transduction; Threonine; Ubiquitination

2016
Anti-cancer activity of
    Die Pharmazie, 2017, Jun-01, Volume: 72, Issue:6

    Topics: Antineoplastic Agents; Bacillus amyloliquefaciens; Cell Line, Tumor; Cell Proliferation; Colorectal Neoplasms; Cyclin D1; Down-Regulation; Gene Expression Regulation, Neoplastic; Glycogen Synthase Kinase 3 beta; Humans; Phosphorylation; Rhizosphere; Soil Microbiology; Threonine

2017
Biological adaptations in the Arctic cervid, the reindeer (
    Science (New York, N.Y.), 2019, 06-21, Volume: 364, Issue:6446

    Topics: Adaptation, Biological; Amino Acid Motifs; Amino Acid Substitution; Animals; Antlers; Arctic Regions; Binding Sites; Circadian Rhythm; Cyclin D1; Female; Period Circadian Proteins; Proline; Reindeer; Threonine; Vitamin D

2019
Non-phosphorylatable cyclin D1 mutant potentiates endometrial hyperplasia and drives carcinoma with Pten loss.
    Oncogene, 2022, Volume: 41, Issue:15

    Topics: Animals; Carcinoma; Cyclin D1; Cyclin-Dependent Kinase 4; Endometrial Hyperplasia; Female; Humans; Inflammation; Mice; PTEN Phosphohydrolase; Threonine

2022
Pregnane X receptor promotes liver enlargement in mice through the spatial induction of hepatocyte hypertrophy and proliferation.
    Chemico-biological interactions, 2022, Nov-01, Volume: 367

    Topics: Animals; Anions; ATP Binding Cassette Transporter, Subfamily B; Cell Proliferation; Cyclin B1; Cyclin D1; Cyclin-Dependent Kinase Inhibitor p27; Cyclin-Dependent Kinases; Cytochrome P-450 CYP3A; Cytochrome P-450 Enzyme System; Digitonin; Hepatocytes; Hepatomegaly; Hypertrophy; Liver; Mice; Mice, Inbred C57BL; NIMA-Related Kinases; Pregnane X Receptor; Receptors, Cytoplasmic and Nuclear; Receptors, Steroid; Retinoblastoma-Like Protein p130; Serine; Threonine; Triglycerides

2022