Compounds > threonine

threonine and chir 090

threonine has been researched along with chir 090 in 13 studies

Research

Studies (13)

Timeframe	Studies, this research(%)	All Research%
pre-1990	0 (0.00)	18.7374
1990's	0 (0.00)	18.2507
2000's	3 (23.08)	29.6817
2010's	10 (76.92)	24.3611
2020's	0 (0.00)	2.80

Authors

Authors	Studies
Andersen, NH; Bowman, JL; Endsley, S; Guan, Z; McClerren, AL; Raetz, CR; Rudolph, J	1
Barb, AW; Jiang, L; Raetz, CR; Zhou, P	1
Barb, AW; Zhou, P	1
Bodewits, K; Campopiano, DJ; Govan, JR; Raetz, CR	1
Angell, HD; Christianson, DW; Cole, KE; Fierke, CA; Gattis, SG	1
Barnes, SW; Caughlan, RE; Dean, CR; Delucia, AM; Jones, AK; Ma, B; Sprague, ER; Walker, JR; Woods, AL; Xie, L; Yang, X	1
Holl, R; Oddo, A	1
Allen, EK; Buurman, ET; Choy, AL; Daryaee, F; Ehmann, DE; Fisher, SL; Grosser, LA; Hajec, L; Hale, MR; Johnstone, M; Marone, V; Murphy-Benenato, K; O'Donnell, J; Patey, SA; Ross, PL; Schuck, VJ; Tonge, PJ; Walker, SG; Walkup, GK; You, Z	1
Bruhn, DF; Frank, MW; Lee, RE; Rock, CO; Yao, J	1
Barrett, MP; Ehmann, DE; Mills, SD; Perros, M; Vincent, IM	1
Gopalaswamy, R; Lee, CJ; Lemaitre, N; Liang, X; Najeeb, J; Sebbane, F; Titecat, M; Toone, EJ; Wu, Q; Zhao, J; Zhou, P	1
Chan, H; De Pascale, G; Dean, CR; Richie, DL; Six, DA; Wang, L; Wei, JR	1
Bi, Y; Bin, L; Chang, Y; Deng, H; Ding, L; Gao, H; Han, N; Hou, F; Huang, Z; Li, Z; Pan, Z; Yang, R; Zhi, F	1

Reviews

1 review(s) available for threonine and chir 090

Article	Year
Mechanism and inhibition of LpxC: an essential zinc-dependent deacetylase of bacterial lipid A synthesis. Current pharmaceutical biotechnology, 2008, Volume: 9, Issue:1 Topics: Amidohydrolases; Animals; Escherichia coli Proteins; Humans; Hydroxamic Acids; Lipid A; Threonine; Zinc	2008

Other Studies

12 other study(ies) available for threonine and chir 090

Article	Year
A slow, tight-binding inhibitor of the zinc-dependent deacetylase LpxC of lipid A biosynthesis with antibiotic activity comparable to ciprofloxacin. Biochemistry, 2005, Dec-20, Volume: 44, Issue:50 Topics: Amidohydrolases; Anti-Bacterial Agents; Ciprofloxacin; Enzyme Inhibitors; Hydroxamic Acids; Lipid A; Magnetic Resonance Spectroscopy; Models, Molecular; Threonine; Zinc	2005
Structure of the deacetylase LpxC bound to the antibiotic CHIR-090: Time-dependent inhibition and specificity in ligand binding. Proceedings of the National Academy of Sciences of the United States of America, 2007, Nov-20, Volume: 104, Issue:47 Topics: Acetylene; Acetylesterase; Amino Acid Sequence; Anti-Bacterial Agents; Bacterial Proteins; Biphenyl Compounds; Catalysis; Conserved Sequence; Enzyme Inhibitors; Hydroxamic Acids; Ligands; Models, Molecular; Molecular Sequence Data; Morpholines; Mutation; Nuclear Magnetic Resonance, Biomolecular; Protein Binding; Protein Structure, Tertiary; Sequence Alignment; Substrate Specificity; Threonine; Time Factors	2007
Antimicrobial activity of CHIR-090, an inhibitor of lipopolysaccharide biosynthesis, against the Burkholderia cepacia complex. Antimicrobial agents and chemotherapy, 2010, Volume: 54, Issue:8 Topics: Amidohydrolases; Burkholderia cepacia complex; Burkholderia Infections; Humans; Hydroxamic Acids; Microbial Sensitivity Tests; Threonine	2010
Structure of the metal-dependent deacetylase LpxC from Yersinia enterocolitica complexed with the potent inhibitor CHIR-090 . Biochemistry, 2011, Jan-18, Volume: 50, Issue:2 Topics: Amidohydrolases; Amino Acid Sequence; Anti-Bacterial Agents; Crystallography, X-Ray; Enzyme Inhibitors; Humans; Hydroxamic Acids; Models, Molecular; Molecular Sequence Data; Protein Conformation; Sequence Alignment; Threonine; Yersinia enterocolitica; Yersinia Infections	2011
Mechanisms decreasing in vitro susceptibility to the LpxC inhibitor CHIR-090 in the gram-negative pathogen Pseudomonas aeruginosa. Antimicrobial agents and chemotherapy, 2012, Volume: 56, Issue:1 Topics: Amidohydrolases; Anti-Bacterial Agents; Bacterial Outer Membrane Proteins; Base Sequence; Cloning, Molecular; Drug Resistance, Multiple, Bacterial; Fatty Acids; Gene Expression Regulation, Bacterial; Genes, Reporter; Hydroxamic Acids; Luminescent Measurements; Membrane Transport Proteins; Microbial Sensitivity Tests; Molecular Sequence Data; Plasmids; Pseudomonas aeruginosa; Pseudomonas Infections; Recombinant Fusion Proteins; Sequence Analysis, DNA; Threonine; Transformation, Bacterial	2012
Design and stereoselective synthesis of a C-aryl furanoside as a conformationally constrained CHIR-090 analogue. Carbohydrate research, 2012, Oct-01, Volume: 359 Topics: Amidohydrolases; Carbohydrate Conformation; Chemistry Techniques, Synthetic; Drug Design; Enzyme Inhibitors; Glycosides; Hydroxamic Acids; Stereoisomerism; Substrate Specificity; Threonine	2012
Translating slow-binding inhibition kinetics into cellular and in vivo effects. Nature chemical biology, 2015, Volume: 11, Issue:6 Topics: Amidohydrolases; Animals; Anti-Bacterial Agents; Enzyme Inhibitors; Hydroxamic Acids; Kinetics; Mice, Inbred Strains; Microbial Sensitivity Tests; Models, Biological; Molecular Structure; Protein Binding; Pseudomonas aeruginosa; Threonine; Time Factors	2015
Activation of Exogenous Fatty Acids to Acyl-Acyl Carrier Protein Cannot Bypass FabI Inhibition in Neisseria. The Journal of biological chemistry, 2016, Jan-01, Volume: 291, Issue:1 Topics: Acyl Carrier Protein; Bacterial Proteins; Benzofurans; Coenzyme A Ligases; Enoyl-(Acyl-Carrier-Protein) Reductase (NADH); Fatty Acids; Hydroxamic Acids; Lipopolysaccharides; Models, Biological; Neisseria; Phospholipids; Pyrones; Threonine	2016
Untargeted Metabolomics To Ascertain Antibiotic Modes of Action. Antimicrobial agents and chemotherapy, 2016, Volume: 60, Issue:4 Topics: Acyltransferases; Adenosine; Anti-Bacterial Agents; Carbonyl Cyanide m-Chlorophenyl Hydrazone; Ceftazidime; Cell Wall; Chromatography, Liquid; DNA, Bacterial; Escherichia coli; Fosfomycin; Gene Expression; HEK293 Cells; Humans; Hydroxamic Acids; Mass Spectrometry; Metabolome; Metabolomics; Nucleoside-Phosphate Kinase; Pyrimidines; Terpenes; Threonine; Triclosan	2016
Drug design from the cryptic inhibitor envelope. Nature communications, 2016, Feb-25, Volume: 7 Topics: Amidohydrolases; Anti-Bacterial Agents; Crystallization; Crystallography, X-Ray; Drug Design; Enzyme Inhibitors; Escherichia coli; Gram-Negative Bacteria; Hydroxamic Acids; Ligands; Magnetic Resonance Spectroscopy; Microbial Sensitivity Tests; Models, Molecular; Molecular Dynamics Simulation; Molecular Targeted Therapy; Protein Conformation; Pseudomonas aeruginosa; Threonine	2016
A pathway-directed positive growth restoration assay to facilitate the discovery of lipid A and fatty acid biosynthesis inhibitors in Acinetobacter baumannii. PloS one, 2018, Volume: 13, Issue:3 Topics: Acinetobacter baumannii; Biological Assay; Cerulenin; Enoyl-(Acyl-Carrier-Protein) Reductase (NADH); Fatty Acid Synthases; Fatty Acid Synthesis Inhibitors; Fatty Acids; Hydroxamic Acids; Lipid A; Threonine	2018
Application of LpxC enzyme inhibitor to inhibit some fast-growing bacteria in human gut bacterial culturomics. BMC microbiology, 2019, 12-30, Volume: 19, Issue:1 Topics: Adult; Amidohydrolases; Anti-Bacterial Agents; Bacteria; Bacteriological Techniques; Blood Culture; DNA, Bacterial; Enzyme Inhibitors; Feces; Gastrointestinal Microbiome; Healthy Volunteers; Humans; Hydroxamic Acids; Sequence Analysis, DNA; Threonine	2019