threonine has been researched along with alpha-synuclein in 33 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 2 (6.06) | 18.2507 |
| 2000's | 15 (45.45) | 29.6817 |
| 2010's | 13 (39.39) | 24.3611 |
| 2020's | 3 (9.09) | 2.80 |
| Authors | Studies |
|---|---|
| Crowther, RA; Goedert, M; Jakes, R; Spillantini, MG | 1 |
| Conway, KA; Harper, JD; Lansbury, PT | 2 |
| Alves da Costa, C; Ancolio, K; Checler, F; Uéda, K | 1 |
| Conway, KA; Lansbury, PT; Rochet, JC | 1 |
| Copeland, NG; Dawson, TM; Jenkins, NA; Lee, MK; Mandir, AS; Price, DL; Qui, D; Stirling, W; Xu, X; Xu, Y | 1 |
| Berger, K; Holzmann, C; Krüger, R; Riess, O; Saecker, AM; Schmitt, I; Schöls, L | 1 |
| Bussell, R; Eliezer, D | 1 |
| Bisceglio, G; Farrer, MJ; Hope, AD; Hulihan, M; Kachergus, J; Lincoln, S; Myhre, R | 1 |
| Auburger, G; Cabin, DE; Gispert-Sanchez, S; Murphy, D; Myers, RR; Nussbaum, RL | 1 |
| Copeland, NG; Jenkins, NA; Lee, MK; Martin, LJ; Pan, Y; Price, AC; Price, DL; Sterling, W | 1 |
| Chung, KC; Kim, HJ; Kim, J; Lee, CH; Lee, D; Paik, SR | 1 |
| Athanassiadou, A; Chung, EJ; Davanos, N; Ki, CS; Kim, JY; Lee, WY; Stavrou, EF | 1 |
| Ikeuchi, T; Ishikawa, A; Ito, G; Iwatsubo, T; Kakita, A; Kaneko, H; Kasuga, K; Kuwano, R; Miyashita, A; Nishizawa, M; Nozaki, H; Onodera, O; Sisodia, SS; Takahashi, H | 1 |
| Bras, J; Calado, A; Dias, M; Guerreiro, R; Hardy, J; Januario, C; Morgadinho, A; Oliveira, C; Ribeiro, M; Semedo, C; Singleton, A | 1 |
| Sotiriou, E; Stefanis, L; Vassilatis, DK; Vila, M | 1 |
| Adame, A; Crews, L; Dallapiccola, B; Marongiu, R; Masliah, E; Patrick, C; Spencer, B; Trejo, M; Valente, EM | 1 |
| Bendixen, C; Bertelsen, MF; Hedegaard, C; Larsen, K | 1 |
| Hamilton, BA | 1 |
| Bax, A; Bodner, CR; Dobson, CM; Maltsev, AS | 1 |
| Chen, Y; Ding, ZT; Jiang, YP; Lan, DM; Liu, FT; Ren, HM; Wang, J; Wu, JJ; Yue, ZY; Zhao, J | 1 |
| Caspell, C; Chen-Plotkin, AS; Chowdhury, S; Coffey, CS; Frasier, M; Irwin, DJ; Jennings, D; Kang, JH; Kieburtz, K; Marek, K; Mollenhauer, B; Pan, S; Shaw, LM; Siderowf, A; Simuni, T; Singleton, A; Tanner, CM; Taylor, P; Toga, AW; Trojanowski, JQ; Waligórska, T | 1 |
| Fujinaga, M; Furutsuka, K; Hashimoto, H; Hatori, A; Kawamura, K; Kumata, K; Nengaki, N; Shimoda, Y; Shiomi, S; Takei, M; Wakizaka, H; Xie, L; Yamasaki, T; Yui, J; Zhang, MR | 1 |
| Boddeke, HW; Copray, JC; Ferrari, MF; Melo, TQ; van Zomeren, KC | 1 |
| Craven, TW; De Leon, CA; Levine, PM; Pratt, MR | 1 |
| Braun, AR; Grossfield, A; Lewis, AK; Romo, TD; Sachs, JN | 1 |
| Dai, L; Kuang, S; Li, J; Rao, Z; Tang, X; Yang, L; Zhong, H; Zhong, Z | 1 |
| Brotchie, JM; Chiu, WH; Decher, N; Geibl, FF; Henrich, MT; Koprich, JB; Lee, B; Matschke, LA; Oertel, WH; Timmermann, L | 1 |
| Beratis, I; Fragkiadaki, S; Kontaxopoulou, D; Koros, C; Marek, K; Papadimitriou, D; Papageorgiou, SG; Papagiannakis, N; Prentakis, A; Seibyl, J; Simitsi, A; Stamelou, M; Stefanis, L; Trapali, XG | 1 |
| Julku, UH; Kilpeläinen, T; Myöhänen, TT; Svarcbahs, R | 1 |
| Galesic, A; Pratt, MR | 1 |
| Braun, AR; Nathan Kochen, N; Pandey, AK; Sachs, JN; Seaney, D; Vasandani, V; Walters, MA | 1 |
| Hayashi, H; Kakita, A; Miki, Y; Mori, F; Ozaki, T; Tanaka, MT; Tanji, K; Wakabayashi, K | 1 |
33 other study(ies) available for threonine and alpha-synuclein
| Article | Year |
|---|---|
Synthetic filaments assembled from C-terminally truncated alpha-synuclein.
Topics: Alanine; alpha-Synuclein; Amino Acid Substitution; Cloning, Molecular; Humans; Microscopy, Electron; Mutagenesis, Site-Directed; Nerve Tissue Proteins; Open Reading Frames; Phosphoproteins; Point Mutation; Proline; Recombinant Proteins; Sequence Deletion; Synucleins; Threonine | 1998 |
Accelerated in vitro fibril formation by a mutant alpha-synuclein linked to early-onset Parkinson disease.
Topics: Age of Onset; Alanine; alpha-Synuclein; Amino Acid Substitution; Circular Dichroism; Humans; Lewy Bodies; Microscopy, Atomic Force; Microscopy, Electron; Mutagenesis, Site-Directed; Nerve Tissue Proteins; Neurons; Parkinson Disease; Phosphoproteins; Point Mutation; Recombinant Proteins; Substantia Nigra; Synucleins; Threonine | 1998 |
Fibrils formed in vitro from alpha-synuclein and two mutant forms linked to Parkinson's disease are typical amyloid.
Topics: Alanine; alpha-Synuclein; Amino Acid Sequence; Amyloid; Benzothiazoles; Binding Sites; Brain; Circular Dichroism; Congo Red; Endopeptidases; Humans; Hydrolysis; Immunohistochemistry; Lewy Bodies; Microscopy, Atomic Force; Microscopy, Polarization; Molecular Sequence Data; Mutation, Missense; Nerve Tissue Proteins; Parkinson Disease; Postmortem Changes; Proline; Protein Structure, Secondary; Recombinant Proteins; Spectrometry, Fluorescence; Spectroscopy, Fourier Transform Infrared; Synucleins; Thiazoles; Threonine | 2000 |
Alpha-synuclein and the Parkinson's disease-related mutant Ala53Thr-alpha-synuclein do not undergo proteasomal degradation in HEK293 and neuronal cells.
Topics: Alanine; alpha-Synuclein; Amino Acid Substitution; Animals; Cell Line; Cysteine Endopeptidases; Humans; Mice; Multienzyme Complexes; Mutation; Nerve Tissue Proteins; Neurons; Parkinson Disease; Proteasome Endopeptidase Complex; Synucleins; Threonine; Transfection | 2000 |
Inhibition of fibrillization and accumulation of prefibrillar oligomers in mixtures of human and mouse alpha-synuclein.
Topics: Alanine; alpha-Synuclein; Amyloid; Animals; Chromatography, Gel; Humans; Mice; Microscopy, Atomic Force; Mutagenesis, Site-Directed; Nerve Tissue Proteins; Parkinson Disease; Protein Conformation; Protein Folding; Protein Precursors; Spectroscopy, Fourier Transform Infrared; Synucleins; Threonine | 2000 |
Human alpha-synuclein-harboring familial Parkinson's disease-linked Ala-53 --> Thr mutation causes neurodegenerative disease with alpha-synuclein aggregation in transgenic mice.
Topics: Alanine; alpha-Synuclein; Animals; Humans; Mice; Mice, Transgenic; Mutation; Nerve Tissue Proteins; Parkinson Disease; Reverse Transcriptase Polymerase Chain Reaction; Synucleins; Threonine | 2002 |
Polymorphisms of the alpha-synuclein promoter: expression analyses and association studies in Parkinson's disease.
Topics: Aged; alpha-Synuclein; Cell Culture Techniques; Cysteine; Enzyme-Linked Immunosorbent Assay; Female; Gene Expression Regulation; Genes, Reporter; Glycine; Haplotypes; Humans; Male; Middle Aged; Nerve Tissue Proteins; Neuroblastoma; Parkinson Disease; Polymerase Chain Reaction; Polymorphism, Genetic; Polymorphism, Single-Stranded Conformational; Promoter Regions, Genetic; Synucleins; Threonine; Transfection | 2003 |
Effects of Parkinson's disease-linked mutations on the structure of lipid-associated alpha-synuclein.
Topics: Alanine; alpha-Synuclein; Humans; Lipid Metabolism; Liposomes; Micelles; Mutation, Missense; Nerve Tissue Proteins; Nuclear Magnetic Resonance, Biomolecular; Parkinson Disease; Phosphatidic Acids; Phosphatidylcholines; Proline; Protein Binding; Protein Structure, Secondary; Recombinant Proteins; Synucleins; Threonine | 2004 |
Alpha-synuclein missense and multiplication mutations in autosomal dominant Parkinson's disease.
Topics: Adult; Age Factors; Alanine; alpha-Synuclein; DNA Mutational Analysis; Exons; Family Health; Female; Humans; Male; Middle Aged; Mutation; Nerve Tissue Proteins; Parkinsonian Disorders; Polymorphism, Single Nucleotide; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Synucleins; Threonine | 2004 |
Exacerbated synucleinopathy in mice expressing A53T SNCA on a Snca null background.
Topics: Age Factors; Alanine; alpha-Synuclein; Animals; Behavior, Animal; Blotting, Western; Disease Models, Animal; Glial Fibrillary Acidic Protein; Humans; Immunohistochemistry; Mice; Mice, Transgenic; Microscopy, Electron, Transmission; Motor Activity; Mutation; Nerve Tissue Proteins; Parkinson Disease; Phenylenediamines; RNA; Sciatic Nerve; Spinal Cord; Synucleins; Threonine; Wallerian Degeneration | 2005 |
Parkinson's disease alpha-synuclein transgenic mice develop neuronal mitochondrial degeneration and cell death.
Topics: Alanine; alpha-Synuclein; Animals; Brain Stem; Cell Death; DNA Damage; Humans; Mice; Mice, Transgenic; Mitochondria; Mutation; Neocortex; Nerve Degeneration; Parkinson Disease; Threonine | 2006 |
Calpain-resistant fragment(s) of alpha-synuclein regulates the synuclein-cleaving activity of 20S proteasome.
Topics: alpha-Synuclein; Amino Acid Sequence; Amino Acid Substitution; Amino Acids; Animals; Calpain; Electrophoresis, Polyacrylamide Gel; Glutamates; Hydrolysis; Models, Biological; Molecular Sequence Data; Mutation; Proline; Proteasome Endopeptidase Complex; Serine; Substrate Specificity; Swine; Threonine | 2006 |
The Ala53Thr mutation in the alpha-synuclein gene in a Korean family with Parkinson disease.
Topics: Adult; Age of Onset; Alanine; alpha-Synuclein; Amino Acid Substitution; Family; Haplotypes; Humans; Korea; Male; Mutation; Parkinson Disease; Pedigree; Threonine | 2007 |
Enhanced accumulation of phosphorylated alpha-synuclein and elevated beta-amyloid 42/40 ratio caused by expression of the presenilin-1 deltaT440 mutant associated with familial Lewy body disease and variant Alzheimer's disease.
Topics: Aged; alpha-Synuclein; Alzheimer Disease; Amyloid beta-Peptides; Animals; Cell Line, Tumor; Enzyme-Linked Immunosorbent Assay; Gene Expression Regulation; Glioma; Humans; Lewy Body Disease; Mice; Middle Aged; Mutation; Neuroblastoma; Phosphorylation; Presenilin-1; Rats; Receptors, Notch; Threonine; Transfection | 2007 |
Analysis of Parkinson disease patients from Portugal for mutations in SNCA, PRKN, PINK1 and LRRK2.
Topics: Aged; alpha-Synuclein; DNA Mutational Analysis; Exons; Family Health; Female; Genetic Predisposition to Disease; Humans; Leucine-Rich Repeat Serine-Threonine Protein Kinase-2; Male; Methionine; Middle Aged; Mutation; Parkinson Disease; Portugal; Protein Kinases; Protein Serine-Threonine Kinases; Threonine; Ubiquitin-Protein Ligases | 2008 |
Selective noradrenergic vulnerability in α-synuclein transgenic mice.
Topics: Alanine; alpha-Synuclein; Animals; Disease Models, Animal; Humans; Mice; Mice, Inbred C3H; Mice, Inbred C57BL; Mice, Transgenic; Norepinephrine; Parkinson Disease; Threonine | 2010 |
Mutant Pink1 induces mitochondrial dysfunction in a neuronal cell model of Parkinson's disease by disturbing calcium flux.
Topics: Adenosine Triphosphate; Alanine; alpha-Synuclein; Analysis of Variance; Animals; Calcium; Cell Line, Tumor; Cobalt; Dose-Response Relationship, Drug; Flufenamic Acid; Gene Expression Regulation; Green Fluorescent Proteins; Microscopy, Electron, Transmission; Microtubule-Associated Proteins; Mitochondria; Mutation; Neuroblastoma; Neurons; Protein Kinases; Rats; Threonine; Transfection; Tryptophan | 2009 |
Threonine 53 in alpha-synuclein is conserved in long-living non-primate animals.
Topics: alpha-Synuclein; Amino Acid Sequence; Animals; Conserved Sequence; Evolution, Molecular; Humans; Longevity; Molecular Sequence Data; Parkinson Disease; Sequence Alignment; Threonine | 2009 |
Letter to the editor on "Threonine 53 in alpha-synuclein is conserved in long-living non-primate animals".
Topics: alpha-Synuclein; Amino Acid Sequence; Animals; Cercopithecidae; Conserved Sequence; Humans; Mutation; Parkinson Disease; Platyrrhini; Threonine | 2010 |
Differential phospholipid binding of alpha-synuclein variants implicated in Parkinson's disease revealed by solution NMR spectroscopy.
Topics: Alanine; alpha-Synuclein; Genetic Variation; Glutamic Acid; Humans; Lysine; Magnetic Resonance Spectroscopy; Mutagenesis, Site-Directed; Parkinson Disease; Peptide Fragments; Phospholipids; Proline; Protein Binding; Protein Structure, Secondary; Protein Structure, Tertiary; Solutions; Threonine | 2010 |
Effect of trehalose on PC12 cells overexpressing wild-type or A53T mutant α-synuclein.
Topics: Adenine; Alanine; alpha-Synuclein; Animals; Autophagy; Blotting, Western; Cell Survival; Dose-Response Relationship, Drug; Fluorescent Antibody Technique; Lysosomes; Microscopy, Electron, Transmission; PC12 Cells; Phagosomes; Phosphoinositide-3 Kinase Inhibitors; Point Mutation; Proteasome Inhibitors; Rats; Signal Transduction; Tetrazolium Salts; Thiazoles; Threonine; Transduction, Genetic; Trehalose; Up-Regulation | 2012 |
Association of cerebrospinal fluid β-amyloid 1-42, T-tau, P-tau181, and α-synuclein levels with clinical features of drug-naive patients with early Parkinson disease.
Topics: alpha-Synuclein; Amyloid beta-Peptides; Case-Control Studies; Cohort Studies; Female; Humans; Male; Memory; Middle Aged; Movement; Neuropsychological Tests; Parkinson Disease; Peptide Fragments; Phosphorylation; Regression Analysis; Severity of Illness Index; Statistics as Topic; tau Proteins; Threonine; Verbal Learning | 2013 |
Dynamic Changes in Striatal mGluR1 But Not mGluR5 during Pathological Progression of Parkinson's Disease in Human Alpha-Synuclein A53T Transgenic Rats: A Multi-PET Imaging Study.
Topics: Alanine; alpha-Synuclein; Animals; Corpus Striatum; Disease Models, Animal; Disease Progression; Excitatory Amino Acid Agents; Exploratory Behavior; Female; Humans; Motor Activity; Oximes; Parkinson Disease; Protein Binding; Pyridines; Radioisotopes; Radionuclide Imaging; Rats; Rats, Transgenic; Receptors, Metabotropic Glutamate; Threonine; Time Factors | 2016 |
Impairment of mitochondria dynamics by human A53T α-synuclein and rescue by NAP (davunetide) in a cell model for Parkinson's disease.
Topics: Alanine; alpha-Synuclein; Cell Differentiation; Cell Line, Tumor; Gene Expression Regulation; Humans; Kymography; Luminescent Proteins; Membrane Potential, Mitochondrial; Microtubule-Associated Proteins; Mitochondria; Neuroblastoma; Oligopeptides; Reactive Oxygen Species; RNA, Messenger; Threonine; Transfection | 2017 |
The Sulfur-Linked Analogue of O-GlcNAc (S-GlcNAc) Is an Enzymatically Stable and Reasonable Structural Surrogate for O-GlcNAc at the Peptide and Protein Levels.
Topics: Acetylglucosamine; alpha-Synuclein; Animals; beta-N-Acetylhexosaminidases; Circular Dichroism; Computational Biology; Humans; Models, Molecular; Nuclear Magnetic Resonance, Biomolecular; Peptide Fragments; Protein Folding; Protein Processing, Post-Translational; Protein Stability; Recombinant Proteins; Serine; Substrate Specificity; Threonine | 2017 |
Minimal Nucleation State of α-Synuclein Is Stabilized by Dynamic Threonine-Water Networks.
Topics: alpha-Synuclein; Animals; Hydrogen Bonding; Kinetics; Molecular Dynamics Simulation; Protein Stability; Protein Structure, Secondary; Solvents; Threonine; Water | 2017 |
Effects of Ginkgo Biloba Extract on A53T α-Synuclein Transgenic Mouse Models of Parkinson's Disease.
Topics: Alanine; alpha-Synuclein; Animals; Antiparkinson Agents; Disease Models, Animal; Dopamine Plasma Membrane Transport Proteins; Dose-Response Relationship, Drug; Ginkgo biloba; Glutathione; Glutathione Peroxidase; Locomotion; Malondialdehyde; Mice; Mice, Transgenic; Muscle Strength; Mutation; Parkinson Disease; Plant Extracts; Superoxide Dismutase; Swimming; Threonine | 2018 |
A53T-α-synuclein overexpression in murine locus coeruleus induces Parkinson's disease-like pathology in neurons and glia.
Topics: Alanine; alpha-Synuclein; Animals; Calcium-Binding Proteins; Disease Models, Animal; Endopeptidase K; Humans; Locus Coeruleus; Male; Mice; Mice, Inbred C57BL; Microfilament Proteins; Mutation; Nerve Tissue Proteins; Neuroglia; Neurons; Parkinson Disease; Protein Aggregates; Protein Transport; Threonine; Time Factors; Transduction, Genetic; Tyrosine 3-Monooxygenase | 2018 |
123I-FP-CIT SPECT [(123) I-2β-carbomethoxy-3β-(4-iodophenyl)-N-(3-fluoropropyl) nortropane single photon emission computed tomography] Imaging in a p.A53T α-synuclein Parkinson's disease cohort versus Parkinson's disease.
Topics: Adult; Alanine; alpha-Synuclein; Cognition Disorders; Cohort Studies; Corpus Striatum; Dopamine; Female; Functional Laterality; Humans; Male; Middle Aged; Mutation; Parkinson Disease; Threonine; Tomography, Emission-Computed, Single-Photon; Tropanes | 2018 |
Behavioural and dopaminergic changes in double mutated human A30P*A53T alpha-synuclein transgenic mouse model of Parkinson´s disease.
Topics: Aging; Alanine; alpha-Synuclein; Amino Acid Substitution; Animals; Behavior, Animal; Disease Models, Animal; Dopaminergic Neurons; Humans; Locomotion; Male; Mice; Mice, Inbred C57BL; Mice, Transgenic; Mutation, Missense; Parkinson Disease; Proline; Threonine | 2019 |
Investigating the Effects of O-GlcNAc Modifications in Parkinson's Disease Using Semisynthetic α-Synuclein.
Topics: Acetylglucosamine; alpha-Synuclein; Cysteine; Escherichia coli; Esters; Gene Expression; Glycosylation; Humans; Parkinson Disease; Peptide Biosynthesis; Peptides; Plasmids; Protein Engineering; Recombinant Proteins; Solid-Phase Synthesis Techniques; Sulfhydryl Compounds; Threonine | 2020 |
Threonine Cavities Are Targetable Motifs That Control Alpha-Synuclein Fibril Growth.
Topics: alpha-Synuclein; Humans; Lewy Body Disease; Mutation; Parkinson Disease; Threonine | 2022 |
Phosphorylation of Tau at Threonine 231 in Patients With Multiple System Atrophy and in a Mouse Model.
Topics: alpha-Synuclein; Animals; Antibodies; Epitopes; Humans; Immunohistochemistry; Mice; Multiple System Atrophy; Neuroglia; Phosphorylation; Threonine | 2022 |