thiourea has been researched along with trimethylsilyl-cyanide* in 3 studies
3 other study(ies) available for thiourea and trimethylsilyl-cyanide
| Article | Year |
|---|---|
Enantioselective synthesis of tertiary α-hydroxy phosphonates catalyzed by carbohydrate/cinchona alkaloid thiourea organocatalysts.
Topics: Carbohydrates; Catalysis; Cinchona Alkaloids; Cyanides; Organophosphonates; Stereoisomerism; Thiourea; Trimethylsilyl Compounds | 2012 |
Cooperative thiourea-Brønsted acid organocatalysis: enantioselective cyanosilylation of aldehydes with TMSCN.
We report a new thiourea-Brønsted acid cooperative catalytic system for the enantioselective cyanosilylation of aldehydes with yields up to 90% and enantioselectivities up to 88%. The addition of an achiral acid was found to be crucial for high asymmetric induction. Mechanistic investigations using a combination of NMR, ESI-MS, and density functional theory computations (including solvent corrections) at the M06/6-31G(d,p) level of theory suggest that the key catalytic species results from the cooperative interaction of bifunctional thioureas and an achiral acid that form well-defined chiral hydrogen-bonding environments. Topics: Acids; Aldehydes; Catalysis; Cyanides; Molecular Structure; Nitriles; Stereoisomerism; Thiourea; Trimethylsilyl Compounds | 2011 |
Thiourea-catalyzed enantioselective cyanosilylation of ketones.
The new chiral amino thiourea catalyst 3d promotes the highly enantioselective cyanosilylation of a wide variety of ketones. The hindered tertiary amine substituent plays a crucial role with regard to both stereoinduction and reactivity, suggesting a cooperative mechanism involving electrophile activation by thiourea and nucleophile activation by the amine. Topics: Catalysis; Cyanides; Ketones; Molecular Conformation; Stereoisomerism; Thiourea; Trimethylsilyl Compounds | 2005 |