thiourea and sulforaphane

thiourea has been researched along with sulforaphane* in 2 studies

Other Studies

2 other study(ies) available for thiourea and sulforaphane

Article	Year
Design and synthesis of novel iminothiazinylbutadienols and divinylpyrimidinethiones as ARE inducers. Bioorganic & medicinal chemistry letters, 2014, Feb-01, Volume: 24, Issue:3 Novel iminothiazinylbutadienols and divinylpyrimidinethiones were designed and synthesized as analogues of curcumin with its diketone moiety masked as a heterocyclic adduct with thiourea. The chemical stability of these novel heterocyclic compounds was improved as compared to curcumin. They exhibit longer half-lives and do not react with nucleophilic thiols under physiological conditions. In an ARE-luciferase reporter assay, some of these new curcumin analogues are more effective ARE activators than curcumin and isothiocyanates. Topics: Antioxidant Response Elements; Curcumin; Drug Design; Isothiocyanates; Molecular Structure; Pyrimidines; Structure-Activity Relationship; Sulfoxides; Thiadiazines; Thiones; Thiourea	2014
Myrosinase hydrolysates of Brassica oleraceae L. var. italica reduce the risk of colon cancer. Phytotherapy research : PTR, 2012, Volume: 26, Issue:5 By means of liquid chromatography-electrospray ionization (LC-ESI) mass spectrometry two glucosinolates, glucoiberin and 3-hydroxy,4(α-L-rhamnopyranosyloxy) benzyl glucosinolate, were identified in the aqueous extract of Brassica oleraceae L var. italica. Further, two compounds were isolated after enzymatic hydrolysis of the aqueous extract by myrosinase, one of them was identified as 4-vinyl-3-pyrazolidinone. The second compound (sulphoraphane) 1-isothiocyanate-4-methyl-sulphinyl butane, converted to the most stable form of thiourea (sulphoraphane thiourea). The crude extract (80% alcohol extract) of broccoli florets was examined for cytotoxic activity against different human cancer cell lines, it showed good inhibition of colon cancer (IC(50) 3.88 µg/mL). On the other hand each of the successive extracts (petroleum ether, chloroform, ethyl acetate and ethanol) showed no significant cytotoxic activity. When myrosinase hydrolysate was tested for cytotoxic activity on the colon cancer cell line it showed very high activity - 95% lethality up to 0.78 µg/mL. Topics: Antineoplastic Agents; Brassica; Cell Line, Tumor; Cell Survival; Chromatography, Liquid; Colonic Neoplasms; Flowers; Glucosinolates; Glycoside Hydrolases; Humans; Hydrolysis; Inhibitory Concentration 50; Isothiocyanates; Plant Extracts; Pyrazolones; Spectrometry, Mass, Electrospray Ionization; Sulfoxides; Thiourea	2012

Article

Year

Design and synthesis of novel iminothiazinylbutadienols and divinylpyrimidinethiones as ARE inducers.

Bioorganic & medicinal chemistry letters, 2014, Feb-01, Volume: 24, Issue:3

Novel iminothiazinylbutadienols and divinylpyrimidinethiones were designed and synthesized as analogues of curcumin with its diketone moiety masked as a heterocyclic adduct with thiourea. The chemical stability of these novel heterocyclic compounds was improved as compared to curcumin. They exhibit longer half-lives and do not react with nucleophilic thiols under physiological conditions. In an ARE-luciferase reporter assay, some of these new curcumin analogues are more effective ARE activators than curcumin and isothiocyanates.

Topics: Antioxidant Response Elements; Curcumin; Drug Design; Isothiocyanates; Molecular Structure; Pyrimidines; Structure-Activity Relationship; Sulfoxides; Thiadiazines; Thiones; Thiourea

2014

Myrosinase hydrolysates of Brassica oleraceae L. var. italica reduce the risk of colon cancer.

Phytotherapy research : PTR, 2012, Volume: 26, Issue:5

By means of liquid chromatography-electrospray ionization (LC-ESI) mass spectrometry two glucosinolates, glucoiberin and 3-hydroxy,4(α-L-rhamnopyranosyloxy) benzyl glucosinolate, were identified in the aqueous extract of Brassica oleraceae L var. italica. Further, two compounds were isolated after enzymatic hydrolysis of the aqueous extract by myrosinase, one of them was identified as 4-vinyl-3-pyrazolidinone. The second compound (sulphoraphane) 1-isothiocyanate-4-methyl-sulphinyl butane, converted to the most stable form of thiourea (sulphoraphane thiourea). The crude extract (80% alcohol extract) of broccoli florets was examined for cytotoxic activity against different human cancer cell lines, it showed good inhibition of colon cancer (IC(50) 3.88 µg/mL). On the other hand each of the successive extracts (petroleum ether, chloroform, ethyl acetate and ethanol) showed no significant cytotoxic activity. When myrosinase hydrolysate was tested for cytotoxic activity on the colon cancer cell line it showed very high activity - 95% lethality up to 0.78 µg/mL.

Topics: Antineoplastic Agents; Brassica; Cell Line, Tumor; Cell Survival; Chromatography, Liquid; Colonic Neoplasms; Flowers; Glucosinolates; Glycoside Hydrolases; Humans; Hydrolysis; Inhibitory Concentration 50; Isothiocyanates; Plant Extracts; Pyrazolones; Spectrometry, Mass, Electrospray Ionization; Sulfoxides; Thiourea

2012