thiourea has been researched along with phosphine* in 4 studies
4 other study(ies) available for thiourea and phosphine
| Article | Year |
|---|---|
Synthesis of Chiral β-Amino Nitroalkanes via Rhodium-Catalyzed Asymmetric Hydrogenation.
The asymmetric hydrogenation of β-amino nitroolefins has been successfully achieved by rhodium/bis(phosphine)-thiourea L1 with excellent enantioselectivities and yields (up to 96% ee, 96% yield, >99% conversion, TON up to 1000) under mild conditions. Chiral β-amino nitroalkane products and their derivatives are versatile intermediates in organic synthesis. Topics: Alkanes; Catalysis; Hydrogenation; Molecular Structure; Nitro Compounds; Phosphines; Rhodium; Stereoisomerism; Thiourea | 2016 |
Catalyst-free synthesis of α
A highly efficient phospha-aldol reaction for the synthesis of α Topics: Aldehydes; Catalysis; Indoles; Isatin; Organophosphonates; Oxindoles; Phosphines; Thiourea | 2016 |
Phospha-Michael addition reaction of maleimides employing N-heterocyclic phosphine-thiourea as a phosphonylation reagent: synthesis of 1-aryl-2,5-dioxopyrrolidine-3-yl-phosphonate derivatives.
N-Heterocyclic phosphine (NHP)-thiourea as a novel phosphonylation reagent has been successfully applied for the phospha-Michael reaction of maleimides under catalyst and additive free reaction conditions. This methodology enables desymmetrization of a variety of maleimide derivatives to provide 1-aryl-2,5-dioxopyrrolidine-3-yl-phosphonates in up to 92% yield. Synthetic manipulation of this Michael adduct afforded an ethylphosphonate and a phosphino lactam. Furthermore, a scale-up experiment for its practical usage as a versatile precursor in organic synthesis was readily demonstrated. Topics: Chemistry Techniques, Synthetic; Indicators and Reagents; Maleimides; Organophosphonates; Phosphines; Pyrrolidines; Stereoisomerism; Thiourea | 2016 |
Enantioselective Morita-Baylis-Hillman reaction promoted by L-threonine-derived phosphine-thiourea catalysts.
A series of bifunctional phosphine-thiourea organic catalysts based on natural amino acid scaffolds were designed and prepared. L-threonine-derived bifunctional phosphine catalysts were found to be very efficient in promoting asymmetric Morita-Baylis-Hillman (MBH) reaction of acrylates with aromatic aldehydes, affording the desired MBH adducts with up to 90% ee. To gain mechanistic insights into the reaction, the effects of adding various additives on the MBH reaction were investigated. We propose that the hydrogen bonding interactions between the thiourea moiety of the catalyst and the enolate intermediate are crucial for the stereochemical outcome of the reaction. The method described in this report may provide a practical solution to the enantioselective MBH reaction of simple acrylates. Topics: Acrylates; Aldehydes; Catalysis; Hydrogen Bonding; Molecular Structure; Phosphines; Stereoisomerism; Thiourea; Threonine | 2011 |