thiourea has been researched along with palladium-chloride* in 1 studies
1 other study(ies) available for thiourea and palladium-chloride
| Article | Year |
|---|---|
Multifaceted Study on a Cytochalasin Scaffold: Lessons on Reactivity, Multidentate Catalysis, and Anticancer Properties.
An intramolecular Diels-Alder (IMDA) reaction efficiently accelerated by Schreiner's thiourea is reported, to build a functionalized cytochalasin scaffold (periconiasin series) for biological purposes. DFT calculation highlighted a unique multidentate cooperative hydrogen bonding in this catalysis. The deprotection end game afforded a collection of diverse structures and showed the peculiar reactivity of the Diels-Alder cycloadducts upon functionalization. Biological studies revealed strong cytotoxicity of a few compounds on breast cancer cell lines while actin polymerization is preserved. Topics: Actin Cytoskeleton; Antineoplastic Agents; Catalysis; Cell Line, Tumor; Cell Survival; Copper; Crystallography, X-Ray; Cycloaddition Reaction; Cytochalasins; Humans; Hydrogen Bonding; Molecular Conformation; Palladium; Stereoisomerism; Thermodynamics; Thiourea | 2018 |