thiourea and maleimide

thiourea has been researched along with maleimide* in 1 studies

Other Studies

1 other study(ies) available for thiourea and maleimide

Article	Year
Search for inhibitors of bacterial and human protein kinases among derivatives of diazepines[1,4] annelated with maleimide and indole cycles. Journal of medicinal chemistry, 2008, Dec-25, Volume: 51, Issue:24 Aminomethylation of 9b,10-dihydro-1H-indolo[1,7:4,5,6]pyrrolo[3,4:2,3][1,4]diazepino-[1,7-a]indole-1,3(2H)-diones or 1H-indolo[1,7:4,5,6]pyrrolo[3,4:2,3][1,4]diazepino[1,7-a]indole-1,3(2H)-diones resulted in dialkylaminomethyl derivatives. Alkylation of the nitrogen atom of maleimide moiety of polyannelated diazepines with 1,3-dibromopropane and subsequent reaction with thiourea or its N-alkyl derivatives gave isothiourea-carrying compounds. The compounds containing isothiourea moiety were active against individual human serine/threonine and tyrosine kinases at low micromolar concentrations. Dialkylaminomethyl derivatives of diazepines sensitized Streptomyces lividans with overexpressed aminoglycoside phosphotransferase type VIII (aphVIII) to kanamycin by inhibiting serine/threonine kinase(s) mediated aphVIII phosphorylation. Topics: Chemistry, Pharmaceutical; Humans; Indoles; Inhibitory Concentration 50; Maleimides; Models, Chemical; Molecular Conformation; Phosphorylation; Protein Kinase Inhibitors; Protein Kinases; Recombinant Proteins; Serine; Streptomyces lividans; Thiourea; Threonine	2008

Article

Year

Search for inhibitors of bacterial and human protein kinases among derivatives of diazepines[1,4] annelated with maleimide and indole cycles.

Journal of medicinal chemistry, 2008, Dec-25, Volume: 51, Issue:24

Aminomethylation of 9b,10-dihydro-1H-indolo[1,7:4,5,6]pyrrolo[3,4:2,3][1,4]diazepino-[1,7-a]indole-1,3(2H)-diones or 1H-indolo[1,7:4,5,6]pyrrolo[3,4:2,3][1,4]diazepino[1,7-a]indole-1,3(2H)-diones resulted in dialkylaminomethyl derivatives. Alkylation of the nitrogen atom of maleimide moiety of polyannelated diazepines with 1,3-dibromopropane and subsequent reaction with thiourea or its N-alkyl derivatives gave isothiourea-carrying compounds. The compounds containing isothiourea moiety were active against individual human serine/threonine and tyrosine kinases at low micromolar concentrations. Dialkylaminomethyl derivatives of diazepines sensitized Streptomyces lividans with overexpressed aminoglycoside phosphotransferase type VIII (aphVIII) to kanamycin by inhibiting serine/threonine kinase(s) mediated aphVIII phosphorylation.

Topics: Chemistry, Pharmaceutical; Humans; Indoles; Inhibitory Concentration 50; Maleimides; Models, Chemical; Molecular Conformation; Phosphorylation; Protein Kinase Inhibitors; Protein Kinases; Recombinant Proteins; Serine; Streptomyces lividans; Thiourea; Threonine

2008