thiourea and indan

thiourea has been researched along with indan* in 1 studies

Other Studies

1 other study(ies) available for thiourea and indan

Article	Year
Conformationally constrained analogues of N'-(4-tert-butylbenzyl)-N-(4-methylsulfonylaminobenzyl)thiourea as TRPV1 antagonists. European journal of medicinal chemistry, 2009, Volume: 44, Issue:1 A series of bicyclic analogues having indan and tetrahydronaphthalene templates in the A-region were designed as conformationally constrained analogues of our previously reported potent TRPV1 antagonists (1, 3). The activities for rat TRPV1 of the conformationally restricted analogues were moderately or markedly diminished, particularly in the case of the tetrahydronaphthalene analogues. The analysis indicated that steric constraints at the benzylic position in the bicyclic analogues may be an important factor for their unfavorable interaction with the receptor. Topics: Animals; Bridged Bicyclo Compounds, Heterocyclic; Indans; Molecular Conformation; Naphthalenes; Rats; Structure-Activity Relationship; Thiourea; TRPV Cation Channels	2009

Article

Year

Conformationally constrained analogues of N'-(4-tert-butylbenzyl)-N-(4-methylsulfonylaminobenzyl)thiourea as TRPV1 antagonists.

European journal of medicinal chemistry, 2009, Volume: 44, Issue:1

A series of bicyclic analogues having indan and tetrahydronaphthalene templates in the A-region were designed as conformationally constrained analogues of our previously reported potent TRPV1 antagonists (1, 3). The activities for rat TRPV1 of the conformationally restricted analogues were moderately or markedly diminished, particularly in the case of the tetrahydronaphthalene analogues. The analysis indicated that steric constraints at the benzylic position in the bicyclic analogues may be an important factor for their unfavorable interaction with the receptor.

Topics: Animals; Bridged Bicyclo Compounds, Heterocyclic; Indans; Molecular Conformation; Naphthalenes; Rats; Structure-Activity Relationship; Thiourea; TRPV Cation Channels

2009