thiourea and hymexazol

thiourea has been researched along with hymexazol* in 1 studies

Other Studies

1 other study(ies) available for thiourea and hymexazol

Article	Year
Cinchona alkaloid derivative-catalyzed enantioselective synthesis via a Mannich-type reaction and antifungal activity of β-amino esters bearing benzoheterocycle moieties. Molecules (Basel, Switzerland), 2014, Apr-01, Volume: 19, Issue:4 An efficient synthesis of highly functionalized chiral β-amino ester derivatives containing benzothiophene and benzothiazole moieties is developed by a Mannich-type reaction using a cinchona alkaloid-derived thiourea catalyst. The desired products were obtained in good yields and high enantioselectivities (~86% yield, >99% ee) using to the optimized reaction conditions. The synthesized compounds were characterized by 1H-NMR, 13C-NMR, IR, and HREI-MS analyses. The bioassays identified that compound 5dr has excellent antifungal activity, with a 60.53% inhibition rate against F. oxysporum, higher than that of the commercial agricultural fungicide hymexazol, whose inhibition rate was 56.12%. Topics: Amino Acids; Antifungal Agents; Benzothiazoles; Catalysis; Cinchona Alkaloids; Esters; Fusarium; Microbial Sensitivity Tests; Oxazoles; Stereoisomerism; Structure-Activity Relationship; Thiophenes; Thiourea	2014

Article

Year

Cinchona alkaloid derivative-catalyzed enantioselective synthesis via a Mannich-type reaction and antifungal activity of β-amino esters bearing benzoheterocycle moieties.

Molecules (Basel, Switzerland), 2014, Apr-01, Volume: 19, Issue:4

An efficient synthesis of highly functionalized chiral β-amino ester derivatives containing benzothiophene and benzothiazole moieties is developed by a Mannich-type reaction using a cinchona alkaloid-derived thiourea catalyst. The desired products were obtained in good yields and high enantioselectivities (~86% yield, >99% ee) using to the optimized reaction conditions. The synthesized compounds were characterized by 1H-NMR, 13C-NMR, IR, and HREI-MS analyses. The bioassays identified that compound 5dr has excellent antifungal activity, with a 60.53% inhibition rate against F. oxysporum, higher than that of the commercial agricultural fungicide hymexazol, whose inhibition rate was 56.12%.

Topics: Amino Acids; Antifungal Agents; Benzothiazoles; Catalysis; Cinchona Alkaloids; Esters; Fusarium; Microbial Sensitivity Tests; Oxazoles; Stereoisomerism; Structure-Activity Relationship; Thiophenes; Thiourea

2014