thiourea has been researched along with guanidine-carboxamide* in 1 studies
1 other study(ies) available for thiourea and guanidine-carboxamide
| Article | Year |
|---|---|
Effect of linkage geometry on biological activity in thiourea- and guanidine-substituted acridines and platinum-acridines.
Novel thiourea- and guanidine-modified acridine-4-carboxamides (4, 7) and a corresponding platinum-intercalator conjugate (4') have been synthesized and evaluated as cytotoxic agents in human promyelocytic leukemia, HL-60, and a non-small cell lung cancer, NCI-H460. Modification of thiourea sulfur in derivative 4 with a DNA platinating moiety, giving 4', resulted in a pronounced cytotoxic enhancement, and the conjugate proved to be the most active of the newly synthesized compounds in NCI-H460 cells. Conjugate 4' represents a new chemotype with potential applications in the treatment of chemoresistant tumors. Topics: Acridines; Antineoplastic Agents; Cell Line, Tumor; Chemistry, Pharmaceutical; Drug Design; Drug Resistance, Neoplasm; Drug Screening Assays, Antitumor; Guanidine; HL-60 Cells; Humans; Inhibitory Concentration 50; Models, Chemical; Platinum; Structure-Activity Relationship; Thiourea; Urea | 2008 |