thiourea has been researched along with furan* in 2 studies
2 other study(ies) available for thiourea and furan
| Article | Year |
|---|---|
Heterocycle-linked phenylbenzyl amides as novel TRPV1 antagonists and their TRPV1 binding modes: constraint-induced enhancement of in vitro and in vivo activities.
A series of heterocycle-linked constrained phenylbenzyl amides were found to be TRPV1 antagonists with promising in vivo profiles. In particular, one of the analogues containing a furan linker exhibited excellent TRPV1 antagonistic activity and in vivo analgesic efficacy. In addition, the binding modes of dibenzyl thiourea, benzylphenethyl amide, and furan-linked phenylbenzyl amide were examined by using the flexible docking study within the rTRPV1 homology model. Topics: Amides; Analgesics; Animals; Binding Sites; Furans; Half-Life; Heterocyclic Compounds; Hyperalgesia; Male; Molecular Docking Simulation; Protein Structure, Tertiary; Rats; Rats, Sprague-Dawley; Recombinant Proteins; Thiourea; TRPV Cation Channels | 2013 |
Antiplasmodial activity of piperazine sulfonamides.
A high-throughput screening program identified two piperazine sulfonamides with activity against Plasmodium falciparum. Both screening positives had three structural features with potential liabilities: furanyl, thiourea and nitrophenyl groups. The furan could be replaced with no loss of activity, replacement of the nitrophenyl led to some loss of activity, and any attempt to replace the thiourea led to a significant decrease in activity, which implicates this reactive functional group's role in the antiplasmodial activity of this compound class. Topics: Antimalarials; Furans; High-Throughput Screening Assays; Piperazine; Piperazines; Plasmodium falciparum; Sulfonamides; Thiourea | 2010 |