thiourea has been researched along with frentizole* in 1 studies
1 other study(ies) available for thiourea and frentizole
| Article | Year |
|---|---|
Synthesis and evaluation of frentizole-based indolyl thiourea analogues as MAO/ABAD inhibitors for Alzheimer's disease treatment.
Alzheimer's disease (AD) is a neurodegenerative disorder associated with an excessive accumulation of amyloid-beta peptide (Aβ). Based on the multifactorial nature of AD, preparation of multi-target-directed ligands presents a viable option to address more pathological events at one time. A novel class of asymmetrical disubstituted indolyl thioureas have been designed and synthesized to interact with monoamine oxidase (MAO) and/or amyloid-binding alcohol dehydrogenase (ABAD). The design combines the features of known MAO inhibitors scaffolds (e.g. rasagiline or ladostigil) and a frentizole moiety with potential to interact with ABAD. Evaluation against MAO identified several compounds that inhibited in the low to moderate micromolar range. The most promising compound (19) inhibited human MAO-A and MAO-B with IC Topics: 3-Hydroxyacyl CoA Dehydrogenases; Alzheimer Disease; Benzothiazoles; Dose-Response Relationship, Drug; Enzyme Inhibitors; Humans; Molecular Structure; Monoamine Oxidase; Phenylurea Compounds; Structure-Activity Relationship; Thiourea | 2017 |