thiourea and castanospermine

thiourea has been researched along with castanospermine* in 1 studies

Other Studies

1 other study(ies) available for thiourea and castanospermine

Article	Year
Glycosidase inhibition by ring-modified castanospermine analogues: tackling enzyme selectivity by inhibitor tailoring. Organic & biomolecular chemistry, 2009, Jul-07, Volume: 7, Issue:13 Synthesis of a panel of iso(thio)urea-type ring-modified castanospermine analogues bearing a freely mutarotating pseudoanomeric hydroxyl group results in tight-binding beta-glucosidase inhibitors with unusual binding signatures; the presence of an N-octyl substituent imparts a remarkable anomeric selectivity, promoting strong binding of the appropriate beta-anomer by the beta-glucosidase. Topics: beta-Glucosidase; Enzyme Inhibitors; Indolizines; Models, Molecular; Molecular Conformation; Stereoisomerism; Structure-Activity Relationship; Thermodynamics; Thiourea	2009

Article

Year

Glycosidase inhibition by ring-modified castanospermine analogues: tackling enzyme selectivity by inhibitor tailoring.

Organic & biomolecular chemistry, 2009, Jul-07, Volume: 7, Issue:13

Synthesis of a panel of iso(thio)urea-type ring-modified castanospermine analogues bearing a freely mutarotating pseudoanomeric hydroxyl group results in tight-binding beta-glucosidase inhibitors with unusual binding signatures; the presence of an N-octyl substituent imparts a remarkable anomeric selectivity, promoting strong binding of the appropriate beta-anomer by the beta-glucosidase.

Topics: beta-Glucosidase; Enzyme Inhibitors; Indolizines; Models, Molecular; Molecular Conformation; Stereoisomerism; Structure-Activity Relationship; Thermodynamics; Thiourea

2009