thiourea has been researched along with benzimidazole* in 3 studies
1 review(s) available for thiourea and benzimidazole
| Article | Year |
|---|---|
Heterocyclic compounds as inflammation inhibitors.
Clinical use of non-steroidal anti-inflammatory drugs (NSAIDs) is associated with significant toxicity particularly in the gastrointestinal tract and kidney. Various approaches such as formulation co-administration (of agents to protect the stomach), chemical manipulation and synthesis of new safer anti-inflammatory drugs reported in the literature to overcome the toxicity of NSAIDs have been summarized. As far as synthesis of new more effective and safer anti-inflammatory drugs is concerned, we have reported recent findings in the area of synthesis of heterocyclic compounds such as pyrimidines, imidazole, benzimidazole, thiazole, thiazolidine, acridine, thiourea, alkanoic acid derivatives and other related heterocyclic compounds and their role as inflammation inhibitors. Topics: Acridines; Alkanes; Animals; Anti-Inflammatory Agents, Non-Steroidal; Benzimidazoles; Carboxylic Acids; Gastrointestinal Diseases; Heterocyclic Compounds; Humans; Imidazoles; Pyrimidines; Thiazoles; Thiourea | 2002 |
2 other study(ies) available for thiourea and benzimidazole
| Article | Year |
|---|---|
Synthesis, molecular docking studies of hybrid benzimidazole as α-glucosidase inhibitor.
Thiourea derivatives having benzimidazole 1-17 have been synthesized, characterized by Topics: Benzimidazoles; Glycoside Hydrolase Inhibitors; Molecular Docking Simulation; Saccharomyces cerevisiae; Thiourea | 2017 |
Synthesis of novel benzimidazole functionalized chiral thioureas and evaluation of their antibacterial and anticancer activities.
A small library of benzimidazole functionalized chiral thioureas was prepared starting from natural amino acids (S)-alanine, (S)-phenylalanine, (S)-valine and (S)-leucine and also their (R)-isomers and studied their antimicrobial activity against a various Gram-positive and Gram-negative bacterial strains. In this study, compounds 5g and 5j were found to exhibit good antibacterial activity against both Gram-positive and Gram-negative bacterial strains such as Staphylococcus aureus, Bacillus subtilis, Micrococcus luteus, Klebsiella planticola, Escherichia coli and Pseudomonas aeruginosa. In the cytotoxicity study, thioureas derived from non-natural amino acids 5a-l showed good activity against human cancer cell lines A549, MCF7, DU145, HeLa, and no cytotoxicity was observed with their antipodes 6a-l. Topics: Anti-Bacterial Agents; Antineoplastic Agents; Benzimidazoles; Cell Line, Tumor; Cell Proliferation; Dose-Response Relationship, Drug; Drug Screening Assays, Antitumor; Gram-Negative Bacteria; Gram-Positive Bacteria; HeLa Cells; Humans; MCF-7 Cells; Microbial Sensitivity Tests; Molecular Structure; Structure-Activity Relationship; Thiourea | 2014 |