thiourea has been researched along with 4-aminoquinoline* in 1 studies
1 other study(ies) available for thiourea and 4-aminoquinoline
| Article | Year |
|---|---|
Synthesis of novel thiourea, thiazolidinedione and thioparabanic acid derivatives of 4-aminoquinoline as potent antimalarials.
In search of new 4-aminoquinolines which are not recognized by CQR mechanism, thiourea, thiazolidinedione and thioparabanic acid derivatives of 4-aminoquinoline were synthesized and screened for their antimalarial activities. Thiourea derivative 3 found to be the most active against CQ sensitive strain 3D7 of Plasmodium falciparum in an in vitro model with an IC(50) of 6.07ng/mL and also showed an in vivo suppression of 99.27% on day 4 against CQ resistant strain N-67 of Plasmodium yoelii. Topics: Aminoquinolines; Animals; Antimalarials; Chemistry, Pharmaceutical; Chlorocebus aethiops; Chloroquine; Drug Design; Drug Resistance; Humans; Inhibitory Concentration 50; Plasmodium falciparum; Plasmodium yoelii; Thiazolidinediones; Thiourea; Vero Cells | 2009 |