thiouracil and willardiine

thiouracil has been researched along with willardiine* in 1 studies

Other Studies

1 other study(ies) available for thiouracil and willardiine

ArticleYear
Biosynthesis of willardiine and isowillardiine in germinating pea seeds and seedlings.
    The Biochemical journal, 1972, Volume: 129, Issue:4

    The synthesis of the pyrimidinyl amino acids willardiine and isowillardiine was studied in vivo and in vitro. Uracil derivatives stimulate the biosynthesis of both compounds; the free base is the most effective. Significant incorporation of [2-(14)C]uracil and [6-(14)C]orotate into willardiine and isowillardiine was found. Incorporation of [6-(14)C]orotate was substantially decreased in the presence of uracil, and to a lesser extent by uridine and UMP. [3-(14)C]Serine was incorporated into the alanine side chain of the two uracilylalanines but not into the ring. The effect of a number of uracil analogues and inhibitors of pyrimidine metabolism was examined. Some were shown to stimulate the biosynthesis; the most noticeable effects were obtained with 6-azauracil and 2-thiouracil. Attempts to obtain extracts capable of synthesizing the uracilylalanines from uracil and serine were unsuccessful, but weak activity was observed when serine was replaced by O-acetylserine.

    Topics: Alanine; Carbon Isotopes; Chromatography, Ion Exchange; Light; Orotic Acid; Pyrimidinones; Seeds; Structure-Activity Relationship; Thiouracil; Uracil

1972